Detailed information for compound 1742458

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 630.342 | Formula: C18H40Cl4N4O11
  • H donors: 11 H acceptors: 7 LogP: -3.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC[C@@H]1O[C@H](O[C@@H]2[C@H](N)C[C@H]([C@H]([C@H]2O[C@@H]2O[C@H](CO)[C@H]([C@@H]([C@@H]2O)O)O)O)N)[C@H]([C@H]([C@@H]1O)O)N.Cl.Cl.Cl.Cl
  • InChi: 1S/C18H36N4O11.4ClH/c19-2-6-10(25)12(27)8(22)17(30-6)32-15-5(21)1-4(20)9(24)16(15)33-18-14(29)13(28)11(26)7(3-23)31-18;;;;/h4-18,23-29H,1-3,19-22H2;4*1H/t4-,5-,6+,7-,8+,9-,10-,11-,12-,13+,14+,15-,16-,17-,18+;;;;/m1..../s1
  • InChiKey: JAHJQKAKSKANOO-JMJFSSASSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0253 0.0083 0.0034
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.157 0.1815 1
Echinococcus granulosus hypothetical protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) TK/FER protein kinase 0.0426 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.157 0.1815 0.1815
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0253 0.0083 0.0083
Mycobacterium ulcerans ion antiporter, NhaP 0.0299 0.0144 1
Leishmania major hypothetical protein, conserved 0.0299 0.0144 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0426 0.0311 0.0263
Echinococcus granulosus tyrosine protein kinase Src64B 0.0426 0.0311 0.0263
Echinococcus multilocularis sodium:hydrogen exchanger 0.157 0.1815 0.1775
Schistosoma mansoni hypothetical protein 0.0299 0.0144 0.0095
Schistosoma mansoni adapter molecule crk 0.0253 0.0083 0.0034
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0253 0.0083 0.0034
Echinococcus multilocularis mitochondrial sodium:hydrogen exchanger 9B2 0.0299 0.0144 0.0095
Echinococcus multilocularis 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0195 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus granulosus tyrosine kinase 0.0426 0.0311 0.0263
Schistosoma mansoni tensin 0.0253 0.0083 0.0034
Brugia malayi Variant SH3 domain containing protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Schistosoma mansoni sodium/hydrogen exchanger 3 (nhe3) 0.0299 0.0144 0.0095
Brugia malayi SH2 domain containing protein 0.0253 0.0083 0.0034
Onchocerca volvulus 0.0299 0.0144 0.0536
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0426 0.0311 0.0263
Echinococcus granulosus disintegrin and metalloproteinase 0.0452 0.0345 0.0297
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0299 0.0144 0.5
Schistosoma mansoni shc transforming protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) TK/FER protein kinase 0.0426 0.0311 0.0311
Echinococcus granulosus adam 0.0538 0.0457 0.041
Schistosoma mansoni GTPase activating protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0227 0.0049 0.0049
Echinococcus multilocularis adam 17 protease 0.1346 0.152 0.1479
Entamoeba histolytica sodium/proton antiporter, putative 0.0299 0.0144 0.2684
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.1075 0.1164 0.1121
Schistosoma mansoni hypothetical protein 0.0299 0.0144 0.0095
Schistosoma mansoni growth factor receptor-bound protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) TK/FER protein kinase 0.0426 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Onchocerca volvulus 0.0426 0.0311 0.1481
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Onchocerca volvulus Matrix metalloproteinase homolog 0.0418 0.0301 0.1423
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0343 0.0201 0.0152
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) sodium/hydrogen exchanger 0.157 0.1815 0.1815
Onchocerca volvulus 0.0253 0.0083 0.0189
Loa Loa (eye worm) hypothetical protein 0.779 1 1
Echinococcus granulosus adam 17 protease 0.1608 0.1865 0.1825
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0253 0.0083 0.0189
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) integrin alpha pat-2 0.023 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Schistosoma mansoni SH2A 0.0253 0.0083 0.0034
Toxoplasma gondii sodium/hydrogen exchanger 3 protein 0.0299 0.0144 0.5
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) melatonin receptor type 1A 0.0227 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0635 0.0586 0.0539
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0227 0.0049 0.0049
Brugia malayi Tyrosine-protein kinase abl-1 0.0426 0.0311 0.0263
Loa Loa (eye worm) hypothetical protein 0.0233 0.0056 0.0056
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.157 0.1815 0.1775
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0253 0.0083 0.0034
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0227 0.0049 0.0049
Loa Loa (eye worm) TK/FER protein kinase 0.0426 0.0311 0.0311
Brugia malayi STAT protein, DNA binding domain containing protein 0.0253 0.0083 0.0034
Schistosoma mansoni sodium/hydrogen exchanger 0.157 0.1815 0.1775
Mycobacterium ulcerans potassium/proton antiporter 0.0299 0.0144 1
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0299 0.0144 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0426 0.0311 0.0263
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0253 0.0083 0.0034
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0426 0.0311 0.0263
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.157 0.1815 0.1775
Brugia malayi Protein kinase domain containing protein 0.0426 0.0311 0.0263
Echinococcus granulosus tensin 0.0253 0.0083 0.0034
Echinococcus multilocularis SH2 domain containing protein 7 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Brugia malayi tRNA modification GTPase TrmE family protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) sodium-hydrogen exchanger NHE1 0.0299 0.0144 0.0144
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.157 0.1815 0.1775
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Brugia malayi SH2 domain containing protein 0.0253 0.0083 0.0034
Schistosoma mansoni Slc9a7 protein 0.0299 0.0144 0.0095
Toxoplasma gondii sodium/hydrogen exchanger NHE2 0.0299 0.0144 0.5
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.1346 0.152 0.1479
Loa Loa (eye worm) hypothetical protein 0.3058 0.3774 0.3774
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus granulosus c src tyrosine kinase 0.0426 0.0311 0.0263
Schistosoma mansoni tensin 0.0253 0.0083 0.0034
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0227 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Loa Loa (eye worm) SRC-1 0.0426 0.0311 0.0311
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0253 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Echinococcus multilocularis c src tyrosine kinase 0.0426 0.0311 0.0263
Toxoplasma gondii Na+/H+ exchanger NHE3 0.0299 0.0144 0.5
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0426 0.0311 0.0263
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus granulosus sodium:hydrogen exchanger 0.157 0.1815 0.1775
Mycobacterium tuberculosis Probable conserved integral membrane transport protein YjcE 0.0299 0.0144 1
Brugia malayi hypothetical protein 0.0299 0.0144 0.0095
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0299 0.0144 0.0095
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Plasmodium falciparum sodium/hydrogen exchanger, Na+, H+ antiporter 0.0299 0.0144 0.5
Brugia malayi SH2 domain containing protein 0.0426 0.0311 0.0263
Echinococcus granulosus tyrosine protein kinase ABL1 0.0426 0.0311 0.0263
Loa Loa (eye worm) hypothetical protein 0.0299 0.0144 0.0144
Loa Loa (eye worm) TK/FER protein kinase 0.0426 0.0311 0.0311
Schistosoma mansoni tyrosine kinase 0.0426 0.0311 0.0263
Brugia malayi hypothetical protein 0.0538 0.0457 0.041
Loa Loa (eye worm) hypothetical protein 0.023 0.0052 0.0052
Schistosoma mansoni tyrosine kinase 0.0426 0.0311 0.0263
Brugia malayi hypothetical protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0253 0.0083 0.0083
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0253 0.0083 0.0034
Schistosoma mansoni tyrosine kinase 0.0426 0.0311 0.0263
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Onchocerca volvulus 0.0426 0.0311 0.1481
Loa Loa (eye worm) TK/FER protein kinase 0.0426 0.0311 0.0311
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.023 0.0052 0.0003
Brugia malayi Protein kinase domain containing protein 0.0426 0.0311 0.0263
Echinococcus multilocularis sodium:hydrogen exchanger 7 0.0299 0.0144 0.0095
Echinococcus granulosus suppressor of cytokine signaling 7 0.0253 0.0083 0.0034
Brugia malayi Hemopexin family protein 0.0268 0.0102 0.0053
Loa Loa (eye worm) SH2 domain-containing protein 0.0253 0.0083 0.0083
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0426 0.0311 0.0263
Echinococcus granulosus SH2 domain containing protein 7 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus multilocularis sodium:hydrogen exchanger 0.157 0.1815 0.1775
Loa Loa (eye worm) TK/FER protein kinase 0.0426 0.0311 0.0311
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.1075 0.1164 0.1121
Echinococcus granulosus tyrosine protein kinase Srms 0.0426 0.0311 0.0263
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) TK protein kinase 0.0426 0.0311 0.0311
Echinococcus granulosus tyrosine protein kinase Src42A 0.0426 0.0311 0.0263
Brugia malayi hypothetical protein 0.0426 0.0311 0.0263
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0686 0.0653 0.0606
Echinococcus multilocularis tensin 0.0253 0.0083 0.0034
Loa Loa (eye worm) TK/ABL protein kinase 0.0426 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.157 0.1815 0.1815
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0426 0.0311 0.0263
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0426 0.0311 1
Schistosoma mansoni tyrosine kinase 0.0426 0.0311 0.0263
Loa Loa (eye worm) G-protein coupled receptor 0.0227 0.0049 0.0049
Echinococcus granulosus expressed conserved protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Onchocerca volvulus Matrilysin homolog 0.0418 0.0301 0.1423
Leishmania major Na/H antiporter-like protein 0.0299 0.0144 0.5
Loa Loa (eye worm) hypothetical protein 0.0426 0.0311 0.0311
Echinococcus granulosus SH2 motif 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus multilocularis N chimaerin 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus granulosus SH2 motif 0.0253 0.0083 0.0034
Schistosoma mansoni tensin 0.0253 0.0083 0.0034
Brugia malayi Sodium/hydrogen exchanger 8 0.0299 0.0144 0.0095
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0426 0.0311 0.0263
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Plasmodium vivax sodium/hydrogen exchanger 1, putative 0.0299 0.0144 0.5
Schistosoma mansoni tensin-related 0.0253 0.0083 0.0034
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0253 0.0083 0.0034
Brugia malayi angiogenesis inhibito 0.0233 0.0056 0.0007
Brugia malayi ADAMTS-like protease 0.0233 0.0056 0.0007
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0253 0.0083 0.0034
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0253 0.0083 0.0034
Loa Loa (eye worm) TK/FER protein kinase 0.0426 0.0311 0.0311
Echinococcus multilocularis tensin 0.0253 0.0083 0.0034
Mycobacterium ulcerans membrane transporter 0.0299 0.0144 1
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0635 0.0586 0.0539
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0426 0.0311 0.0263
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.157 0.1815 1
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0299 0.0144 0.5
Echinococcus granulosus tyrosine kinase 0.0426 0.0311 0.0263
Brugia malayi Sex muscle abnormal protein 5 0.0253 0.0083 0.0034
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0253 0.0083 0.0083
Schistosoma mansoni nck2/grb4 0.0253 0.0083 0.0034
Brugia malayi SH2 domain containing protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Brugia malayi SH2 domain containing protein 0.0253 0.0083 0.0034
Onchocerca volvulus 0.0253 0.0083 0.0189
Wolbachia endosymbiont of Brugia malayi Kef-type K+ transport system, membrane component 0.0299 0.0144 0.5
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Brugia malayi Protein kinase domain containing protein 0.0426 0.0311 0.0263
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Onchocerca volvulus 0.0268 0.0102 0.0299
Echinococcus granulosus mitochondrial sodium:hydrogen exchanger 9B2 0.0299 0.0144 0.0095
Brugia malayi Variant SH3 domain containing protein 0.0253 0.0083 0.0034
Echinococcus multilocularis NCK adaptor protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) TK/FER protein kinase 0.0426 0.0311 0.0311
Echinococcus multilocularis SH2 motif 0.0253 0.0083 0.0034
Brugia malayi RhoGAP domain containing protein 0.0253 0.0083 0.0034
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0253 0.0083 0.0034
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0253 0.0083 0.0034
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0635 0.0586 0.0539
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0253 0.0083 0.0034
Echinococcus granulosus SH2 domain containing adapter protein F 0.0253 0.0083 0.0034
Schistosoma mansoni tyrosine kinase 0.0426 0.0311 0.0263
Echinococcus multilocularis SHC transforming protein 3 0.0253 0.0083 0.0034
Schistosoma mansoni growth factor receptor-bound protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) TYRA-2 protein 0.0227 0.0049 0.0049
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0635 0.0586 0.0539
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.157 0.1815 0.1775
Echinococcus multilocularis tyrosine protein kinase Srms 0.0426 0.0311 0.0263
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0343 0.0201 0.0152
Brugia malayi Protein kinase domain containing protein 0.0426 0.0311 0.0263
Echinococcus multilocularis tyrosine protein kinase shark 0.0426 0.0311 0.0263
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.157 0.1815 0.1775
Loa Loa (eye worm) hypothetical protein 0.157 0.1815 0.1815
Echinococcus multilocularis tyrosine protein kinase Blk 0.0426 0.0311 0.0263
Schistosoma mansoni hypothetical protein 0.0268 0.0102 0.0053
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0253 0.0083 0.0034
Toxoplasma gondii Na+/H+ exchanger NHE1 0.0299 0.0144 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0426 0.0311 0.0263
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0426 0.0311 0.0263
Loa Loa (eye worm) STAT protein 0.0253 0.0083 0.0083
Loa Loa (eye worm) reprolysin 0.0343 0.0201 0.0201
Echinococcus granulosus sodium:hydrogen exchanger 0.157 0.1815 0.1775
Schistosoma mansoni tensin-related 0.0253 0.0083 0.0034
Schistosoma mansoni tyrosine kinase 0.0426 0.0311 0.0263
Echinococcus granulosus growth factor receptor bound protein 2 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus multilocularis SH2 motif 0.0253 0.0083 0.0034
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0299 0.0144 1
Brugia malayi SH2 domain containing protein 0.0253 0.0083 0.0034
Schistosoma mansoni signal transduction protein lnk-related 0.0253 0.0083 0.0034
Echinococcus multilocularis signal transduction protein lnk realted 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0299 0.0144 0.0144
Loa Loa (eye worm) TK/FER protein kinase 0.0426 0.0311 0.0311
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0343 0.0201 0.0152
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0426 0.0311 0.0263
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0253 0.0083 0.0034
Echinococcus multilocularis disintegrin and metalloproteinase 0.0452 0.0345 0.0297
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.779 1 1
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0253 0.0083 0.0189
Echinococcus granulosus sodium:hydrogen exchanger 7 0.0299 0.0144 0.0095
Brugia malayi Tensin 0.0253 0.0083 0.0034
Brugia malayi Matrixin family protein 0.0456 0.035 0.0303
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0253 0.0083 0.0034
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0538 0.0457 0.041
Giardia lamblia Sodium/hydrogen exchanger 3 0.157 0.1815 0.5
Brugia malayi protein-tyrosine kinase 0.0426 0.0311 0.0263
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Onchocerca volvulus 0.0253 0.0083 0.0189
Loa Loa (eye worm) hypothetical protein 0.0233 0.0056 0.0056
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.157 0.1815 1
Loa Loa (eye worm) hypothetical protein 0.0343 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Brugia malayi SH2 domain containing protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) matrixin family protein 0.0418 0.0301 0.0301
Echinococcus granulosus NCK adaptor protein 0.0253 0.0083 0.0034
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0426 0.0311 0.0263
Schistosoma mansoni suppressor of cytokine signaling 0.0253 0.0083 0.0034
Schistosoma mansoni hypothetical protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0253 0.0083 0.0083
Echinococcus multilocularis growth factor receptor bound protein 2 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0686 0.0653 0.0606
Schistosoma mansoni vav2 0.0253 0.0083 0.0034
Schistosoma mansoni dihydroceramide desaturase 0.0452 0.0345 0.0297
Brugia malayi SH2 domain containing protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) G-protein coupled receptor 0.0227 0.0049 0.0049
Echinococcus granulosus signal transduction protein lnk realted 0.0253 0.0083 0.0034
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.779 1 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.127 0.1421 0.1379
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus granulosus tyrosine protein kinase Blk 0.0426 0.0311 0.0263
Echinococcus multilocularis SH2 motif 0.0253 0.0083 0.0034
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0253 0.0083 0.0083
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0426 0.0311 0.0263
Onchocerca volvulus 0.0253 0.0083 0.0189
Loa Loa (eye worm) neuropeptide F receptor 0.0227 0.0049 0.0049
Loa Loa (eye worm) neuropeptide F receptor 0.0227 0.0049 0.0049
Loa Loa (eye worm) SH2 domain-containing protein 0.0253 0.0083 0.0083
Onchocerca volvulus 0.0253 0.0083 0.0189
Echinococcus granulosus suppressor of cytokine signaling 6 0.0253 0.0083 0.0034
Brugia malayi SRC-1 0.0426 0.0311 0.0263
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0426 0.0311 0.0263
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0253 0.0083 0.0034
Echinococcus granulosus tyrosine protein kinase Fyn 0.0426 0.0311 0.0263
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus multilocularis tyrosine kinase 0.0426 0.0311 0.0263
Entamoeba histolytica sodium/proton antiporter, putative 0.0299 0.0144 0.2684
Onchocerca volvulus 0.0426 0.0311 0.1481
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0426 0.0311 0.0263
Brugia malayi Protein kinase domain containing protein 0.0426 0.0311 0.0263
Echinococcus granulosus tyrosine protein kinase Lyn 0.0426 0.0311 0.0263
Brugia malayi Variant SH3 domain containing protein 0.0253 0.0083 0.0034
Loa Loa (eye worm) NHE-3 0.157 0.1815 0.1815
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.127 0.1421 0.1379
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus multilocularis adam 0.0538 0.0457 0.041
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.157 0.1815 0.1775
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Brugia malayi SH2 domain containing protein 0.0426 0.0311 0.0263
Brugia malayi Variant SH3 domain containing protein 0.0253 0.0083 0.0034
Brugia malayi ADAM-TS Spacer 1 family protein 0.0233 0.0056 0.0007
Schistosoma mansoni suppressor of cytokine signaling 0.0253 0.0083 0.0034
Onchocerca volvulus 0.0253 0.0083 0.0189
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0299 0.0144 0.5
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0253 0.0083 0.0034
Brugia malayi cytokine inducible SH2-containing protein 5 0.0253 0.0083 0.0034
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.157 0.1815 0.1775
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Echinococcus granulosus N chimaerin 0.0253 0.0083 0.0034
Echinococcus granulosus tyrosine protein kinase Src42A 0.0253 0.0083 0.0034
Echinococcus granulosus tyrosine protein kinase Fyn 0.0426 0.0311 0.0263
Echinococcus granulosus tyrosine protein kinase shark 0.0426 0.0311 0.0263
Loa Loa (eye worm) hypothetical protein 0.0253 0.0083 0.0083
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0253 0.0083 0.0034
Brugia malayi Disintegrin family protein 0.0452 0.0345 0.0297
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.779 1 1
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0343 0.0201 0.0152
Onchocerca volvulus 0.0426 0.0311 0.1481
Echinococcus multilocularis tyrosine protein kinase Abl 0.0426 0.0311 0.0263
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0253 0.0083 0.0034
Mycobacterium leprae probable conserved integral membrane transport protein 0.0299 0.0144 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.0049 0.0049
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0426 0.0311 0.0263
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Onchocerca volvulus 0.0426 0.0311 0.1481
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.157 0.1815 0.1815
Onchocerca volvulus 0.0426 0.0311 0.1481
Echinococcus granulosus SHC transforming protein 3 0.0253 0.0083 0.0034
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0426 0.0311 0.0263
Echinococcus granulosus tyrosine protein kinase Fyn 0.0426 0.0311 0.0263
Loa Loa (eye worm) SH2 domain-containing protein 0.0253 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0227 0.0049 0.0049
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.157 0.1815 0.1775
Onchocerca volvulus 0.0299 0.0144 0.0536
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0253 0.0083 0.0034
Loa Loa (eye worm) matrixin family protein 0.0456 0.035 0.035
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0426 0.0311 0.0263

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 11 uM Minimum inhibitory concentration required against Escherichia coli ChEMBL. 15357959

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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