Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | folate/biopterin transporter, putative | 0.0108 | 0.0074 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1078 | 0.6647 | 1 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0108 | 0.0074 | 1 |
Echinococcus granulosus | nervana 2 | 0.097 | 0.5915 | 0.8899 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0505 | 0.2769 | 0.2769 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK17, putative | 0.0108 | 0.0074 | 0.0111 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.0074 | 0.0074 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0505 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0603 | 0.3427 | 0.3427 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Echinococcus multilocularis | protein kinase c iota type | 0.0505 | 0.2769 | 0.4166 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0505 | 0.2769 | 0.4166 |
Onchocerca volvulus | 0.0097 | 0 | 0.5 | |
Onchocerca volvulus | Abnormal cell migration protein 10 homolog | 0.0097 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Onchocerca volvulus | Putative zinc finger protein | 0.0097 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.1572 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0505 | 0.2769 | 0.4166 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0505 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.098 | 0.5989 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0108 | 0.0074 | 0.0074 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.097 | 0.5915 | 0.8899 |
Onchocerca volvulus | 0.0097 | 0 | 0.5 | |
Trichomonas vaginalis | 3-phosphoinositide dependent protein kinase-1, putative | 0.0108 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0505 | 0.2769 | 0.2769 |
Schistosoma mansoni | serine/threonine kinase | 0.0505 | 0.2769 | 0.4166 |
Trypanosoma brucei | serine/threonine-protein kinase NRKB, putative | 0.0108 | 0.0074 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0505 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0505 | 0.2769 | 0.4166 |
Entamoeba histolytica | protein kinase, putative | 0.0108 | 0.0074 | 0.0074 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0505 | 0.2769 | 0.4166 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0505 | 0.2769 | 0.4166 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0108 | 0.0074 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0505 | 0.2769 | 0.4166 |
Brugia malayi | Protein kinase domain containing protein | 0.0505 | 0.2769 | 0.2769 |
Toxoplasma gondii | AGC kinase | 0.1475 | 0.9342 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0505 | 0.2769 | 0.4166 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0108 | 0.0074 | 0.0074 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.0108 | 0.0074 | 0.0111 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Echinococcus multilocularis | nervana 2 | 0.097 | 0.5915 | 0.8899 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0505 | 0.2769 | 0.4166 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.098 | 0.5989 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.1475 | 0.9342 | 0.9342 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.1572 | 1 | 1 |
Trypanosoma cruzi | serine/threonine-protein kinase NRKB, putative | 0.0108 | 0.0074 | 0.0111 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.0108 | 0.0074 | 0.0111 |
Onchocerca volvulus | 0.0097 | 0 | 0.5 | |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.0108 | 0.0074 | 0.0111 |
Toxoplasma gondii | protein kinase domain-containing protein | 0.0108 | 0.0074 | 0.0079 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0108 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Echinococcus granulosus | nervana 2 | 0.097 | 0.5915 | 0.8899 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK17, putative | 0.0108 | 0.0074 | 0.0111 |
Trichomonas vaginalis | AGC family protein kinase | 0.1572 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Giardia lamblia | Kinase, AGC PKA | 0.098 | 0.5989 | 0.5 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0505 | 0.2769 | 0.4166 |
Onchocerca volvulus | 0.0097 | 0 | 0.5 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.098 | 0.5989 | 0.901 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.002 | 0.002 |
Entamoeba histolytica | protein kinase, putative | 0.0108 | 0.0074 | 0.0074 |
Echinococcus granulosus | protein kinase C gamma type | 0.0505 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0108 | 0.0074 | 0.0111 |
Schistosoma mansoni | atypical protein kinase C | 0.0505 | 0.2769 | 0.4166 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0495 | 0.2695 | 0.2695 |
Entamoeba histolytica | protein kinase 2, putative | 0.098 | 0.5989 | 0.5989 |
Trichomonas vaginalis | ribosomal protein S6 kinase, 90kD, polypeptide, putative | 0.0108 | 0.0074 | 0.0074 |
Toxoplasma gondii | calcium dependent protein kinase CDPK7 | 0.0108 | 0.0074 | 0.0079 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0108 | 0.0074 | 0.0111 |
Echinococcus granulosus | serine/threonine protein kinase | 0.1078 | 0.6647 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.1475 | 0.9342 | 0.9342 |
Onchocerca volvulus | 0.0097 | 0 | 0.5 | |
Entamoeba histolytica | protein kinase, putative | 0.1572 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0505 | 0.2769 | 0.4166 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0505 | 0.2769 | 0.4166 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0505 | 0.2769 | 0.2769 |
Entamoeba histolytica | protein kinase, putative | 0.0108 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0505 | 0.2769 | 0.2769 |
Entamoeba histolytica | protein kinase, putative | 0.0108 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.1572 | 1 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1078 | 0.6647 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.098 | 0.5989 | 0.901 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1078 | 0.6647 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.1572 | 1 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0108 | 0.0074 | 0.0074 |
Leishmania major | protein kinase, putative | 0.0108 | 0.0074 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Trypanosoma brucei | protein kinase, putative | 0.0108 | 0.0074 | 0.0074 |
Entamoeba histolytica | protein kinase, putative | 0.0505 | 0.2769 | 0.2769 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1078 | 0.6647 | 0.6647 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0505 | 0.2769 | 0.2769 |
Plasmodium vivax | calcium-dependent protein kinase 7, putative | 0.0108 | 0.0074 | 0.0123 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0508 | 0.2784 | 0.4189 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.1475 | 0.9342 | 0.9342 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK21, putative | 0.0108 | 0.0074 | 0.0074 |
Echinococcus multilocularis | nervana 2 | 0.097 | 0.5915 | 0.8899 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Trypanosoma brucei | serine/threonine-protein kinase NrkA | 0.0108 | 0.0074 | 0.0074 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0505 | 0.2769 | 0.4166 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0505 | 0.2769 | 0.2769 |
Onchocerca volvulus | 0.0097 | 0 | 0.5 | |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.097 | 0.5915 | 0.8899 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.1078 | 0.6647 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0108 | 0.0074 | 0.0074 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0108 | 0.0074 | 0.0074 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.002 | 0.003 |
Trichomonas vaginalis | AGC family protein kinase | 0.1572 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0505 | 0.2769 | 0.2769 |
Leishmania major | protein kinase, putative | 0.0108 | 0.0074 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1572 | 1 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.0505 | 0.2769 | 0.2769 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0505 | 0.2769 | 0.4166 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.2769 | 0.2769 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Onchocerca volvulus | 0.0097 | 0 | 0.5 | |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0505 | 0.2769 | 0.2769 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK21, putative | 0.0108 | 0.0074 | 0.0111 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1078 | 0.6647 | 0.6647 |
Echinococcus granulosus | NDR protein kinase | 0.0505 | 0.2769 | 0.4166 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.097 | 0.5915 | 0.8899 |
Trichomonas vaginalis | AGC family protein kinase | 0.1572 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0505 | 0.2769 | 0.4166 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.098 | 0.5989 | 0.901 |
Trichomonas vaginalis | AGC family protein kinase | 0.1572 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0505 | 0.2769 | 0.2769 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.097 | 0.5915 | 0.8899 |
Onchocerca volvulus | Putative neuronal RhoA GEF protein | 0.0097 | 0 | 0.5 |
Onchocerca volvulus | outspread protein homolog | 0.0097 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0505 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0108 | 0.0074 | 0.0074 |
Echinococcus granulosus | protein kinase c iota type | 0.0505 | 0.2769 | 0.4166 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0505 | 0.2769 | 0.4166 |
Brugia malayi | Protein kinase domain containing protein | 0.0505 | 0.2769 | 0.2769 |
Trypanosoma brucei | NEK family Serine/threonine-protein kinase, putative | 0.0108 | 0.0074 | 0.0074 |
Brugia malayi | protein kinase C II. | 0.0505 | 0.2769 | 0.2769 |
Plasmodium falciparum | calcium-dependent protein kinase 7 | 0.0108 | 0.0074 | 0.0123 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.098 | 0.5989 | 0.901 |
Onchocerca volvulus | Protein melted homolog | 0.0097 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0108 | 0.0074 | 0.0074 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0505 | 0.2769 | 0.4166 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0108 | 0.0074 | 1 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK21, putative | 0.0108 | 0.0074 | 0.0111 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0505 | 0.2769 | 0.4166 |
Trichomonas vaginalis | AGC family protein kinase | 0.1572 | 1 | 1 |
Trypanosoma cruzi | Protein kinase B | 0.1078 | 0.6647 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 25.7 uM | Concentration of the compound required to reduce the viability of mock-infected CEM cells by 50% | ChEMBL. | 11714616 |
EC50 (functional) | > 10 uM | Effective concentration required to inhibit HIV-1 induced cytopathicity by 50% in CEM cells | ChEMBL. | 11714616 |
EC50 (functional) | > 10 uM | Effective concentration required to inhibit HIV-2 induced cytopathicity by 50% in CEM cells | ChEMBL. | 11714616 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.