TDR Targets

Basic information

Technical information

TDR Targets ID: 172725
Name: (4-methoxyphenyl)-[2-methyl-1-[2-(4-methylmor pholin-4-ium-4-yl)ethyl]indol-3-yl]methanone
MW: 393.499 | Formula: C24H29N2O3+
H donors: 0 H acceptors: 1 LogP: 3.33 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C(=O)c1c(C)n(c2c1cccc2)CC[N+]1(C)CCOCC1
InChi: 1S/C24H29N2O3/c1-18-23(24(27)19-8-10-20(28-3)11-9-19)21-6-4-5-7-22(21)25(18)12-13-26(2)14-16-29-17-15-26/h4-11H,12-17H2,1-3H3/q+1
InChiKey: XNGGKKVXOPZGNV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4-methoxyphenyl)-[2-methyl-1-[2-(4-methyl-4-morpholin-4-iumyl)ethyl]-3-indolyl]methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0112	0.1282	0.1282
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0047	0.0417	0.0417
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0394	0.5027	0.5027
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0047	0.0417	0.0417
Loa Loa (eye worm)	LGC-31 protein	0.0112	0.1282	0.1282
Onchocerca volvulus		0.0294	0.3699	0.3425
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Onchocerca volvulus		0.0273	0.3426	0.314
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0273	0.3426	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.066	0.066
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0387	0.0387
Echinococcus multilocularis	glycine receptor subunit beta	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0112	0.1282	0.1282
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0112	0.1282	0.1282
Schistosoma mansoni	nAChR subunit	0.0047	0.0417	0.0417
Schistosoma mansoni	acetylcholine receptor-related	0.0047	0.0417	0.0417
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0065	0.066	0.066
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0347	0.4405	0.4405
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0122	0.0122
Echinococcus multilocularis	nAChR subunit	0.0112	0.1282	0.1282
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0065	0.066	0.066
Brugia malayi	hypothetical protein	0.0025	0.0122	0.0122
Brugia malayi	YY1-associated factor 2	0.0273	0.3426	0.3426
Loa Loa (eye worm)	pax transcription factor protein 2	0.0234	0.2904	0.2904
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0769	1	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0112	0.1282	0.1282
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0065	0.066	0.066
Echinococcus granulosus	fatty acid binding protein FABP2	0.0042	0.0349	0.0349
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0112	0.1282	0.1282
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0112	0.1282	0.1282
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0273	0.3426	0.3426
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0047	0.0417	0.0417
Chlamydia trachomatis	DNA topoisomerase I	0.0769	1	0.5
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0047	0.0417	0.0417
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0273	0.3426	0.3426
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Echinococcus multilocularis	zinc finger protein Ran binding	0.0273	0.3426	0.3426
Trypanosoma cruzi	hypothetical protein, conserved	0.0273	0.3426	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.0769	1	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0769	1	1
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0047	0.0417	0.0417
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0273	0.3426	0.3426
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0122	0.0122
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0387	0.0387
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0065	0.066	0.066
Trypanosoma cruzi	hypothetical protein, conserved	0.0273	0.3426	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0394	0.5027	0.5027
Chlamydia trachomatis	SWIB complex protein	0.0769	1	0.5
Brugia malayi	brahma associated protein 60 kDa	0.0769	1	1
Schistosoma mansoni	fatty acid binding protein	0.0042	0.0349	0.0349
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0112	0.1282	0.1282
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0047	0.0417	0.0417
Onchocerca volvulus		0.0394	0.5027	0.481
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0273	0.3426	0.3426
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Schistosoma mansoni	neurotransmitter gated ion channel	0.0047	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0273	0.3426	0.3426
Echinococcus multilocularis	ring and YY1 binding protein	0.0273	0.3426	0.3426
Trypanosoma cruzi	hypothetical protein, conserved	0.0273	0.3426	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.066	0.066
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.1282	0.1282
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0112	0.1282	0.1282
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0273	0.3426	1
Trypanosoma brucei	hypothetical protein, conserved	0.0273	0.3426	1
Echinococcus granulosus	ring and YY1 binding protein	0.0273	0.3426	0.3426
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3426	0.3426
Brugia malayi	hypothetical protein	0.0047	0.0417	0.0417
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0112	0.1282	0.1282
Onchocerca volvulus		0.0394	0.5027	0.481
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0273	0.3426	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0122	0.0355
Onchocerca volvulus	Putative nachr subunit	0.0112	0.1282	0.0902
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0273	0.3426	0.3426
Schistosoma mansoni	hypothetical protein	0.0273	0.3426	0.3426
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Plasmodium vivax	hypothetical protein, conserved	0.0769	1	1
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0047	0.0417	0.0417
Loa Loa (eye worm)	ACC-1 protein	0.0112	0.1282	0.1282
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.1282	0.1282
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0112	0.1282	0.1282
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0769	1	1
Schistosoma mansoni	hypothetical protein	0.0769	1	1
Onchocerca volvulus		0.0273	0.3426	0.314
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0112	0.1282	0.1282
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0387	0.0387
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Onchocerca volvulus		0.0112	0.1282	0.0902
Schistosoma mansoni	nAChR subunit	0.0112	0.1282	0.1282
Echinococcus multilocularis	SWI:SNF matrix associated	0.0769	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0122	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3426	0.3426
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0273	0.3426	1
Echinococcus granulosus	nAChR subunit	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Trichomonas vaginalis	conserved hypothetical protein	0.0769	1	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.1282	0.1282
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0387	0.0387
Loa Loa (eye worm)	acetylcholine receptor protein	0.0047	0.0417	0.0417
Leishmania major	hypothetical protein, conserved	0.0273	0.3426	1
Brugia malayi	MH2 domain containing protein	0.0116	0.1338	0.1338
Brugia malayi	hypothetical protein	0.0016	0.0006	0.0006
Onchocerca volvulus		0.0234	0.2904	0.2596
Echinococcus granulosus	glycine receptor subunit beta	0.0112	0.1282	0.1282
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0112	0.1282	0.1282
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0273	0.3426	0.314
Echinococcus granulosus	nAChR subunit	0.0065	0.066	0.066
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0112	0.1282	0.1282
Echinococcus multilocularis	nAChR subunit	0.0065	0.066	0.066
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Onchocerca volvulus		0.0394	0.5027	0.481
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3426	0.3426
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Trypanosoma brucei	hypothetical protein, conserved	0.0273	0.3426	1
Brugia malayi	hypothetical protein	0.0047	0.0417	0.0417
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0112	0.1282	0.1282
Brugia malayi	Pax transcription factor protein 2	0.0234	0.2904	0.2904
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Brugia malayi	hypothetical protein	0.0047	0.0417	0.0417
Echinococcus multilocularis	SWI:SNF matrix associated	0.0769	1	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Brugia malayi	hypothetical protein	0.0294	0.3699	0.3699
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0273	0.3426	0.3426
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0112	0.1282	0.1282
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0273	0.3426	1
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0047	0.0417	0.0417
Schistosoma mansoni	nAChR subunit	0.0112	0.1282	0.1282
Echinococcus granulosus	fatty acid binding protein FABP2	0.0042	0.0349	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3426	0.3426
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0112	0.1282	0.1282
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0112	0.1282	0.1282
Onchocerca volvulus		0.0273	0.3426	0.314
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0065	0.066	0.066
Leishmania major	hypothetical protein, conserved	0.0273	0.3426	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0122	0.0355
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1338	0.1338
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Brugia malayi	Cation transporter family protein	0.0112	0.1282	0.1282
Brugia malayi	SWIB/MDM2 domain containing protein	0.0769	1	1
Loa Loa (eye worm)	lipocalin/cytosolic fatty-acid binding protein family protein	0.0042	0.0349	0.0349
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Brugia malayi	Cation transporter family protein	0.0112	0.1282	0.1282
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0769	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Schistosoma mansoni	fusion	0.0273	0.3426	0.3426
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0112	0.1282	0.1282
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0273	0.3426	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0122	0.0355
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0	0.5
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0112	0.1282	0.1282
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0112	0.1282	0.1282
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0394	0.5027	0.5027
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0273	0.3426	0.3426
Loa Loa (eye worm)	hypothetical protein	0.0065	0.066	0.066
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0047	0.0417	0.0417
Trypanosoma cruzi	WLM domain containing protein, putative	0.0273	0.3426	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0047	0.0417	0.0417
Schistosoma mansoni	brg-1 associated factor	0.0769	1	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0769	1	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0112	0.1282	0.1282
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0112	0.1282	0.1282
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0273	0.3426	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Toxoplasma gondii	ran binding protein	0.0273	0.3426	0.3426
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0112	0.1282	0.1282
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0112	0.1282	0.1282
Schistosoma mansoni	zinc finger protein	0.0273	0.3426	0.3426
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1338	0.1338
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0047	0.0417	0.0417
Brugia malayi	hypothetical protein	0.0047	0.0417	0.0417
Echinococcus granulosus	glycine receptor subunit beta	0.0112	0.1282	0.1282
Echinococcus granulosus	Zinc finger RanBP2 type	0.0273	0.3426	0.3426
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0769	1	1
Schistosoma mansoni	nAChR subunit	0.0112	0.1282	0.1282
Schistosoma mansoni	fatty acid binding protein	0.0042	0.0349	0.0349
Brugia malayi	hypothetical protein	0.0047	0.0417	0.0417
Onchocerca volvulus		0.0065	0.066	0.0254
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0112	0.1282	0.1282
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0112	0.1282	0.1282
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0387	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0417	0.0417
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0112	0.1282	0.1282
Echinococcus multilocularis	glycine receptor subunit beta	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0394	0.5027	0.5027
Loa Loa (eye worm)	hypothetical protein	0.0294	0.3699	0.3699
Onchocerca volvulus		0.0065	0.066	0.0254
Schistosoma mansoni	nAChR subunit	0.0047	0.0417	0.0417
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0112	0.1282	0.1282
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0065	0.066	0.066
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3426	0.3426
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0047	0.0417	0.0417
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Trypanosoma cruzi	WLM domain containing protein, putative	0.0273	0.3426	1
Loa Loa (eye worm)	ACC-1 protein	0.0112	0.1282	0.1282
Schistosoma mansoni	RNA binding protein	0.0273	0.3426	0.3426
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0047	0.0417	0.0417
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0042	0.0349	0.0349
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0273	0.3426	0.3426
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0112	0.1282	0.1282
Schistosoma mansoni	TRABID protein (C64 family)	0.0273	0.3426	0.3426
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0112	0.1282	0.1282
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0112	0.1282	0.1282
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0042	0.0349	0.0349
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0387	0.0387
Schistosoma mansoni	nAChR subunit	0.0112	0.1282	0.1282
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0769	1	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0112	0.1282	0.1282
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0112	0.1282	0.1282
Schistosoma mansoni	neurotransmitter gated ion channel	0.0047	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0065	0.066	0.066
Entamoeba histolytica	hypothetical protein	0.0065	0.066	0.5
Schistosoma mansoni	hypothetical protein	0.0769	1	1
Schistosoma mansoni	nAChR subunit	0.0112	0.1282	0.1282
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0112	0.1282	0.1282
Leishmania major	hypothetical protein, conserved	0.0273	0.3426	1
Onchocerca volvulus		0.0273	0.3426	0.314
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0112	0.1282	0.1282
Onchocerca volvulus		0.0112	0.1282	0.0902
Schistosoma mansoni	nAChR subunit	0.0112	0.1282	0.1282
Schistosoma mansoni	nAChR subunit	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1282	0.1282
Brugia malayi	Lipocalin / cytosolic fatty-acid binding protein family protein	0.0042	0.0349	0.0349
Loa Loa (eye worm)	GABA receptor subunit	0.0065	0.066	0.066
Loa Loa (eye worm)	brahma associated protein	0.0769	1	1
Brugia malayi	Cation transporter family protein	0.0394	0.5027	0.5027
Leishmania major	hypothetical protein, conserved	0.0273	0.3426	1
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0065	0.066	0.066
Schistosoma mansoni	hypothetical protein	0.0769	1	1
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0769	1	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0065	0.066	0.066
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0387	0.0387
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0112	0.1282	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0065	0.066	0.066
Brugia malayi	excitatory GABA receptor EXP-1A	0.0112	0.1282	0.1282
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0112	0.1282	0.1282
Onchocerca volvulus		0.0769	1	1
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0047	0.0417	0.0417
Onchocerca volvulus		0.0112	0.1282	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0065	0.066	0.066
Leishmania major	hypothetical protein, conserved	0.0273	0.3426	1
Echinococcus granulosus	zinc finger protein Ran binding	0.0273	0.3426	0.3426
Echinococcus granulosus	SWI:SNF matrix associated	0.0769	1	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0065	0.066	0.066

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 4314 nM	Concentration required to inhibit electrically induced contractions in isolated mouse vas deferens preparation in vitro	ChEMBL.	7636873
IC50 (functional)	= 4314 nM	Concentration required to inhibit electrically induced contractions in isolated mouse vas deferens preparation in vitro	ChEMBL.	7636873
Inhibition (binding)	= -16 %	Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.	ChEMBL.	7636873
Inhibition (binding)	= -16 %	Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.	ChEMBL.	7636873

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	7636873

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL321297
PubChem: 10370677

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 172725