Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | catabolite gene activator | 0.0041 | 0.0065 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.0065 | 0.0477 |
Echinococcus granulosus | cGMP dependent protein kinase | 0.0042 | 0.0066 | 0.01 |
Leishmania major | protein kinase, putative | 0.0042 | 0.0066 | 0.0058 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0065 | 0.0186 | 0.0279 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0066 | 0.01 |
Giardia lamblia | Kinase, PLK | 0.0094 | 0.0334 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0094 | 0.0334 | 0.0408 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0065 | 0.0186 | 0.0279 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0334 | 0.2461 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0065 | 0.0186 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.1323 | 0.6665 | 0.6643 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0316 | 0.1478 | 0.2218 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0094 | 0.0334 | 0.0501 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0065 | 0.0186 | 0.0279 |
Mycobacterium ulcerans | transmembrane transport protein | 0.0041 | 0.0065 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-transport ATP-binding protein ABC transporter GlnQ | 0.0041 | 0.0065 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0094 | 0.0334 | 0.0501 |
Schistosoma mansoni | cyclic nucleotide-gated ion channel | 0.0041 | 0.0065 | 0.0097 |
Echinococcus granulosus | calcium release activated calcium channel | 0.1323 | 0.6665 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0334 | 0.2461 |
Treponema pallidum | cyclic nucleotide binding protein | 0.0041 | 0.0065 | 0.5 |
Leishmania major | protein kinase, putative | 0.0042 | 0.0066 | 0.0058 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0334 | 0.2461 |
Chlamydia trachomatis | cAMP-dependent protein kinase regulatory subunit | 0.0041 | 0.0065 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0094 | 0.0334 | 0.0271 |
Echinococcus granulosus | cAMP dependent protein kinase type I beta | 0.0041 | 0.0065 | 0.0097 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0065 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0094 | 0.0334 | 1 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0042 | 0.0066 | 0.0002 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.1265 | 0.1208 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0065 | 0.0186 | 0.0279 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0065 | 0.0186 | 0.0279 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0066 | 0.01 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0334 | 0.2461 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.0334 | 0.0501 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0042 | 0.0066 | 0.01 |
Trypanosoma brucei | cyclic nucleotide-binding domain containing protein, putative | 0.0041 | 0.0065 | 0.1901 |
Mycobacterium ulcerans | transcriptional regulatory protein | 0.0041 | 0.0065 | 0.5 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0065 | 0.0186 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0334 | 0.0271 |
Plasmodium falciparum | cGMP-dependent protein kinase | 0.0042 | 0.0066 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0041 | 0.0065 | 0.5 |
Schistosoma mansoni | similar to Protein C20orf152 homolog | 0.0041 | 0.0065 | 0.0097 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0292 | 0.1357 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0186 | 0.0122 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0052 | 0.0121 | 0.0182 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0041 | 0.0065 | 0.0097 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0065 | 0.0186 | 0.0279 |
Schistosoma mansoni | Protein orai-1 | 0.1323 | 0.6665 | 1 |
Trypanosoma brucei | protein kinase A regulatory subunit | 0.0041 | 0.0065 | 0.1901 |
Trypanosoma brucei | Flagellar Member 6 | 0.0041 | 0.0065 | 0.1901 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.0042 | 0.0066 | 0.0002 |
Schistosoma mansoni | camp-dependent protein kinase regulatory chain | 0.0041 | 0.0065 | 0.0097 |
Brugia malayi | Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog | 0.0041 | 0.0065 | 0.0097 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0065 | 0.0186 | 0.0279 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0334 | 0.2461 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0344 | 0.1626 | 0.244 |
Loa Loa (eye worm) | AGC/PKG protein kinase | 0.0042 | 0.0066 | 0.0002 |
Echinococcus granulosus | voltage gated potassium channel | 0.0094 | 0.0334 | 0.0501 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0094 | 0.0334 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0091 | 0.0667 |
Mycobacterium ulcerans | regulatory protein | 0.0041 | 0.0065 | 0.5 |
Schistosoma mansoni | 60S ribosomal protein L21 | 0.0052 | 0.0121 | 0.0182 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0041 | 0.0065 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.0334 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0065 | 0.0186 | 0.0183 |
Trichomonas vaginalis | cAMP-dependent protein kinase regulatory subunit, putative | 0.0041 | 0.0065 | 0.0477 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0292 | 0.1357 | 1 |
Brugia malayi | olfactory channel protein osm-9 | 0.0114 | 0.0439 | 0.0658 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0334 | 0.2461 |
Plasmodium vivax | CAMP-dependent protein kinase regulatory subunit, putative | 0.0041 | 0.0065 | 0.5 |
Schistosoma mansoni | kinase | 0.0048 | 0.0097 | 0.0145 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0065 | 0.0186 | 0.0279 |
Brugia malayi | N-terminal motif family protein | 0.0041 | 0.0065 | 0.0097 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0041 | 0.0065 | 0.0097 |
Trypanosoma brucei | cyclic nucleotide-binding domain containing protein, putative | 0.0041 | 0.0065 | 0.1901 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0041 | 0.0065 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0046 | 0.0091 | 0.0667 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.0042 | 0.0066 | 0.01 |
Echinococcus granulosus | patatin phospholipase domain containing protein | 0.0041 | 0.0065 | 0.0097 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0316 | 0.1478 | 0.1422 |
Echinococcus granulosus | cAMP dependent protein kinase type II regulatory | 0.0041 | 0.0065 | 0.0097 |
Treponema pallidum | catabolite gene activator (Crp) | 0.0041 | 0.0065 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0065 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.0334 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0065 | 0.0186 | 0.0122 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0065 | 0.0186 | 0.0183 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0316 | 0.1478 | 0.2141 |
Schistosoma mansoni | camp-dependent protein kinase type II regulatory subunit | 0.0041 | 0.0065 | 0.0097 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0065 | 0.0186 | 0.0183 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0094 | 0.0334 | 0.0501 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0344 | 0.1626 | 0.244 |
Mycobacterium tuberculosis | Probable conserved transmembrane transport protein | 0.0041 | 0.0065 | 0.5 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0041 | 0.0065 | 0.0097 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0316 | 0.1478 | 0.2218 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein Cmr | 0.0041 | 0.0065 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.0334 | 0.2461 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0065 | 0.0477 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0065 | 0.0186 | 0.0279 |
Trichomonas vaginalis | cAMP-dependent protein kinase type I-beta regulatory subunit, putative | 0.0041 | 0.0065 | 0.0477 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0065 | 0.0097 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.0065 | 0.0477 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0065 | 0.0186 | 0.0279 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0094 | 0.0334 | 0.5 |
Toxoplasma gondii | protein kinase G AGC kinase family member PKG | 0.0042 | 0.0066 | 0.0002 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0094 | 0.0334 | 0.0501 |
Trypanosoma brucei | cAMP binding protein, putative | 0.0041 | 0.0065 | 0.1901 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0065 | 0.0186 | 0.0122 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0094 | 0.0334 | 0.0408 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0094 | 0.0334 | 0.0408 |
Schistosoma mansoni | camp-dependent protein kinase type I-beta regulatory subunit | 0.0041 | 0.0065 | 0.0097 |
Trypanosoma brucei | polo-like protein kinase | 0.0094 | 0.0334 | 1 |
Trypanosoma brucei | cAMP response protein 1, putative | 0.0041 | 0.0065 | 0.1901 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0065 | 0.0186 | 0.0279 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0066 | 0.01 |
Echinococcus multilocularis | expressed conserved protein | 0.0042 | 0.0066 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0439 | 0.0376 |
Schistosoma mansoni | camp-dependent rap1 guanine-nucleotide exchange factor | 0.0041 | 0.0065 | 0.0097 |
Schistosoma mansoni | Protein orai-1 | 0.1323 | 0.6665 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0065 | 0.0186 | 0.137 |
Brugia malayi | Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative | 0.0041 | 0.0065 | 0.0097 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0041 | 0.0065 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0094 | 0.0334 | 0.0501 |
Brugia malayi | Egg laying defective protein 4 | 0.0042 | 0.0066 | 0.01 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0065 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0041 | 0.0065 | 0.0097 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.1323 | 0.6665 | 1 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0065 | 0.0186 | 0.0183 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0094 | 0.0334 | 0.0501 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0065 | 0.5 |
Brugia malayi | hypothetical protein | 0.1323 | 0.6665 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0041 | 0.0065 | 0.0097 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0065 | 0.0186 | 0.137 |
Brugia malayi | cAMP-dependent protein kinase regulatory chain, putative | 0.0041 | 0.0065 | 0.0097 |
Plasmodium vivax | rap guanine nucleotide exchange factor, putative | 0.0041 | 0.0065 | 0.5 |
Echinococcus granulosus | cAMP dependent protein kinase regulatory | 0.0041 | 0.0065 | 0.0097 |
Treponema pallidum | cyclic nucleotide binding protein | 0.0041 | 0.0065 | 0.5 |
Schistosoma mansoni | camp-dependent protein kinase type II-alpha regulatory subunit | 0.0041 | 0.0065 | 0.0097 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0065 | 0.0186 | 0.0279 |
Schistosoma mansoni | camp-dependent protein kinase type I-beta regulatory subunit | 0.0041 | 0.0065 | 0.0097 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.7 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.693 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.605 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.478 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.451 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.37 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.328 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.15 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.141 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.