Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Mu opioid receptor | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Delta opioid receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Mu opioid receptor | 398 aa | 397 aa | 22.7 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Delta opioid receptor | 372 aa | 330 aa | 24.5 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 353 aa | 21.0 % | |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 344 aa | 22.1 % | |
Schistosoma japonicum | Rhodopsin, putative | Mu opioid receptor | 398 aa | 328 aa | 23.2 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Delta opioid receptor | 372 aa | 330 aa | 24.2 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Delta opioid receptor | 372 aa | 320 aa | 25.6 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Delta opioid receptor | 372 aa | 353 aa | 29.2 % |
Schistosoma mansoni | neuropeptide F-like receptor | Mu opioid receptor | 398 aa | 335 aa | 20.6 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 316 aa | 26.9 % | |
Echinococcus granulosus | allatostatin A receptor | Delta opioid receptor | 372 aa | 302 aa | 27.8 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 386 aa | 22.8 % | |
Brugia malayi | ORL1-like opioid receptor | Delta opioid receptor | 372 aa | 300 aa | 24.7 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Delta opioid receptor | 372 aa | 315 aa | 28.6 % |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | Delta opioid receptor | 372 aa | 366 aa | 22.7 % |
Onchocerca volvulus | Programmed cell death protein 5 homolog | Mu opioid receptor | 398 aa | 323 aa | 24.1 % |
Loa Loa (eye worm) | neuropeptide F receptor | Delta opioid receptor | 372 aa | 317 aa | 23.3 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Mu opioid receptor | 398 aa | 334 aa | 23.1 % |
Brugia malayi | GnHR receptor homolog | Delta opioid receptor | 372 aa | 313 aa | 18.5 % |
Echinococcus multilocularis | allatostatin A receptor | Delta opioid receptor | 372 aa | 302 aa | 28.5 % |
Onchocerca volvulus | Delta opioid receptor | 372 aa | 349 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0762 | 0.2522 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0762 | 0.2522 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0762 | 0.2522 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0762 | 0.2522 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0762 | 0.2522 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0634 | 0.1688 | 0.1688 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0762 | 0.2522 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0762 | 0.2522 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0762 | 0.2522 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 0.1688 | 0.1688 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0762 | 0.2522 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 16 nM | Displacement of [3H]diprenorphine from rat MOR expressed in rat C6 cells after 1 hr by liquid scintillation counting analysis | ChEMBL. | 23419026 |
Ki (binding) | = 120 nM | Displacement of [3H]diprenorphine from rat DOR expressed in rat C6 cells after 1 hr by liquid scintillation counting analysis | ChEMBL. | 23419026 |
Ki (binding) | = 1200 nM | Displacement of [3H]diprenorphine from human KOR expressed in CHO cells after 1 hr by liquid scintillation counting analysis | ChEMBL. | 23419026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.