TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 288.26 | Formula: C10H13N2O4PS
H donors: 1 H acceptors: 2 LogP: 3.1 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1)OP1(=S)NCCCO1)[N+](=O)[O-]
InChi: 1S/C10H13N2O4PS/c1-8-3-4-9(12(13)14)10(7-8)16-17(18)11-5-2-6-15-17/h3-4,7H,2,5-6H2,1H3,(H,11,18)
InChiKey: ZLHIQHYQQNBGHS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0032	0.0612	0.2349
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0132	0.0504
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0005	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0032	0.0612	0.2349
Brugia malayi	AKH receptor	0.0032	0.0612	0.0612
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	neuropeptide F-like receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	TYRA-2 protein	0.0032	0.0612	0.0612
Trypanosoma brucei	cAMP binding protein, putative	0.0005	0	1
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0612	0.2349
Brugia malayi	G protein-coupled receptor F59B2.13	0.0032	0.0612	0.0612
Brugia malayi	follicle stimulating hormone receptor	0.0032	0.0612	0.0612
Leishmania major	protein kinase, putative	0.0006	0.0034	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	hypothetical protein	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0032	0.0612	0.2349
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0005	0	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Brugia malayi	neuropeptide F receptor	0.0032	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.08	0.3071
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0032	0.0612	0.2349
Echinococcus granulosus	orexin receptor type 2	0.0032	0.0612	0.2349
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0032	0.0612	0.2349
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0005	0	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0032	0.0612	0.2349
Echinococcus granulosus	tm gpcr rhodopsin	0.0032	0.0612	0.2349
Mycobacterium ulcerans	regulatory protein	0.0005	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0032	0.0612	0.2349
Echinococcus multilocularis	neuropeptide Y receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0612	0.2349
Echinococcus multilocularis	neuropeptide receptor	0.0032	0.0612	0.2349
Onchocerca volvulus		0.0032	0.0612	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0612	0.2349
Brugia malayi	ORL1-like opioid receptor	0.0032	0.0612	0.0612
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0006	0.0034	0.0127
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0007	0.0055	0.082
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0005	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0132	0.0131
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0011	0.0132	0.0504
Brugia malayi	Dopamine receptor	0.0032	0.0612	0.0612
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0007	0.0055	0.0211
Onchocerca volvulus		0.0032	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Brugia malayi	hypothetical protein	0.0032	0.0612	0.0612
Brugia malayi	RE15519p	0.0032	0.0612	0.0612
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Schistosoma mansoni	opsin-like receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0032	0.0612	0.2349
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0032	0.0612	0.2349
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0007	0.0055	0.0211
Echinococcus multilocularis	neuropeptide receptor	0.0032	0.0612	0.2349
Onchocerca volvulus		0.0032	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Onchocerca volvulus		0.0032	0.0612	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0032	0.0612	0.0612
Schistosoma mansoni	neuropeptide f receptor 76f	0.0032	0.0612	0.2349
Schistosoma mansoni	voltage-gated potassium channel	0.0007	0.0055	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0006	0.0034	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0007	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0005	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Brugia malayi	sulfakinin receptor protein	0.0032	0.0612	0.0612
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0132	0.0504
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0032	0.0612	0.2349
Brugia malayi	hypothetical protein	0.0032	0.0612	0.0612
Schistosoma mansoni	60S ribosomal protein L21	0.0006	0.0022	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0612	0.2349
Loa Loa (eye worm)	camk/mapkapk/mnk protein kinase	0.0447	1	1
Echinococcus multilocularis	somatostatin receptor	0.0032	0.0612	0.2349
Echinococcus multilocularis	neuropeptide Y receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	amine GPCR	0.0032	0.0612	0.2349
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0007	0.0055	0.0211
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0007	0.0055	0.0211
Echinococcus multilocularis	fmrfamide receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Brugia malayi	G-protein coupled receptor	0.0032	0.0612	0.0612
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0006	0.0034	0.0127
Echinococcus granulosus	neuropeptide Y receptor	0.0032	0.0612	0.2349
Echinococcus multilocularis	G protein coupled receptor 139	0.0032	0.0612	0.2349
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0005	0	1
Echinococcus multilocularis	g protein coupled receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0612	0.2349
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0612	0.2349
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0005	0	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0032	0.0612	0.2349
Brugia malayi	Melatonin receptor type 1A	0.0032	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0032	0.0612	0.0612
Brugia malayi	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	tm gpcr rhodopsin	0.0032	0.0612	0.2349
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0032	0.0612	0.0612
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0032	0.0612	0.2349
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Treponema pallidum	catabolite gene activator (Crp)	0.0005	0	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0032	0.0612	0.2349
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0005	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0612	0.2349
Echinococcus multilocularis	fmrfamide receptor	0.0032	0.0612	0.2349
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0005	0	0.5
Brugia malayi	G protein-coupled receptor	0.0032	0.0612	0.0612
Onchocerca volvulus		0.0032	0.0612	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0032	0.0612	0.0612
Echinococcus granulosus	g protein coupled receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0612	0.0612
Echinococcus granulosus	neuropeptide s receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	opsin-like receptor	0.0032	0.0612	0.2349
Mycobacterium tuberculosis	Conserved protein	0.0005	0	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0032	0.0612	0.0612
Echinococcus granulosus	neuropeptide receptor	0.0032	0.0612	0.2349
Onchocerca volvulus		0.0032	0.0612	1
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0006	0.0034	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Schistosoma mansoni	growth hormone secretagogue receptor	0.0032	0.0612	0.2349
Brugia malayi	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Onchocerca volvulus		0.0032	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0724	0.2777
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0055	0.0211
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0034	0.0127
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Onchocerca volvulus		0.0032	0.0612	1
Echinococcus granulosus	neuropeptide Y receptor	0.0032	0.0612	0.2349
Trypanosoma cruzi	cAMP binding protein, putative	0.0005	0	0.5
Schistosoma mansoni	amine GPCR	0.0032	0.0612	0.2349
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0005	0	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	amine GPCR	0.0032	0.0612	0.2349
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0724	0.0724
Trypanosoma cruzi	cAMP response protein 1	0.0005	0	0.5
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0007	0.0055	0.0211
Onchocerca volvulus		0.0032	0.0612	1
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0612	0.2349
Brugia malayi	hypothetical protein	0.0032	0.0612	0.0612
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0612	0.2349
Brugia malayi	Serotonin receptor	0.0032	0.0612	0.0612
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0007	0.0055	0.0211
Echinococcus granulosus	neuropeptide FF receptor 2	0.0032	0.0612	0.2349
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0007	0.0055	0.0211
Echinococcus granulosus	sex peptide receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0612	0.2349
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0724	0.0724
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0032	0.0612	0.0612
Echinococcus multilocularis	dro:myosuppressin receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	histamine h1 receptor	0.0032	0.0612	0.2349
Onchocerca volvulus		0.0032	0.0612	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0032	0.0612	0.0612
Echinococcus multilocularis	g protein coupled receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0055	0.0055
Onchocerca volvulus		0.0032	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus multilocularis	allatostatin A receptor	0.0032	0.0612	0.2349
Treponema pallidum	cyclic nucleotide binding protein	0.0005	0	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0032	0.0612	1
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0132	0.0504
Trypanosoma brucei	protein kinase A regulatory subunit	0.0005	0	1
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Schistosoma mansoni	hypothetical protein	0.0032	0.0612	0.2349
Plasmodium falciparum	cGMP-dependent protein kinase	0.0006	0.0034	1
Brugia malayi	Serotonin receptor	0.0032	0.0612	0.0612
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0032	0.0612	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0724	0.2777
Schistosoma mansoni	hypothetical protein	0.0032	0.0612	0.2349
Schistosoma mansoni	amine GPCR	0.0032	0.0612	0.2349
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0032	0.0612	0.2349
Brugia malayi	hypothetical protein	0.0032	0.0612	0.0612
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0005	0	0.5
Schistosoma mansoni	myosin xvIII	0.0032	0.0612	0.2349
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0005	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0032	0.0612	0.2349
Schistosoma mansoni	neuropeptide F-like receptor	0.0032	0.0612	0.2349
Onchocerca volvulus		0.0032	0.0612	1
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0006	0.0034	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0007	0.0055	0.0211
Brugia malayi	Dopamine receptor protein 1	0.0032	0.0612	0.0612
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0007	0.0055	0.0055
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0032	0.0612	0.2349
Echinococcus granulosus	hyperpolarization activated cyclic	0.0007	0.0055	0.0211
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0011	0.0132	0.0504
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Echinococcus granulosus	G protein coupled receptor 139	0.0032	0.0612	0.2349
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0032	0.0612	0.2349
Echinococcus multilocularis	sex peptide receptor	0.0032	0.0612	0.2349
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0032	0.0612	0.2349
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0032	0.0612	0.2349
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0034	0.0127
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0005	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Mycobacterium ulcerans	transcriptional regulatory protein	0.0005	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0612	0.0612
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0032	0.0612	0.0612
Echinococcus multilocularis	serine:threonine protein kinase Chk2	0.012	0.2606	1
Echinococcus multilocularis	orexin receptor type 2	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	serine:threonine protein kinase Chk2	0.012	0.2606	1
Trypanosoma brucei	Flagellar Member 6	0.0005	0	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0032	0.0612	0.0612
Brugia malayi	Egg laying defective protein 4	0.0006	0.0034	0.0033
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0132	0.0504
Echinococcus granulosus	calcium:calmodulin dependent protein kinase I	0.012	0.2605	0.9996
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	serine/threonine protein kinase	0.012	0.2606	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0032	0.0612	0.2349
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase I	0.012	0.2605	0.9996
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0032	0.0612	0.2349
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0669	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0007	0.0055	0.082
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0055	0.0211
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0032	0.0612	0.2349
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0032	0.0612	0.2349
Mycobacterium ulcerans	transmembrane transport protein	0.0005	0	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.08	0.3071
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0612	0.2349
Echinococcus granulosus	7tm_1 domain containing protein	0.0032	0.0612	0.2349
Brugia malayi	neuropeptide F receptor	0.0032	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0612	0.2349
Onchocerca volvulus		0.0032	0.0612	1
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0007	0.0055	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0612	0.2349
Schistosoma mansoni	voltage-gated potassium channel	0.0006	0.0022	0.0082
Brugia malayi	larval opioid receptor	0.0032	0.0612	0.0612
Echinococcus multilocularis	serotonin receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0032	0.0612	0.2349
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0005	0	0.5
Brugia malayi	GnHR receptor homolog	0.0032	0.0612	0.0612
Echinococcus multilocularis	neuropeptides capa receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	fmrfamide receptor	0.0032	0.0612	0.2349
Echinococcus granulosus	neuropeptide receptor A26	0.0032	0.0612	0.2349
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0007	0.0055	0.0211
Loa Loa (eye worm)	melatonin receptor type 1A	0.0032	0.0612	0.0612
Loa Loa (eye worm)	G-protein coupled receptor	0.0032	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0032	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus multilocularis	serotonin receptor	0.0032	0.0612	0.2349
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0011	0.0132	0.0131
Echinococcus granulosus	allatostatin A receptor	0.0032	0.0612	0.2349
Echinococcus granulosus	neuropeptides capa receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0007	0.0055	0.0055
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0005	0	0.5
Entamoeba histolytica	protein kinase, putative	0.012	0.2606	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0032	0.0612	0.2349
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0032	0.0612	0.2349
Echinococcus granulosus	dro:myosuppressin receptor	0.0032	0.0612	0.2349
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Echinococcus multilocularis	neuropeptide s receptor	0.0032	0.0612	0.2349
Brugia malayi	hypothetical protein	0.0032	0.0612	0.0612
Brugia malayi	Dopamine receptor protein 2	0.0032	0.0612	0.0612
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0032	0.0612	0.2349
Schistosoma mansoni	hypothetical protein	0.0032	0.0612	0.2349
Brugia malayi	putative neuropeptide receptor	0.0032	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Entamoeba histolytica	protein kinase, putative	0.012	0.2606	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0032	0.0612	0.0612
Echinococcus granulosus	neuropeptides capa receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Schistosoma mansoni	adenoreceptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0006	0.0034	0.0033
Echinococcus granulosus	7TM GPCR rhodopsin	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Onchocerca volvulus		0.0032	0.0612	1
Echinococcus granulosus	serotonin receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	hyperpolarization activated cyclic	0.0007	0.0055	0.0211
Schistosoma mansoni	opsin-like receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Mycobacterium leprae	Conserved hypothetical protein	0.0005	0	0.5
Echinococcus multilocularis	expressed conserved protein	0.0006	0.0034	0.0127
Echinococcus multilocularis	neuropeptide receptor A26	0.0032	0.0612	0.2349
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0032	0.0612	0.2349
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0032	0.0612	0.2349
Mycobacterium ulcerans	hypothetical protein	0.0005	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Trypanosoma brucei	cAMP response protein 1, putative	0.0005	0	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0614	0.0613
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Schistosoma mansoni	amine GPCR	0.0032	0.0612	0.2349
Schistosoma mansoni	neuropeptide receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	somatostatin receptor	0.0032	0.0612	0.2349
Loa Loa (eye worm)	neuropeptide F receptor	0.0032	0.0612	0.0612
Trypanosoma cruzi	Flagellar Member 6	0.0005	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Treponema pallidum	catabolite gene activator	0.0005	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0032	0.0612	0.2349
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0007	0.0055	0.0211
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0669	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0032	0.0612	0.0612
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Mycobacterium ulcerans	hypothetical protein	0.0005	0	0.5
Brugia malayi	G-protein coupled receptor	0.0032	0.0612	0.0612
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0005	0	0.5
Leishmania major	protein kinase, putative	0.0006	0.0034	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Echinococcus multilocularis	g-protein coupled receptor	0.0032	0.0612	0.2349
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0032	0.0612	0.2349
Echinococcus granulosus	g-protein coupled receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0032	0.0612	0.2349
Schistosoma mansoni	hypothetical protein	0.0032	0.0612	0.2349
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0034	0.0127
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Brugia malayi	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Echinococcus granulosus	cGMP dependent protein kinase	0.0006	0.0034	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Mycobacterium ulcerans	hypothetical protein	0.0005	0	0.5
Onchocerca volvulus		0.0032	0.0612	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0055	0.0211
Trypanosoma cruzi	cAMP response protein 1, putative	0.0005	0	0.5
Onchocerca volvulus		0.0032	0.0612	1
Treponema pallidum	cyclic nucleotide binding protein	0.0005	0	0.5
Brugia malayi	hypothetical protein	0.0032	0.0612	0.0612
Brugia malayi	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Echinococcus granulosus	tm gpcr rhodopsin	0.0032	0.0612	0.2349
Trypanosoma cruzi	hypothetical protein, conserved	0.0005	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0612	0.0612
Echinococcus granulosus	rhodopsin orphan GPCR	0.0032	0.0612	0.2349
Echinococcus multilocularis	g protein coupled receptor	0.0032	0.0612	0.2349
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0032	0.0612	0.2349
Onchocerca volvulus		0.0032	0.0612	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0032	0.0612	0.2349
Mycobacterium ulcerans	hypothetical protein	0.0005	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0032	0.0612	0.2349

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 128 uM	Antimalarial activity against Plasmodium falciparum 3D7 infected in O positive erythrocytes assessed as parasite lactate dehydrogenase activity after 72 hrs	ChEMBL.	23659857

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2391959

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1779934