Detailed information for compound 1758823

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.424 | Formula: C16H14N2O3S2
  • H donors: 2 H acceptors: 4 LogP: 2.85 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CS/C(=C/c2sc(c(n2)c2ccccc2)C(C(=O)O)C)/N1
  • InChi: 1S/C16H14N2O3S2/c1-9(16(20)21)15-14(10-5-3-2-4-6-10)18-13(23-15)7-12-17-11(19)8-22-12/h2-7,9H,8H2,1H3,(H,17,19)(H,20,21)/b12-7+
  • InChiKey: PLHDPJMDBRGPIQ-KPKJPENVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus a disintegrin and metalloproteinase with Get druggable targets OG5_126771 All targets in OG5_126771
Schistosoma japonicum ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative Get druggable targets OG5_126771 All targets in OG5_126771
Schistosoma mansoni ADAMTS5 peptidase (M12 family) Get druggable targets OG5_126771 All targets in OG5_126771
Brugia malayi ADAM-TS Spacer 1 family protein Get druggable targets OG5_126771 All targets in OG5_126771
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126771 All targets in OG5_126771
Echinococcus multilocularis a disintegrin and metalloproteinase with Get druggable targets OG5_126771 All targets in OG5_126771
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0082 0.0032 0.002
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.0287 0.1726
Toxoplasma gondii PAN domain-containing protein 0.0232 0.0457 0.0389
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.0117 0.017
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.0117 0.017
Toxoplasma gondii hypothetical protein 0.0232 0.0457 0.0389
Echinococcus multilocularis FTZ F1 alpha 0.0082 0.0032 0.002
Loa Loa (eye worm) hypothetical protein 0.0232 0.0457 0.1829
Echinococcus granulosus geminin 0.0351 0.0794 0.0981
Brugia malayi PAN domain containing protein 0.0232 0.0457 0.1829
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.0032 0.013
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0172 0.0687
Echinococcus multilocularis adam 0.0126 0.0157 0.0177
Brugia malayi PAN domain containing protein 0.0232 0.0457 0.1829
Brugia malayi angiogenesis inhibito 0.0112 0.0117 0.0468
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.0117 0.017
Brugia malayi photoreceptor-specific nuclear receptor 0.0082 0.0032 0.013
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0077 0.0017 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.0082 0.0032 0.013
Echinococcus multilocularis tissue type plasminogen activator 0.0095 0.007 0.0067
Brugia malayi PAN domain containing protein 0.0232 0.0457 0.1829
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0082 0.0032 0.013
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0223 0.0431 0.0626
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0313 0.1027
Brugia malayi nuclear receptor NHR-88 0.0082 0.0032 0.013
Onchocerca volvulus 0.0112 0.0117 0.0683
Brugia malayi Trypsin family protein 0.0649 0.1635 0.6549
Loa Loa (eye worm) hypothetical protein 0.0112 0.0117 0.0469
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0082 0.0032 0.013
Schistosoma mansoni hypothetical protein 0.0112 0.0117 0.017
Brugia malayi PAN domain containing protein 0.0232 0.0457 0.1829
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0112 0.0117 0.0127
Schistosoma mansoni RAR-like nuclear receptor 0.0082 0.0032 0.0047
Onchocerca volvulus 0.0095 0.007 0.0395
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.0117 0.017
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.02 0.0367 0.0442
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.0542 0.2172
Brugia malayi PAN domain containing protein 0.0232 0.0457 0.1829
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.014 0.0196 0.0226
Echinococcus granulosus a disintegrin and metalloproteinase with 0.02 0.0367 0.0442
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0112 0.0117 0.017
Echinococcus granulosus adam 17 protease 0.0245 0.0493 0.0602
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0542 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0032 0.013
Onchocerca volvulus 0.0112 0.0117 0.0683
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0172 0.0249
Onchocerca volvulus 0.0232 0.0457 0.2767
Loa Loa (eye worm) hypothetical protein 0.0232 0.0457 0.1829
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0082 0.0032 0.013
Loa Loa (eye worm) hypothetical protein 0.0468 0.1125 0.4505
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.0032 0.013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.0032 0.013
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0953 0.2497 0.3131
Loa Loa (eye worm) steroid hormone receptor 0.0082 0.0032 0.013
Brugia malayi Protein kinase domain containing protein 0.0095 0.007 0.0281
Loa Loa (eye worm) hypothetical protein 0.0232 0.0457 0.1829
Loa Loa (eye worm) hypothetical protein 0.0082 0.0032 0.013
Echinococcus multilocularis enteropeptidase 0.0112 0.0117 0.0127
Onchocerca volvulus 0.0232 0.0457 0.2767
Onchocerca volvulus 0.0232 0.0457 0.2767
Loa Loa (eye worm) PAN domain-containing protein 0.0232 0.0457 0.1829
Schistosoma mansoni coup transcription factor 0.0082 0.0032 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0953 0.2497 1
Schistosoma mansoni nuclear hormone receptor 0.0082 0.0032 0.0047
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.0117 0.017
Loa Loa (eye worm) PAN domain-containing protein 0.0232 0.0457 0.1829
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0542 1
Brugia malayi PAN domain containing protein 0.0232 0.0457 0.1829
Brugia malayi Kinesin motor domain containing protein 0.0374 0.0858 0.3434
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0082 0.0032 0.002
Toxoplasma gondii microneme protein MIC17A 0.0232 0.0457 0.0389
Brugia malayi hypothetical protein 0.0112 0.0117 0.0469
Onchocerca volvulus 0.0232 0.0457 0.2767
Brugia malayi Trypsin family protein 0.0112 0.0117 0.0469
Toxoplasma gondii PAN domain-containing protein 0.0232 0.0457 0.0389
Loa Loa (eye worm) hypothetical protein 0.0082 0.0032 0.013
Toxoplasma gondii kinesin motor domain-containing protein 0.0374 0.0858 0.0793
Schistosoma mansoni hypothetical protein 0.0112 0.0117 0.017
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0268 0.0318
Loa Loa (eye worm) hypothetical protein 0.0095 0.007 0.0281
Loa Loa (eye worm) hypothetical protein 0.0082 0.0032 0.013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0092 0.037
Brugia malayi ADAM-TS Spacer 1 family protein 0.0264 0.0546 0.2185
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.014 0.0196 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0542 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0017 0.0067
Loa Loa (eye worm) hypothetical protein 0.0082 0.0032 0.013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0082 0.0032 0.0047
Loa Loa (eye worm) trypsin family protein 0.0112 0.0117 0.0469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0082 0.0032 0.013
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.091 0.2374 0.345
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.0032 0.013
Schistosoma mansoni alpha-glucosidase 0.0142 0.0203 0.0295
Onchocerca volvulus 0.0537 0.1318 0.8055
Echinococcus granulosus enteropeptidase 0.0112 0.0117 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0082 0.0032 0.013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0953 0.2497 0.3131
Echinococcus granulosus kinesin family 1 0.2878 0.7939 1
Schistosoma mansoni hypothetical protein 0.2504 0.6882 1
Brugia malayi PAN domain containing protein 0.0232 0.0457 0.1829
Brugia malayi nuclear hormone receptor 0.0082 0.0032 0.013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0112 0.0117 0.017
Loa Loa (eye worm) hypothetical protein 0.0264 0.0546 0.2185
Echinococcus multilocularis kinesin family 1 0.2878 0.7939 1
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0542 1
Loa Loa (eye worm) kinesin-like protein KLP2 0.0374 0.0858 0.3434
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0232 0.0457 0.0389
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0542 1
Toxoplasma gondii microneme protein MIC17B 0.0232 0.0457 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0953 0.2497 1
Toxoplasma gondii PAN domain-containing protein 0.0232 0.0457 0.0389
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0082 0.0032 0.002
Loa Loa (eye worm) hypothetical protein 0.0073 0.0006 0.0023
Schistosoma mansoni hypothetical protein 0.0351 0.0794 0.1153
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0112 0.0117 0.0127
Loa Loa (eye worm) hypothetical protein 0.0082 0.0032 0.013
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.02 0.0367 0.0533
Brugia malayi Trypsin family protein 0.0112 0.0117 0.0469
Loa Loa (eye worm) reprolysin 0.0077 0.0017 0.0067
Toxoplasma gondii PAN/Apple domain-containing protein 0.0232 0.0457 0.0389
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0112 0.0117 0.0127
Echinococcus granulosus adam 0.0126 0.0157 0.0177
Echinococcus multilocularis glycoprotein Antigen 5 0.0112 0.0117 0.0127
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0082 0.0032 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0082 0.0032 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0082 0.0032 0.013
Onchocerca volvulus Bile acid receptor homolog 0.0082 0.0032 0.0163
Brugia malayi steroid hormone receptor 0.0082 0.0032 0.013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.0032 0.002
Brugia malayi Kringle domain containing protein 0.0095 0.007 0.0281
Loa Loa (eye worm) hypothetical protein 0.0649 0.1635 0.6549
Echinococcus multilocularis Mastin 0.0112 0.0117 0.0127
Loa Loa (eye worm) hypothetical protein 0.0103 0.0092 0.037
Echinococcus granulosus glycoprotein Antigen 5 0.0112 0.0117 0.0127
Loa Loa (eye worm) PAN domain-containing protein 0.0232 0.0457 0.1829
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0172 0.0249
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0112 0.0117 0.0127
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0172 0.0249
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.0542 0.2172
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.0117 0.017
Echinococcus granulosus transmembrane protease serine 3 0.0112 0.0117 0.0127
Brugia malayi RNA binding protein 0.0131 0.0172 0.0687
Echinococcus granulosus tissue type plasminogen activator 0.0095 0.007 0.0067
Mycobacterium ulcerans hypothetical protein 0.0112 0.0117 0.5
Onchocerca volvulus 0.0649 0.1635 1
Brugia malayi Steroid receptor seven-up type 2 0.0082 0.0032 0.013
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.0117 0.017
Loa Loa (eye worm) hypothetical protein 0.0082 0.0032 0.013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0082 0.0032 0.013
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.007 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0092 0.037
Loa Loa (eye worm) hypothetical protein 0.0232 0.0457 0.1829
Loa Loa (eye worm) RNA binding protein 0.0131 0.0172 0.0687
Loa Loa (eye worm) TK/ROR protein kinase 0.0095 0.007 0.0281
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0092 0.037
Onchocerca volvulus 0.0082 0.0032 0.0163
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0649 0.1635 0.2376
Toxoplasma gondii subtilisin SUB12 0.0232 0.0457 0.0389
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0077 0.0017 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0172 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0542 1
Loa Loa (eye worm) hypothetical protein 0.0649 0.1635 0.6549
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0268 0.1075
Schistosoma mansoni hypothetical protein 0.0351 0.0794 0.1153
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0268 0.1075
Loa Loa (eye worm) hypothetical protein 0.0232 0.0457 0.1829
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0172 0.0249
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0172 0.0687
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0112 0.0117 0.0469
Echinococcus multilocularis thyroid hormone receptor alpha 0.0082 0.0032 0.002
Echinococcus multilocularis geminin 0.0351 0.0794 0.0981
Loa Loa (eye worm) hypothetical protein 0.0232 0.0457 0.1829
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0105 0.0098 0.0392
Loa Loa (eye worm) hypothetical protein 0.0082 0.0032 0.013
Brugia malayi PAN domain containing protein 0.0232 0.0457 0.1829
Loa Loa (eye worm) hypothetical protein 0.0112 0.0117 0.0469
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0082 0.0032 0.0163
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0082 0.0032 0.0047
Onchocerca volvulus 0.0232 0.0457 0.2767
Echinococcus granulosus tar DNA binding protein 0.0131 0.0172 0.0196
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0112 0.0117 0.017
Loa Loa (eye worm) hypothetical protein 0.0104 0.0094 0.0377
Brugia malayi Trypsin family protein 0.0112 0.0117 0.0469
Onchocerca volvulus 0.0232 0.0457 0.2767
Schistosoma mansoni thyroid hormone receptor 0.0082 0.0032 0.0047
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0112 0.0117 0.017
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.0117 0.017
Toxoplasma gondii microneme protein, putative 0.0232 0.0457 0.0389
Schistosoma mansoni retinoic acid receptor RXR 0.0082 0.0032 0.0047
Brugia malayi ecdysteroid receptor 0.0082 0.0032 0.013
Toxoplasma gondii microneme protein MIC17C 0.0232 0.0457 0.0389
Echinococcus multilocularis ecdysone induced protein 78C 0.0082 0.0032 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0082 0.0032 0.013
Echinococcus granulosus ecdysone induced protein 78C 0.0082 0.0032 0.002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0268 0.0318
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0268 0.0318
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0112 0.0117 0.017
Onchocerca volvulus 0.0232 0.0457 0.2767
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0082 0.0032 0.002
Loa Loa (eye worm) hypothetical protein 0.0112 0.0117 0.0469
Onchocerca volvulus 0.0112 0.0117 0.0683
Brugia malayi Trypsin-like protease protein 5 0.0112 0.0117 0.0469
Onchocerca volvulus 0.0096 0.0071 0.04
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0082 0.0032 0.013
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.0117 0.017
Toxoplasma gondii PAN domain-containing protein 0.3606 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0082 0.0032 0.0047
Plasmodium vivax kinesin-5 0.0374 0.0858 1
Schistosoma mansoni thyroid hormone receptor 0.0082 0.0032 0.0047
Entamoeba histolytica kinesin, putative 0.0374 0.0858 0.5
Onchocerca volvulus 0.0232 0.0457 0.2767
Toxoplasma gondii microneme protein MIC4 0.0232 0.0457 0.0389
Loa Loa (eye worm) PAN domain-containing protein 0.0232 0.0457 0.1829
Onchocerca volvulus 0.0232 0.0457 0.2767
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.0032 0.002
Brugia malayi TAR-binding protein 0.0131 0.0172 0.0687
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0082 0.0032 0.0047
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0172 0.0687
Toxoplasma gondii hypothetical protein 0.0232 0.0457 0.0389
Brugia malayi hypothetical protein 0.0126 0.0157 0.0628
Brugia malayi PAN domain containing protein 0.0232 0.0457 0.1829
Onchocerca volvulus 0.0232 0.0457 0.2767
Echinococcus granulosus FTZ F1 alpha 0.0082 0.0032 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0082 0.0032 0.0047
Loa Loa (eye worm) hypothetical protein 0.0112 0.0117 0.0469
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.0117 0.017
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0082 0.0032 0.013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0082 0.0032 0.002
Echinococcus multilocularis transmembrane protease serine 3 0.0112 0.0117 0.0127
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0126 0.0157 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0082 0.0032 0.013
Echinococcus granulosus Mastin 0.0112 0.0117 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0082 0.0032 0.013
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0172 0.0196
Schistosoma mansoni cercarial elastase (S01 family) 0.0112 0.0117 0.017
Loa Loa (eye worm) PAN domain-containing protein 0.0232 0.0457 0.1829
Onchocerca volvulus 0.0112 0.0117 0.0683
Brugia malayi PAN domain containing protein 0.0232 0.0457 0.1829
Echinococcus multilocularis adam 17 protease 0.0223 0.0431 0.0523
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0082 0.0032 0.0047
Schistosoma mansoni hypothetical protein 0.0095 0.007 0.0102
Schistosoma mansoni alpha-glucosidase 0.0142 0.0203 0.0295
Onchocerca volvulus 0.0232 0.0457 0.2767
Onchocerca volvulus 0.0112 0.0117 0.0683
Onchocerca volvulus Protein ultraspiracle homolog 0.0082 0.0032 0.0163
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.0032 0.002
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0649 0.1635 0.2376
Giardia lamblia Kinesin-5 0.0374 0.0858 0.5
Plasmodium falciparum kinesin-5 0.0374 0.0858 1
Toxoplasma gondii PAN domain-containing protein 0.0232 0.0457 0.0389
Loa Loa (eye worm) hypothetical protein 0.0112 0.0117 0.0469
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.0032 0.013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.0032 0.002
Leishmania major hypothetical protein, conserved 0.0095 0.007 0.5
Loa Loa (eye worm) hypothetical protein 0.0232 0.0457 0.1829
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.0032 0.013
Brugia malayi ADAMTS-like protease 0.0112 0.0117 0.0468
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0112 0.0117 0.017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0082 0.0032 0.002
Schistosoma mansoni kinesin eg-5 0.0374 0.0858 0.1246
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0313 0.1027

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.73 uM Inhibition of human His-tagged ADAMTS-5 using QF-peptide as substrate by FRET method ChEMBL. 23453070

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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