Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | immunophilin | 0.0059 | 0.0071 | 0.0071 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0059 | 0.0071 | 0.0071 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0191 | 0.1238 | 0.1238 |
Schistosoma mansoni | fatty acid binding protein | 0.1188 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0059 | 0.0071 | 0.0071 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0156 | 0.0925 | 0.0925 |
Brugia malayi | TAZ zinc finger family protein | 0.0334 | 0.2489 | 0.2435 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0091 | 0.0352 | 0.2406 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0191 | 0.1238 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0231 | 0.1587 | 0.1587 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0191 | 0.1238 | 1 |
Loa Loa (eye worm) | lipocalin/cytosolic fatty-acid binding protein family protein | 0.1188 | 1 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0191 | 0.1238 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.1278 | 0.1278 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0059 | 0.0071 | 0.0071 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0156 | 0.0925 | 0.0925 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0104 | 0.0467 | 0.339 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0156 | 0.0925 | 0.0861 |
Loa Loa (eye worm) | CBP-B | 0.0234 | 0.1612 | 0.1612 |
Brugia malayi | N-myristoyltransferase 2 | 0.0191 | 0.1238 | 0.1176 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0156 | 0.0925 | 0.7318 |
Giardia lamblia | CDC72 | 0.0191 | 0.1238 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0059 | 0.0071 | 0.0071 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0191 | 0.1238 | 1 |
Echinococcus granulosus | fatty acid binding protein FABP2 | 0.1188 | 1 | 1 |
Echinococcus multilocularis | fatty acid binding protein FABP2 | 0.1188 | 1 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0315 | 0.2329 | 0.2329 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0191 | 0.1238 | 0.1238 |
Echinococcus multilocularis | CREB binding protein | 0.0053 | 0.0026 | 0.0026 |
Schistosoma mansoni | N-myristoyltransferase | 0.0191 | 0.1238 | 0.1238 |
Trypanosoma brucei | N-myristoyltransferase | 0.0191 | 0.1238 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0104 | 0.0467 | 0.339 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0059 | 0.0071 | 0.0071 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0156 | 0.0925 | 0.7318 |
Echinococcus multilocularis | CREB binding protein | 0.0053 | 0.0026 | 0.0026 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0315 | 0.2329 | 0.2329 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0191 | 0.1238 | 0.1238 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0104 | 0.0467 | 0.5 |
Loa Loa (eye worm) | FKBP5 protein | 0.0059 | 0.0071 | 0.0071 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0315 | 0.2329 | 0.2274 |
Schistosoma mansoni | immunophilin | 0.0059 | 0.0071 | 0.0071 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0104 | 0.0467 | 0.339 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0196 | 0.1278 | 0.1278 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0191 | 0.1238 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0104 | 0.0467 | 0.0467 |
Echinococcus multilocularis | fatty acid binding protein FABP2 | 0.1188 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0104 | 0.0467 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.0059 | 0.0071 | 0.0071 |
Echinococcus granulosus | fatty acid binding protein FABP2 | 0.1188 | 1 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0315 | 0.2329 | 0.2329 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0091 | 0.0352 | 0.2406 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0059 | 0.0071 | 0.5 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0191 | 0.1238 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0053 | 0.0026 | 0.0026 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0334 | 0.2489 | 0.2489 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0191 | 0.1238 | 1 |
Echinococcus granulosus | CREB binding protein | 0.0053 | 0.0026 | 0.0026 |
Brugia malayi | Choline O-acetyltransferase | 0.0196 | 0.1278 | 0.1216 |
Schistosoma mansoni | choline o-acyltransferase | 0.0196 | 0.1278 | 0.1278 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0091 | 0.0352 | 0.2406 |
Echinococcus granulosus | choline O acetyltransferase | 0.0196 | 0.1278 | 0.1278 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0925 | 0.0925 |
Echinococcus granulosus | CREB binding protein | 0.0053 | 0.0026 | 0.0026 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0334 | 0.2489 | 0.2489 |
Leishmania major | N-myristoyl transferase, putative | 0.0191 | 0.1238 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0126 | 0.0661 | 0.5056 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0292 | 0.212 | 0.212 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0156 | 0.0925 | 0.7318 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0059 | 0.0071 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0902 | 0.0902 |
Echinococcus granulosus | CREB binding protein | 0.0209 | 0.1389 | 0.1389 |
Echinococcus granulosus | CREB binding protein | 0.0334 | 0.2489 | 0.2489 |
Brugia malayi | Choline O-acetyltransferase | 0.0196 | 0.1278 | 0.1216 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0196 | 0.1278 | 0.1278 |
Schistosoma mansoni | fatty acid binding protein | 0.1188 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 40 uM | Growth inhibition against HL-60 after 72 hours incubation period | ChEMBL. | 2840503 |
ID50 (functional) | = 83 uM | Growth inhibition against HL-60 after 48 hours incubation period | ChEMBL. | 2840503 |
ID50 (functional) | = 257 uM | Growth inhibition against HL-60 after 24 hr incubation period | ChEMBL. | 2840503 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.