Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0067 | 0.0357 | 0.0795 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0204 | 0.5717 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0111 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0357 | 0.0249 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0067 | 0.0357 | 0.0312 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0067 | 0.0357 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0268 | 0.0597 |
Brugia malayi | Choline O-acetyltransferase | 0.0067 | 0.0357 | 0.0312 |
Onchocerca volvulus | 0.0067 | 0.0357 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0067 | 0.0357 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0067 | 0.0357 | 0.0249 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0067 | 0.0357 | 0.0795 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0067 | 0.0357 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0268 | 0.0597 |
Loa Loa (eye worm) | hypothetical protein | 0.0758 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0268 | 0.0159 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0067 | 0.0357 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0067 | 0.0357 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0067 | 0.0357 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0067 | 0.0357 | 0.0312 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0363 | 0.4494 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0363 | 0.4494 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0067 | 0.0357 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0067 | 0.0357 | 0.0312 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0067 | 0.0357 | 0.0249 |
Onchocerca volvulus | 0.0067 | 0.0357 | 0.5 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0067 | 0.0357 | 0.0795 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0067 | 0.0357 | 0.0795 |
Onchocerca volvulus | 0.0067 | 0.0357 | 0.5 | |
Onchocerca volvulus | 0.0067 | 0.0357 | 0.5 | |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0363 | 0.4494 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0363 | 0.4494 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0363 | 0.4494 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0067 | 0.0357 | 0.0249 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
%max (binding) | = 23.2 % | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux at 30 uM after 45 mins relative to glutamate | ChEMBL. | 23932792 |
IC50 (binding) | > 5 | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux after 45 mins | ChEMBL. | 23932792 |
IC50 (binding) | > 10000 nM | Negative allosteric modulation of human mGlu1 receptor expressed in HEK293A TREx cells assessed as calcium flux after 45 mins | ChEMBL. | 23932792 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.