Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0048 | 0.0009 | 0.0009 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2024 | 1 | 1 |
Echinococcus multilocularis | uridine 5' monophosphate synthase | 0.0474 | 0.2164 | 0.2164 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0281 | 0.1189 | 0.1182 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0009 | 0.0002 |
Giardia lamblia | Guanine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0048 | 0.0009 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Onchocerca volvulus | Adenine phosphoribosyltransferase homolog | 0.0474 | 0.2164 | 0.2156 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0048 | 0.0009 | 0.0002 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0148 | 0.0517 | 0.0517 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0148 | 0.0517 | 0.12 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0048 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1189 | 0.2781 |
Toxoplasma gondii | orotate phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2156 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.2024 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0888 | 0.4255 | 0.4251 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0048 | 0.0009 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0048 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0048 | 0.0009 | 0.0002 |
Echinococcus granulosus | uridine 5' monophosphate synthase | 0.0474 | 0.2164 | 0.2158 |
Brugia malayi | orotate phosphoribosyltransferase family protein | 0.0474 | 0.2164 | 0.2158 |
Loa Loa (eye worm) | orotate phosphoribosyltransferase | 0.0474 | 0.2164 | 0.5076 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.0166 | 0.0159 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Trichomonas vaginalis | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2024 | 1 | 1 |
Loa Loa (eye worm) | adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.5076 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0281 | 0.1189 | 0.1182 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Schistosoma mansoni | orotidine 5'-phosphate decarboxylase | 0.0474 | 0.2164 | 0.2158 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0888 | 0.4255 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.008 | 0.0171 | 0.0163 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0047 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Treponema pallidum | adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 1 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Plasmodium vivax | orotate phosphoribosyltransferase, putative | 0.0474 | 0.2164 | 0.2156 |
Wolbachia endosymbiont of Brugia malayi | orotate phosphoribosyltransferase | 0.0474 | 0.2164 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0281 | 0.1189 | 0.2781 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1189 | 0.2781 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0009 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.008 | 0.0171 | 0.0171 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0048 | 0.0009 | 0.0002 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0148 | 0.0517 | 0.051 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0048 | 0.0009 | 0.0004 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Echinococcus multilocularis | serotonin transporter | 0.0281 | 0.1189 | 0.1189 |
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0281 | 0.1189 | 0.2781 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0048 | 0.0009 | 0.0002 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0281 | 0.1189 | 0.1182 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0048 | 0.0009 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.005 | 0.0022 | 0.0014 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0048 | 0.0009 | 0.0009 |
Treponema pallidum | hypothetical protein | 0.0474 | 0.2164 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0281 | 0.1189 | 0.2781 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2024 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0148 | 0.0517 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0009 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.1189 | 0.2781 |
Echinococcus multilocularis | adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2164 |
Echinococcus multilocularis | insulin receptor | 0.0047 | 0.0008 | 0.0008 |
Echinococcus granulosus | adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Leishmania major | xanthine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Schistosoma mansoni | Adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0048 | 0.0009 | 0.0002 |
Echinococcus granulosus | epidermal growth factor receptor | 0.008 | 0.0171 | 0.0163 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Brugia malayi | Adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Onchocerca volvulus | 0.2024 | 1 | 1 | |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Plasmodium falciparum | orotate phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2156 |
Schistosoma mansoni | uracil phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.0166 | 0.0159 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0888 | 0.4255 | 0.4251 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.155 | 0.7604 | 1 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2024 | 1 | 1 |
Toxoplasma gondii | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT | 0.2024 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0148 | 0.0517 | 0.051 |
Wolbachia endosymbiont of Brugia malayi | amidophosphoribosyltransferase | 0.0474 | 0.2164 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0171 | 0.0163 |
Schistosoma mansoni | Adenine phosphoribosyltransferase | 0.0474 | 0.2164 | 0.2158 |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2024 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | tyrosine kinase | 0.008 | 0.0171 | 0.0163 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0048 | 0.0009 | 0.0002 |
Leishmania major | hypoxanthine-guanine phosphoribosyltransferase | 0.2024 | 1 | 1 |
Onchocerca volvulus | 0.0281 | 0.1189 | 0.1181 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0281 | 0.1189 | 0.1182 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.155 | 0.7604 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0048 | 0.0009 | 0.0002 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2024 | 1 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0048 | 0.0009 | 0.0004 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.0166 | 0.0159 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.2024 | 1 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0048 | 0.0009 | 0.0002 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0048 | 0.0009 | 0.0002 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0048 | 0.0009 | 0.0002 |
Treponema pallidum | phosphoribosylpyrophosphate synthetase | 0.0474 | 0.2164 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.