Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | trehalase | 0.0286 | 0.1597 | 0.1597 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.0833 | 0.4966 |
Trypanosoma cruzi | glycosyl hydrolase, putative | 0.0139 | 0.0373 | 1 |
Trichomonas vaginalis | trehalase, putative | 0.0286 | 0.1597 | 0.9524 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0295 | 0.1676 | 0.4146 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0045 | 0.0045 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.017 | 0.1013 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.017 | 0.5 |
Brugia malayi | hypothetical protein | 0.0099 | 0.0045 | 0.0111 |
Loa Loa (eye worm) | TRE-1 protein | 0.0286 | 0.1597 | 0.1597 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0045 | 0.0045 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.1676 | 1 |
Onchocerca volvulus | 0.0286 | 0.1597 | 0.6224 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0197 | 0.0861 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.1676 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.058 | 0.4044 | 0.8819 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.058 | 0.4044 | 0.8819 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0045 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0646 | 0.4585 | 0.4585 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.017 | 0.1013 |
Brugia malayi | hypothetical protein | 0.0099 | 0.0045 | 0.0111 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.0833 | 0.4966 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1597 | 0.1597 |
Toxoplasma gondii | melibiase subfamily protein | 0.0094 | 0 | 0.5 |
Brugia malayi | Trehalase family protein | 0.0286 | 0.1597 | 0.3948 |
Schistosoma mansoni | alpha-glucosidase | 0.058 | 0.4044 | 0.8819 |
Brugia malayi | hypothetical protein | 0.0099 | 0.0045 | 0.0111 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.017 | 0.037 |
Mycobacterium tuberculosis | Conserved protein | 0.0139 | 0.0373 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1597 | 0.1597 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0204 | 0.0919 | 0.5484 |
Schistosoma mansoni | beta-galactosidase | 0.0646 | 0.4585 | 1 |
Onchocerca volvulus | 0.0286 | 0.1597 | 0.6224 | |
Brugia malayi | Trehalase family protein | 0.0286 | 0.1597 | 0.3948 |
Onchocerca volvulus | 0.039 | 0.2462 | 1 | |
Schistosoma mansoni | alpha-glucosidase | 0.058 | 0.4044 | 0.8819 |
Loa Loa (eye worm) | TRE-2 protein | 0.0286 | 0.1597 | 0.1597 |
Mycobacterium leprae | Possible hydrolase | 0.0139 | 0.0373 | 0.5 |
Loa Loa (eye worm) | trehalase | 0.0099 | 0.0045 | 0.0045 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0286 | 0.1597 | 0.9524 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.017 | 0.1013 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.0833 | 0.4966 |
Brugia malayi | trehalase I | 0.0099 | 0.0045 | 0.0111 |
Brugia malayi | Trehalase family protein | 0.0286 | 0.1597 | 0.3948 |
Onchocerca volvulus | 0.0286 | 0.1597 | 0.6224 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.017 | 0.1013 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.017 | 0.037 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.0833 | 0.4966 |
Mycobacterium ulcerans | glycosyl hydrolase | 0.0139 | 0.0373 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.0774 | 0.0774 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.1676 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.017 | 0.1013 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0295 | 0.1676 | 0.1676 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.017 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.058 | 0.4044 | 1 |
Brugia malayi | trehalase | 0.0099 | 0.0045 | 0.0111 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0197 | 0.0861 | 0.5 |
Brugia malayi | Trehalase family protein | 0.0099 | 0.0045 | 0.0111 |
Onchocerca volvulus | 0.0286 | 0.1597 | 0.6224 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.017 | 0.1013 |
Loa Loa (eye worm) | trehalase | 0.0286 | 0.1597 | 0.1597 |
Loa Loa (eye worm) | trehalase | 0.0286 | 0.1597 | 0.1597 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.0833 | 0.4966 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0204 | 0.0919 | 0.5484 |
Brugia malayi | hypothetical protein | 0.0286 | 0.1597 | 0.3948 |
Brugia malayi | Trehalase family protein | 0.0099 | 0.0045 | 0.0111 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.1676 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1597 | 0.1597 |
Echinococcus granulosus | beta galactosidase | 0.0646 | 0.4585 | 1 |
Onchocerca volvulus | Trehalase homolog | 0.0286 | 0.1597 | 0.6224 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.017 | 0.037 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.058 | 0.4044 | 0.4044 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.0833 | 0.4966 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1597 | 0.1597 |
Loa Loa (eye worm) | trehalase | 0.0099 | 0.0045 | 0.0045 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.1676 | 1 |
Brugia malayi | Trehalase protein 5 | 0.0099 | 0.0045 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.1597 | 0.1597 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0194 | 0.0833 | 0.4966 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0045 | 0.0045 |
Onchocerca volvulus | 0.0286 | 0.1597 | 0.6224 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.058 | 0.4044 | 0.8819 |
Trypanosoma brucei | glycosyl hydrolase, putative | 0.0139 | 0.0373 | 1 |
Echinococcus multilocularis | beta galactosidase | 0.0646 | 0.4585 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.017 | 0.042 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0295 | 0.1676 | 1 |
Brugia malayi | Trehalase family protein | 0.0286 | 0.1597 | 0.3948 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0194 | 0.0833 | 0.2891 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.017 | 0.017 |
Leishmania major | glycosyl hydrolase, putative | 0.0139 | 0.0373 | 1 |
Treponema pallidum | hypothetical protein | 0.0099 | 0.0045 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.017 | 0.1013 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 270 nM | Antiproliferative activity against human HT-29 cells after 72 hrs by Cell Titer-Glo Assay | ChEMBL. | 23664874 |
IC50 (binding) | = 170 nM | Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assay | ChEMBL. | 23664874 |
t1/2 (binding) | Inhibition of PLK1 (21 to 351) (unknown origin) assessed as half life of dissociation rate using FAM-mTOR peptide as substrate | ChEMBL. | 23664874 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23664874 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.