Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0306 | 0.3948 | 0.528 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0217 | 0.2228 | 0.2941 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0348 | 0.4752 | 0.6337 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0212 | 0.213 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0212 | 0.213 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0133 | 0.061 | 0.0817 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0273 | 0.3311 | 0.4398 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0328 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0113 | 0.0229 | 0.0306 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0212 | 0.213 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.049 | 0.7476 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0348 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.049 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.049 | 0.7476 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0348 | 0.4752 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0318 | 0.4168 | 0.5576 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0328 | 0.4361 | 0.5834 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0212 | 0.213 | 0.252 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0212 | 0.213 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0212 | 0.213 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0348 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0212 | 0.213 | 0.1523 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0328 | 0.4361 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0328 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0268 | 0.3214 | 0.4299 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0217 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0328 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | thioesterase TesA | 0.0273 | 0.3311 | 0.443 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0103 | 0.0042 | 0.0056 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0591 | 0.9416 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0348 | 0.4752 | 0.6337 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0328 | 0.4361 | 0.4361 |
Mycobacterium ulcerans | polyketide synthase | 0.0348 | 0.4752 | 0.6357 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0212 | 0.213 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0348 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0236 | 0.2588 | 0.3461 |
Brugia malayi | AMP-binding enzyme family protein | 0.0306 | 0.3948 | 0.3948 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0212 | 0.213 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0234 | 0.2547 | 0.3708 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0348 | 0.4752 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.8643 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0328 | 0.4361 | 0.5834 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0212 | 0.213 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0264 | 0.3131 | 0.4188 |
Brugia malayi | MAP kinase sur-1 | 0.0212 | 0.213 | 0.213 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.049 | 0.7476 | 1 |
Onchocerca volvulus | 0.0571 | 0.9025 | 0.9285 | |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0217 | 0.2228 | 0.2981 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0212 | 0.213 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0212 | 0.213 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0273 | 0.3311 | 0.443 |
Trypanosoma brucei | protein kinase, putative | 0.0212 | 0.213 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0318 | 0.4168 | 0.5576 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0306 | 0.3948 | 0.3889 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0348 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0103 | 0.0042 | 0.0056 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0264 | 0.3131 | 0.4188 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0212 | 0.213 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0328 | 0.4361 | 0.581 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0212 | 0.213 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.1592 | 0.0823 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0213 | 0.2149 | 0.2574 |
Mycobacterium ulcerans | polyketide synthase | 0.0328 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0186 | 0.1644 | 0.2199 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0212 | 0.213 | 0.5 |
Loa Loa (eye worm) | fatty acid synthase | 0.0324 | 0.4277 | 0.4318 |
Mycobacterium ulcerans | thioesterase | 0.0273 | 0.3311 | 0.443 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0212 | 0.213 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0212 | 0.213 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0328 | 0.4361 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0264 | 0.3131 | 0.4155 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0328 | 0.4361 | 0.5834 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0212 | 0.213 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0212 | 0.213 | 0.5 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0348 | 0.4752 | 0.6357 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 128 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 8099 after 24 hrs by NCCLS method | ChEMBL. | 23466234 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.