TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.289 | Formula: C10H10N6O4S
H donors: 2 H acceptors: 4 LogP: 1.33 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(=S)N/N=C/1\CCN(c2c1cc(cc2)[N+](=O)[O-])[N+](=O)[O-]
InChi: 1S/C10H10N6O4S/c11-10(21)13-12-8-3-4-14(16(19)20)9-2-1-6(15(17)18)5-7(8)9/h1-2,5H,3-4H2,(H3,11,13,21)/b12-8+
InChiKey: LNSPXTPCTNBACN-XYOKQWHBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0042	0.1496	0.1496
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.086	0.086
Echinococcus granulosus	NCK adaptor protein	0.0031	0.0787	0.0787
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0031	0.0787	0.0787
Brugia malayi	protein-tyrosine kinase	0.0042	0.1496	0.1496
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0031	0.0787	0.0528
Brugia malayi	Tyrosine-protein kinase abl-1	0.0042	0.1496	0.1496
Echinococcus multilocularis	tyrosine protein kinase shark	0.0042	0.1496	0.1496
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Brugia malayi	SH2 domain containing protein	0.0031	0.0787	0.0787
Echinococcus multilocularis		0.0031	0.0787	0.0787
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0031	0.0787	0.0787
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.2688	1
Echinococcus multilocularis	SH2 motif	0.0031	0.0787	0.0787
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0042	0.1496	0.1496
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Schistosoma mansoni	nck2/grb4	0.0031	0.0787	0.0787
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0274	0.1018
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.086	0.5751
Onchocerca volvulus		0.0031	0.0787	0.4202
Loa Loa (eye worm)	hypothetical protein	0.0032	0.086	0.0603
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Brugia malayi	Sex muscle abnormal protein 5	0.0031	0.0787	0.0787
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0042	0.1496	0.1496
Schistosoma mansoni	growth factor receptor-bound protein	0.0031	0.0787	0.0787
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0031	0.0787	0.0787
Onchocerca volvulus		0.0031	0.0787	0.4202
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0023	0.0274	0.0274
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.1496	0.1496
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.086	0.086
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.1496	0.1496
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Brugia malayi	Protein kinase domain containing protein	0.0042	0.1496	0.1496
Brugia malayi	Variant SH3 domain containing protein	0.0031	0.0787	0.0787
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0031	0.0787	0.0787
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Brugia malayi	Protein kinase domain containing protein	0.0042	0.1496	0.1496
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0042	0.1496	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.1496	0.1257
Echinococcus multilocularis	signal transduction protein lnk realted	0.0031	0.0787	0.0787
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0042	0.1496	0.1496
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0031	0.0787	0.0787
Brugia malayi	cathepsin L-like precursor	0.0023	0.0274	0.0274
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Onchocerca volvulus		0.0031	0.0787	0.4202
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.1496	0.1257
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.1496	0.1257
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0031	0.0787	0.0528
Schistosoma mansoni	tyrosine kinase	0.0042	0.1496	0.1496
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0042	0.1496	0.1496
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.086	0.0603
Loa Loa (eye worm)	cathepsin B	0.006	0.2688	0.2482
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.086	0.4799
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0031	0.0787	0.0787
Echinococcus granulosus	cathepsin b	0.0171	1	1
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Onchocerca volvulus		0.0032	0.086	0.4799
Onchocerca volvulus		0.0031	0.0787	0.4202
Echinococcus multilocularis	SH2 motif	0.0031	0.0787	0.0787
Schistosoma mansoni	tensin-related	0.0031	0.0787	0.0787
Echinococcus multilocularis	SH2 domain containing protein 7	0.0031	0.0787	0.0787
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0042	0.1496	0.1496
Giardia lamblia	Cathepsin B precursor	0.006	0.2688	0.5
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.086	0.086
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0031	0.0787	0.4202
Onchocerca volvulus		0.0042	0.1496	1
Brugia malayi	SRC-1	0.0042	0.1496	0.1496
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0031	0.0787	0.0787
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.086	0.086
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0031	0.0787	0.0787
Schistosoma mansoni	tyrosine kinase	0.0042	0.1496	0.1496
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0031	0.0787	0.0787
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.086	1
Brugia malayi	Variant SH3 domain containing protein	0.0031	0.0787	0.0787
Schistosoma mansoni	tyrosine kinase	0.0042	0.1496	0.1496
Brugia malayi	Tensin	0.0031	0.0787	0.0787
Entamoeba histolytica	cysteine protease, putative	0.0032	0.086	0.5751
Loa Loa (eye worm)	STAT protein	0.0031	0.0787	0.0528
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.2688	0.2688
Brugia malayi	SH2 domain containing protein	0.0042	0.1496	0.1496
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	tyrosine kinase	0.0042	0.1496	0.1496
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0042	0.1496	0.1496
Giardia lamblia	Cathepsin B precursor	0.006	0.2688	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.086	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Schistosoma mansoni	growth factor receptor-bound protein	0.0031	0.0787	0.0787
Brugia malayi	Protein kinase domain containing protein	0.0042	0.1496	0.1496
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Plasmodium vivax	vivapain-2	0.0032	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Echinococcus multilocularis	NCK adaptor protein	0.0031	0.0787	0.0787
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0031	0.0787	0.5263
Echinococcus granulosus	N chimaerin	0.0031	0.0787	0.0787
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.086	0.086
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus multilocularis	tensin	0.0031	0.0787	0.0787
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0031	0.0787	0.0787
Brugia malayi	SH2 domain containing protein	0.0031	0.0787	0.0787
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0031	0.0787	0.0787
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0274	0.183
Entamoeba histolytica	SH2 domain containing protein	0.0031	0.0787	0.5263
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0274	0.0274
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0042	0.1496	0.1496
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0031	0.0787	0.0787
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0031	0.0787	0.0787
Loa Loa (eye worm)	SH2 domain-containing protein	0.0031	0.0787	0.0528
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0031	0.0787	0.0528
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0274	0.0274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Brugia malayi	SH2 domain containing protein	0.0042	0.1496	0.1496
Echinococcus multilocularis	SH2 motif	0.0031	0.0787	0.0787
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0042	0.1496	0.1496
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.086	0.4799
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Loa Loa (eye worm)	cysteine protease	0.0032	0.086	0.0603
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0042	0.1496	0.1496
Brugia malayi	SH2 domain containing protein	0.0031	0.0787	0.0787
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	tyrosine protein kinase shark	0.0042	0.1496	0.1496
Echinococcus multilocularis	N chimaerin	0.0031	0.0787	0.0787
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0031	0.0787	0.0528
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.086	0.5751
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0031	0.0787	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Giardia lamblia	Cathepsin B precursor	0.006	0.2688	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.1496	0.1496
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0042	0.1496	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Onchocerca volvulus		0.0042	0.1496	1
Echinococcus multilocularis	cysteine protease	0.0032	0.086	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Brugia malayi	Protein kinase domain containing protein	0.0042	0.1496	0.1496
Schistosoma mansoni	hypothetical protein	0.0031	0.0787	0.0787
Schistosoma mansoni	tensin	0.0031	0.0787	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0042	0.1496	0.1496
Echinococcus granulosus	SHC transforming protein 3	0.0031	0.0787	0.0787
Echinococcus multilocularis	SHC transforming protein 3	0.0031	0.0787	0.0787
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.1496	0.1496
Echinococcus multilocularis	c src tyrosine kinase	0.0042	0.1496	0.1496
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0031	0.0787	0.4202
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.1496	0.1257
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.086	0.086
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.1496	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0042	0.1496	0.1496
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.1496	0.1257
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.1496	0.1496
Schistosoma mansoni	adapter molecule crk	0.0031	0.0787	0.0787
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.1496	0.1257
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0031	0.0787	0.0787
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Schistosoma mansoni	shc transforming protein	0.0031	0.0787	0.0787
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	SH2 motif	0.0031	0.0787	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Echinococcus granulosus	tyrosine protein kinase Blk	0.0042	0.1496	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0274	0.1018
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0031	0.0787	0.0528
Onchocerca volvulus		0.0031	0.0787	0.4202
Echinococcus granulosus	expressed conserved protein	0.0031	0.0787	0.0787
Onchocerca volvulus		0.0042	0.1496	1
Brugia malayi	SH2 domain containing protein	0.0031	0.0787	0.0787
Schistosoma mansoni	tyrosine kinase	0.0042	0.1496	0.1496
Echinococcus multilocularis	tensin	0.0031	0.0787	0.0787
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.1496	0.1496
Brugia malayi	Protein kinase domain containing protein	0.0042	0.1496	0.1496
Schistosoma mansoni	tensin	0.0031	0.0787	0.0787
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0031	0.0787	0.0787
Onchocerca volvulus		0.0032	0.086	0.4799
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.2688	0.2688
Loa Loa (eye worm)	ctsf protein	0.0032	0.086	0.0603
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0031	0.0787	0.0787
Loa Loa (eye worm)	fibroinase	0.0032	0.086	0.0603
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.086	0.086
Onchocerca volvulus		0.0032	0.086	0.4799
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.086	0.086
Brugia malayi	RhoGAP domain containing protein	0.0031	0.0787	0.0787
Loa Loa (eye worm)	SH2 domain-containing protein	0.0031	0.0787	0.0528
Brugia malayi	hypothetical protein	0.0031	0.0787	0.0787
Onchocerca volvulus		0.0032	0.086	0.4799
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	1	1
Loa Loa (eye worm)	TK protein kinase	0.0042	0.1496	0.1257
Brugia malayi	hypothetical protein	0.0042	0.1496	0.1496
Schistosoma mansoni	suppressor of cytokine signaling	0.0031	0.0787	0.0787
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0031	0.0787	0.0787
Schistosoma mansoni	suppressor of cytokine signaling	0.0031	0.0787	0.0787
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.086	0.086
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.086	0.086
Entamoeba histolytica	protein kinase, putative	0.0031	0.0787	0.5263
Schistosoma mansoni	signal transduction protein lnk-related	0.0031	0.0787	0.0787
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.1496	0.1257
Echinococcus granulosus	tyrosine protein kinase Srms	0.0042	0.1496	0.1496
Echinococcus multilocularis	cysteine protease	0.0032	0.086	0.086
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0042	0.1496	0.1496
Loa Loa (eye worm)	SRC-1	0.0042	0.1496	0.1257
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Onchocerca volvulus		0.0031	0.0787	0.4202
Echinococcus granulosus	signal transduction protein lnk realted	0.0031	0.0787	0.0787
Schistosoma mansoni	tyrosine kinase	0.0042	0.1496	0.1496
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0042	0.1496	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0042	0.1496	0.1496
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.086	0.3201
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.2688	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Loa Loa (eye worm)	SH2 domain-containing protein	0.0031	0.0787	0.0528
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Schistosoma mansoni	SH2A	0.0031	0.0787	0.0787
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Echinococcus granulosus	growth factor receptor bound protein 2	0.0031	0.0787	0.0787
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0787	0.0528
Loa Loa (eye worm)	TK/ABL protein kinase	0.0042	0.1496	0.1257
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0031	0.0787	0.0787
Onchocerca volvulus		0.0032	0.086	0.4799
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.086	0.3201
Onchocerca volvulus		0.0042	0.1496	1
Schistosoma mansoni	tensin-related	0.0031	0.0787	0.0787
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0031	0.0787	0.0787
Schistosoma mansoni	tensin	0.0031	0.0787	0.0787
Echinococcus granulosus	tensin	0.0031	0.0787	0.0787
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.1496	0.1257
Toxoplasma gondii	cathepsin B	0.006	0.2688	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.086	0.086
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0031	0.0787	0.0787
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0042	0.1496	0.1496
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0031	0.0787	0.0787
Echinococcus multilocularis	tyrosine kinase	0.0042	0.1496	0.1496
Brugia malayi	SH2 domain containing protein	0.0031	0.0787	0.0787
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0042	0.1496	0.1496
Plasmodium vivax	vivapain-2	0.0032	0.086	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0042	0.1496	0.1496
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.086	0.0603
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.1496	0.1257
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Echinococcus granulosus	hypothetical protein	0.0031	0.0787	0.0787
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Schistosoma mansoni	tyrosine kinase	0.0042	0.1496	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1496	0.1257
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0031	0.0787	0.0787
Brugia malayi	SH2 domain containing protein	0.0031	0.0787	0.0787
Onchocerca volvulus		0.0042	0.1496	1
Onchocerca volvulus		0.0042	0.1496	1
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Echinococcus granulosus	tyrosine kinase	0.0042	0.1496	0.1496
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0274	0.0274
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0042	0.1496	0.1496
Brugia malayi	Variant SH3 domain containing protein	0.0031	0.0787	0.0787
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0031	0.0787	0.0787
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.086	0.4799
Schistosoma mansoni	hypothetical protein	0.0031	0.0787	0.0787
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0031	0.0787	0.0787
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.2688	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0031	0.0787	0.0528
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0031	0.0787	0.0787
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0042	0.1496	0.1496
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.086	0.086
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0031	0.0787	0.0787
Brugia malayi	SH2 domain containing protein	0.0031	0.0787	0.0787
Echinococcus granulosus	cathepsin l1	0.0032	0.086	0.086
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0031	0.0787	0.0787
Echinococcus granulosus	cathepsin b	0.0171	1	1
Onchocerca volvulus		0.0032	0.086	0.4799
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	cathepsin l1	0.0023	0.0274	0.0274
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0274	0.0274
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0031	0.0787	0.0787
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.086	0.086
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0042	0.1496	0.1496
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.086	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0171	1	1
Schistosoma mansoni	vav2	0.0031	0.0787	0.0787
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	SH2 motif	0.0031	0.0787	0.0787
Schistosoma mansoni	GTPase activating protein	0.0031	0.0787	0.0787
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.1496	0.1496
Brugia malayi	Variant SH3 domain containing protein	0.0031	0.0787	0.0787
Onchocerca volvulus		0.0032	0.086	0.4799
Echinococcus granulosus	c src tyrosine kinase	0.0042	0.1496	0.1496

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 228 nM	Inhibition of human liver Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorometric analysis	ChEMBL.	23540644
IC50 (binding)	> 10000 nM	Inhibition of human liver Cathepsin B using Z-Arg-Arg-aminomethylcoumarin as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorometric analysis	ChEMBL.	23540644

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2376003

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1764263