TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 292.332 | Formula: C18H16N2O2
H donors: 2 H acceptors: 2 LogP: 3.8 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)/C=C/c1n[nH]c(c1)c1ccc(cc1)O
InChi: 1S/C18H16N2O2/c1-22-17-10-3-13(4-11-17)2-7-15-12-18(20-19-15)14-5-8-16(21)9-6-14/h2-12,21H,1H3,(H,19,20)/b7-2+
InChiKey: GZPNQCDAKGCMRG-FARCUNLSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TK family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Brugia malayi	beta-lactamase family protein	0.0039	0.0733	0.1291
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Schistosoma mansoni	serine/threonine RGC	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0141	0.3105	0.3094
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0095	0.2028	0.3764
Loa Loa (eye worm)	TK protein kinase	0.0095	0.2028	0.3761
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0975	0.0961
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.5295	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Echinococcus granulosus	insulin receptor	0.0095	0.2028	0.2016
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0095	0.2028	0.2016
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0095	0.2028	0.3761
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0095	0.2028	0.2016
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0095	0.2028	0.2016
Echinococcus multilocularis	tyrosine kinase	0.0236	0.5295	0.5288
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.2028	1
Echinococcus granulosus	tensin	0.0141	0.3105	0.3094
Toxoplasma gondii	protein kinase domain-containing protein	0.0095	0.2028	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0975	0.0961
Onchocerca volvulus		0.0236	0.5295	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0095	0.2028	0.3764
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Brugia malayi	Raf kinase	0.0095	0.2028	0.3764
Trichomonas vaginalis	STE family protein kinase	0.0095	0.2028	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0095	0.2028	0.2016
Brugia malayi	SRC-1	0.0236	0.5295	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0141	0.3105	0.3094
Schistosoma mansoni	protein kinase	0.0095	0.2028	0.2016
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.5295	1
Schistosoma mansoni	tensin	0.0141	0.3105	0.3094
Brugia malayi	SH2 domain containing protein	0.0141	0.3105	0.582
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0141	0.3105	0.5383
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0095	0.2028	1
Brugia malayi	Guanylyl cyclase protein 23	0.0095	0.2028	0.3764
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0236	0.5295	0.5288
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0733	0.3613
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.2028	0.2016
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Entamoeba histolytica	tyrosin kinase, putative	0.0095	0.2028	0.2803
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0095	0.2028	0.2016
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Entamoeba histolytica	hypothetical protein	0.0095	0.2028	0.2803
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0095	0.2028	0.2016
Loa Loa (eye worm)	TK protein kinase	0.0095	0.2028	0.3761
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0095	0.2028	0.2016
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0975	0.0961
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0141	0.3105	0.582
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0141	0.3105	0.5817
Loa Loa (eye worm)	TK/CSK protein kinase	0.0095	0.2028	0.3761
Echinococcus granulosus	tyrosine kinase	0.0236	0.5295	0.5288
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0095	0.2028	0.3761
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0236	0.5295	0.5288
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0733	0.0718
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0141	0.3105	0.5817
Schistosoma mansoni	tensin-related	0.0141	0.3105	0.3094
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.1077	0.1944
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0095	0.2028	0.2016
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Schistosoma mansoni	tensin	0.0141	0.3105	0.3094
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0733	0.1291
Brugia malayi	Variant SH3 domain containing protein	0.0141	0.3105	0.582
Echinococcus multilocularis	tyrosine protein kinase csk	0.0095	0.2028	0.2016
Brugia malayi	Protein kinase domain containing protein	0.0236	0.5295	1
Schistosoma mansoni	protein kinase	0.0095	0.2028	0.2016
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Echinococcus granulosus	activated cdc42 kinase 1	0.0095	0.2028	0.2016
Brugia malayi	Variant SH3 domain containing protein	0.0141	0.3105	0.582
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0095	0.2028	0.2803
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0095	0.2028	0.2016
Schistosoma mansoni	cpg binding protein	0.0031	0.0552	0.0537
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.5295	1
Schistosoma mansoni	protein kinase	0.0095	0.2028	0.2016
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.0756	0.0742
Brugia malayi	Protein kinase domain containing protein	0.0236	0.5295	1
Onchocerca volvulus		0.0141	0.3105	0.5383
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0733	0.0718
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0141	0.3105	0.582
Echinococcus multilocularis	SH2 motif	0.0141	0.3105	0.3094
Leishmania major	hypothetical protein, conserved	0.0039	0.0733	0.1715
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0236	0.5295	0.5288
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0552	0.0941
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0095	0.2028	0.2016
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0685	0.1195
Echinococcus multilocularis	SH2 domain containing protein 7	0.0141	0.3105	0.3094
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0756	0.3727
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0059	0.0044
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0141	0.3105	0.3094
Onchocerca volvulus		0.0095	0.2028	0.3113
Schistosoma mansoni	protein kinase	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Entamoeba histolytica	serine/threonine kinase, putative	0.0095	0.2028	0.2803
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0095	0.2028	0.3113
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0733	0.0718
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0141	0.3105	0.582
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.119	0.4639
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0095	0.2028	0.3761
Onchocerca volvulus		0.0141	0.3105	0.5383
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0141	0.3105	0.5175
Loa Loa (eye worm)	TK/FER protein kinase	0.0095	0.2028	0.3761
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0095	0.2028	0.3761
Brugia malayi	RhoGAP domain containing protein	0.0141	0.3105	0.582
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.023	0.0215
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0247	0.5553	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0141	0.3105	0.3094
Schistosoma mansoni	inositol monophosphatase	0.004	0.0756	0.0742
Schistosoma mansoni	tensin-related	0.0141	0.3105	0.3094
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Entamoeba histolytica	cysteine surface protein, putative	0.0095	0.2028	0.2803
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0095	0.2028	0.3764
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0095	0.2028	0.2016
Echinococcus multilocularis	protein tyrosine kinase	0.0095	0.2028	0.2016
Echinococcus multilocularis	SH2 motif	0.0141	0.3105	0.3094
Giardia lamblia	Kinase	0.0095	0.2028	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.5295	1
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0141	0.3105	0.3094
Brugia malayi	Protein kinase domain containing protein	0.0236	0.5295	1
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0095	0.2028	1
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Echinococcus multilocularis	integrin linked protein kinase	0.0095	0.2028	0.2016
Brugia malayi	integrin-linked kinase	0.0095	0.2028	0.3764
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0095	0.2028	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0119	0.0104
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.5295	1
Echinococcus granulosus	SH2 motif	0.0141	0.3105	0.3094
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Brugia malayi	Furin-like cysteine rich region family protein	0.0095	0.2028	0.3764
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0095	0.2028	1
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.0756	0.0742
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0733	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0975	0.1749
Entamoeba histolytica	hypothetical protein	0.0095	0.2028	0.2803
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0141	0.3105	0.3094
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0236	0.5295	0.5288
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0095	0.2028	0.2803
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Brugia malayi	SH2 domain containing protein	0.0141	0.3105	0.582
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0236	0.5295	0.5288
Brugia malayi	Sex muscle abnormal protein 5	0.0141	0.3105	0.582
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0236	0.5295	0.5288
Brugia malayi	beta-lactamase	0.0039	0.0733	0.1291
Schistosoma mansoni	protein kinase	0.0095	0.2028	0.2016
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0236	0.5295	0.5288
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0236	0.5295	0.5288
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0095	0.2028	0.2016
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0733	0.3613
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0095	0.2028	0.2016
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0733	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Onchocerca volvulus		0.0236	0.5295	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.023	0.0215
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Trichomonas vaginalis	CAMK family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0095	0.2028	0.2016
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0685	0.12
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0733	0.0149
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0141	0.3105	0.3094
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Loa Loa (eye worm)	TK/FER protein kinase	0.0095	0.2028	0.3761
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0236	0.5295	0.5288
Onchocerca volvulus		0.0141	0.3105	0.5383
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0975	0.0961
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0141	0.3105	0.3094
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0236	0.5295	0.5288
Loa Loa (eye worm)	TK/RYK protein kinase	0.0095	0.2028	0.3761
Schistosoma mansoni	protein kinase	0.0095	0.2028	0.2016
Loa Loa (eye worm)	TK/FAK protein kinase	0.0095	0.2028	0.3761
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0733	0.0149
Entamoeba histolytica	tyrosin kinase, putative	0.0095	0.2028	0.2803
Echinococcus granulosus	tyrosine protein kinase Srms	0.0236	0.5295	0.5288
Echinococcus granulosus	integrin linked protein kinase	0.0095	0.2028	0.2016
Brugia malayi	hypothetical protein	0.0017	0.0243	0.0356
Entamoeba histolytica	hypothetical protein, conserved	0.0095	0.2028	0.2803
Echinococcus granulosus	tyrosine protein kinase	0.0095	0.2028	0.2016
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.2028	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0095	0.2028	0.3761
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Plasmodium falciparum	protein kinase, putative	0.0095	0.2028	1
Onchocerca volvulus		0.0141	0.3105	0.5383
Schistosoma mansoni	tensin	0.0141	0.3105	0.3094
Brugia malayi	beta-lactamase family protein	0.0039	0.0733	0.1291
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Trypanosoma brucei	Pseudokinase, putative	0.0095	0.2028	1
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0236	0.5295	0.5288
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0095	0.2028	0.3764
Loa Loa (eye worm)	TK/ALK protein kinase	0.0095	0.2028	0.3761
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Onchocerca volvulus		0.0095	0.2028	0.3113
Schistosoma mansoni	hypothetical protein	0.0017	0.023	0.0215
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0733	0.0149
Entamoeba histolytica	protein kinase, putative	0.0141	0.3105	0.5175
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0733	0.1715
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Schistosoma mansoni	protein kinase	0.0095	0.2028	0.2016
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0119	0.0104
Plasmodium falciparum	protein kinase, putative	0.0095	0.2028	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0095	0.2028	0.2016
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Echinococcus multilocularis	tensin	0.0141	0.3105	0.3094
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0733	0.3613
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Echinococcus granulosus	activated cdc42 kinase 1	0.0095	0.2028	0.2016
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Onchocerca volvulus	Tyrosine kinase homolog	0.0095	0.2028	0.3113
Schistosoma mansoni	protein kinase	0.0095	0.2028	0.2016
Entamoeba histolytica	tyrosin kinase, putative	0.0095	0.2028	0.2803
Schistosoma mansoni	tyrosine kinase	0.0236	0.5295	0.5288
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Loa Loa (eye worm)	TK protein kinase	0.0095	0.2028	0.3761
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0141	0.3105	0.5817
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0095	0.2028	0.3761
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0975	0.1753
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0733	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus multilocularis	insulin receptor	0.0095	0.2028	0.2016
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0095	0.2028	0.2016
Echinococcus multilocularis	tensin	0.0141	0.3105	0.3094
Entamoeba histolytica	SH2 domain containing protein	0.0141	0.3105	0.5175
Entamoeba histolytica	serine/threonine kinase, putative	0.0095	0.2028	0.2803
Schistosoma mansoni	hypothetical protein	0.0141	0.3105	0.3094
Echinococcus multilocularis	activated cdc42 kinase 1	0.0095	0.2028	0.2016
Brugia malayi	SH2 domain containing protein	0.0236	0.5295	1
Entamoeba histolytica	hypothetical protein	0.0095	0.2028	0.2803
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0095	0.2028	0.3764
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0095	0.2028	0.2016
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0095	0.2028	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0095	0.2028	0.2016
Loa Loa (eye worm)	TK/FER protein kinase	0.0095	0.2028	0.3761
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0095	0.2028	0.3761
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0141	0.3105	0.3094
Echinococcus multilocularis	activin receptor type	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.023	0.0215
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0733	0.0149
Echinococcus multilocularis	NCK adaptor protein	0.0141	0.3105	0.3094
Loa Loa (eye worm)	TK protein kinase	0.0095	0.2028	0.3761
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0236	0.5295	0.5288
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0975	0.0961
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0236	0.5295	0.5288
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Schistosoma mansoni	signal transduction protein lnk-related	0.0141	0.3105	0.3094
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0095	0.2028	0.3764
Brugia malayi	Tyrosine-protein kinase abl-1	0.0236	0.5295	1
Onchocerca volvulus		0.0039	0.0733	0.0382
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0141	0.3105	0.5817
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0095	0.2028	0.2016
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0733	0.0149
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Entamoeba histolytica	tyrosin kinase, putative	0.0095	0.2028	0.2803
Giardia lamblia	Kinase, NEK	0.0095	0.2028	0.5
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Schistosoma mansoni	suppressor of cytokine signaling	0.0141	0.3105	0.3094
Onchocerca volvulus		0.0039	0.0733	0.0382
Echinococcus granulosus	tyrosine protein kinase csk	0.0095	0.2028	0.2016
Entamoeba histolytica	hypothetical protein	0.0095	0.2028	0.2803
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0095	0.2028	0.2016
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.1077	0.1948
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0141	0.3105	0.3094
Schistosoma mansoni	protein kinase	0.0095	0.2028	0.2016
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.0756	0.3727
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Echinococcus multilocularis	GPCR, family 2	0.0017	0.023	0.0215
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Schistosoma mansoni	GTPase activating protein	0.0141	0.3105	0.3094
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Loa Loa (eye worm)	TK protein kinase	0.0095	0.2028	0.3761
Schistosoma mansoni	tyrosine kinase	0.0236	0.5295	0.5288
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0141	0.3105	0.3094
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0095	0.2028	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.023	0.0215
Entamoeba histolytica	ankyrin repeat protein	0.0095	0.2028	0.2803
Entamoeba histolytica	receptor protein kinase, putative	0.0095	0.2028	0.2803
Echinococcus granulosus	raf serine:threonine protein kinase	0.0095	0.2028	0.2016
Echinococcus multilocularis	SHC transforming protein 3	0.0141	0.3105	0.3094
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.1352	0.1338
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0141	0.3105	0.3094
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.5295	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0756	0.1863
Entamoeba histolytica	hypothetical protein	0.0095	0.2028	0.2803
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Onchocerca volvulus		0.0236	0.5295	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0141	0.3105	0.5817
Brugia malayi	C-terminal src kinase protein 1	0.0095	0.2028	0.3764
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Entamoeba histolytica	hypothetical protein	0.0095	0.2028	0.2803
Loa Loa (eye worm)	serine/threonine protein kinase	0.0095	0.2028	0.3761
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0236	0.5295	0.5288
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0095	0.2028	0.2016
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.2028	0.2016
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Entamoeba histolytica	serine/threonine kinase, putative	0.0095	0.2028	0.2803
Onchocerca volvulus		0.0236	0.5295	1
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0095	0.2028	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0236	0.5295	0.5288
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0465	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Echinococcus granulosus	protein tyrosine kinase	0.0095	0.2028	0.2016
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Schistosoma mansoni	growth factor receptor-bound protein	0.0141	0.3105	0.3094
Echinococcus granulosus	tyrosine protein kinase csk	0.0095	0.2028	0.2016
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Loa Loa (eye worm)	TK/FER protein kinase	0.0095	0.2028	0.3761
Brugia malayi	Protein kinase domain containing protein	0.0236	0.5295	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0593	0.0578
Schistosoma mansoni	hypothetical protein	0.0037	0.0685	0.067
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0095	0.2028	0.2016
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0236	0.5295	0.5288
Echinococcus multilocularis	tyrosine protein kinase	0.0095	0.2028	0.2016
Echinococcus granulosus	tyrosine protein kinase pr2	0.0095	0.2028	0.2016
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus multilocularis	cpg binding protein	0.0033	0.0593	0.0578
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus granulosus	GPCR family 2	0.0017	0.023	0.0215
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0236	0.5295	0.5288
Schistosoma mansoni	protein kinase	0.0095	0.2028	0.2016
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0095	0.2028	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0756	0.1863
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0095	0.2028	0.3764
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0095	0.2028	0.2016
Echinococcus multilocularis	SH2 motif	0.0141	0.3105	0.3094
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0095	0.2028	0.3761
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0095	0.2028	0.2016
Echinococcus granulosus	SH2 motif	0.0141	0.3105	0.3094
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.5295	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Brugia malayi	Tensin	0.0141	0.3105	0.582
Onchocerca volvulus		0.0095	0.2028	0.3113
Echinococcus granulosus	ephrin type A receptor 4 A	0.0095	0.2028	0.2016
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0733	0.1715
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.0756	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0236	0.5295	0.5288
Schistosoma mansoni	hypothetical protein	0.0439	1	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Schistosoma mansoni	ephrin receptor	0.0095	0.2028	0.2016
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0733	0.1715
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0095	0.2028	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0095	0.2028	0.3761
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0095	0.2028	0.3761
Schistosoma mansoni	suppressor of cytokine signaling	0.0141	0.3105	0.3094
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0236	0.5295	0.5288
Schistosoma mansoni	tyrosine protein kinase	0.0095	0.2028	0.2016
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0733	0.0718
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0095	0.2028	0.3761
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0236	0.5295	0.5288
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0095	0.2028	0.3113
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.0756	0.1863
Brugia malayi	SH2 domain containing protein	0.0236	0.5295	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Loa Loa (eye worm)	SRC-1	0.0236	0.5295	1
Brugia malayi	protein-tyrosine kinase	0.0236	0.5295	1
Entamoeba histolytica	ankyrin repeat protein	0.0095	0.2028	0.2803
Brugia malayi	Variant SH3 domain containing protein	0.0141	0.3105	0.582
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0733	0.1715
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Trichomonas vaginalis	esterase, putative	0.0039	0.0733	0.3613
Entamoeba histolytica	hypothetical protein	0.0095	0.2028	0.2803
Schistosoma mansoni	tyrosine kinase	0.0236	0.5295	0.5288
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0141	0.3105	0.5817
Toxoplasma gondii	STE kinase	0.0095	0.2028	1
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Trypanosoma cruzi	protein kinase, putative	0.0095	0.2028	1
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.2028	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0095	0.2028	0.2016
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0756	0.1863
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0095	0.2028	0.2803
Echinococcus multilocularis	tyrosine protein kinase csk	0.0095	0.2028	0.2016
Echinococcus granulosus	hypothetical protein	0.0141	0.3105	0.3094
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0141	0.3105	0.3094
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Echinococcus granulosus	SHC transforming protein 3	0.0141	0.3105	0.3094
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus multilocularis	dnaJ subfamily B	0.0439	1	1
Echinococcus granulosus	NCK adaptor protein	0.0141	0.3105	0.3094
Schistosoma mansoni	hypothetical protein	0.0017	0.023	0.0215
Loa Loa (eye worm)	SH2 domain-containing protein	0.0141	0.3105	0.5817
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0141	0.3105	0.3094
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Schistosoma mansoni	cpg binding protein	0.0033	0.0593	0.0578
Echinococcus granulosus	signal transduction protein lnk realted	0.0141	0.3105	0.3094
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0756	0.3727
Loa Loa (eye worm)	TK/FER protein kinase	0.0095	0.2028	0.3761
Echinococcus granulosus	N chimaerin	0.0141	0.3105	0.3094
Brugia malayi	hypothetical protein	0.0236	0.5295	1
Loa Loa (eye worm)	inositol-1	0.004	0.0756	0.1331
Echinococcus multilocularis	heat shock protein 70	0.0095	0.2028	0.2016
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.0756	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0095	0.2028	0.3761
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0141	0.3105	0.3094
Trichomonas vaginalis	protein kinase atn1, putative	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Brugia malayi	SH2 domain containing protein	0.0141	0.3105	0.582
Schistosoma mansoni	hypothetical protein	0.0012	0.0119	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0733	0.1287
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.1077	0.1948
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Onchocerca volvulus		0.0141	0.3105	0.5383
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0141	0.3105	0.3094
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.5295	1
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Echinococcus granulosus	expressed conserved protein	0.0141	0.3105	0.3094
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.2028	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0141	0.3105	0.3094
Echinococcus multilocularis	epidermal growth factor receptor	0.0095	0.2028	0.2016
Schistosoma mansoni	vav2	0.0141	0.3105	0.3094
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0236	0.5295	0.5288
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0236	0.5295	0.5288
Echinococcus multilocularis	transfer RNA-Thr	0.0095	0.2028	0.2016
Toxoplasma gondii	protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.5295	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0236	0.5295	0.5288
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0095	0.2028	0.2016
Brugia malayi	Tyrosine-protein kinase PR2	0.0095	0.2028	0.3764
Brugia malayi	hypothetical protein	0.0141	0.3105	0.582
Echinococcus multilocularis	epidermal growth factor receptor	0.0095	0.2028	0.2016
Leishmania major	protein kinase, putative	0.0095	0.2028	1
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Loa Loa (eye worm)	TK protein kinase	0.0236	0.5295	1
Brugia malayi	SH2 domain containing protein	0.0141	0.3105	0.582
Onchocerca volvulus		0.0095	0.2028	0.3113
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0236	0.5295	0.5288
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0141	0.3105	0.3094
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0095	0.2028	0.2016
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.023	0.0327
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Brugia malayi	Variant SH3 domain containing protein	0.0141	0.3105	0.582
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Loa Loa (eye worm)	TK protein kinase	0.0095	0.2028	0.3761
Onchocerca volvulus		0.0095	0.2028	0.3113
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0141	0.3105	0.5817
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0141	0.3105	0.5383
Echinococcus multilocularis	c src tyrosine kinase	0.0236	0.5295	0.5288
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0095	0.2028	0.2016
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0733	0.0149
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0733	0.3613
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0095	0.2028	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0733	0.1287
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Entamoeba histolytica	hypothetical protein	0.0095	0.2028	0.2803
Echinococcus multilocularis	N chimaerin	0.0141	0.3105	0.3094
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0756	0.1863
Toxoplasma gondii	ABC1 family protein	0.0039	0.0733	0.1715
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.2028	0.2016
Giardia lamblia	Protein 21.1	0.0095	0.2028	0.5
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Echinococcus granulosus	tyrosine protein kinase Blk	0.0236	0.5295	0.5288
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Onchocerca volvulus		0.0039	0.0733	0.0382
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0095	0.2028	0.2016
Brugia malayi	Inositol-1	0.004	0.0756	0.1336
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0095	0.2028	0.2016
Schistosoma mansoni	tyrosine kinase	0.0236	0.5295	0.5288
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.023	0.0332
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0095	0.2028	0.3761
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0095	0.2028	0.3761
Echinococcus multilocularis		0.0141	0.3105	0.3094
Onchocerca volvulus		0.0095	0.2028	0.3113
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0141	0.3105	0.3094
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0733	0.0149
Onchocerca volvulus		0.0236	0.5295	1
Onchocerca volvulus		0.0095	0.2028	0.3113
Loa Loa (eye worm)	TK/ABL protein kinase	0.0236	0.5295	1
Echinococcus granulosus	epidermal growth factor receptor	0.0095	0.2028	0.2016
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.2028	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0095	0.2028	0.3761
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0095	0.2028	0.2016
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0095	0.2028	0.3764
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Loa Loa (eye worm)	hypothetical protein	0.0017	0.023	0.0327
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Schistosoma mansoni	hypothetical protein	0.0017	0.023	0.0215
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0975	0.0961
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Loa Loa (eye worm)	TK protein kinase	0.0095	0.2028	0.3761
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.2028	1
Brugia malayi	hypothetical protein	0.0095	0.2028	0.3764
Loa Loa (eye worm)	hypothetical protein	0.0236	0.5295	1
Trypanosoma cruzi	protein kinase, putative	0.0095	0.2028	1
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0095	0.2028	0.2016
Plasmodium falciparum	protein kinase, putative	0.0095	0.2028	1
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Onchocerca volvulus		0.0095	0.2028	0.3113
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.5295	1
Echinococcus granulosus	tyrosine kinase	0.0236	0.5295	0.5288
Echinococcus granulosus	tyrosine kinase	0.0095	0.2028	0.2016
Loa Loa (eye worm)	TK protein kinase	0.0095	0.2028	0.3761
Entamoeba histolytica	hypothetical protein	0.0095	0.2028	0.2803
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0095	0.2028	0.3764
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0095	0.2028	0.2016
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0236	0.5295	0.5288
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0733	0.1287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0141	0.3105	0.3094
Entamoeba histolytica	hypothetical protein	0.0095	0.2028	0.2803
Schistosoma mansoni	tyrosine kinase	0.0236	0.5295	0.5288
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Entamoeba histolytica	hypothetical protein	0.0095	0.2028	0.2803
Trypanosoma brucei	protein kinase, putative	0.0095	0.2028	1
Echinococcus granulosus	cpg binding protein	0.0033	0.0593	0.0578
Schistosoma mansoni	tyrosine kinase	0.0236	0.5295	0.5288
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0733	0.1287
Echinococcus multilocularis	protein kinase	0.0095	0.2028	0.2016
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0733	0.0149
Brugia malayi	ephrin receptor 1 precursor	0.0095	0.2028	0.3764
Onchocerca volvulus		0.0236	0.5295	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Echinococcus granulosus	SH2 domain containing protein 7	0.0141	0.3105	0.3094
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0733	0.1287
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0141	0.3105	0.582
Entamoeba histolytica	serine/threonine kinase, putative	0.0095	0.2028	0.2803
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0141	0.3105	0.3094
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0141	0.3105	0.3094
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Echinococcus granulosus	growth factor receptor bound protein 2	0.0141	0.3105	0.3094
Onchocerca volvulus		0.0141	0.3105	0.5383
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0236	0.5295	0.5288
Loa Loa (eye worm)	TK/INSR protein kinase	0.0095	0.2028	0.3761
Brugia malayi	SH2 domain containing protein	0.0141	0.3105	0.582
Schistosoma mansoni	nck2/grb4	0.0141	0.3105	0.3094
Brugia malayi	Receptor family ligand binding region containing protein	0.0095	0.2028	0.3764
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Trichomonas vaginalis	conserved hypothetical protein	0.0095	0.2028	1
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0095	0.2028	1
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0059	0.0044
Leishmania major	hypothetical protein, conserved	0.0095	0.2028	1
Onchocerca volvulus		0.0095	0.2028	0.3113
Echinococcus granulosus	tyrosine protein kinase csk	0.0095	0.2028	0.2016
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Schistosoma mansoni	serine/threonine protein kinase	0.0095	0.2028	0.2016
Schistosoma mansoni	ephrin receptor	0.0095	0.2028	0.2016
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0095	0.2028	0.2016
Brugia malayi	hypothetical protein	0.0095	0.2028	0.3764
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0095	0.2028	0.2016
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0095	0.2028	0.2016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0975	0.0961
Schistosoma mansoni	hypothetical protein	0.0017	0.023	0.0215
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Giardia lamblia	Kinase, NEK	0.0095	0.2028	0.5
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0733	0.1287
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0733	0.1287
Plasmodium falciparum	tyrosine kinase-like protein	0.0095	0.2028	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0095	0.2028	0.2803
Echinococcus granulosus	protein kinase	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Brugia malayi	Protein kinase domain containing protein	0.0236	0.5295	1
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Schistosoma mansoni	hypothetical protein	0.0141	0.3105	0.3094
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0095	0.2028	0.3761
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0095	0.2028	0.2016
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0095	0.2028	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0095	0.2028	0.3761
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0095	0.2028	0.2016
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0236	0.5295	0.5288
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Echinococcus multilocularis	FL cytokine receptor	0.0095	0.2028	0.2016
Schistosoma mansoni	growth factor receptor-bound protein	0.0141	0.3105	0.3094
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Leishmania major	protein kinase, putative	0.0095	0.2028	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.023	0.0332
Echinococcus granulosus	c src tyrosine kinase	0.0236	0.5295	0.5288
Brugia malayi	SH2 domain containing protein	0.0141	0.3105	0.582
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Echinococcus multilocularis	tyrosine protein kinase csk	0.0095	0.2028	0.2016
Schistosoma mansoni	SH2A	0.0141	0.3105	0.3094
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0236	0.5295	0.5288
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0095	0.2028	0.2803
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0236	0.5295	0.5288
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0552	0.0946
Schistosoma mansoni	adapter molecule crk	0.0141	0.3105	0.3094
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0095	0.2028	0.2016
Loa Loa (eye worm)	TK protein kinase	0.0095	0.2028	0.3761
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Loa Loa (eye worm)	SH2 domain-containing protein	0.0141	0.3105	0.5817
Entamoeba histolytica	serine/threonine kinase, putative	0.0095	0.2028	0.2803
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0095	0.2028	0.2016
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0095	0.2028	1
Schistosoma mansoni	inositol monophosphatase	0.004	0.0756	0.0742
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0141	0.3105	0.3094
Trichomonas vaginalis	AGC family protein kinase	0.0095	0.2028	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0095	0.2028	0.3761
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0733	0.3613
Echinococcus granulosus	receptor type guanylyl cyclase	0.0095	0.2028	0.2016
Schistosoma mansoni	protein tyrosine kinase	0.0095	0.2028	0.2016
Trichomonas vaginalis	TKL family protein kinase	0.0095	0.2028	1
Echinococcus multilocularis	protein kinase	0.0095	0.2028	0.2016
Schistosoma mansoni	hypothetical protein	0.0095	0.2028	0.2016
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0733	0.1287
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Loa Loa (eye worm)	STAT protein	0.0141	0.3105	0.5817
Loa Loa (eye worm)	hypothetical protein	0.0141	0.3105	0.5817
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0236	0.5295	0.5288
Schistosoma mansoni	tyrosine kinase	0.0095	0.2028	0.2016
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0095	0.2028	0.2016
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0141	0.3105	0.3094
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0095	0.2028	1
Entamoeba histolytica	tyrosine kinase, putative	0.0095	0.2028	0.2803
Entamoeba histolytica	receptor protein kinase, putative	0.0095	0.2028	0.2803
Echinococcus multilocularis	tyrosine kinase	0.0095	0.2028	0.2016
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0236	0.5295	0.5288
Echinococcus granulosus	epidermal growth factor receptor	0.0095	0.2028	0.2016
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Loa Loa (eye worm)	TK/FER protein kinase	0.0095	0.2028	0.3761
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0095	0.2028	0.3761
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0095	0.2028	1
Echinococcus granulosus	activin receptor type	0.0095	0.2028	0.2016
Brugia malayi	SH2 domain containing protein	0.0141	0.3105	0.582
Plasmodium vivax	protein kinase, putative	0.0095	0.2028	1
Schistosoma mansoni	shc transforming protein	0.0141	0.3105	0.3094
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0733	0.0149
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0095	0.2028	0.3761
Schistosoma mansoni	protein kinase	0.0095	0.2028	0.2016
Echinococcus multilocularis	tyrosine protein kinase csk	0.0095	0.2028	0.2016
Entamoeba histolytica	protein kinase domain containing protein	0.0095	0.2028	0.2803
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0095	0.2028	0.2016
Brugia malayi	Protein kinase domain containing protein	0.0095	0.2028	0.3764
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2028	0.3761
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0236	0.5295	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1077	0.1944
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0141	0.3105	0.3094
Entamoeba histolytica	protein kinase, putative	0.0095	0.2028	0.2803
Brugia malayi	hypothetical protein	0.0027	0.0465	0.0779

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 81 %	Cytotoxicity against human MeWo cells assessed as cell viability at 10 uM after 48 hrs by MTT assay relative to vehicle-treated control	ChEMBL.	23830698

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2413468

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1772509