TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 420.507 | Formula: C23H28N6O2
H donors: 2 H acceptors: 4 LogP: 2.33 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OCCn1nc(c2c1C(=O)NCC(=N2)c1ccc(cc1)n1ccnc1C)C(CC)CC
InChi: 1S/C23H28N6O2/c1-4-16(5-2)20-21-22(29(27-20)12-13-30)23(31)25-14-19(26-21)17-6-8-18(9-7-17)28-11-10-24-15(28)3/h6-11,16,30H,4-5,12-14H2,1-3H3,(H,25,31)
InChiKey: WEQGMRQXQLCLPO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 2A, cGMP-stimulated	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 4B, cAMP-specific	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 4A, cAMP-specific		References
Homo sapiens	phosphodiesterase 4C, cAMP-specific		References
Homo sapiens	phosphodiesterase 4D, cAMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	Get druggable targets OG5_135549	All targets in OG5_135549
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	Get druggable targets OG5_135549	All targets in OG5_135549
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative	Get druggable targets OG5_135549	All targets in OG5_135549
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135549	All targets in OG5_135549
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	phosphodiesterase 2A, cGMP-stimulated	934 aa	748 aa	27.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0061	0.0634	0.2294
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0453	1	1
Trichomonas vaginalis	cyclin B, putative	0.01	0.1551	0.6941
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0042	0.0181	0.0181
Echinococcus granulosus	cyclins	0.0052	0.0403	0.0403
Trypanosoma brucei	cdc2-related kinase 3	0.0042	0.0181	0.1166
Loa Loa (eye worm)	hypothetical protein	0.0041	0.016	0.016
Entamoeba histolytica	cyclin family protein	0.0052	0.0403	0.1625
Leishmania major	cyclin	0.01	0.1551	1
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0181	0.0181
Giardia lamblia	Cyclin A	0.0052	0.0403	0.0227
Giardia lamblia	Hypothetical protein	0.0061	0.0634	0.0461
Echinococcus granulosus	cyclins	0.0052	0.0403	0.0403
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0079	0.1054	0.1054
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0061	0.0634	0.2294
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Giardia lamblia	G2/mitotic-specific cyclin B	0.01	0.1551	0.1395
Loa Loa (eye worm)	hypothetical protein	0.0183	0.3542	0.3542
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0061	0.0634	0.0634
Echinococcus multilocularis	protein kinase shaggy	0.0047	0.0294	0.0294
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0061	0.0634	1
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0061	0.0634	0.4086
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0079	0.1054	0.4425
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0061	0.0634	0.4086
Echinococcus multilocularis	cyclins	0.0052	0.0403	0.0403
Echinococcus multilocularis	cyclins	0.0052	0.0403	0.0403
Giardia lamblia	Hypothetical protein	0.0052	0.0403	0.0227
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0061	0.0634	0.0634
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0061	0.0634	0.2294
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0634	0.4086
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Trichomonas vaginalis	cyclin B, putative	0.0052	0.0403	0.1128
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0079	0.1054	0.6798
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0061	0.0634	0.0634
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0125	0.2155	1
Giardia lamblia	Kinase, CMGC GSK	0.0047	0.0294	0.0115
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0061	0.0634	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0107	0.1734	0.787
Echinococcus granulosus	cyclin dependent kinase 1	0.0042	0.0181	0.0181
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0392	0.854	0.854
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0079	0.1054	0.1234
Trypanosoma cruzi	cyclin, putative	0.01	0.1551	1
Trypanosoma brucei	hypothetical protein, conserved	0.0061	0.0634	0.4086
Trichomonas vaginalis	cyclin B, putative	0.01	0.1551	0.6941
Echinococcus multilocularis	cyclins	0.0052	0.0403	0.0403
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0061	0.0634	0.2294
Brugia malayi	Cyclin, N-terminal domain containing protein	0.01	0.1551	0.1816
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0061	0.0634	0.0634
Onchocerca volvulus		0.01	0.1551	1
Trichomonas vaginalis	cyclin B, putative	0.01	0.1551	0.6941
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0125	0.2155	1
Leishmania major	hypothetical protein, conserved	0.0061	0.0634	0.4086
Brugia malayi	cell division control protein 2 homolog	0.0042	0.0181	0.0212
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0453	1	1
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0061	0.0634	0.0634
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0453	1	1
Echinococcus granulosus	cyclins	0.0052	0.0403	0.0403
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0047	0.0294	0.2503
Echinococcus granulosus	cyclin b3	0.0052	0.0403	0.0403
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0107	0.1734	0.787
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0159	0.2974	0.2974
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0061	0.0634	0.2294
Plasmodium falciparum	glycogen synthase kinase 3	0.0047	0.0294	0.2503
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0061	0.0634	0.4086
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0634	0.4086
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0634	0.4086
Trichomonas vaginalis	cyclin B, putative	0.01	0.1551	0.6941
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0061	0.0634	0.0634
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0042	0.0181	0.0181
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0061	0.0634	0.0634
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0079	0.1054	0.4425
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0634	0.0634
Echinococcus multilocularis	cyclin B	0.01	0.1551	0.1551
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0064	0.0694	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Echinococcus multilocularis	cyclin b3	0.0052	0.0403	0.0403
Echinococcus multilocularis	cyclins	0.0052	0.0403	0.0403
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0061	0.0634	0.2294
Trichomonas vaginalis	cyclin D, putative	0.0052	0.0403	0.1128
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0061	0.0634	0.0634
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Trypanosoma cruzi	cdc2-related kinase 3	0.0042	0.0181	0.1166
Loa Loa (eye worm)	hypothetical protein	0.01	0.1551	0.1551
Trypanosoma cruzi	cdc2-related kinase 3	0.0042	0.0181	0.1166
Trichomonas vaginalis	cyclin D, putative	0.0052	0.0403	0.1128
Loa Loa (eye worm)	PDE1B protein	0.0061	0.0634	0.0634
Trypanosoma cruzi	cyclin 6, putative	0.01	0.1551	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.0046	0.0274	0.1765
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0061	0.0634	0.0742
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0079	0.1054	0.6798
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0079	0.1054	0.1054
Echinococcus granulosus	cyclin B	0.01	0.1551	0.1551
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0061	0.0634	0.4086
Echinococcus granulosus	cyclin dependent kinase 5	0.0042	0.0181	0.0181
Echinococcus granulosus	cyclins	0.0052	0.0403	0.0403
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0403	0.1128
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0079	0.1054	0.4425
Trichomonas vaginalis	cyclin B3, putative	0.0052	0.0403	0.1128
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0159	0.2974	0.3482
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0047	0.0294	0.0294
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0634	0.2294
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0181	0.0212
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0181	0.0181
Echinococcus multilocularis	cyclins	0.0052	0.0403	0.0403
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0061	0.0634	0.0742
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0047	0.0294	0.0294
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0392	0.854	1
Trichomonas vaginalis	cyclins, putative	0.006	0.0617	0.2212
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0061	0.0634	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0392	0.854	0.854
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0061	0.0634	0.0634
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0061	0.0634	0.0634
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0453	1	1
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0047	0.0294	0.0294
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0061	0.0634	0.0742
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0061	0.0634	0.4086
Trypanosoma cruzi	GAF domain/TIP41-like family, putative	0.0046	0.0274	0.1765
Trichomonas vaginalis	conserved hypothetical protein	0.0125	0.2155	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Trypanosoma brucei	cdc2-related kinase 1	0.0042	0.0181	0.1166
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0079	0.1054	0.4425
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0061	0.0634	0.4086
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0453	1	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.01	0.1551	0.1816
Plasmodium vivax	phosphodiesterase gamma, putative	0.0061	0.0634	1
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0634	0.2294
Giardia lamblia	Kinase, CMGC GSK	0.0047	0.0294	0.0115
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0042	0.0181	0.0075
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0079	0.1054	0.6798
Trypanosoma cruzi	cyclin, putative	0.01	0.1551	1
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0061	0.0634	0.4086
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0079	0.1054	0.4425
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0042	0.0181	0.0181
Trypanosoma cruzi	cdc2-related kinase 1	0.0042	0.0181	0.1166
Echinococcus multilocularis	cyclin B3 1	0.0052	0.0403	0.0403
Entamoeba histolytica	protein kinase, putative	0.0047	0.0294	0.0827
Entamoeba histolytica	cyclin, putative	0.0052	0.0403	0.1625
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0159	0.2974	0.2974
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Giardia lamblia	hypothetical protein	0.0061	0.0634	0.0461
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0047	0.0294	0.019
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0061	0.0634	1
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0061	0.0634	0.4086
Entamoeba histolytica	protein kinase domain containing protein	0.0047	0.0294	0.0827
Leishmania major	hypothetical protein, conserved	0.0046	0.0274	0.1765
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0079	0.1054	0.4425
Echinococcus multilocularis	cyclin dependent kinase 1	0.0042	0.0181	0.0181
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0183	0.3542	0.4148
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0079	0.1054	0.6798
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0047	0.0294	0.0294
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0125	0.2155	1
Echinococcus multilocularis	cyclin dependent kinase	0.0042	0.0181	0.0181
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.01	0.1551	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0061	0.0634	0.0742
Trypanosoma brucei	mitotic cyclin 6	0.01	0.1551	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0634	0.4086
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0042	0.0181	0.0181
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0079	0.1054	0.6798
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0061	0.0634	0.2294
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0079	0.1054	0.1054
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0061	0.0634	0.0634
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0321	0.0321
Trichomonas vaginalis	cyclins, putative	0.01	0.1551	0.6941
Trichomonas vaginalis	cyclins, putative	0.01	0.1551	0.6941
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0392	0.854	0.854
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0061	0.0634	0.4086
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0079	0.1054	0.4425
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Schistosoma mansoni	cyclin B3	0.0159	0.2974	0.2974
Brugia malayi	intracellular kinase	0.0047	0.0294	0.0344
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0061	0.0634	0.4086
Trypanosoma cruzi	cdc2-related kinase 1	0.0042	0.0181	0.1166
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0634	0.4086
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0061	0.0634	0.2294
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0061	0.0634	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0061	0.0634	0.4086
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0042	0.0181	0.1166
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0042	0.0181	0.1166
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Loa Loa (eye worm)	hypothetical protein	0.0453	1	1
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0079	0.1054	0.4425
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0047	0.0294	0.1897
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0453	1	1
Echinococcus multilocularis	cyclin dependent kinase 1	0.0042	0.0181	0.0181
Echinococcus multilocularis	cyclins	0.0052	0.0403	0.0403
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0061	0.0634	0.0634
Schistosoma mansoni	cyclin B	0.01	0.1551	0.1551
Echinococcus granulosus	cyclin B3 1	0.0052	0.0403	0.0403
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0079	0.1054	0.4425
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0079	0.1054	0.1054
Trichomonas vaginalis	CMGC family protein kinase	0.0047	0.0294	0.0574
Trichomonas vaginalis	cyclins, putative	0.0052	0.0403	0.1128
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0061	0.0634	0.0533
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0061	0.0634	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.0159	0.2974	0.2974
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0634	0.0634
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Trichomonas vaginalis	cyclins, putative	0.01	0.1551	0.6941
Plasmodium falciparum	cyclin	0.0052	0.0403	0.4917
Trichomonas vaginalis	cyclin A, putative	0.01	0.1551	0.6941
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0064	0.0694	0.5
Schistosoma mansoni	cyclins	0.0052	0.0403	0.0403
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0061	0.0634	0.0634
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0047	0.0294	0.0294
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0061	0.0634	0.0634
Entamoeba histolytica	cyclin, putative	0.01	0.1551	1
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0079	0.1054	0.1054
Trypanosoma brucei	GAF domain/TIP41-like family, putative	0.0046	0.0274	0.1765
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Leishmania major	hypothetical protein, conserved	0.0061	0.0634	0.4086
Echinococcus multilocularis	cyclin dependent kinase 5	0.0042	0.0181	0.0181
Trypanosoma brucei	protein kinase, putative	0.0047	0.0294	0.1897
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0061	0.0634	0.2294
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0061	0.0634	0.0634
Trypanosoma cruzi	CYC2-like cyclin, putative	0.01	0.1551	1
Echinococcus multilocularis	cyclins	0.0052	0.0403	0.0403
Echinococcus granulosus	protein kinase shaggy	0.0047	0.0294	0.0294
Echinococcus granulosus	cyclin dependent kinase	0.0042	0.0181	0.0181
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0079	0.1054	0.4425
Trichomonas vaginalis	cyclins, putative	0.01	0.1551	0.6941
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0061	0.0634	0.2294
Entamoeba histolytica	cyclin family protein	0.0052	0.0403	0.1625
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0061	0.0634	0.0634
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0061	0.0634	1
Trichomonas vaginalis	CMGC family protein kinase	0.0047	0.0294	0.0574
Echinococcus granulosus	cyclins	0.0052	0.0403	0.0403
Loa Loa (eye worm)	hypothetical protein	0.01	0.1551	0.1551
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0183	0.3542	0.3542
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0079	0.1054	0.4425
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0061	0.0634	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0634	0.4086
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0061	0.0634	0.0634
Plasmodium falciparum	phosphodiesterase delta, putative	0.0061	0.0634	1
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0047	0.0294	0.1897
Entamoeba histolytica	protein kinase domain containing protein	0.0047	0.0294	0.0827

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 54 nM	Inhibition of PDE2 (unknown origin)	ChEMBL.	23582272
IC50 (binding)	= 538 nM	Inhibition of PDE4 (unknown origin)	ChEMBL.	23582272
IC50 (binding)	= 583 nM	Inhibition of PDE4B (unknown origin)	ChEMBL.	23582272

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2387021

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1781074