Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0305 | 0.2616 | 0.3495 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0451 | 0.4773 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0425 | 0.4383 | 0.5834 |
Giardia lamblia | Methyltransferase like 2 | 0.0128 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0451 | 0.4773 | 0.6376 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0425 | 0.4383 | 0.5856 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0451 | 0.4773 | 0.6337 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0635 | 0.7486 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0451 | 0.4773 | 0.6337 |
Loa Loa (eye worm) | fatty acid synthase | 0.0419 | 0.43 | 0.4318 |
Loa Loa (eye worm) | hypothetical protein | 0.0714 | 0.8648 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0425 | 0.4383 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0342 | 0.3157 | 0.4188 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0342 | 0.3157 | 0.4155 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0451 | 0.4773 | 0.6376 |
Mycobacterium ulcerans | thioesterase | 0.0354 | 0.3337 | 0.443 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0281 | 0.2258 | 0.2941 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0425 | 0.4383 | 0.5856 |
Onchocerca volvulus | 0.074 | 0.9028 | 0.9285 | |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0766 | 0.9418 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0128 | 0 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0425 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0242 | 0.1676 | 0.224 |
Mycobacterium ulcerans | polyketide synthase | 0.0451 | 0.4773 | 0.6357 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0451 | 0.4773 | 0.6337 |
Schistosoma mansoni | methyltransferase-related | 0.0128 | 0 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0425 | 0.4383 | 0.5834 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0128 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0172 | 0.0647 | 0.0864 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0354 | 0.3337 | 0.4398 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.1625 | 0.0823 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0635 | 0.7486 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0425 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0348 | 0.324 | 0.4329 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0281 | 0.2258 | 0.2981 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0635 | 0.7486 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0281 | 0.2258 | 0.2981 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0133 | 0.0081 | 0.0056 |
Brugia malayi | AMP-binding enzyme family protein | 0.0131 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | thioesterase TesA | 0.0354 | 0.3337 | 0.443 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0425 | 0.4383 | 0.5856 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0451 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0635 | 0.7486 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0397 | 0.3971 | 0.5305 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0397 | 0.3971 | 0.3889 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0425 | 0.4383 | 0.581 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0131 | 0.0039 | 0.0052 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0451 | 0.4773 | 0.6376 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0302 | 0.2576 | 0.3708 |
Brugia malayi | AMP-binding enzyme family protein | 0.0397 | 0.3971 | 0.3971 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0425 | 0.4383 | 0.4383 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0133 | 0.0081 | 0.0108 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0451 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0412 | 0.4191 | 0.5599 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0354 | 0.3337 | 0.4459 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0276 | 0.218 | 0.2574 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0342 | 0.3157 | 0.4188 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0425 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0146 | 0.0267 | 0.0356 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0412 | 0.4191 | 0.5599 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.