Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 7 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, nicotinic, alpha 4 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, nicotinic, beta 2 (neuronal) | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cation transporter family protein | cholinergic receptor, nicotinic, beta 2 (neuronal) | 502 aa | 482 aa | 32.4 % |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | cholinergic receptor, nicotinic, alpha 7 (neuronal) | 502 aa | 513 aa | 33.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.1384 | 0.0846 | 1 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.0492 | 0.0142 | 0.0142 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.3633 | 0.2622 | 1 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.3633 | 0.2622 | 1 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.1384 | 0.0846 | 0.0714 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1384 | 0.0846 | 0.3226 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.0492 | 0.0142 | 0.1676 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.1384 | 0.0846 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.1384 | 0.0846 | 0.0714 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.2629 | 0.1829 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.2629 | 0.1829 | 1 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.1384 | 0.0846 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1384 | 0.0846 | 0.0846 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1384 | 0.0846 | 0.0846 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.0492 | 0.0142 | 0.0541 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1384 | 0.0846 | 0.5531 |
Loa Loa (eye worm) | hypothetical protein | 1.2973 | 1 | 1 |
Toxoplasma gondii | acyl-CoA carboxyltransferase beta chain, putative | 0.0492 | 0.0142 | 0.0541 |
Echinococcus granulosus | peroxidasin | 0.0701 | 0.0307 | 0.0168 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.3506 | 0.2522 | 0.2285 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.5261 | 0.3908 | 0.3908 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.2249 | 0.1529 | 1 |
Schistosoma mansoni | peroxidasin | 0.0701 | 0.0307 | 0.0307 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.0492 | 0.0142 | 0.1676 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.0492 | 0.0142 | 0.1676 |
Leishmania major | carboxylase, putative | 0.1384 | 0.0846 | 0.3226 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.0492 | 0.0142 | 0.1676 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0927 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.3633 | 0.2622 | 1 |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.0492 | 0.0142 | 0.1676 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0541 |
Echinococcus multilocularis | peroxidasin | 0.0701 | 0.0307 | 0.0168 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1384 | 0.0846 | 0.5531 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0927 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.1384 | 0.0846 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.3633 | 0.2622 | 0.2622 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.062 | 0.0242 | 0.5 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.3633 | 0.2622 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.7713 | 0.5845 | 0.5845 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.1384 | 0.0846 | 1 |
Schistosoma mansoni | peroxidasin | 0.0701 | 0.0307 | 0.0307 |
Schistosoma mansoni | pyruvate carboxylase | 0.1384 | 0.0846 | 0.0846 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.3506 | 0.2522 | 0.2285 |
Chlamydia trachomatis | biotin carboxylase | 0.1257 | 0.0745 | 1 |
Onchocerca volvulus | 1.2973 | 1 | 1 | |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.1384 | 0.0846 | 0.3226 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1384 | 0.0846 | 0.3226 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.1384 | 0.0846 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl-CoA carboxylase, carboxyltransferase component | 0.0492 | 0.0142 | 0.1676 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.0492 | 0.0142 | 0.0927 |
Toxoplasma gondii | pyruvate carboxylase | 0.1384 | 0.0846 | 0.3226 |
Trypanosoma brucei | unspecified product | 0.091 | 0.0471 | 0.1798 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.1384 | 0.0846 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.1384 | 0.0846 | 1 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.3633 | 0.2622 | 0.2516 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.062 | 0.0242 | 0.5 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.3633 | 0.2622 | 0.2516 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.0492 | 0.0142 | 0.1676 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 1.2973 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0541 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | nM | Binding affinity at homopentameric Nicotinic acetylcholine receptor alpha7 subtype using [3H]-S-(-)-nicotine as radioligand; Not determined | ChEMBL. | 10447950 |
Ki (binding) | 0 nM | Binding affinity at homopentameric Nicotinic acetylcholine receptor alpha7 subtype using [3H]-S-(-)-nicotine as radioligand; Not determined | ChEMBL. | 10447950 |
Ki (binding) | = 1 nM | Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-beta2 subtype using [3H]-bungarotoxin as radioligand | ChEMBL. | 10447950 |
Ki (binding) | = 1 nM | Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-beta2 subtype using [3H]-bungarotoxin as radioligand | ChEMBL. | 10447950 |
Ki (binding) | = 2.9 nM | Displacement of [3H]nicotine human alpha4beta2 nAChR in SH-EP1 cell membranes | ChEMBL. | 23126648 |
Ki (binding) | = 40 nM | Displacement of [3H]epibatidine form human alpha7 nAchR expressed in HEK293 cells | ChEMBL. | 23126648 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.