Detailed information for compound 176199

Basic information

Technical information
  • TDR Targets ID: 176199
  • Name: 3-(2,6-dichlorophenyl)-1-methyl-7-(4-morpholi n-4-ylanilino)-1,6-naphthyridin-2-one
  • MW: 481.374 | Formula: C25H22Cl2N4O2
  • H donors: 1 H acceptors: 2 LogP: 4.96 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1c1cc2cnc(cc2n(c1=O)C)Nc1ccc(cc1)N1CCOCC1)Cl
  • InChi: 1S/C25H22Cl2N4O2/c1-30-22-14-23(29-17-5-7-18(8-6-17)31-9-11-33-12-10-31)28-15-16(22)13-19(25(30)32)24-20(26)3-2-4-21(24)27/h2-8,13-15H,9-12H2,1H3,(H,28,29)
  • InChiKey: GWHOPAUAFXUMEC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(2,6-dichlorophenyl)-1-methyl-7-(4-morpholinoanilino)-1,6-naphthyridin-2-one
  • 3-(2,6-dichlorophenyl)-1-methyl-7-[(4-morpholin-4-ylphenyl)amino]-1,6-naphthyridin-2-one
  • 3-(2,6-dichlorophenyl)-1-methyl-7-[(4-morpholinophenyl)amino]-1,6-naphthyridin-2-one
  • 1,6-naphthyridin-2(1H)-one deriv. 7v

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fibroblast growth factor receptor 1 Starlite/ChEMBL References
Mus musculus platelet derived growth factor receptor, beta polypeptide Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis fibroblast growth factor receptor 4 Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Fibroblast growth factor receptor precursor, putative Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus basic fibroblast growth factor receptor 1 A Get druggable targets OG5_128769 All targets in OG5_128769
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_128769 All targets in OG5_128769
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine kinase 0.0044 0.0029 0.0028
Schistosoma mansoni na/ca exchanger 0.0275 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0275 0.0242 0.0227
Schistosoma mansoni tyrosine kinase 0.0013 0.0001 0.0001
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0275 0.0242 0.0241
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0123 0.0102 0.0101
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0033 0.0032
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0033 0.0032
Echinococcus multilocularis sodium calcium exchanger 1.0892 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0044 0.0029 0.0028
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0026 0.0025
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0123 0.0102 0.0101
Echinococcus multilocularis neuroglian 0.0032 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.0275 0.0242 0.0242
Plasmodium vivax cation/H+ antiporter, putative 0.0275 0.0242 0.5
Schistosoma mansoni tyrosine kinase 0.0123 0.0102 0.0102
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0028 0.0015 0.0014
Loa Loa (eye worm) solute carrier family 8 1.0892 1 1
Echinococcus granulosus Immunoglobulin 0.0028 0.0015 0.0014
Schistosoma mansoni vesicular amine transporter 0.0028 0.0015 0.0015
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.0033 0.0032
Echinococcus granulosus roundabout 2 0.0036 0.0022 0.0022
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0275 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0275 0.0242 0.0227
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0275 0.0242 0.0242
Schistosoma mansoni tyrosine kinase 0.0013 0.0001 0.0001
Loa Loa (eye worm) SRC-1 0.0048 0.0033 0.0018
Echinococcus granulosus tyrosine protein kinase Lyn 0.0048 0.0033 0.0032
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0275 0.0242 0.0241
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0275 0.0242 0.0603
Echinococcus granulosus defective proboscis extension response 0.0028 0.0015 0.0014
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0275 0.0242 0.0227
Toxoplasma gondii manganese resistance 1 protein, putative 0.0275 0.0242 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0044 0.0029 0.0028
Echinococcus granulosus twitchin 0.0032 0.0018 0.0017
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0029 0.0028
Echinococcus granulosus tyrosine protein kinase HCK 0.0039 0.0025 0.0024
Echinococcus multilocularis Immunoglobulin 0.0028 0.0015 0.0014
Loa Loa (eye worm) TK protein kinase 0.0126 0.0105 0.0091
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.0033 0.0032
Brugia malayi protein-tyrosine kinase 0.0044 0.0029 0.0071
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0028 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase HCK 0.0039 0.0025 0.0024
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.0033 0.0032
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0033 0.0032
Onchocerca volvulus Sodium\/potassium\/calcium exchanger 0.0275 0.0242 0.5
Echinococcus multilocularis tyrosine protein kinase Blk 0.0044 0.0029 0.0028
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0028 0.0015 0.0015
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0023 0.0055
Brugia malayi hypothetical protein 0.0028 0.0015 0.0035
Trichomonas vaginalis alpha-L-fucosidase, putative 0.1921 0.1755 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0123 0.0102 0.0101
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.0033 0.0032
Mycobacterium tuberculosis Probable ionic transporter integral membrane protein ChaA 0.0275 0.0242 0.5
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0033
Schistosoma mansoni sodium/calcium exchanger 1.0892 1 1
Brugia malayi Fibronectin type III domain containing protein 0.0028 0.0015 0.0035
Loa Loa (eye worm) hypothetical protein 0.0275 0.0242 0.0227
Schistosoma mansoni cell adhesion molecule 0.0033 0.0019 0.0019
Brugia malayi SRC-1 0.0048 0.0033 0.0081
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.4357 0.3994 0.3985
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0105 0.0262
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0036 0.0023 0.0008
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.0033 0.0032
Trichomonas vaginalis alpha-L-fucosidase, putative 0.1921 0.1755 1
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0275 0.0242 0.0241
Echinococcus granulosus neuroglian 0.0032 0.0018 0.0017
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0275 0.0242 0.0241
Echinococcus multilocularis Immunoglobulin 0.0028 0.0015 0.0014
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.0033 0.0032
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0033 0.0032
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.0033 0.0032
Mycobacterium leprae Probable ionic transporter integral membrane protein ChaA 0.0275 0.0242 0.5
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0275 0.0242 0.0603
Loa Loa (eye worm) TK protein kinase 0.0039 0.0025 0.001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0033 0.0032
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0275 0.0242 1
Brugia malayi Sodium/calcium exchanger protein 0.4357 0.3994 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0026 0.0025
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.0033 0.0032
Schistosoma mansoni nephrin 0.0032 0.0018 0.0018
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0033 0.0019 0.0018
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.0033 0.0032
Echinococcus multilocularis roundabout 2 0.0036 0.0022 0.0022
Treponema pallidum hypothetical protein 0.0275 0.0242 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0044 0.0029 0.0028
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.0008
Loa Loa (eye worm) TK protein kinase 0.0044 0.0029 0.0014
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0033
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0123 0.0102 0.0101
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0033 0.0019 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0015 0.0035
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.0008
Plasmodium falciparum cation/H+ antiporter 0.0275 0.0242 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.0033 0.0032

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.25 uM Inhibitory activity against avian c-Src tyrosine kinase was determined. ChEMBL. 10956222
IC50 (binding) = 0.25 uM Inhibitory activity against avian c-Src tyrosine kinase was determined. ChEMBL. 10956222
IC50 (binding) = 2.8 uM Inhibitory activity against mouse PDGF beta receptor tyrosine kinase ChEMBL. 10956222
IC50 (binding) = 2.8 uM Inhibitory activity against mouse PDGF beta receptor tyrosine kinase ChEMBL. 10956222
IC50 (binding) = 8.7 uM Inhibitory activity against fibroblast growth factor receptor 1 ChEMBL. 10956222
IC50 (binding) = 8.7 uM Inhibitory activity against fibroblast growth factor receptor 1 ChEMBL. 10956222

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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