Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Kinase, CMGC MAPK | 0.0415 | 0.2435 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0415 | 0.2435 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0025 | 0.0101 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0174 | 0.0479 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0174 | 0.0479 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0415 | 0.2435 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0415 | 0.2435 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0415 | 0.2435 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0025 | 0.0101 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0415 | 0.2435 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0174 | 0.0479 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0415 | 0.2435 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0415 | 0.2435 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.1343 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0415 | 0.2435 | 0.5 |
Brugia malayi | hypothetical protein | 0.0119 | 0.0025 | 0.0101 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0415 | 0.2435 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0415 | 0.2435 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0174 | 0.0479 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0415 | 0.2435 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0415 | 0.2435 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0415 | 0.2435 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0415 | 0.2435 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0415 | 0.2435 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.1343 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0415 | 0.2435 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0174 | 0.0479 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0415 | 0.2435 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.1343 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0415 | 0.2435 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.0025 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0415 | 0.2435 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0415 | 0.2435 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.1343 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.1343 | 1 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.0025 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1343 | 1 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.1343 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Concentration of the compound inhibiting Candida beta-1,3-glucan synthesis was determined in a Candida albicans cell culture | ChEMBL. | 1495015 |
MFC (functional) | > 64 ug ml-1 | Antifungal activity of the compound on Candida albicans MY1055. | ChEMBL. | 1495015 |
MFC (functional) | > 64 ug ml-1 | Antifungal activity of the compound on Candida albicans MY1208. | ChEMBL. | 1495015 |
MFC (functional) | > 64 ug ml-1 | Antifungal activity of the compound on Candida albicans MY1028. | ChEMBL. | 1495015 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Candida albicans | ChEMBL23 | 1495015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.