Detailed information for compound 1758563

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 542.665 | Formula: C33H38N2O5
  • H donors: 1 H acceptors: 2 LogP: 3.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H]1COC[C@@H]2[C@@H](N(C1)Cc1ccc(cc1)Oc1ccccc1)CC[C@H](O2)CC(=O)N1CCc2c(C1)cccc2
  • InChi: 1S/C33H38N2O5/c36-27-21-35(19-24-10-12-29(13-11-24)39-28-8-2-1-3-9-28)31-15-14-30(40-32(31)23-38-22-27)18-33(37)34-17-16-25-6-4-5-7-26(25)20-34/h1-13,27,30-32,36H,14-23H2/t27-,30+,31+,32-/m1/s1
  • InChiKey: HJQSQTAMFLANGO-CDFDACKPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cyclins, putative 0.0755 0.3946 0.3946
Entamoeba histolytica protein kinase domain containing protein 0.005 0.0029 0.0029
Echinococcus multilocularis cyclin G2 0.0182 0.0764 0.0764
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0036 0.0036
Giardia lamblia G2/mitotic-specific cyclin B 0.0755 0.3946 0.3946
Echinococcus granulosus Cyclin L1 0.0182 0.0764 0.0764
Echinococcus granulosus cyclin B3 1 0.0755 0.3946 0.3946
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0182 0.0764 0.0764
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Brugia malayi Cyclin, N-terminal domain containing protein 0.0182 0.0764 0.0764
Trypanosoma cruzi hypothetical protein, conserved 0.0182 0.0764 0.0764
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.1844 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0122 0.043 0.043
Entamoeba histolytica cyclin family protein 0.0755 0.3946 0.3946
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0281 0.1313 0.1313
Leishmania major serine/threonine-protein kinase a, putative 0.0051 0.0036 0.0036
Echinococcus granulosus cyclin t1 0.0182 0.0764 0.0764
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0158 0.0628 0.0628
Loa Loa (eye worm) TK protein kinase 0.0096 0.0283 0.0283
Echinococcus granulosus activin receptor type 0.005 0.0029 0.0029
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0051 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0755 0.3946 0.3946
Plasmodium falciparum calcium-dependent protein kinase 7 0.0051 0.0036 0.0007
Echinococcus granulosus cyclins 0.0755 0.3946 0.3946
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.1844 1 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0062 0.0097 0.0097
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0122 0.043 0.043
Trichomonas vaginalis cyclin B, putative 0.0755 0.3946 0.3946
Brugia malayi Protein kinase domain containing protein 0.0082 0.021 0.021
Entamoeba histolytica hypothetical protein 0.0051 0.0036 0.0036
Schistosoma mansoni tyrosine kinase 0.0069 0.0137 0.0137
Echinococcus multilocularis cyclin b3 0.0755 0.3946 0.3946
Schistosoma mansoni tyrosine kinase 0.0072 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0182 0.0764 0.0764
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0051 0.0036 0.0036
Trypanosoma brucei cdc2-related kinase 1 0.1844 1 1
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0182 0.0764 0.0764
Trichomonas vaginalis cyclin D, putative 0.0182 0.0764 0.0764
Echinococcus multilocularis cyclin dependent kinase 5 0.1844 1 1
Echinococcus granulosus cyclin k 0.0182 0.0764 0.0764
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.0764 0.0764
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0308 0.1464 0.1464
Trichomonas vaginalis cyclins, putative 0.0755 0.3946 0.3946
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.1844 1 1
Trichomonas vaginalis cyclins, putative 0.0755 0.3946 0.3946
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0051 0.0036 0.0036
Schistosoma mansoni tyrosine kinase 0.0158 0.0628 0.0628
Loa Loa (eye worm) phosphatidylinositol 3 0.0278 0.1296 0.1296
Echinococcus multilocularis tyrosine protein kinase Abl 0.0072 0.0152 0.0152
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0122 0.043 0.043
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0593 0.305 0.305
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0182 0.0764 0.0737
Leishmania major cyclin 9, putative 0.0182 0.0764 0.0764
Entamoeba histolytica cyclin, domain containing protein 0.0182 0.0764 0.0764
Giardia lamblia Hypothetical protein 0.0182 0.0764 0.0764
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0072 0.0152 0.0152
Schistosoma mansoni serine/threonine-protein kinase 0.0051 0.0036 0.0036
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0182 0.0764 0.0764
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.1844 1 1
Loa Loa (eye worm) cyclin C 0.0182 0.0764 0.0764
Trichomonas vaginalis cyclins, putative 0.0755 0.3946 0.3946
Echinococcus granulosus cyclin y 0.0182 0.0764 0.0764
Loa Loa (eye worm) TK/EGFR protein kinase 0.0069 0.0137 0.0137
Leishmania major phosphatidylinositol 3-kinase, putative 0.0122 0.043 0.043
Echinococcus multilocularis c src tyrosine kinase 0.0072 0.0152 0.0152
Onchocerca volvulus Cyclin L homolog 0.0182 0.0764 0.1629
Brugia malayi protein-tyrosine kinase 0.0127 0.0457 0.0457
Onchocerca volvulus 0.0755 0.3946 1
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Echinococcus multilocularis cyclin dependent kinase 1 0.1844 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0308 0.1464 0.1464
Echinococcus granulosus tyrosine protein kinase Src42A 0.0117 0.0402 0.0402
Schistosoma mansoni cyclin k 0.0182 0.0764 0.0764
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0407 0.2016 0.2016
Echinococcus multilocularis cyclins 0.0755 0.3946 0.3946
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.0764 0.0764
Trypanosoma cruzi cdc2-related kinase 3 0.1844 1 1
Echinococcus multilocularis cyclin y 0.0182 0.0764 0.0764
Echinococcus granulosus tyrosine protein kinase Src42A 0.0158 0.0628 0.0628
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0122 0.043 0.043
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0593 0.305 0.305
Echinococcus multilocularis cyclin B 0.0755 0.3946 0.3946
Onchocerca volvulus Cyclin L homolog 0.0182 0.0764 0.1629
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0051 0.0036 0.0036
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0884 0.4665 0.4665
Loa Loa (eye worm) hypothetical protein 0.0755 0.3946 0.3946
Echinococcus granulosus cyclins 0.0755 0.3946 0.3946
Trichomonas vaginalis cyclin B, putative 0.0182 0.0764 0.0764
Plasmodium falciparum cyclin 1 0.0182 0.0764 0.0737
Schistosoma mansoni tyrosine kinase 0.0158 0.0628 0.0628
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0069 0.0137 0.0137
Giardia lamblia Hypothetical protein 0.0755 0.3946 0.3946
Schistosoma mansoni tyrosine kinase 0.0142 0.054 0.054
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0051 0.0036 0.0036
Entamoeba histolytica cell division protein kinase 2, putative 0.1844 1 1
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0051 0.0036 0.0036
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1616 0.8731 0.8731
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0122 0.043 0.043
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1616 0.8731 0.8731
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0122 0.043 0.0396
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.005 0.0029 0.0029
Trichomonas vaginalis cyclin B3, putative 0.0755 0.3946 0.3946
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0182 0.0764 0.0764
Trichomonas vaginalis CMGC family protein kinase 0.1844 1 1
Giardia lamblia Kinase, CMGC CDK 0.1844 1 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0755 0.3946 0.3946
Echinococcus multilocularis cyclin 0.0182 0.0764 0.0764
Echinococcus granulosus tyrosine protein kinase Fyn 0.0158 0.0628 0.0628
Trichomonas vaginalis cyclin A, putative 0.0755 0.3946 0.3946
Trichomonas vaginalis cyclin B, putative 0.0182 0.0764 0.0764
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0122 0.043 0.043
Trypanosoma cruzi NIMA-related kinase, putative 0.0051 0.0036 0.0036
Brugia malayi Cyclin, N-terminal domain containing protein 0.0182 0.0764 0.0764
Giardia lamblia Cyclin A 0.0755 0.3946 0.3946
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0051 0.0036 0.0036
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0308 0.1464 0.1464
Echinococcus granulosus tyrosine protein kinase Blk 0.0127 0.0457 0.0457
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Leishmania major protein kinase, putative 0.005 0.0029 0.0029
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0755 0.3946 0.3946
Echinococcus granulosus cyclin A3 4 0.0182 0.0764 0.0764
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0122 0.043 0.043
Leishmania major protein kinase, putative 0.0051 0.0036 0.0036
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0728 0.38 0.38
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0083 0.0211 0.0176
Trichomonas vaginalis cyclins, putative 0.0182 0.0764 0.0764
Toxoplasma gondii cyclin 4, putative 0.0182 0.0764 0.0764
Entamoeba histolytica cyclin family protein 0.0755 0.3946 0.3946
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0182 0.0764 0.0764
Trichomonas vaginalis CMGC family protein kinase 0.1844 1 1
Echinococcus multilocularis cyclin t1 0.0182 0.0764 0.0764
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0216 0.0955 0.0955
Giardia lamblia Hypothetical protein 0.0182 0.0764 0.0764
Echinococcus multilocularis cyclin dependent kinase 6 0.0416 0.2062 0.2062
Entamoeba histolytica protein kinase, putative 0.0051 0.0036 0.0036
Echinococcus multilocularis epidermal growth factor receptor 0.0069 0.0137 0.0137
Schistosoma mansoni cyclin l 0.0182 0.0764 0.0764
Trypanosoma brucei cdc2-related kinase 3 0.1844 1 1
Schistosoma mansoni acetyl-CoA carboxylase 0.0114 0.0387 0.0387
Toxoplasma gondii cyclin dependent kinase binding protein 0.0182 0.0764 0.0764
Entamoeba histolytica protein kinase, putative 0.0051 0.0036 0.0036
Schistosoma mansoni serine/threonine-protein kinase 0.0051 0.0036 0.0036
Trichomonas vaginalis cyclin D, putative 0.0755 0.3946 0.3946
Echinococcus granulosus cyclins 0.0755 0.3946 0.3946
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0122 0.043 0.043
Trypanosoma cruzi acetyl-CoA carboxylase 0.0071 0.0145 0.0145
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Giardia lamblia Kinase, CMGC CDK 0.1844 1 1
Trichomonas vaginalis cyclin B, putative 0.0755 0.3946 0.3946
Trypanosoma cruzi cdc2-related kinase 1 0.1844 1 1
Entamoeba histolytica cyclin, putative 0.0755 0.3946 0.3946
Plasmodium vivax cyclin homologue, putative 0.0182 0.0764 0.0731
Loa Loa (eye worm) cyclin domain-containing protein 0.0182 0.0764 0.0764
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Loa Loa (eye worm) cyclin domain-containing protein 0.0182 0.0764 0.0764
Echinococcus granulosus cyclins 0.0182 0.0764 0.0764
Trichomonas vaginalis cyclin B3, putative 0.0182 0.0764 0.0764
Echinococcus granulosus cyclin y 0.0182 0.0764 0.0764
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0051 0.0036 0.0036
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0127 0.0457 0.0457
Trypanosoma cruzi mitotic cyclin, putative 0.0182 0.0764 0.0764
Brugia malayi Protein kinase domain containing protein 0.0051 0.0036 0.0036
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0051 0.0036 0.0036
Echinococcus granulosus tyrosine kinase 0.0127 0.0457 0.0457
Echinococcus granulosus tyrosine protein kinase Lyn 0.0198 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0321 0.1536 0.1536
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0158 0.0628 0.0628
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0308 0.1464 0.1464
Echinococcus granulosus dual specificity testis-specific protein kinase 0.005 0.0029 0.0029
Echinococcus granulosus epidermal growth factor receptor 0.0069 0.0137 0.0137
Giardia lamblia Cyclin fold protein 1, putative 0.0182 0.0764 0.0764
Trichomonas vaginalis cyclin A, putative 0.0182 0.0764 0.0764
Trypanosoma cruzi cyclin, putative 0.0755 0.3946 0.3946
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0071 0.0149 0.0149
Schistosoma mansoni growth factor receptor-bound protein 0.0062 0.0097 0.0097
Brugia malayi Protein kinase domain containing protein 0.0142 0.054 0.054
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0182 0.0764 0.0764
Toxoplasma gondii hypothetical protein 0.0182 0.0764 0.0764
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0122 0.043 0.043
Schistosoma mansoni serine/threonine protein kinase 0.0416 0.2062 0.2062
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0308 0.1464 0.1464
Schistosoma mansoni cyclin G2 0.0182 0.0764 0.0764
Trypanosoma brucei protein kinase, putative 0.0051 0.0036 0.0036
Echinococcus multilocularis Cyclin L1 0.0182 0.0764 0.0764
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0629 0.3248 0.3248
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0914 0.4834 0.4834
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0051 0.0036 0.0036
Echinococcus granulosus serine/threonine protein kinase 0.0051 0.0036 0.0036
Brugia malayi Cyclin C 0.0182 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0158 0.0628 0.0628
Echinococcus granulosus cyclin B 0.0755 0.3946 0.3946
Trypanosoma cruzi NIMA-related kinase, putative 0.0051 0.0036 0.0036
Brugia malayi Cyclin, N-terminal domain containing protein 0.0755 0.3946 0.3946
Loa Loa (eye worm) hypothetical protein 0.1804 0.9778 0.9778
Brugia malayi Protein kinase domain containing protein 0.1844 1 1
Echinococcus granulosus cyclins 0.0755 0.3946 0.3946
Plasmodium vivax hypothetical protein, conserved 0.0182 0.0764 0.0731
Brugia malayi Variant SH3 domain containing protein 0.0062 0.0097 0.0097
Echinococcus granulosus G1:S specific cyclin D1 0.0522 0.2652 0.2652
Echinococcus multilocularis G1:S specific cyclin D1 0.0522 0.2652 0.2652
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0122 0.043 0.043
Trypanosoma brucei rac serine-threonine kinase, putative 0.0051 0.0036 0.0036
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0036 0.0036
Trypanosoma brucei cyclin 9 0.0182 0.0764 0.0764
Trichomonas vaginalis cyclins, putative 0.0755 0.3946 0.3946
Brugia malayi Sex muscle abnormal protein 5 0.0062 0.0097 0.0097
Plasmodium falciparum cyclin 0.0755 0.3946 0.3928
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0182 0.0764 0.0764
Entamoeba histolytica cyclin, putative 0.0755 0.3946 0.3946
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0158 0.0628 0.0628
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0122 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0062 0.0097 0.0097
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0142 0.054 0.054
Leishmania major hypothetical protein, conserved 0.0119 0.0414 0.0414
Loa Loa (eye worm) cyclin domain-containing protein 0.0182 0.0764 0.0764
Echinococcus multilocularis cyclin dependent kinase 1 0.1844 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0062 0.0097 0.0097
Loa Loa (eye worm) TK/INSR protein kinase 0.0142 0.054 0.054
Schistosoma mansoni g1/s-specific cyclin C 0.0182 0.0764 0.0764
Echinococcus multilocularis cyclins 0.0755 0.3946 0.3946
Brugia malayi Cyclin, N-terminal domain containing protein 0.0182 0.0764 0.0764
Brugia malayi Cyclin, N-terminal domain containing protein 0.0755 0.3946 0.3946
Echinococcus granulosus tyrosine protein kinase Btk29A 0.115 0.6145 0.6145
Entamoeba histolytica cyclin, domain containing protein 0.0182 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0158 0.0628 0.0628
Schistosoma mansoni tyrosine kinase 0.112 0.5974 0.5974
Trypanosoma cruzi cyclin 6, putative 0.0755 0.3946 0.3946
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0914 0.4834 0.4834
Schistosoma mansoni cyclins 0.0755 0.3946 0.3946
Schistosoma mansoni cyclin B 0.0755 0.3946 0.3946
Trypanosoma cruzi cyclin, putative 0.0755 0.3946 0.3946
Loa Loa (eye worm) TK protein kinase 0.0127 0.0457 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0755 0.3946 0.3946
Plasmodium vivax cyclin 4, putative 0.0182 0.0764 0.0731
Brugia malayi Cyclin, N-terminal domain containing protein 0.0182 0.0764 0.0764
Echinococcus multilocularis tyrosine protein kinase Blk 0.0127 0.0457 0.0457
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0051 0.0036 0.0036
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0122 0.043 0.043
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0127 0.0457 0.0457
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0122 0.043 0.043
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0914 0.4834 0.4834
Echinococcus granulosus tyrosine protein kinase Src64B 0.0158 0.0628 0.0628
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0308 0.1464 0.1464
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0914 0.4834 0.4834
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0083 0.0211 0.0183
Trypanosoma brucei mitotic cyclin 6 0.0755 0.3946 0.3946
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0122 0.043 0.043
Brugia malayi Cyclin, N-terminal domain containing protein 0.0182 0.0764 0.0764
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Schistosoma mansoni cyclin B3 0.0755 0.3946 0.3946
Entamoeba histolytica protein kinase, putative 0.0051 0.0036 0.0036
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0701 0.3649 0.3649
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.005 0.0029 0.0029
Entamoeba histolytica p21-activated kinase 0.0051 0.0036 0.0036
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0158 0.0628 0.0628
Brugia malayi hypothetical protein 0.0182 0.0764 0.0764
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0114 0.0387 0.0387
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0158 0.0628 0.0628
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0158 0.0628 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.0764 0.0764
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0036 0.0036
Loa Loa (eye worm) AGC/AKT protein kinase 0.0051 0.0036 0.0036
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1616 0.8731 0.8731
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0158 0.0628 0.0628
Entamoeba histolytica protein kinase, putative 0.0096 0.0283 0.0283
Trichomonas vaginalis cyclin B, putative 0.0755 0.3946 0.3946
Echinococcus multilocularis epidermal growth factor receptor 0.0069 0.0137 0.0137
Schistosoma mansoni tyrosine kinase 0.0072 0.0152 0.0152
Echinococcus granulosus cyclin G2 0.0182 0.0764 0.0764
Entamoeba histolytica protein kinase, putative 0.0051 0.0036 0.0036
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0051 0.0036 0.0036
Entamoeba histolytica protein kinase, putative 0.0071 0.0149 0.0149
Schistosoma mansoni growth factor receptor-bound protein 0.0062 0.0097 0.0097
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Echinococcus granulosus NCK adaptor protein 0.0062 0.0097 0.0097
Entamoeba histolytica cell division protein kinase 2, putative 0.1844 1 1
Entamoeba histolytica protein kinase, putative 0.0051 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0182 0.0764 0.0764
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0158 0.0628 0.0628
Echinococcus multilocularis NCK adaptor protein 0.0062 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0182 0.0764 0.0764
Trypanosoma cruzi Protein kinase B 0.0051 0.0036 0.0036
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0122 0.043 0.043
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0051 0.0036 0.0036
Trypanosoma cruzi cdc2-related kinase 3 0.1844 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0245 0.0245
Schistosoma mansoni tyrosine kinase 0.0059 0.0082 0.0082
Schistosoma mansoni tyrosine kinase 0.0069 0.0137 0.0137
Trichomonas vaginalis cyclin D, putative 0.0755 0.3946 0.3946
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0629 0.3248 0.3248
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0914 0.4834 0.4834
Echinococcus granulosus cyclin dependent kinase 6 0.0416 0.2062 0.2062
Echinococcus multilocularis insulin receptor 0.0142 0.054 0.054
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0182 0.0764 0.0737
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.1844 1 1
Echinococcus multilocularis cyclins 0.0755 0.3946 0.3946
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Echinococcus multilocularis cyclin dependent kinase 0.1844 1 1
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Trypanosoma cruzi mitotic cyclin, putative 0.0182 0.0764 0.0764
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0755 0.3946 0.3946
Entamoeba histolytica protein kinase, putative 0.0051 0.0036 0.0036
Brugia malayi Furin-like cysteine rich region family protein 0.0069 0.0137 0.0137
Schistosoma mansoni tyrosine kinase 0.0059 0.0082 0.0082
Brugia malayi Variant SH3 domain containing protein 0.0062 0.0097 0.0097
Trypanosoma cruzi CYC2-like cyclin, putative 0.0755 0.3946 0.3946
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0051 0.0036 0.0036
Echinococcus multilocularis cyclin y 0.0182 0.0764 0.0764
Leishmania major protein kinase, putative 0.0051 0.0036 0.0036
Echinococcus multilocularis rac serine:threonine kinase 0.0051 0.0036 0.0036
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0281 0.1313 0.1313
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Brugia malayi SRC-1 0.0158 0.0628 0.0628
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0182 0.0764 0.0764
Schistosoma mansoni cyclin G 0.0182 0.0764 0.0764
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0051 0.0036 0.0036
Echinococcus multilocularis cyclin A3 4 0.0182 0.0764 0.0764
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Toxoplasma gondii hypothetical protein 0.0573 0.2934 0.2934
Onchocerca volvulus Protein CNPPD1 homolog 0.0182 0.0764 0.1629
Echinococcus granulosus tyrosine protein kinase HCK 0.0096 0.0283 0.0283
Loa Loa (eye worm) cyclin domain-containing protein 0.0182 0.0764 0.0764
Loa Loa (eye worm) cyclin domain-containing protein 0.0182 0.0764 0.0764
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0122 0.043 0.043
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.005 0.0029 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0308 0.1464 0.1464
Brugia malayi hypothetical protein 0.0182 0.0764 0.0764
Trichomonas vaginalis cyclin B, putative 0.0755 0.3946 0.3946
Loa Loa (eye worm) hypothetical protein 0.0593 0.305 0.305
Echinococcus granulosus growth factor receptor bound protein 2 0.0062 0.0097 0.0097
Trypanosoma cruzi cdc2-related kinase 1 0.1844 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0308 0.1464 0.1464
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0114 0.0387 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.0764 0.0764
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Echinococcus multilocularis activin receptor type 0.005 0.0029 0.0029
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0114 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0522 0.2652 0.2652
Echinococcus multilocularis tyrosine protein kinase HCK 0.0096 0.0283 0.0283
Loa Loa (eye worm) cyclin domain-containing protein 0.0182 0.0764 0.0764
Echinococcus multilocularis cyclins 0.0755 0.3946 0.3946
Schistosoma mansoni protein kinase 0.005 0.0029 0.0029
Brugia malayi Cyclin, N-terminal domain containing protein 0.0755 0.3946 0.3946
Entamoeba histolytica hypothetical protein 0.0182 0.0764 0.0764
Loa Loa (eye worm) CYL-1 protein 0.0182 0.0764 0.0764
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0914 0.4834 0.4834
Echinococcus granulosus c src tyrosine kinase 0.0072 0.0152 0.0152
Schistosoma mansoni tyrosine kinase 0.0142 0.054 0.054
Leishmania major cyclin 0.0755 0.3946 0.3946
Echinococcus granulosus cyclin 0.0182 0.0764 0.0764
Leishmania major acetyl-CoA carboxylase, putative 0.0114 0.0387 0.0387
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0062 0.0097 0.0097
Loa Loa (eye worm) phosphatidylinositol 3 0.143 0.7697 0.7697
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0142 0.054 0.054
Giardia lamblia Cyclin B-like protein 0.0182 0.0764 0.0764
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0036 0.0036
Onchocerca volvulus 0.0182 0.0764 0.1629
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0158 0.0628 0.0628
Schistosoma mansoni protein kinase 0.005 0.0029 0.0029
Echinococcus multilocularis cyclins 0.0755 0.3946 0.3946
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0051 0.0036 0.0036
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0122 0.043 0.043
Entamoeba histolytica hypothetical protein 0.0728 0.38 0.38
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0036 0.0036
Trypanosoma cruzi cyclin 9, putative 0.0182 0.0764 0.0764
Echinococcus granulosus cyclin dependent kinase 0.1844 1 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0127 0.0457 0.0457
Trichomonas vaginalis cyclins, putative 0.0182 0.0764 0.0764
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0278 0.1296 0.1296
Trypanosoma brucei mitotic cyclin 0.0182 0.0764 0.0764
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.005 0.0029 0.0029
Schistosoma mansoni cyclin d 0.0522 0.2652 0.2652
Schistosoma mansoni Cyclin fold protein 0.0182 0.0764 0.0764
Schistosoma mansoni nck2/grb4 0.0062 0.0097 0.0097
Trichomonas vaginalis CMGC family protein kinase 0.1844 1 1
Trypanosoma brucei protein kinase, putative 0.005 0.0029 0.0029
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.011 0.0364 0.0364
Plasmodium vivax protein kinase Crk2 0.1844 1 1
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Echinococcus multilocularis cyclins 0.0755 0.3946 0.3946
Echinococcus multilocularis cyclin k 0.0182 0.0764 0.0764
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0593 0.305 0.305
Echinococcus multilocularis Zinc finger, PHD finger 0.0122 0.043 0.043
Echinococcus granulosus insulin receptor 0.0142 0.054 0.054
Echinococcus granulosus cyclin dependent kinase 5 0.1844 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0914 0.4834 0.4834
Loa Loa (eye worm) cyclin domain-containing protein 0.0755 0.3946 0.3946
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.115 0.6145 0.6145
Schistosoma mansoni serine/threonine protein kinase 0.1844 1 1
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Brugia malayi Carboxyl transferase domain containing protein 0.011 0.0364 0.0364
Echinococcus granulosus tyrosine protein kinase Fyn 0.0158 0.0628 0.0628
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0308 0.1464 0.1464
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.1844 1 1
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0182 0.0764 0.0764
Entamoeba histolytica cyclin C, putative 0.0182 0.0764 0.0764
Leishmania major folate/biopterin transporter, putative 0.0051 0.0036 0.0036
Echinococcus granulosus cyclin G2 0.0182 0.0764 0.0764
Schistosoma mansoni tyrosine kinase 0.0069 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.0051 0.0036 0.0036
Echinococcus granulosus tyrosine protein kinase Fyn 0.0158 0.0628 0.0628
Echinococcus granulosus cyclin b3 0.0755 0.3946 0.3946
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.1844 1 1
Echinococcus multilocularis cyclin G2 0.0182 0.0764 0.0764
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0114 0.0387 0.0387
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0182 0.0764 0.0731
Brugia malayi Cyclin, N-terminal domain containing protein 0.0522 0.2652 0.2652
Schistosoma mansoni adapter molecule crk 0.0062 0.0097 0.0097
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Echinococcus multilocularis dual specificity testis specific protein kinase 0.005 0.0029 0.0029
Trichomonas vaginalis cyclin B, putative 0.0755 0.3946 0.3946
Leishmania major mitotic cyclin, putative 0.0182 0.0764 0.0764
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0122 0.043 0.0402
Trichomonas vaginalis cyclins, putative 0.0182 0.0764 0.0764
Echinococcus granulosus cyclins 0.0755 0.3946 0.3946
Plasmodium falciparum protein kinase 5 0.1844 1 1
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0051 0.0036 0.0036
Echinococcus multilocularis cyclin B3 1 0.0755 0.3946 0.3946
Loa Loa (eye worm) SRC-1 0.0158 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0073 0.0155 0.0155
Trypanosoma brucei cyclin 3 0.0182 0.0764 0.0764
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0051 0.0036 0.0036
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0122 0.043 0.043
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0062 0.0097 0.0097
Leishmania major mitotic cyclin, putative 0.0182 0.0764 0.0764
Toxoplasma gondii protein kinase domain-containing protein 0.0051 0.0036 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.1844 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0072 0.0152 0.0152
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0443 0.2214 0.2214
Echinococcus granulosus cyclin dependent kinase 1 0.1844 1 1
Brugia malayi cyclin fold protein 1 variant b 0.0182 0.0764 0.0764
Trypanosoma brucei acetyl-CoA carboxylase 0.0114 0.0387 0.0387
Schistosoma mansoni tyrosine kinase 0.0059 0.0082 0.0082
Echinococcus granulosus epidermal growth factor receptor 0.0069 0.0137 0.0137
Entamoeba histolytica protein kinase, putative 0.0051 0.0036 0.0036
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0117 0.0402 0.0402
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Entamoeba histolytica PH domain containing protein kinase, putative 0.0051 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0036 0.0036
Echinococcus multilocularis cyclins 0.0755 0.3946 0.3946
Trichomonas vaginalis cyclin B3, putative 0.0182 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.034 0.164 0.164
Schistosoma mansoni protein kinase 0.005 0.0029 0.0029
Brugia malayi Cyclin, N-terminal domain containing protein 0.0182 0.0764 0.0764

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.