TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 607.623 | Formula: C32H32F3N5O4
H donors: 2 H acceptors: 2 LogP: 5.84 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc2c(ccnc2cc1OCCCN1CCCCC1)Oc1ccc(cc1F)NC(=O)N/N=C/c1ccc(cc1F)F
InChi: 1S/C32H32F3N5O4/c1-42-30-18-24-27(19-31(30)43-15-5-14-40-12-3-2-4-13-40)36-11-10-28(24)44-29-9-8-23(17-26(29)35)38-32(41)39-37-20-21-6-7-22(33)16-25(21)34/h6-11,16-20H,2-5,12-15H2,1H3,(H2,38,39,41)/b37-20+
InChiKey: XHBKQWXDUHRNOS-HASSKWOGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	MET proto-oncogene, receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	voltage-gated cation channel	0.0095	0.1194	0.1246
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0095	0.1194	0.1297
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0049	0.0495	0.0538
Onchocerca volvulus		0.0032	0.0238	0.0744
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0095	0.1194	0.1297
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0095	0.1194	0.1246
Echinococcus granulosus	hyperpolarization activated cyclic	0.0095	0.1194	0.1194
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0495	0.0538
Echinococcus multilocularis	transient receptor potential gamma protein	0.0095	0.1194	0.1297
Echinococcus multilocularis	potassium voltage gated channel protein	0.0095	0.1194	0.1297
Schistosoma mansoni	voltage-dependent calcium channel	0.0095	0.1194	0.1246
Echinococcus granulosus	shaker cognate	0.0095	0.1194	0.1194
Echinococcus multilocularis	transient receptor potential cation channel	0.0095	0.1194	0.1297
Echinococcus multilocularis	neuroglian	0.0056	0.0611	0.0664
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0095	0.1194	0.1297
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Onchocerca volvulus		0.0095	0.1194	0.4606
Echinococcus granulosus	potassium voltage gated channel protein	0.0095	0.1194	0.1194
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Schistosoma mansoni	transient receptor potential channel	0.0095	0.1194	0.1246
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0095	0.1194	0.4606
Echinococcus multilocularis	voltage dependent calcium channel	0.0095	0.1194	0.1297
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0095	0.1194	0.1297
Echinococcus multilocularis	transient receptor potential cation channel	0.0095	0.1194	0.1297
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Loa Loa (eye worm)	sema domain-containing protein	0.002	0.0054	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus multilocularis	potassium voltage gated channel protein	0.0095	0.1194	0.1297
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0095	0.1194	0.1194
Echinococcus multilocularis	Immunoglobulin	0.0049	0.0495	0.0538
Brugia malayi	hypothetical protein	0.0049	0.0495	0.0538
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0095	0.1194	0.1297
Toxoplasma gondii	transporter, cation channel family protein	0.0095	0.1194	0.5
Echinococcus granulosus	semaphorin 5B	0.002	0.0054	0.0054
Loa Loa (eye worm)	voltage-gated potassium channel	0.0095	0.1194	0.1297
Echinococcus multilocularis	roundabout 2	0.006	0.0667	0.0724
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0095	0.1194	0.1297
Echinococcus granulosus	sodium channel protein	0.0095	0.1194	0.1194
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0095	0.1194	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1248	0.1356
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0095	0.1194	0.1194
Echinococcus granulosus	voltage dependent calcium channel	0.0095	0.1194	0.1194
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0227	0.3207	0.3485
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0095	0.1194	0.1246
Toxoplasma gondii	hypothetical protein	0.0095	0.1194	0.5
Echinococcus multilocularis	transient receptor potential cation channel	0.0098	0.1248	0.1356
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Echinococcus granulosus	plexin a4	0.004	0.0368	0.0368
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0095	0.1194	0.1246
Schistosoma mansoni	two-pore calcium channel	0.0095	0.1194	0.1246
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0095	0.1194	0.4606
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0095	0.1194	0.1246
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0095	0.1194	0.1194
Echinococcus multilocularis	conserved hypothetical protein	0.0095	0.1194	0.1297
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0095	0.1194	0.1297
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0095	0.1194	0.1194
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0095	0.1194	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0238	0.0259
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0495	0.0538
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Echinococcus granulosus	voltage gated potassium channel	0.0095	0.1194	0.1194
Echinococcus granulosus	potassium voltage gated channel protein	0.0095	0.1194	0.1194
Echinococcus granulosus	TRP transient receptor potential channel	0.0095	0.1194	0.1194
Echinococcus multilocularis	sodium channel protein	0.0095	0.1194	0.1297
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0049	0.0495	0.0482
Schistosoma mansoni	calcium-activated potassium channel	0.0095	0.1194	0.1246
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0052	0.055	0.055
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0227	0.3207	0.3485
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus granulosus	transient receptor potential cation channel	0.0095	0.1194	0.1194
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0095	0.1194	0.1246
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0095	0.1194	0.1194
Entamoeba histolytica	tyrosin kinase, putative	0.0017	0.0014	0.5
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0095	0.1194	0.1297
Echinococcus multilocularis	hypothetical protein	0.002	0.0054	0.0058
Echinococcus granulosus	voltage gated potassium channel	0.0095	0.1194	0.1194
Loa Loa (eye worm)	voltage-gated calcium channel	0.0095	0.1194	0.1297
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0095	0.1194	0.1246
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0095	0.1194	0.1194
Leishmania major	hypothetical protein, conserved	0.0095	0.1194	0.5
Echinococcus granulosus	defective proboscis extension response	0.0049	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.002	0.0054	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Schistosoma mansoni	plexin	0.0032	0.0238	0.0201
Echinococcus multilocularis	transfer RNA-Gly	0.0095	0.1194	0.1297
Brugia malayi	voltage-dependent calcium channel	0.0095	0.1194	0.1297
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0095	0.1194	0.1297
Echinococcus multilocularis	potassium voltage gated channel protein	0.0095	0.1194	0.1297
Brugia malayi	cation channel family protein	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0095	0.1194	0.1246
Loa Loa (eye worm)	hypothetical protein	0.002	0.0054	0.0058
Loa Loa (eye worm)	hypothetical protein	0.002	0.0054	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0495	0.0538
Echinococcus granulosus	potassium voltage gated channel protein	0.0095	0.1194	0.1194
Loa Loa (eye worm)	plexin A	0.004	0.0368	0.04
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Echinococcus granulosus	neuroglian	0.0056	0.0611	0.0611
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0095	0.1194	0.5
Echinococcus multilocularis	short transient receptor potential channel 6	0.0098	0.1248	0.1356
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0095	0.1194	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0495	0.0538
Onchocerca volvulus		0.0167	0.2285	0.9015
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0495	0.0538
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0095	0.1194	0.1194
Echinococcus granulosus	semaphorin 1A	0.002	0.0054	0.0054
Echinococcus granulosus	Immunoglobulin	0.0049	0.0495	0.0495
Onchocerca volvulus	Tyrosine kinase homolog	0.0183	0.2529	1
Brugia malayi	SET domain containing protein	0.0623	0.9202	1
Loa Loa (eye worm)	SET domain-containing protein	0.0623	0.9202	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0054	0.0058
Echinococcus granulosus	short transient receptor potential channel 6	0.0095	0.1194	0.1194
Echinococcus multilocularis	histone lysine N methyltransferase E(z)	0.0623	0.9202	1
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0095	0.1194	0.1194
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0095	0.1194	0.1194
Brugia malayi	cation channel family protein	0.0095	0.1194	0.1297
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0095	0.1194	0.1297
Echinococcus granulosus	twitchin	0.0056	0.0611	0.0611
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0095	0.1194	0.1194
Schistosoma mansoni	enhancer of zeste ezh	0.0623	0.9202	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus multilocularis	ryanodine receptor 44f	0.0095	0.1194	0.1297
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0095	0.1194	0.1297
Brugia malayi	Transient-receptor-potential like protein	0.0095	0.1194	0.1297
Echinococcus granulosus	potassium voltage gated channel protein	0.0095	0.1194	0.1194
Echinococcus granulosus	hypothetical protein	0.0095	0.1194	0.1194
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0049	0.0495	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Toxoplasma gondii	transporter, cation channel family protein	0.0095	0.1194	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0095	0.1194	0.5
Brugia malayi	Plexin repeat family protein	0.0032	0.0238	0.0259
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0095	0.1194	0.1297
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Schistosoma mansoni	transient receptor potential channel	0.0098	0.1248	0.1306
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0095	0.1194	0.1297
Echinococcus multilocularis	transient receptor potential cation channel	0.0098	0.1248	0.1356
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus multilocularis	shaker cognate	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0095	0.1194	0.1297
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0095	0.1194	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0095	0.1194	0.1194
Echinococcus granulosus	short transient receptor potential channel 6	0.0098	0.1248	0.1248
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0095	0.1194	0.1297
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0095	0.1194	0.1297
Brugia malayi	Sema domain containing protein	0.002	0.0054	0.0058
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0095	0.1194	0.5
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0095	0.1194	0.1246
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus granulosus	transient receptor potential cation channel	0.0098	0.1248	0.1248
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Echinococcus multilocularis	semaphorin 5B	0.002	0.0054	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0495	0.0538
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0095	0.1194	0.5
Echinococcus multilocularis	potassium large conductance calcium activated	0.0095	0.1194	0.1297
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0095	0.1194	0.5
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0095	0.1194	0.5
Schistosoma mansoni	transient receptor potential channel	0.0095	0.1194	0.1246
Echinococcus multilocularis	short transient receptor potential channel 6	0.0095	0.1194	0.1297
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0095	0.1194	0.1194
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0095	0.1194	0.1194
Echinococcus granulosus	transient receptor potential cation channel	0.0095	0.1194	0.1194
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0095	0.1194	0.1246
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0095	0.1194	0.1297
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Schistosoma mansoni	nephrin	0.0056	0.0611	0.0609
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0095	0.1194	0.1297
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0095	0.1194	0.1297
Brugia malayi	hypothetical protein	0.002	0.0054	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus granulosus	two pore calcium channel protein 1	0.0095	0.1194	0.1194
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0095	0.1194	0.1297
Loa Loa (eye worm)	voltage-gated potassium channel	0.0095	0.1194	0.1297
Echinococcus granulosus	transient receptor potential cation channel	0.0095	0.1194	0.1194
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0095	0.1194	0.1297
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0049	0.0495	0.0482
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0095	0.1194	0.1297
Echinococcus multilocularis	transient receptor potential cation channel	0.0095	0.1194	0.1297
Echinococcus granulosus	two pore calcium channel protein 2	0.0095	0.1194	0.1194
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Brugia malayi	Fibronectin type III domain containing protein	0.0049	0.0495	0.0538
Echinococcus multilocularis	sodium leak channel non selective protein	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Toxoplasma gondii	transporter, cation channel family protein	0.0095	0.1194	0.5
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0095	0.1194	0.1297
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.002	0.0054	0.0058
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0095	0.1194	0.1297
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0095	0.1194	0.1246
Echinococcus granulosus	potassium large conductance calcium activated	0.0095	0.1194	0.1194
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0095	0.1194	0.1297
Echinococcus multilocularis	potassium voltage gated channel protein	0.0095	0.1194	0.1297
Echinococcus multilocularis	voltage gated potassium channel	0.0095	0.1194	0.1297
Echinococcus granulosus	roundabout 2	0.006	0.0667	0.0667
Echinococcus multilocularis	voltage gated potassium channel	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.006	0.0667	0.0724
Echinococcus granulosus	calcium activated potassium channel	0.0095	0.1194	0.1194
Schistosoma mansoni	voltage-gated ion channel	0.0095	0.1194	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0052	0.055	0.0598
Loa Loa (eye worm)	ryanodine receptor	0.0095	0.1194	0.1297
Echinococcus multilocularis	transient receptor potential cation channel	0.0095	0.1194	0.1297
Echinococcus multilocularis	Immunoglobulin	0.0049	0.0495	0.0538
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0095	0.1194	0.1297
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0095	0.1194	0.1297
Echinococcus granulosus	voltage dependent calcium channel	0.0095	0.1194	0.1194
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0095	0.1194	0.1194
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0095	0.1194	0.5
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0095	0.1194	0.1297
Schistosoma mansoni	voltage-gated potassium channel	0.0095	0.1194	0.1246
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0095	0.1194	0.1246
Schistosoma mansoni	60S ribosomal protein L21	0.0095	0.1194	0.1246
Loa Loa (eye worm)	sema domain-containing protein	0.002	0.0054	0.0058
Echinococcus granulosus	transient receptor potential cation channel	0.0095	0.1194	0.1194
Brugia malayi	plexin A	0.004	0.0368	0.04
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0095	0.1194	0.1297
Echinococcus granulosus	histone lysine N methyltransferase Ez	0.0623	0.9202	0.9202
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0095	0.1194	0.1194
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1194	0.1297
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0095	0.1194	0.1194
Loa Loa (eye worm)	hypothetical protein	0.006	0.0667	0.0724
Entamoeba histolytica	protein kinase domain containing protein	0.0017	0.0014	0.5
Brugia malayi	olfactory channel protein osm-9	0.0098	0.1248	0.1356
Toxoplasma gondii	hypothetical protein	0.0095	0.1194	0.5
Echinococcus granulosus	sodium leak channel non selective protein	0.0095	0.1194	0.1194
Schistosoma mansoni	cell adhesion molecule	0.0052	0.055	0.0543
Schistosoma mansoni	vesicular amine transporter	0.0143	0.1933	0.2054
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0095	0.1194	0.1194
Schistosoma mansoni	hypothetical protein	0.0095	0.1194	0.1246
Brugia malayi	hypothetical protein	0.002	0.0054	0.0058
Echinococcus granulosus	potassium voltage gated channel protein	0.0095	0.1194	0.1194
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0095	0.1194	0.1297
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0095	0.1194	0.1246
Echinococcus granulosus	ryanodine receptor 44f	0.0095	0.1194	0.1194
Echinococcus multilocularis	two pore calcium channel protein 1	0.0095	0.1194	0.1297
Loa Loa (eye worm)	hypothetical protein	0.002	0.0054	0.0058
Schistosoma mansoni	transient receptor potential channel 4	0.0095	0.1194	0.1246
Echinococcus granulosus	transient receptor potential gamma protein	0.0095	0.1194	0.1194
Brugia malayi	ion channel NompC	0.0095	0.1194	0.1297
Brugia malayi	hypothetical protein	0.0095	0.1194	0.1297
Loa Loa (eye worm)	calcium channel	0.0095	0.1194	0.1297
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0095	0.1194	0.1246
Brugia malayi	Sema domain containing protein	0.002	0.0054	0.0058
Schistosoma mansoni	ryanodine receptor related	0.0095	0.1194	0.1246
Schistosoma mansoni	tyrosine kinase	0.002	0.0056	0.0002
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0095	0.1194	0.1297
Echinococcus multilocularis	calcium activated potassium channel	0.0095	0.1194	0.1297
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0095	0.1194	0.1246
Leishmania major	hypothetical protein, unknown function	0.0095	0.1194	0.5
Echinococcus granulosus	transient receptor potential cation channel	0.0095	0.1194	0.1194
Echinococcus multilocularis	voltage dependent calcium channel	0.0095	0.1194	0.1297
Echinococcus multilocularis	plexin a4	0.004	0.0368	0.04
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0095	0.1194	0.5
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0095	0.1194	0.1297
Echinococcus multilocularis	two pore calcium channel protein 2	0.0095	0.1194	0.1297
Echinococcus granulosus	hyperpolarization activated cyclic	0.0095	0.1194	0.1194
Loa Loa (eye worm)	ion channel NompC	0.0095	0.1194	0.1297
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0095	0.1194	0.1194

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.0044 uM	Inhibition of c-MET (unknown origin) using poly(Glu,Tyr) as substrate after 30 mins by HTRF assay	ChEMBL.	23838381
IC50 (functional)	= 0.3 uM	Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay	ChEMBL.	23838381

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23838381

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2419667

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1768099