Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase c protein 2 | 0.0115 | 0.257 | 1 |
Onchocerca volvulus | 0.0285 | 0.8539 | 1 | |
Giardia lamblia | Kinase, CMGC GSK | 0.0101 | 0.2085 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.0126 | 0.2948 | 0.7495 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0101 | 0.2085 | 0.53 |
Echinococcus multilocularis | protein kinase shaggy | 0.0101 | 0.2085 | 0.53 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.8539 | 0.8539 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0101 | 0.2085 | 0.2085 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0101 | 0.2085 | 0.5 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0081 | 0.1397 | 0.3551 |
Echinococcus multilocularis | protein kinase c iota type | 0.007 | 0.0985 | 0.2505 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1225 | 0.3115 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.8539 | 0.8539 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1225 | 0.3115 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0154 | 0.3934 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1225 | 0.1225 |
Echinococcus granulosus | protein kinase shaggy | 0.0101 | 0.2085 | 0.53 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1225 | 0.4769 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0087 | 0.1584 | 0.1584 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1225 | 0.3115 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1225 | 0.4769 |
Giardia lamblia | Kinase, CMGC GSK | 0.0101 | 0.2085 | 0.5 |
Echinococcus granulosus | protein kinase c iota type | 0.007 | 0.0985 | 0.2505 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0101 | 0.2085 | 0.2085 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0101 | 0.2085 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1225 | 0.4769 |
Trypanosoma brucei | protein kinase, putative | 0.0101 | 0.2085 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0101 | 0.2085 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1225 | 0.3115 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0072 | 0.1076 | 0.2736 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1225 | 0.1225 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0101 | 0.2085 | 0.53 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0154 | 0.3934 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.8539 | 0.8539 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0101 | 0.2085 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.007 | 0.0985 | 0.2505 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0081 | 0.1397 | 0.3551 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0154 | 0.3934 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0072 | 0.1076 | 0.1076 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.9525 | 0.9525 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0101 | 0.2085 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1397 | 0.1397 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0072 | 0.1076 | 0.2736 |
Brugia malayi | intracellular kinase | 0.0101 | 0.2085 | 0.8112 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0101 | 0.2085 | 0.53 |
Entamoeba histolytica | protein kinase, putative | 0.0101 | 0.2085 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1225 | 0.3115 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0072 | 0.1076 | 0.2736 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0126 | 0.2948 | 0.7495 |
Brugia malayi | protein kinase C II. | 0.0072 | 0.1076 | 0.4188 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0101 | 0.2085 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1225 | 0.3115 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.2382 | 0.2382 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0101 | 0.2085 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1225 | 0.3115 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0101 | 0.2085 | 0.5 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0154 | 0.3934 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1225 | 0.1225 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0081 | 0.1397 | 0.3551 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0101 | 0.2085 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.