Detailed information for compound 1750072

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 293.116 | Formula: C12H9BrN2O2
  • H donors: 1 H acceptors: 2 LogP: 2.07 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)c1noc2c1C(=O)NCC2
  • InChi: 1S/C12H9BrN2O2/c13-8-3-1-7(2-4-8)11-10-9(17-15-11)5-6-14-12(10)16/h1-4H,5-6H2,(H,14,16)
  • InChiKey: WLUUGFKDQHOGGT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis regulator of G protein signaling 7 0.0181 0.1314 0.1526
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.1126 0.8601 1
Brugia malayi PXA domain containing protein 0.0181 0.1314 0.1314
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0824 0.0955
Echinococcus granulosus regulator of G protein signaling 3 0.0181 0.1314 0.1526
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0194 0.2031
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0074 0.0507
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0824 0.5747
Brugia malayi hypothetical protein 0.0181 0.1314 0.1314
Brugia malayi regulator of G-protein signaling rgs-7 0.0181 0.1314 0.1314
Plasmodium vivax acyl-CoA synthetase, putative 0.0015 0.0034 0.078
Echinococcus multilocularis axis inhibition protein axin 0.0181 0.1314 0.1526
Schistosoma mansoni pyruvate kinase 0.0036 0.0194 0.0174
Schistosoma mansoni hypothetical protein 0.0014 0.0021 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0221 0.0254
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0059 0.2202
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0096 0.0093
Echinococcus multilocularis survival motor neuron protein 1 0.0205 0.1495 0.1736
Loa Loa (eye worm) hypothetical protein 0.003 0.0143 0.0141
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0074 0.0074
Schistosoma mansoni pyruvate kinase 0.0019 0.0059 0.0038
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0074 0.0074
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0161 0.8082
Schistosoma mansoni microtubule-associated protein tau 0.0598 0.4525 0.4514
Echinococcus granulosus pyruvate kinase 0.0036 0.0194 0.0223
Plasmodium falciparum acyl-CoA synthetase 0.0015 0.0034 0.078
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0143 0.0143
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0824 0.6045
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0702 0.5332 0.6198
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.004 0.0221 0.0219
Echinococcus multilocularis pyruvate kinase 0.0036 0.0194 0.0223
Echinococcus multilocularis phd:f box containing protein 0.0014 0.002 0.0021
Schistosoma mansoni survival motor neuron protein 0.0042 0.0238 0.0218
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Plasmodium falciparum pyruvate kinase 0.0036 0.0194 1
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0065
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0194 0.0289
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.1126 0.8601 0.8601
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0059 0.2202
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0051 0.0308 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.004 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.1348 0.133
Brugia malayi phosphofructokinase 0.0118 0.0824 0.0824
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0194 0.0194
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0065
Entamoeba histolytica hypothetical protein 0.0181 0.1314 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0014 0.002 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0824 0.5747
Echinococcus multilocularis musashi 0.0023 0.0096 0.0108
Brugia malayi 6-phosphofructokinase 0.0118 0.0824 0.0824
Schistosoma mansoni regulator of G protein signaling 0.0181 0.1314 0.1297
Schistosoma mansoni axis inhibition protein axin 0.0181 0.1314 0.1297
Echinococcus granulosus microtubule associated protein 2 0.0598 0.4525 0.5259
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0021 0.0021
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0194 0.7349
Echinococcus granulosus survival motor neuron protein 1 0.0205 0.1495 0.1736
Brugia malayi Calcitonin receptor-like protein seb-1 0.0043 0.0249 0.0249
Entamoeba histolytica hypothetical protein 0.0181 0.1314 1
Mycobacterium ulcerans hypothetical protein 0.0021 0.0074 0.0507
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0321 0.3636
Leishmania major pyruvate kinase 0.0036 0.0194 0.2165
Loa Loa (eye worm) hypothetical protein 0.0014 0.0021 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.0321 0.0301
Echinococcus granulosus lysine specific demethylase 6a 0.0014 0.002 0.0021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.0238 0.0238
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0074 0.0507
Brugia malayi Regulator of G protein signaling domain containing protein 0.0181 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0071
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0065
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0181 0.1314 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0053 0.0321 0.0371
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0161 0.4675
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0065
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0194 1
Echinococcus granulosus neuropeptide s receptor 0.0401 0.3004 0.3491
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0824 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0181 0.1314 0.1314
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0021 0.0074 0.0507
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.1348 0.133
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0161 0.4675
Echinococcus multilocularis regulator of G protein signaling 3 0.0181 0.1314 0.1526
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0021 0.0021
Echinococcus granulosus expressed protein 0.0181 0.1314 0.1526
Echinococcus granulosus lamin 0.0023 0.0096 0.0108
Echinococcus multilocularis regulator of G protein signaling 3 0.0181 0.1314 0.1526
Echinococcus multilocularis Regulator of G protein signaling 20 0.0181 0.1314 0.1526
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0074 0.0507
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0194 0.7349
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0194 0.0289
Schistosoma mansoni intermediate filament proteins 0.0023 0.0096 0.0076
Loa Loa (eye worm) hypothetical protein 0.0205 0.1495 0.1493
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0043 0.0249 0.0246
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0194 0.2165
Loa Loa (eye worm) hypothetical protein 0.0043 0.0249 0.0246
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0012 0.0012
Brugia malayi jmjC domain containing protein 0.0014 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0031
Chlamydia trachomatis pyruvate kinase 0.0036 0.0194 1
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0194 0.7349
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0221 0.0201
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.002 0.0018
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0021 0.0074 0.0584
Brugia malayi regulator of G-protein signaling egl-10 0.0181 0.1314 0.1314
Schistosoma mansoni serine/threonine protein kinase 0.1308 1 1
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0824 0.0822
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1308 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0031
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0194 0.5784
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0161 0.792
Schistosoma mansoni lamin 0.0023 0.0096 0.0076
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0053 0.0321 0.3744
Schistosoma mansoni regulator of G protein signaling 0.0181 0.1314 0.1297
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0074 0.0667
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0161 0.0701
Echinococcus multilocularis lysine specific demethylase 5A 0.0051 0.0308 0.0356
Schistosoma mansoni hypothetical protein 0.0042 0.0238 0.0218
Echinococcus multilocularis regulator of G protein signaling 0.0181 0.1314 0.1526
Schistosoma mansoni regulator of G protein signaling 0.0181 0.1314 0.1297
Echinococcus multilocularis neuropeptide s receptor 0.0401 0.3004 0.3491
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0824 0.5747
Brugia malayi 6-phosphofructokinase 0.0118 0.0824 0.0824
Echinococcus granulosus pyruvate kinase 0.0036 0.0194 0.0223
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0194 0.2165
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0074 0.0507
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0074 0.0507
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0021 0.0018
Schistosoma mansoni regulator of G protein signaling 0.0181 0.1314 0.1297
Echinococcus multilocularis expressed protein 0.0181 0.1314 0.1526
Echinococcus multilocularis pyruvate kinase 0.0029 0.0136 0.0155
Schistosoma mansoni hypothetical protein 0.0014 0.0021 0.0001
Schistosoma mansoni z-protein (S1r protein) 0.0181 0.1314 0.1297
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0824 1
Onchocerca volvulus 0.0023 0.0096 0.1329
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Schistosoma mansoni hypothetical protein 0.0014 0.0021 0.0001
Echinococcus multilocularis lamin 0.0023 0.0096 0.0108
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0824 0.6045
Brugia malayi Regulator of G protein signaling domain containing protein 0.0181 0.1314 0.1314
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0181 0.1314 0.1312
Brugia malayi hypothetical protein 0.0181 0.1314 0.1314
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0824 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0031
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0824 0.6045
Echinococcus granulosus pyruvate kinase 0.0019 0.0059 0.0065
Schistosoma mansoni axis inhibition protein axin 0.0181 0.1314 0.1297
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0308 0.0306
Brugia malayi jmjC domain containing protein 0.0051 0.0308 0.0308
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0074 0.0667
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.002 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0074 0.0667
Echinococcus multilocularis GPCR, family 2 0.0014 0.0021 0.0021
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0181 0.1314 0.1526
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0161 0.8082
Echinococcus multilocularis lysine specific demethylase 6a 0.0014 0.002 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Brugia malayi intermediate filament protein 0.0023 0.0096 0.0096
Echinococcus multilocularis jumonji domain containing 1A 0.0014 0.002 0.0021
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0096 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0021 0.0021
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.002 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0021 0.0021
Echinococcus granulosus jumonji domain containing 1A 0.0014 0.002 0.0021
Loa Loa (eye worm) RGS-3 protein 0.0181 0.1314 0.1312
Brugia malayi jmjC domain containing protein 0.0014 0.002 0.002
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0096 0.0093
Onchocerca volvulus 0.0023 0.0096 0.1329
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0321 0.3636
Echinococcus multilocularis axis inhibition protein axin 0.0181 0.1314 0.1526
Toxoplasma gondii aldehyde dehydrogenase 0.0053 0.0321 1
Schistosoma mansoni regulator of G protein signaling 0.0181 0.1314 0.1297
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.004 0.0221 0.0254
Leishmania major pyruvate kinase 0.0036 0.0194 0.2165
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0824 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.1126 0.8601 0.8601
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.002 0.0018
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0181 0.1314 0.1297
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0824 0.0822
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.1314 1
Schistosoma mansoni lamin 0.0023 0.0096 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0221 0.0201
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0194 0.1605
Echinococcus granulosus beta-adrenergic receptor kinase 0.0186 0.1348 0.1565
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0018
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0194 0.2095
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0021 0.0074 0.0507
Echinococcus multilocularis microtubule associated protein 2 0.0598 0.4525 0.5259
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0824 0.0955
Brugia malayi jmjC domain containing protein 0.0051 0.0308 0.0308
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0021 0.0021
Echinococcus granulosus regulator of G protein signaling 7 0.0181 0.1314 0.1526
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0015 0.0034 0.0081
Echinococcus granulosus axis inhibition protein axin 0.0181 0.1314 0.1526
Echinococcus multilocularis regulator of G protein signaling 7 0.0181 0.1314 0.1526
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0053 0.0321 0.0371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.004 0.0221 0.0201
Echinococcus multilocularis neuropeptide receptor A26 0.0401 0.3004 0.3491
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.0321 0.0301
Brugia malayi PXA domain containing protein 0.0181 0.1314 0.1314
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0071
Onchocerca volvulus 0.0042 0.0238 1
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0161 0.4675
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0161 0.8082
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0021 0.0021
Echinococcus multilocularis lamin dm0 0.0023 0.0096 0.0108
Schistosoma mansoni hypothetical protein 0.003 0.0143 0.0123
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0194 0.0192
Giardia lamblia Pyruvate kinase 0.0036 0.0194 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0012 0.001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0051 0.0308 0.0356
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0194 0.2165
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0194 0.2165
Schistosoma mansoni pyruvate kinase 0.0036 0.0194 0.0174
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0181 0.1314 0.1297
Echinococcus granulosus JmjC domain containing protein 4 0.0014 0.002 0.0021
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0194 0.0192
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0053 0.0321 0.3688
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0018
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0824 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0824 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0194 0.0192
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0308 0.0289
Schistosoma mansoni hypothetical protein 0.0014 0.0021 0.0001
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0824 0.0805
Loa Loa (eye worm) PXA domain-containing protein 0.0181 0.1314 0.1312
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0161 0.7541
Entamoeba histolytica hypothetical protein 0.0181 0.1314 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0161 0.8082
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0824 0.5747
Echinococcus granulosus regulator of G protein signaling 3 0.0181 0.1314 0.1526
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.002 0.0021
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0181 0.1314 0.1297
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0161 0.792
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0321 0.3636
Echinococcus multilocularis beta adrenergic receptor kinase 0.0186 0.1348 0.1565
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0824 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0221 0.0254
Echinococcus multilocularis G protein coupled receptor kinase 6 0.1126 0.8601 1
Brugia malayi jmjC domain containing protein 0.0014 0.002 0.002
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.1126 0.8601 0.8601
Loa Loa (eye worm) hypothetical protein 0.0021 0.0074 0.0071
Echinococcus granulosus GPCR family 2 0.0014 0.0021 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.004 0.0221 0.0254
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.011 0.0291
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0186 0.1348 0.1346
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0096 0.0093
Echinococcus granulosus neuropeptide receptor A26 0.0401 0.3004 0.3491
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0308 0.0289
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0074 0.0074
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0059 0.1274
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Brugia malayi jmjC domain containing protein 0.0014 0.002 0.002
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0824 0.0822
Echinococcus granulosus regulator of G protein signaling 7 0.0181 0.1314 0.1526
Loa Loa (eye worm) hypothetical protein 0.0181 0.1314 0.1312
Echinococcus granulosus phd:f box containing protein 0.0014 0.002 0.0021
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0194 0.0192
Echinococcus granulosus intermediate filament protein 0.0023 0.0096 0.0108
Loa Loa (eye worm) hypothetical protein 0.0025 0.011 0.0107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0074 0.0584
Echinococcus granulosus lysine specific demethylase 5A 0.0051 0.0308 0.0356
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0181 0.1314 0.1526
Brugia malayi hypothetical protein 0.0205 0.1495 0.1495
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.011 0.0107
Echinococcus granulosus lamin dm0 0.0023 0.0096 0.0108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0043 0.0249 0.0249
Echinococcus multilocularis pyruvate kinase 0.0036 0.0194 0.0223
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0824 0.0805
Echinococcus granulosus Regulator of G protein signaling 20 0.0181 0.1314 0.1526
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0031
Echinococcus multilocularis pyruvate kinase 0.0019 0.0059 0.0065
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.009
Schistosoma mansoni jumonji domain containing protein 0.0051 0.0308 0.0289
Echinococcus granulosus axis inhibition protein axin 0.0181 0.1314 0.1526

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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