Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1521 | 0.5607 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0254 | 0.2856 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0217 | 0.0814 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0217 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0217 | 0.08 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0217 | 0.076 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0217 | 0.076 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0217 | 0.0814 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0217 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0479 | 0.5601 | 0.6609 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0217 | 0.08 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0217 | 0.08 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0217 | 0.0217 |
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | 0.0242 | 0.2713 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0714 | 0.8475 | 0.8475 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0217 | 0.0814 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.0217 | 0.5 | |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0217 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0217 | 0.0814 |
Echinococcus granulosus | neuropeptide s receptor | 0.0479 | 0.5601 | 0.6609 |
Brugia malayi | manba-prov protein | 0.0082 | 0.0766 | 0.2823 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0217 | 0.076 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0217 | 0.0814 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0479 | 0.5601 | 0.5601 |
Onchocerca volvulus | 0.0037 | 0.0217 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1626 | 0.5993 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0217 | 0.08 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0217 | 1 |
Loa Loa (eye worm) | beta-glucuronidase | 0.0235 | 0.2629 | 0.9692 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0217 | 0.08 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0217 | 0.08 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0217 | 0.0814 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0217 | 0.076 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0217 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0479 | 0.5601 | 0.5601 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0217 | 0.08 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0714 | 0.8475 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0993 | 0.1172 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0217 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0217 | 0.2186 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0217 | 0.08 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0217 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0217 | 0.08 |
Onchocerca volvulus | 0.0037 | 0.0217 | 0.5 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0238 | 0.2667 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0217 | 0.0814 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0217 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0217 | 0.0256 |
Trichomonas vaginalis | glycoside hydrolase, putative | 0.0254 | 0.2856 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0217 | 0.08 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0217 | 0.076 |
Entamoeba histolytica | beta-galactosidase, putative | 0.0171 | 0.1853 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0217 | 0.08 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0217 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0217 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 2 | 0.0242 | 0.2713 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1521 | 0.5607 |
Schistosoma mansoni | beta-mannosidase | 0.0082 | 0.0766 | 0.0904 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0714 | 0.8475 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0089 | 0.0849 | 0.1002 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0217 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0217 | 0.0256 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0217 | 0.076 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0217 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0217 | 0.0256 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.0254 | 0.2856 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0217 | 0.0814 |
Brugia malayi | Beta-glucuronidase precursor | 0.0235 | 0.2629 | 0.9692 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1521 | 0.5607 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0217 | 0.0814 |
Trichomonas vaginalis | beta-mannosidase, putative | 0.0082 | 0.0766 | 0.2681 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0217 | 0.08 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0217 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0101 | 0.0993 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.