Detailed information for compound 1773525

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 680.802 | Formula: C42H36N10
  • H donors: 0 H acceptors: 6 LogP: 6.69 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: c1ccc2c(c1)cc(cc2)Cn1nnc(c1)CN(Cc1nnn(c1)Cc1ccc2c(c1)cccc2)Cc1nnn(c1)Cc1ccc2c(c1)cccc2
  • InChi: 1S/C42H36N10/c1-4-10-37-19-31(13-16-34(37)7-1)22-50-28-40(43-46-50)25-49(26-41-29-51(47-44-41)23-32-14-17-35-8-2-5-11-38(35)20-32)27-42-30-52(48-45-42)24-33-15-18-36-9-3-6-12-39(36)21-33/h1-21,28-30H,22-27H2
  • InChiKey: RHZRCMIMQMCMJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class B member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 90, putative heat shock protein 90kDa alpha (cytosolic), class B member 1 724 aa 725 aa 35.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0077 0.5
Brugia malayi beta-lactamase family protein 0.0332 0.1472 1
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0077 0.0522
Loa Loa (eye worm) hypothetical protein 0.0332 0.1472 0.7751
Echinococcus granulosus dual specificity mitogen activated protein 0.013 0.0509 0.3281
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Trypanosoma cruzi hypothetical protein, conserved 0.0332 0.1472 1
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Brugia malayi beta-lactamase family protein 0.0332 0.1472 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0039 0.5
Loa Loa (eye worm) hypothetical protein 0.0332 0.1472 0.7751
Treponema pallidum heat shock protein 90 0.0031 0.0039 0.5
Mycobacterium tuberculosis Conserved protein 0.0332 0.1472 0.1439
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0039 0.0262
Mycobacterium ulcerans hypothetical protein 0.0332 0.1472 0.2522
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0332 0.1472 1
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0077 0.0522
Loa Loa (eye worm) STE/STE7/MEK7 protein kinase 0.013 0.0509 0.24
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.1222 0.5722 0.5706
Leishmania major hypothetical protein, conserved 0.0332 0.1472 1
Onchocerca volvulus 0.0332 0.1472 0.5
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0077 0.0494
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0332 0.1472 0.2522
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Trichomonas vaginalis D-aminoacylase, putative 0.0332 0.1472 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0332 0.1472 0.1439
Trichomonas vaginalis D-aminoacylase, putative 0.0332 0.1472 1
Loa Loa (eye worm) hypothetical protein 0.0332 0.1472 0.7751
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Mycobacterium tuberculosis Probable lipase LipD 0.0332 0.1472 0.1439
Toxoplasma gondii ABC1 family protein 0.0332 0.1472 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0332 0.1472 1
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Mycobacterium tuberculosis Probable lipase LipE 0.0332 0.1472 0.1439
Plasmodium vivax hypothetical protein, conserved 0.0332 0.1472 1
Plasmodium falciparum heat shock protein 90 0.0039 0.0077 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0332 0.1472 1
Echinococcus multilocularis heat shock protein 90 0.0039 0.0077 0.0266
Loa Loa (eye worm) STE/STE7/MEK7 protein kinase 0.013 0.0509 0.24
Brugia malayi Dual specificity mitogen-activated protein kinase kinase 7. -TRUNCATED- 0.013 0.0509 0.3097
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0039 0.0234
Mycobacterium tuberculosis Conserved protein 0.0332 0.1472 0.1439
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0077 0.0522
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0587 0.2689 1
Trypanosoma cruzi hypothetical protein, conserved 0.0332 0.1472 1
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Echinococcus multilocularis beta LACTamase domain containing family member 0.0332 0.1472 1
Mycobacterium tuberculosis Conserved protein 0.0332 0.1472 0.1439
Loa Loa (eye worm) hypothetical protein 0.0332 0.1472 0.7751
Mycobacterium ulcerans esterase/lipase LipP 0.0332 0.1472 0.2522
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0039 0.0262
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0039 0.0234
Trichomonas vaginalis esterase, putative 0.0332 0.1472 1
Loa Loa (eye worm) hypothetical protein 0.0416 0.1877 1
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0039 0.0234
Mycobacterium ulcerans lipase LipD 0.0332 0.1472 0.2522
Mycobacterium leprae Probable lipase LipE 0.0332 0.1472 0.5407
Loa Loa (eye worm) hypothetical protein 0.0332 0.1472 0.7751
Trichomonas vaginalis D-aminoacylase, putative 0.0332 0.1472 1
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0077 0.0522
Echinococcus granulosus heat shock protein 90 0.0039 0.0077 0.0266
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Trichomonas vaginalis penicillin-binding protein, putative 0.0332 0.1472 1
Trypanosoma brucei hypothetical protein, conserved 0.0332 0.1472 0.534
Mycobacterium tuberculosis Probable hydrolase 0.0332 0.1472 0.1439
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Echinococcus multilocularis dual specificity mitogen activated protein 0.013 0.0509 0.3281
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0332 0.1472 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0077 1
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0587 0.2689 0.2661
Mycobacterium tuberculosis Probable esterase LipL 0.0332 0.1472 0.1439
Loa Loa (eye worm) beta-lactamase 0.0332 0.1472 0.7751
Echinococcus granulosus heat shock protein 0.0039 0.0077 0.0266
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0332 0.1472 0.1439
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0077 0.0522
Onchocerca volvulus 0.0332 0.1472 0.5
Mycobacterium ulcerans lipoprotein LpqF 0.0587 0.2689 0.4663
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0332 0.1472 0.1439
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0077 0.5
Echinococcus multilocularis heat shock protein 0.0039 0.0077 0.0266
Onchocerca volvulus 0.0332 0.1472 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0332 0.1472 0.7751
Mycobacterium leprae conserved hypothetical protein 0.0332 0.1472 0.5407
Brugia malayi beta-lactamase 0.0332 0.1472 1
Loa Loa (eye worm) hypothetical protein 0.0332 0.1472 0.7751
Echinococcus granulosus beta LACTamase domain containing family member 0.0332 0.1472 1
Mycobacterium ulcerans beta-lactamase 0.0332 0.1472 0.2522
Loa Loa (eye worm) hypothetical protein 0.0416 0.1877 1
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.1222 0.5722 1
Trypanosoma brucei beta lactamase 0.0587 0.2689 1
Schistosoma mansoni protein kinase 0.013 0.0509 0.3097
Leishmania major heat shock protein 83-1 0.0039 0.0077 0.0266

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 16 uM Inhibition of human Hsp90 ATPase activity assessed as inhibition of ATP hydrolysis after 60 mins by fluorimetric analysis ChEMBL. 23770448
Inhibition (binding) Inhibition of human Hsp90 ATPase activity assessed as inhibition of ATP hydrolysis after 60 mins by fluorimetric analysis ChEMBL. 23770448
Inhibition (binding) Inhibition of human Hsp90 chaperone activity assessed as citrate synthase thermal-induced aggregation at 0.3 uM by fluorimetric analysis ChEMBL. 23770448
Kd (binding) = 55 nM Binding affinity to human Hsp90 by surface plasmon resonance analysis ChEMBL. 23770448

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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