Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glutamate symporter | 0.1783 | 1 | 1 |
Echinococcus granulosus | neutral amino acid transporter | 0.1783 | 1 | 0.5 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.1783 | 1 | 1 |
Echinococcus multilocularis | excitatory amino acid transporter 3 | 0.1783 | 1 | 1 |
Echinococcus granulosus | neutral amino acid transporter A | 0.1783 | 1 | 0.5 |
Echinococcus multilocularis | neutral amino acid transporter excitatory amino acid transporter | 0.1783 | 1 | 1 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.1783 | 1 | 1 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.1783 | 1 | 0.5 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.1783 | 1 | 0.5 |
Echinococcus multilocularis | Excitatory amino acid transporter | 0.1783 | 1 | 1 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.1783 | 1 | 1 |
Onchocerca volvulus | Excitatory amino acid transporter homolog | 0.1783 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Na+/H+-dicarboxylate symporter | 0.1783 | 1 | 0.5 |
Echinococcus multilocularis | neutral amino acid transporter A | 0.1783 | 1 | 1 |
Echinococcus granulosus | Excitatory amino acid transporter | 0.1783 | 1 | 0.5 |
Treponema pallidum | glutamate/aspartate transporter | 0.079 | 0 | 0.5 |
Echinococcus granulosus | sodium:dicarboxylate symporter | 0.1783 | 1 | 0.5 |
Treponema pallidum | glutamate transporter | 0.079 | 0 | 0.5 |
Schistosoma mansoni | solute carrier family 1 (glial high affinity glutamate transporter | 0.1783 | 1 | 1 |
Echinococcus granulosus | neutral amino acid transporter A | 0.1783 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable C4-dicarboxylate-transport transmembrane protein DctA | 0.1783 | 1 | 0.5 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.1783 | 1 | 1 |
Loa Loa (eye worm) | excitatory amino acid transporter | 0.1783 | 1 | 0.5 |
Echinococcus granulosus | excitatory amino acid transporter 3 | 0.1783 | 1 | 0.5 |
Echinococcus granulosus | excitatory amino acid transporter 2 | 0.1783 | 1 | 0.5 |
Echinococcus multilocularis | excitatory amino acid transporter 2 | 0.1783 | 1 | 1 |
Echinococcus multilocularis | sodium:dicarboxylate symporter | 0.1783 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.083 uM | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins prior to substrate addition by Ellman's method | ChEMBL. | 23932451 |
IC50 (binding) | = 1.713 uM | Inhibition of equine serum BChE using butylthiocholine chloride as substrate preincubated for 15 mins prior to substrate addition by Ellman's method | ChEMBL. | 23932451 |
Inhibition (binding) | = 74.8 % | Inhibition of amyloid beta (1-42) (unknown origin) aggregation at 20 uM after 48 hrs by thioflavin-T based fluorimetric assay relative to control | ChEMBL. | 23932451 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.