Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | DNA gyrase subunit B | 0.0317 | 0.1595 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.1241 | 0.785 | 0.7443 |
Schistosoma mansoni | heat shock protein | 0.0638 | 0.377 | 0.377 |
Trichomonas vaginalis | heat shock protein, putative | 0.1241 | 0.785 | 0.7443 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0317 | 0.1595 | 0.1595 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0638 | 0.377 | 0.2588 |
Plasmodium vivax | heat shock protein 90, putative | 0.0638 | 0.377 | 0.2588 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.1241 | 0.785 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0317 | 0.1595 | 0.1595 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0638 | 0.377 | 0.2588 |
Leishmania major | heat shock protein, putative | 0.0638 | 0.377 | 0.2588 |
Trichomonas vaginalis | heat shock protein, putative | 0.1241 | 0.785 | 0.7443 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0317 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.1595 | 0.1595 |
Echinococcus multilocularis | heat shock protein 75 kDa, mitochondrial | 0.0638 | 0.377 | 0.377 |
Mycobacterium ulcerans | heat shock protein 90 | 0.1241 | 0.785 | 1 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.1241 | 0.785 | 0.785 |
Trichomonas vaginalis | heat shock protein, putative | 0.0956 | 0.592 | 0.5145 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.092 | 0.5675 | 0.4855 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.1241 | 0.785 | 1 |
Brugia malayi | Hsp90 protein | 0.0638 | 0.377 | 0.377 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0317 | 0.1595 | 0.1595 |
Brugia malayi | kinase, mitochondrial precursor | 0.0317 | 0.1595 | 0.1595 |
Treponema pallidum | heat shock protein 90 | 0.1241 | 0.785 | 1 |
Toxoplasma gondii | heat shock protein 75, putative | 0.0638 | 0.377 | 0.2588 |
Echinococcus multilocularis | heat shock protein 90 | 0.1241 | 0.785 | 0.785 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0317 | 0.1595 | 0.5 |
Plasmodium falciparum | endoplasmin, putative | 0.0956 | 0.592 | 0.5145 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0638 | 0.377 | 1 |
Echinococcus multilocularis | endoplasmin | 0.1241 | 0.785 | 0.785 |
Echinococcus granulosus | endoplasmin | 0.1241 | 0.785 | 0.785 |
Trichomonas vaginalis | heat shock protein, putative | 0.0638 | 0.377 | 0.2588 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0317 | 0.1595 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0317 | 0.1595 | 0.1595 |
Echinococcus granulosus | heat shock protein 75 kDa mitochondrial | 0.0638 | 0.377 | 0.377 |
Plasmodium vivax | heat shock protein, putative | 0.0638 | 0.377 | 0.2588 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0317 | 0.1595 | 0.1595 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0638 | 0.377 | 0.2588 |
Trypanosoma cruzi | heat shock protein, putative | 0.0638 | 0.377 | 0.2588 |
Trypanosoma brucei | heat shock protein 84, putative | 0.0638 | 0.377 | 0.2588 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.1241 | 0.785 | 0.7443 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.1595 | 0.1595 |
Giardia lamblia | Grp94/Hsp90 | 0.1241 | 0.785 | 0.7443 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.1241 | 0.785 | 0.7443 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0317 | 0.1595 | 0.1595 |
Brugia malayi | Probable DNA topoisomerase II | 0.0317 | 0.1595 | 0.1595 |
Echinococcus granulosus | heat shock protein 90 | 0.1241 | 0.785 | 0.785 |
Trichomonas vaginalis | endoplasmin, putative | 0.0956 | 0.592 | 0.5145 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.1241 | 0.785 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0317 | 0.1595 | 0.1595 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0317 | 0.1595 | 0.1595 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.1241 | 0.785 | 0.7443 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.1241 | 0.785 | 0.7443 |
Entamoeba histolytica | 90 kDa heat shock protein, putative | 0.0638 | 0.377 | 0.2588 |
Loa Loa (eye worm) | heat shock protein 75 | 0.0638 | 0.377 | 0.377 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0317 | 0.1595 | 0.1595 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0317 | 0.1595 | 0.1595 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 530 nM | Inhibition of AChE in Sprague-Dawley rat cortices using acetylthiocholine iodide as substrate by Ellman's method | ChEMBL. | 23273608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.