TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 614.343 | Formula: C18H40Cl4N4O10
H donors: 10 H acceptors: 6 LogP: -3.24 Rotable bonds: 5
Rule of 5 violations (Lipinski): 3
SMILES: NC[C@@H]1O[C@H](O[C@@H]2[C@H](N)C[C@H]([C@H]([C@H]2O[C@@H]2O[C@@H](C)[C@H]([C@@H]([C@@H]2O)O)O)O)N)[C@H]([C@H]([C@@H]1O)O)N.Cl.Cl.Cl.Cl
InChi: 1S/C18H36N4O10.4ClH/c1-4-9(23)13(27)14(28)18(29-4)32-16-10(24)5(20)2-6(21)15(16)31-17-8(22)12(26)11(25)7(3-19)30-17;;;;/h4-18,23-28H,2-3,19-22H2,1H3;4*1H/t4-,5+,6+,7-,8-,9+,10+,11+,12+,13-,14-,15+,16+,17+,18-;;;;/m0..../s1
InChiKey: YVCVDXNWIZPKKV-ZXLWUJFSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	sodium/hydrogen exchanger 3 (nhe3)	0.0299	0.0144	0.0095
Brugia malayi	SH2 domain containing protein	0.0253	0.0083	0.0034
Onchocerca volvulus		0.0299	0.0144	0.0536
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0426	0.0311	0.0263
Echinococcus multilocularis		0.0253	0.0083	0.0034
Echinococcus multilocularis	mitochondrial sodium:hydrogen exchanger 9B2	0.0299	0.0144	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Echinococcus granulosus	tyrosine kinase	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0007	0.0007
Schistosoma mansoni	tensin	0.0253	0.0083	0.0034
Brugia malayi	Variant SH3 domain containing protein	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Echinococcus granulosus	disintegrin and metalloproteinase	0.0452	0.0345	0.0297
Schistosoma mansoni	shc transforming protein	0.0253	0.0083	0.0034
Trypanosoma cruzi	sodium/hydrogen exchanger, putative	0.0299	0.0144	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0426	0.0311	0.0311
Schistosoma mansoni	GTPase activating protein	0.0253	0.0083	0.0034
Echinococcus granulosus	adam	0.0538	0.0457	0.041
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0227	0.0049	0.0049
Entamoeba histolytica	sodium/proton antiporter, putative	0.0299	0.0144	0.2684
Echinococcus multilocularis	adam 17 protease	0.1346	0.152	0.1479
Mycobacterium ulcerans	ion antiporter, NhaP	0.0299	0.0144	1
Leishmania major	hypothetical protein, conserved	0.0299	0.0144	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0426	0.0311	0.0263
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0253	0.0083	0.0034
Onchocerca volvulus	Sodium\/hydrogen exchanger homolog	0.157	0.1815	1
Echinococcus granulosus	hypothetical protein	0.0253	0.0083	0.0034
Loa Loa (eye worm)	TK/FER protein kinase	0.0426	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.157	0.1815	0.1815
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0253	0.0083	0.0083
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0253	0.0083	0.0034
Echinococcus multilocularis	sodium:hydrogen exchanger	0.157	0.1815	0.1775
Schistosoma mansoni	hypothetical protein	0.0299	0.0144	0.0095
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0253	0.0083	0.0034
Schistosoma mansoni	adapter molecule crk	0.0253	0.0083	0.0034
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0426	0.0311	0.0263
Loa Loa (eye worm)	melatonin receptor type 1A	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Brugia malayi	metalloprotease disintegrin 16 with thrombospondin type I motif	0.0635	0.0586	0.0539
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Schistosoma mansoni	SH2A	0.0253	0.0083	0.0034
Toxoplasma gondii	sodium/hydrogen exchanger 3 protein	0.0299	0.0144	0.5
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0253	0.0083	0.0034
Schistosoma mansoni	sodium/hydrogen exchanger	0.157	0.1815	0.1775
Trypanosoma cruzi	Na/H antiporter-like protein, putative	0.0299	0.0144	0.5
Mycobacterium ulcerans	potassium/proton antiporter	0.0299	0.0144	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0426	0.0311	0.0263
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0253	0.0083	0.0034
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0426	0.0311	0.0263
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.157	0.1815	0.1775
Brugia malayi	Protein kinase domain containing protein	0.0426	0.0311	0.0263
Echinococcus granulosus	tensin	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0233	0.0056	0.0056
Schistosoma mansoni	sodium/hydrogen exchanger 2 (nhe2)	0.157	0.1815	0.1775
Brugia malayi	Tyrosine-protein kinase abl-1	0.0426	0.0311	0.0263
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0253	0.0083	0.0034
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0227	0.0049	0.0049
Loa Loa (eye worm)	TK/FER protein kinase	0.0426	0.0311	0.0311
Schistosoma mansoni	growth factor receptor-bound protein	0.0253	0.0083	0.0034
Schistosoma mansoni	hypothetical protein	0.0299	0.0144	0.0095
Loa Loa (eye worm)	TK/FER protein kinase	0.0426	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Onchocerca volvulus		0.0426	0.0311	0.1481
Echinococcus multilocularis	Blood coagulation inhibitor, Disintegrin	0.1075	0.1164	0.1121
Loa Loa (eye worm)	hypothetical protein	0.779	1	1
Onchocerca volvulus		0.0253	0.0083	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	integrin alpha pat-2	0.023	0.0053	0.0053
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0253	0.0083	0.0189
Echinococcus granulosus	adam 17 protease	0.1608	0.1865	0.1825
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0418	0.0301	0.1423
Echinococcus multilocularis	subfamily M12B unassigned peptidase	0.0343	0.0201	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	sodium/hydrogen exchanger	0.157	0.1815	0.1815
Echinococcus granulosus	sodium:hydrogen exchanger	0.157	0.1815	0.1775
Brugia malayi	hypothetical protein	0.0299	0.0144	0.0095
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein YjcE	0.0299	0.0144	1
Brugia malayi	sodium/hydrogen exchanger 3 family protein	0.0299	0.0144	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Echinococcus multilocularis	c src tyrosine kinase	0.0426	0.0311	0.0263
Toxoplasma gondii	Na+/H+ exchanger NHE3	0.0299	0.0144	0.5
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0426	0.0311	0.0263
Brugia malayi	SH2 domain containing protein	0.0426	0.0311	0.0263
Loa Loa (eye worm)	TK/FER protein kinase	0.0426	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Plasmodium falciparum	sodium/hydrogen exchanger, Na+, H+ antiporter	0.0299	0.0144	0.5
Loa Loa (eye worm)	sodium-hydrogen exchanger NHE1	0.0299	0.0144	0.0144
Brugia malayi	sodium/hydrogen exchanger 3 family protein	0.157	0.1815	0.1775
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus multilocularis	SH2 domain containing protein 7	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.3058	0.3774	0.3774
Echinococcus granulosus	c src tyrosine kinase	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0227	0.0049	0.0049
Schistosoma mansoni	tensin	0.0253	0.0083	0.0034
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0253	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Loa Loa (eye worm)	SRC-1	0.0426	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Brugia malayi	SH2 domain containing protein	0.0253	0.0083	0.0034
Schistosoma mansoni	Slc9a7 protein	0.0299	0.0144	0.0095
Toxoplasma gondii	sodium/hydrogen exchanger NHE2	0.0299	0.0144	0.5
Schistosoma mansoni	ADAM17 peptidase (M12 family)	0.1346	0.152	0.1479
Leishmania major	Na/H antiporter-like protein	0.0299	0.0144	0.5
Loa Loa (eye worm)	hypothetical protein	0.0426	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus granulosus	SH2 motif	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus granulosus	SH2 motif	0.0253	0.0083	0.0034
Schistosoma mansoni	tensin	0.0253	0.0083	0.0034
Echinococcus multilocularis	N chimaerin	0.0253	0.0083	0.0034
Brugia malayi	Sodium/hydrogen exchanger 8	0.0299	0.0144	0.0095
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Loa Loa (eye worm)	G-protein coupled receptor	0.0227	0.0049	0.0049
Schistosoma mansoni	tyrosine kinase	0.0426	0.0311	0.0263
Echinococcus granulosus	expressed conserved protein	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Onchocerca volvulus	Matrilysin homolog	0.0418	0.0301	0.1423
Brugia malayi	ADAMTS-like protease	0.0233	0.0056	0.0007
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0253	0.0083	0.0034
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0253	0.0083	0.0034
Plasmodium vivax	sodium/hydrogen exchanger 1, putative	0.0299	0.0144	0.5
Schistosoma mansoni	tensin-related	0.0253	0.0083	0.0034
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0253	0.0083	0.0034
Brugia malayi	angiogenesis inhibito	0.0233	0.0056	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Onchocerca volvulus		0.0426	0.0311	0.1481
Loa Loa (eye worm)	TK/FER protein kinase	0.0426	0.0311	0.0311
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.023	0.0052	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0426	0.0311	0.0263
Echinococcus multilocularis	sodium:hydrogen exchanger 7	0.0299	0.0144	0.0095
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0253	0.0083	0.0034
Brugia malayi	Hemopexin family protein	0.0268	0.0102	0.0053
Schistosoma mansoni	tyrosine kinase	0.0426	0.0311	0.0263
Brugia malayi	hypothetical protein	0.0538	0.0457	0.041
Schistosoma mansoni	tyrosine kinase	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.023	0.0052	0.0052
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0253	0.0083	0.0083
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0253	0.0083	0.0034
Brugia malayi	hypothetical protein	0.0253	0.0083	0.0034
Schistosoma mansoni	tyrosine kinase	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Schistosoma mansoni	hypothetical protein	0.0253	0.0083	0.0034
Brugia malayi	hypothetical protein	0.0426	0.0311	0.0263
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0426	0.0311	0.0263
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0686	0.0653	0.0606
Echinococcus multilocularis	tensin	0.0253	0.0083	0.0034
Loa Loa (eye worm)	TK/ABL protein kinase	0.0426	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.157	0.1815	0.1815
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0426	0.0311	0.0263
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0426	0.0311	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0253	0.0083	0.0083
Echinococcus granulosus	SH2 domain containing protein 7	0.0253	0.0083	0.0034
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0426	0.0311	0.0263
Echinococcus multilocularis	sodium:hydrogen exchanger	0.157	0.1815	0.1775
Loa Loa (eye worm)	TK/FER protein kinase	0.0426	0.0311	0.0311
Echinococcus granulosus	Blood coagulation inhibitor Disintegrin	0.1075	0.1164	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus granulosus	tyrosine protein kinase Srms	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	TK protein kinase	0.0426	0.0311	0.0311
Loa Loa (eye worm)	TYRA-2 protein	0.0227	0.0049	0.0049
Echinococcus granulosus	a disintegrin and metalloproteinase with	0.0635	0.0586	0.0539
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0426	0.0311	0.0263
Echinococcus granulosus	sodium:hydrogen exchanger 2 nhe2	0.157	0.1815	0.1775
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0343	0.0201	0.0152
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0253	0.0083	0.0034
Echinococcus multilocularis	a disintegrin and metalloproteinase with	0.0635	0.0586	0.0539
Brugia malayi	RhoGAP domain containing protein	0.0253	0.0083	0.0034
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0253	0.0083	0.0034
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0253	0.0083	0.0034
Schistosoma mansoni	tyrosine kinase	0.0426	0.0311	0.0263
Echinococcus multilocularis	SHC transforming protein 3	0.0253	0.0083	0.0034
Schistosoma mansoni	growth factor receptor-bound protein	0.0253	0.0083	0.0034
Toxoplasma gondii	Na+/H+ exchanger NHE1	0.0299	0.0144	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0426	0.0311	0.0263
Brugia malayi	Protein kinase domain containing protein	0.0426	0.0311	0.0263
Echinococcus multilocularis	tyrosine protein kinase shark	0.0426	0.0311	0.0263
Echinococcus granulosus	sodium:hydrogen exchanger 2 nhe2	0.157	0.1815	0.1775
Loa Loa (eye worm)	hypothetical protein	0.157	0.1815	0.1815
Schistosoma mansoni	hypothetical protein	0.0268	0.0102	0.0053
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0426	0.0311	0.0263
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0253	0.0083	0.0034
Echinococcus granulosus	tyrosine kinase	0.0426	0.0311	0.0263
Trypanosoma cruzi	sodium/hydrogen exchanger, putative	0.0299	0.0144	0.5
Onchocerca volvulus	Sodium\/hydrogen exchanger homolog	0.157	0.1815	1
Brugia malayi	Sex muscle abnormal protein 5	0.0253	0.0083	0.0034
Schistosoma mansoni	nck2/grb4	0.0253	0.0083	0.0034
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0253	0.0083	0.0083
Brugia malayi	SH2 domain containing protein	0.0253	0.0083	0.0034
Onchocerca volvulus		0.0253	0.0083	0.0189
Brugia malayi	SH2 domain containing protein	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Wolbachia endosymbiont of Brugia malayi	Kef-type K+ transport system, membrane component	0.0299	0.0144	0.5
Brugia malayi	Protein kinase domain containing protein	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	TK/FER protein kinase	0.0426	0.0311	0.0311
Echinococcus multilocularis	tensin	0.0253	0.0083	0.0034
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0426	0.0311	0.0263
Mycobacterium ulcerans	membrane transporter	0.0299	0.0144	1
Schistosoma mansoni	ADAMTS5 peptidase (M12 family)	0.0635	0.0586	0.0539
Echinococcus multilocularis	NCK adaptor protein	0.0253	0.0083	0.0034
Loa Loa (eye worm)	TK/FER protein kinase	0.0426	0.0311	0.0311
Echinococcus multilocularis	SH2 motif	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Onchocerca volvulus		0.0268	0.0102	0.0299
Echinococcus granulosus	mitochondrial sodium:hydrogen exchanger 9B2	0.0299	0.0144	0.0095
Brugia malayi	Variant SH3 domain containing protein	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0343	0.0201	0.0201
Onchocerca volvulus	Sodium\/hydrogen exchanger homolog	0.157	0.1815	1
Loa Loa (eye worm)	hypothetical protein	0.0233	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0253	0.0083	0.0034
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0538	0.0457	0.041
Giardia lamblia	Sodium/hydrogen exchanger 3	0.157	0.1815	0.5
Brugia malayi	protein-tyrosine kinase	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Onchocerca volvulus		0.0253	0.0083	0.0189
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0426	0.0311	0.0263
Echinococcus granulosus	NCK adaptor protein	0.0253	0.0083	0.0034
Schistosoma mansoni	suppressor of cytokine signaling	0.0253	0.0083	0.0034
Schistosoma mansoni	hypothetical protein	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0253	0.0083	0.0034
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0253	0.0083	0.0083
Brugia malayi	SH2 domain containing protein	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Loa Loa (eye worm)	matrixin family protein	0.0418	0.0301	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus multilocularis	SH2 motif	0.0253	0.0083	0.0034
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0299	0.0144	1
Brugia malayi	SH2 domain containing protein	0.0253	0.0083	0.0034
Echinococcus multilocularis	signal transduction protein lnk realted	0.0253	0.0083	0.0034
Schistosoma mansoni	signal transduction protein lnk-related	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0144	0.0144
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0426	0.0311	0.0263
Loa Loa (eye worm)	reprolysin	0.0343	0.0201	0.0201
Loa Loa (eye worm)	STAT protein	0.0253	0.0083	0.0083
Echinococcus granulosus	sodium:hydrogen exchanger	0.157	0.1815	0.1775
Schistosoma mansoni	tensin-related	0.0253	0.0083	0.0034
Schistosoma mansoni	tyrosine kinase	0.0426	0.0311	0.0263
Echinococcus granulosus	growth factor receptor bound protein 2	0.0253	0.0083	0.0034
Brugia malayi	Tensin	0.0253	0.0083	0.0034
Brugia malayi	Matrixin family protein	0.0456	0.035	0.0303
Loa Loa (eye worm)	TK/FER protein kinase	0.0426	0.0311	0.0311
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0343	0.0201	0.0152
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0426	0.0311	0.0263
Echinococcus multilocularis	disintegrin and metalloproteinase	0.0452	0.0345	0.0297
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.779	1	1
Echinococcus granulosus	sodium:hydrogen exchanger 7	0.0299	0.0144	0.0095
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0253	0.0083	0.0189
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0426	0.0311	0.0263
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0253	0.0083	0.0034
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0426	0.0311	0.0263
Brugia malayi	Variant SH3 domain containing protein	0.0253	0.0083	0.0034
Loa Loa (eye worm)	NHE-3	0.157	0.1815	0.1815
Echinococcus granulosus	sodium:hydrogen exchanger 2 (nhe2)	0.127	0.1421	0.1379
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus multilocularis	adam	0.0538	0.0457	0.041
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Entamoeba histolytica	sodium/proton antiporter, putative	0.0299	0.0144	0.2684
Echinococcus multilocularis	tyrosine kinase	0.0426	0.0311	0.0263
Onchocerca volvulus		0.0426	0.0311	0.1481
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0426	0.0311	0.0263
Brugia malayi	Protein kinase domain containing protein	0.0426	0.0311	0.0263
Echinococcus granulosus	signal transduction protein lnk realted	0.0253	0.0083	0.0034
Loa Loa (eye worm)	G-protein coupled receptor	0.0227	0.0049	0.0049
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.779	1	1
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.127	0.1421	0.1379
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus granulosus	tyrosine protein kinase Blk	0.0426	0.0311	0.0263
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0253	0.0083	0.0083
Echinococcus multilocularis	SH2 motif	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Schistosoma mansoni	vav2	0.0253	0.0083	0.0034
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0686	0.0653	0.0606
Schistosoma mansoni	dihydroceramide desaturase	0.0452	0.0345	0.0297
Brugia malayi	SH2 domain containing protein	0.0253	0.0083	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Onchocerca volvulus		0.0253	0.0083	0.0189
Loa Loa (eye worm)	neuropeptide F receptor	0.0227	0.0049	0.0049
Loa Loa (eye worm)	neuropeptide F receptor	0.0227	0.0049	0.0049
Loa Loa (eye worm)	SH2 domain-containing protein	0.0253	0.0083	0.0083
Onchocerca volvulus		0.0253	0.0083	0.0189
Brugia malayi	SRC-1	0.0426	0.0311	0.0263
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0253	0.0083	0.0034
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0426	0.0311	0.0263
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0253	0.0083	0.0034
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0227	0.0049	0.0049
Mycobacterium leprae	probable conserved integral membrane transport protein	0.0299	0.0144	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus granulosus	subfamily M12B unassigned peptidase	0.0343	0.0201	0.0152
Onchocerca volvulus		0.0426	0.0311	0.1481
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.157	0.1815	0.1775
Onchocerca volvulus		0.0299	0.0144	0.0536
Loa Loa (eye worm)	matrixin family protein	0.0456	0.035	0.035
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0253	0.0083	0.0034
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0426	0.0311	0.0263
Onchocerca volvulus		0.0426	0.0311	0.1481
Loa Loa (eye worm)	sodium/hydrogen exchanger 3 family protein	0.157	0.1815	0.1815
Onchocerca volvulus		0.0426	0.0311	0.1481
Echinococcus granulosus	SHC transforming protein 3	0.0253	0.0083	0.0034
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0426	0.0311	0.0263
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0426	0.0311	0.0263
Loa Loa (eye worm)	SH2 domain-containing protein	0.0253	0.0083	0.0083
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0233	0.0056	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Schistosoma mansoni	suppressor of cytokine signaling	0.0253	0.0083	0.0034
Onchocerca volvulus		0.0253	0.0083	0.0189
Trypanosoma cruzi	Na/H antiporter-like protein, putative	0.0299	0.0144	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0253	0.0083	0.0034
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0253	0.0083	0.0034
Echinococcus granulosus	sodium:hydrogen exchanger 2 nhe2	0.157	0.1815	0.1775
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Echinococcus multilocularis	sodium:hydrogen exchanger 2 (nhe2)	0.157	0.1815	0.1775
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0049	0.0049
Brugia malayi	Variant SH3 domain containing protein	0.0253	0.0083	0.0034
Brugia malayi	SH2 domain containing protein	0.0426	0.0311	0.0263
Echinococcus granulosus	tyrosine protein kinase shark	0.0426	0.0311	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0253	0.0083	0.0034
Brugia malayi	Disintegrin family protein	0.0452	0.0345	0.0297
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.779	1	1
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0083	0.0083
Echinococcus granulosus	N chimaerin	0.0253	0.0083	0.0034
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0253	0.0083	0.0034
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0426	0.0311	0.0263

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 19 uM	Minimum inhibitory concentration required against Escherichia coli	ChEMBL.	15357959
MIC (functional)	= 91 uM	Minimum inhibitory concentration required against Escherichia coli	ChEMBL.	15357959

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2368383

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1742457