Detailed information for compound 1750072

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 293.116 | Formula: C12H9BrN2O2
  • H donors: 1 H acceptors: 2 LogP: 2.07 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)c1noc2c1C(=O)NCC2
  • InChi: 1S/C12H9BrN2O2/c13-8-3-1-7(2-4-8)11-10-9(17-15-11)5-6-14-12(10)16/h1-4H,5-6H2,(H,14,16)
  • InChiKey: WLUUGFKDQHOGGT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0221 0.0254
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0181 0.1314 0.1526
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Echinococcus multilocularis regulator of G protein signaling 7 0.0181 0.1314 0.1526
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.002 0.0021
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0194 0.2095
Echinococcus multilocularis regulator of G protein signaling 7 0.0181 0.1314 0.1526
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0021 0.0018
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0096 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Schistosoma mansoni hypothetical protein 0.0014 0.0021 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0071
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0194 0.2165
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0824 0.0955
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0194 0.7349
Echinococcus multilocularis lamin 0.0023 0.0096 0.0108
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0194 0.0192
Brugia malayi PXA domain containing protein 0.0181 0.1314 0.1314
Echinococcus multilocularis jumonji domain containing 1A 0.0014 0.002 0.0021
Echinococcus multilocularis musashi 0.0023 0.0096 0.0108
Leishmania major pyruvate kinase 0.0036 0.0194 0.2165
Echinococcus granulosus survival motor neuron protein 1 0.0205 0.1495 0.1736
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0021 0.0021
Plasmodium vivax acyl-CoA synthetase, putative 0.0015 0.0034 0.078
Echinococcus granulosus axis inhibition protein axin 0.0181 0.1314 0.1526
Echinococcus multilocularis axis inhibition protein axin 0.0181 0.1314 0.1526
Echinococcus multilocularis phd:f box containing protein 0.0014 0.002 0.0021
Echinococcus granulosus regulator of G protein signaling 3 0.0181 0.1314 0.1526
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0194 0.1605
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0221 0.0201
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Echinococcus granulosus phd:f box containing protein 0.0014 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0205 0.1495 0.1493
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0824 0.6045
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.0321 0.0301
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.1348 0.133
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0053 0.0321 0.3688
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0012 0.0012
Schistosoma mansoni lamin 0.0023 0.0096 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0221 0.0201
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0194 0.0194
Echinococcus granulosus regulator of G protein signaling 7 0.0181 0.1314 0.1526
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0096 0.0093
Schistosoma mansoni hypothetical protein 0.0014 0.0021 0.0001
Leishmania major pyruvate kinase 0.0036 0.0194 0.2165
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0161 0.8082
Schistosoma mansoni z-protein (S1r protein) 0.0181 0.1314 0.1297
Schistosoma mansoni microtubule-associated protein tau 0.0598 0.4525 0.4514
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.0238 0.0238
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0043 0.0249 0.0249
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0074 0.0507
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1126 0.8601 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1126 0.8601 0.8601
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0074 0.0507
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0181 0.1314 0.1297
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0321 0.3636
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0194 0.7349
Brugia malayi jmjC domain containing protein 0.0014 0.002 0.002
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0194 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0181 0.1314 0.1526
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0194 0.7349
Entamoeba histolytica hypothetical protein 0.0181 0.1314 1
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0824 0.6045
Echinococcus multilocularis lamin dm0 0.0023 0.0096 0.0108
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0824 0.0805
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0194 0.2165
Brugia malayi jmjC domain containing protein 0.0051 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0036 0.0194 0.0192
Echinococcus granulosus pyruvate kinase 0.0036 0.0194 0.0223
Schistosoma mansoni pyruvate kinase 0.0036 0.0194 0.0174
Echinococcus granulosus regulator of G protein signaling 3 0.0181 0.1314 0.1526
Echinococcus granulosus regulator of G protein signaling 7 0.0181 0.1314 0.1526
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0194 0.0192
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0194 0.2165
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0059 0.2202
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.011 0.0107
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0018
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0021 0.0021
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0051 0.0308 0.0356
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0161 0.4675
Brugia malayi hypothetical protein 0.0181 0.1314 0.1314
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1126 0.8601 0.8601
Loa Loa (eye worm) hypothetical protein 0.0023 0.0096 0.0093
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0031
Echinococcus multilocularis neuropeptide receptor A26 0.0401 0.3004 0.3491
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0221 0.0254
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0161 0.8082
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0161 0.8082
Echinococcus multilocularis pyruvate kinase 0.0036 0.0194 0.0223
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0065
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0059 0.1274
Brugia malayi Calcitonin receptor-like protein seb-1 0.0043 0.0249 0.0249
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0321 0.3636
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0143 0.0143
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0824 1
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0194 0.2165
Onchocerca volvulus 0.0023 0.0096 0.1329
Brugia malayi jmjC domain containing protein 0.0014 0.002 0.002
Plasmodium falciparum acyl-CoA synthetase 0.0015 0.0034 0.078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0031
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0194 0.0194
Echinococcus multilocularis regulator of G protein signaling 3 0.0181 0.1314 0.1526
Brugia malayi Regulator of G protein signaling domain containing protein 0.0181 0.1314 0.1314
Brugia malayi PXA domain containing protein 0.0181 0.1314 0.1314
Echinococcus multilocularis expressed protein 0.0181 0.1314 0.1526
Echinococcus granulosus neuropeptide s receptor 0.0401 0.3004 0.3491
Schistosoma mansoni regulator of G protein signaling 0.0181 0.1314 0.1297
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0021 0.0021
Schistosoma mansoni jumonji domain containing protein 0.0051 0.0308 0.0289
Schistosoma mansoni hypothetical protein 0.0014 0.0021 0.0001
Brugia malayi A-kinase anchor protein 10, precursor 0.0181 0.1314 0.1314
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0043 0.0249 0.0246
Echinococcus granulosus beta-adrenergic receptor kinase 0.0186 0.1348 0.1565
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0051 0.0308 0.0356
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0074 0.0074
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0181 0.1314 0.1297
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0824 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0181 0.1314 0.1314
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0096 0.0096
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0308 0.0306
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0065
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0824 0.0822
Schistosoma mansoni regulator of G protein signaling 0.0181 0.1314 0.1297
Brugia malayi phosphofructokinase 0.0118 0.0824 0.0824
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0194 0.0289
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0015 0.0034 0.0081
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0824 0.0822
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0194 0.2031
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0181 0.1314 0.1526
Echinococcus granulosus lysine specific demethylase 5A 0.0051 0.0308 0.0356
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0018
Schistosoma mansoni lamin 0.0023 0.0096 0.0076
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0824 1
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0161 0.4675
Echinococcus multilocularis survival motor neuron protein 1 0.0205 0.1495 0.1736
Echinococcus granulosus microtubule associated protein 2 0.0598 0.4525 0.5259
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0824 1
Brugia malayi 6-phosphofructokinase 0.0118 0.0824 0.0824
Schistosoma mansoni axis inhibition protein axin 0.0181 0.1314 0.1297
Echinococcus granulosus pyruvate kinase 0.0036 0.0194 0.0223
Loa Loa (eye worm) hypothetical protein 0.003 0.0143 0.0141
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0161 0.0701
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0308 0.0289
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0161 0.792
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0059 0.2202
Schistosoma mansoni regulator of G protein signaling 0.0181 0.1314 0.1297
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0021 0.0074 0.0507
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.0221 0.0219
Toxoplasma gondii aldehyde dehydrogenase 0.0053 0.0321 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0186 0.1348 0.1565
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0181 0.1314 0.1297
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0031
Schistosoma mansoni pyruvate kinase 0.0036 0.0194 0.0174
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0161 0.4675
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0161 0.8082
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0053 0.0321 0.3744
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0065
Schistosoma mansoni regulator of G protein signaling 0.0181 0.1314 0.1297
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.0221 0.0221
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0181 0.1314 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0031
Brugia malayi hypothetical protein 0.0181 0.1314 0.1314
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0824 0.5747
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0194 0.0192
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0074 0.0507
Schistosoma mansoni pyruvate kinase 0.0019 0.0059 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0031
Schistosoma mansoni hypothetical protein 0.003 0.0143 0.0123
Echinococcus multilocularis lysine specific demethylase 6a 0.0014 0.002 0.0021
Mycobacterium ulcerans hypothetical protein 0.0021 0.0074 0.0507
Giardia lamblia Pyruvate kinase 0.0036 0.0194 1
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.1348 0.133
Loa Loa (eye worm) hypothetical protein 0.0043 0.0249 0.0246
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0021 0.0074 0.0507
Echinococcus granulosus intermediate filament protein 0.0023 0.0096 0.0108
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0065
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.002 0.0021
Schistosoma mansoni intermediate filament proteins 0.0023 0.0096 0.0076
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0824 0.5747
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0012 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0074 0.0667
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0824 1
Echinococcus granulosus axis inhibition protein axin 0.0181 0.1314 0.1526
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0702 0.5332 0.6198
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.002 0.0018
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0021 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0221 0.0254
Echinococcus granulosus expressed protein 0.0181 0.1314 0.1526
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0074 0.0667
Echinococcus multilocularis pyruvate kinase 0.0036 0.0194 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.1308 1 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Brugia malayi jmjC domain containing protein 0.0051 0.0308 0.0308
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.011 0.0291
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0161 0.7541
Onchocerca volvulus 0.0042 0.0238 1
Brugia malayi regulator of G-protein signaling egl-10 0.0181 0.1314 0.1314
Loa Loa (eye worm) RGS-3 protein 0.0181 0.1314 0.1312
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0074 0.0507
Brugia malayi jmjC domain containing protein 0.0014 0.002 0.002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0053 0.0321 0.0371
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.002 0.0018
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0186 0.1348 0.1346
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0042 0.0238 0.0218
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0824 0.0955
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0221 0.0254
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0021 0.0021
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0065
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0194 0.0289
Brugia malayi intermediate filament protein 0.0023 0.0096 0.0096
Echinococcus multilocularis lysine specific demethylase 5A 0.0051 0.0308 0.0356
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0824 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0321 0.3636
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0824 0.0822
Plasmodium falciparum pyruvate kinase 0.0036 0.0194 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0181 0.1314 0.1312
Echinococcus granulosus Regulator of G protein signaling 20 0.0181 0.1314 0.1526
Echinococcus multilocularis microtubule associated protein 2 0.0598 0.4525 0.5259
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0074 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.009
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0824 0.5747
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0824 0.5747
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0824 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0074 0.0507
Echinococcus granulosus lamin dm0 0.0023 0.0096 0.0108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0074 0.0584
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0071
Echinococcus multilocularis regulator of G protein signaling 3 0.0181 0.1314 0.1526
Schistosoma mansoni axis inhibition protein axin 0.0181 0.1314 0.1297
Echinococcus granulosus lysine specific demethylase 6a 0.0014 0.002 0.0021
Echinococcus granulosus JmjC domain containing protein 4 0.0014 0.002 0.0021
Echinococcus granulosus GPCR family 2 0.0014 0.0021 0.0021
Echinococcus multilocularis GPCR, family 2 0.0014 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0181 0.1314 1
Schistosoma mansoni regulator of G protein signaling 0.0181 0.1314 0.1297
Echinococcus granulosus lamin 0.0023 0.0096 0.0108
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1126 0.8601 1
Echinococcus granulosus jumonji domain containing 1A 0.0014 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0025 0.011 0.0107
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Echinococcus multilocularis regulator of G protein signaling 0.0181 0.1314 0.1526
Echinococcus multilocularis JmjC domain containing protein 4 0.0014 0.002 0.0021
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0053 0.0321 0.0371
Brugia malayi hypothetical protein 0.0205 0.1495 0.1495
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.0321 0.0301
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0824 0.6045
Loa Loa (eye worm) PXA domain-containing protein 0.0181 0.1314 0.1312
Brugia malayi jmjC domain containing protein 0.0014 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0221 0.0201
Echinococcus granulosus neuropeptide receptor A26 0.0401 0.3004 0.3491
Brugia malayi 6-phosphofructokinase 0.0118 0.0824 0.0824
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0308 0.0289
Schistosoma mansoni survival motor neuron protein 0.0042 0.0238 0.0218
Entamoeba histolytica hypothetical protein 0.0181 0.1314 1
Chlamydia trachomatis pyruvate kinase 0.0036 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Schistosoma mansoni hypothetical protein 0.0014 0.0021 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0018
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1308 1 1
Echinococcus multilocularis axis inhibition protein axin 0.0181 0.1314 0.1526
Onchocerca volvulus 0.0023 0.0096 0.1329
Echinococcus multilocularis pyruvate kinase 0.0029 0.0136 0.0155
Brugia malayi regulator of G-protein signaling rgs-7 0.0181 0.1314 0.1314
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0074 0.0074
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0824 0.0805
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1126 0.8601 0.8601
Echinococcus multilocularis neuropeptide s receptor 0.0401 0.3004 0.3491
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0065
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0194 0.5784
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0021 0.0074 0.0584
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0161 0.792

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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