Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cryptosporidium parvum | inosine-5-monophosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.6653 | 1 | 1 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0134 | 0 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0134 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0864 | 0.112 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 0 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0134 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.6653 | 1 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0134 | 0 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0134 | 0 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0134 | 0 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.0134 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0864 | 0.112 | 0.5 |
Toxoplasma gondii | IMP dehydrogenas | 0.0134 | 0 | 0.5 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0134 | 0 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.0134 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0864 | 0.112 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.6653 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 0 | 0.5 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0134 | 0 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0134 | 0 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.6653 | 1 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.6653 | 1 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0134 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.6653 | 1 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0864 | 0.112 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.6653 | 1 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0864 | 0.112 | 0.5 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0134 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of recombinant Cryptosporidium parvum IMPDH assessed as production of NADH by fluorescence assay in presence of 0.05% BSA | ChEMBL. | 23324406 | |
IC50 (binding) | > 5000 nM | Inhibition of recombinant Cryptosporidium parvum IMPDH assessed as production of NADH by fluorescence assay | ChEMBL. | 23324406 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.