Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.5096 | 0.5096 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0226 | 0.7461 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.5096 | 0.5096 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.7461 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.5096 | 0.6831 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.5096 | 0.6831 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.7461 | 1 |
Onchocerca volvulus | 0.0293 | 1 | 0.5 | |
Plasmodium vivax | unspecified product | 0.0226 | 0.7461 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.5096 | 0.5096 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0226 | 0.7461 | 1 |
Brugia malayi | Casein kinase II, alpha chain | 0.0226 | 0.7461 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.7461 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.5096 | 0.6831 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0226 | 0.7461 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.5096 | 0.6831 |
Trypanosoma cruzi | casein kinase II, putative | 0.0226 | 0.7461 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.5096 | 0.6831 |
Schistosoma mansoni | protein kinase | 0.0226 | 0.7461 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.7461 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.5096 | 0.5096 |
Mycobacterium leprae | Possible transporter protein | 0.0029 | 0 | 0.5 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0226 | 0.7461 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0226 | 0.7461 | 0.5 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0226 | 0.7461 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.7461 | 1 |
Entamoeba histolytica | casein kinase, putative | 0.0226 | 0.7461 | 0.5 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0226 | 0.7461 | 0.7461 |
Trypanosoma brucei | Casein kinase II | 0.0226 | 0.7461 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0226 | 0.7461 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.5096 | 0.6831 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.5096 | 0.6831 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.5096 | 0.6831 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.7461 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.7461 | 1 |
Leishmania major | casein kinase II, putative | 0.0226 | 0.7461 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.5096 | 0.6831 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.1 nM | Inhibition of electric eel acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins followed by substrate addition measured for 2 mins by Ellman's method | ChEMBL. | 23501115 |
IC50 (binding) | = 3488 nM | Inhibition of horse serum butyrylcholinesterase using butylthiocholine as substrate incubated for 15 mins followed by substrate addition measured for 2 mins by Ellman's method | ChEMBL. | 23501115 |
Imax (binding) | = 53.7 % | Inhibition of amyloid beta(1 to 42) (unknown origin) self-aggregation at 25 uM after 48 hrs by ThT fluorescence assay relative to control | ChEMBL. | 23501115 |
Imax (binding) | = 89.6 % | Inhibition of acetylcholinesterase (unknown origin)-induced amyloid beta(1 to 42) aggregation at 25 uM after 48 hrs by ThT fluorescence assay relative to control | ChEMBL. | 23501115 |
Inhibition (binding) | = 20 % | Inhibition of electric eel acetylcholinesterase using acetylthiocholine as substrate up to 100 uM incubated for 15 mins followed by substrate addition measured for 2 mins by Ellman's method relative to control | ChEMBL. | 23501115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.