Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Echinococcus multilocularis | sodium:nucleoside cotransporter 2 | 0.2193 | 0.648 | 0.648 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Brugia malayi | Fibronectin type III domain containing protein | 0.004 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 28 | 0.3362 | 1 | 1 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | myotactin form B | 0.004 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Brugia malayi | Fibronectin type III domain containing protein | 0.004 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0388 | 0.1049 | 0.5 |
Brugia malayi | protein-tyrosine phosphatase Lar-like precursor, putative | 0.004 | 0 | 0.5 |
Echinococcus granulosus | concentrative Na nucleoside cotransporter | 0.3362 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | concentrative Na+ nucleoside cotransporter | 0.3362 | 1 | 1 |
Loa Loa (eye worm) | CAMK protein kinase | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | myotactin form A | 0.004 | 0 | 0.5 |
Echinococcus granulosus | high affinity cgmp specific 3' 5' cyclic | 0.0388 | 0.1049 | 0.1049 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Trypanosoma brucei | Fibronectin type III domain containing protein, putative | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Schistosoma mansoni | high-affinity cgmp-specific 35-cyclic phosphodiesterase | 0.0388 | 0.1049 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.004 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | myotactin form A | 0.004 | 0 | 0.5 |
Plasmodium falciparum | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.0388 | 0.1049 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.004 | 0 | 0.5 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Brugia malayi | protein unc-22 | 0.004 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 30. | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Echinococcus granulosus | Na+ dependent nucleoside transporter | 0.3362 | 1 | 1 |
Loa Loa (eye worm) | projectin | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | high affinity cgmp specific 3' 5' cyclic | 0.0388 | 0.1049 | 0.1049 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.004 | 0 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 32 | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | Lethal protein 805 | 0.004 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | lethal protein 805 | 0.004 | 0 | 0.5 |
Onchocerca volvulus | 0.004 | 0 | 0.5 | |
Loa Loa (eye worm) | UNCoordinated family member | 0.004 | 0 | 0.5 |
Brugia malayi | SPRY domain containing protein | 0.004 | 0 | 0.5 |
Brugia malayi | Lethal protein 805 | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.004 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 87.1 % | Inhibition of recombinant human PTP1B assessed as inhibition of hydrolysis of pNPP at 100 uM by spectrophotometry | ChEMBL. | 23499238 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.