Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0241 | 0.0245 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.053 | 0.652 | 0.8665 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.3128 | 0.318 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0241 | 0.0245 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0264 | 0.3153 | 0.419 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0241 | 0.0245 |
Plasmodium falciparum | MO15-related protein kinase | 0.0015 | 0 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0034 | 0.0241 | 0.0245 |
Loa Loa (eye worm) | haspin protein kinase | 0.0075 | 0.0758 | 0.0771 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0034 | 0.0241 | 0.0245 |
Giardia lamblia | Kinase, CAMK CAMKL | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0038 | 0.0296 | 0.0454 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0264 | 0.3153 | 0.4836 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0015 | 0 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase KIN, putative | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0264 | 0.3153 | 0.4836 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0075 | 0.0758 | 0.1008 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.0264 | 0.3153 | 0.419 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0241 | 0.0245 |
Echinococcus granulosus | twitchin | 0.004 | 0.0321 | 0.0427 |
Brugia malayi | hypothetical protein | 0.0075 | 0.0758 | 0.0771 |
Echinococcus granulosus | roundabout 2 | 0.0038 | 0.0296 | 0.0394 |
Brugia malayi | Serotonin receptor | 0.0561 | 0.6914 | 0.7029 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0038 | 0.0296 | 0.0394 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0758 | 0.0758 |
Brugia malayi | Kinase associated domain 1 family protein | 0.0262 | 0.3128 | 0.318 |
Brugia malayi | Protein kinase domain containing protein | 0.0792 | 0.9836 | 1 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0075 | 0.0758 | 0.1008 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0034 | 0.0241 | 0.0321 |
Trypanosoma brucei | protein kinase, putative | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | Mitogen-activated protein kinase 10, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0241 | 0.0245 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0609 | 0.7524 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.0792 | 0.9836 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.053 | 0.652 | 0.6628 |
Echinococcus multilocularis | Immunoglobulin | 0.0034 | 0.0241 | 0.037 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0075 | 0.0758 | 0.1163 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0264 | 0.3153 | 0.3153 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.053 | 0.652 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0264 | 0.3153 | 0.3153 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0241 | 0.0245 |
Loa Loa (eye worm) | haspin protein kinase | 0.0077 | 0.0783 | 0.0796 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0264 | 0.3153 | 0.3153 |
Leishmania major | serine/threonine kinase-like protein, putative | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase haspin | 0.0075 | 0.0758 | 0.1163 |
Giardia lamblia | Kinase, CAMK CAMKL | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | haspin protein kinase | 0.0075 | 0.0758 | 0.0771 |
Echinococcus granulosus | defective proboscis extension response | 0.0034 | 0.0241 | 0.0321 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0264 | 0.3153 | 0.3153 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0015 | 0 | 0.5 |
Brugia malayi | GSG2 | 0.0075 | 0.0758 | 0.0771 |
Echinococcus multilocularis | Immunoglobulin | 0.0034 | 0.0241 | 0.037 |
Trypanosoma cruzi | Mitogen-activated protein kinase 10, putative | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0296 | 0.0301 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0264 | 0.3153 | 0.4836 |
Schistosoma mansoni | nephrin | 0.0038 | 0.0296 | 0.0296 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.3128 | 0.3128 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0241 | 0.0245 |
Echinococcus granulosus | calcium activated potassium channel | 0.0264 | 0.3153 | 0.419 |
Leishmania major | mitogen-activated protein kinase, putative,map kinase-like protein | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | vesicular amine transporter | 0.0034 | 0.0241 | 0.0241 |
Echinococcus multilocularis | hypothetical protein | 0.0262 | 0.3128 | 0.4797 |
Echinococcus granulosus | serine:threonine protein kinase haspin | 0.0075 | 0.0758 | 0.1008 |
Schistosoma mansoni | hypothetical protein | 0.0262 | 0.3128 | 0.3128 |
Giardia lamblia | Kinase, CAMK CAMKL | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0038 | 0.0296 | 0.0454 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0241 | 0.0245 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0039 | 0.03 | 0.0305 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0039 | 0.03 | 0.0305 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0792 | 0.9836 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0034 | 0.0241 | 0.0241 |
Trichomonas vaginalis | CAMK family protein kinase | 0.053 | 0.652 | 0.6628 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0296 | 0.0301 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0034 | 0.0241 | 0.037 |
Schistosoma mansoni | cell adhesion molecule | 0.0034 | 0.0241 | 0.0241 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0034 | 0.0241 | 0.0241 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0264 | 0.3153 | 0.3153 |
Echinococcus granulosus | Immunoglobulin | 0.0034 | 0.0241 | 0.0321 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 96.3 nM | Antagonist activity at serotonin-activated human recombinant 5HT-2A receptor expressed in HEK293 cells assessed as decrease in intracellular calcium level after 5 mins measured for 1 min by fluorescence assay | ChEMBL. | 23537943 |
IC50 (binding) | = 333 nM | Displacement of [3H]-mesulergine from human recombinant 5HT-2C receptor expressed in CHOK1 cell membranes after 30 mins | ChEMBL. | 23537943 |
IC50 (binding) | = 1271 nM | Displacement of [3H]-ketanserin from human recombinant 5HT-2A receptor expressed in CHOK1 cell membranes after 60 mins | ChEMBL. | 23537943 |
Inhibition (functional) | = 18.44 % | Antiobesity activity in C57BL/6 mouse assessed as inhibition of food intake at 50 mg/kg, ip measured after 2 to 12 hrs relative to vehicle-treated control | ChEMBL. | 23537943 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.