TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 509.581 | Formula: C24H27N7O4S
H donors: 3 H acceptors: 5 LogP: 2.72 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: CS(=O)(=O)N1CCOC(C1)CNc1nc(cc(n1)Cc1ccccc1)Nc1n[nH]c(c1)c1ccco1
InChi: 1S/C24H27N7O4S/c1-36(32,33)31-9-11-34-19(16-31)15-25-24-26-18(12-17-6-3-2-4-7-17)13-22(28-24)27-23-14-20(29-30-23)21-8-5-10-35-21/h2-8,10,13-14,19H,9,11-12,15-16H2,1H3,(H3,25,26,27,28,29,30)
InChiKey: AARZYPZTMIRNPN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	IL2-inducible T-cell kinase	Starlite/ChEMBL	References
Homo sapiens	aurora kinase B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Tyrosine-protein kinase BTK, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nck2/grb4	0.0015	0.0337	0.0353
Brugia malayi	Matrixin family protein	0.0012	0.0163	0.0297
Loa Loa (eye worm)	TK/ABL protein kinase	0.0012	0.0146	0.0266
Loa Loa (eye worm)	SRC-1	0.0019	0.058	0.106
Echinococcus granulosus	tyrosine protein kinase Srms	0.0012	0.0146	0.0089
Echinococcus granulosus	plexin a4	0.0048	0.2301	0.2257
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0018	0.052	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0857	0.1565
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0068	0.3464	1
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.3464	0.6328
Loa Loa (eye worm)	plexin A	0.0048	0.2301	0.4204
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.3464	1
Schistosoma mansoni	ap endonuclease	0.0016	0.0373	0.039
Schistosoma mansoni	pyruvate dehydrogenase	0.0102	0.5474	0.5722
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.4054	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0016	0.0373	0.0151
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0019	0.058	0.0526
Echinococcus multilocularis	hypothetical protein	0.0017	0.0462	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0337	0.0616
Brugia malayi	serine/threonine protein kinase 6	0.0068	0.3464	0.6328
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0016	0.0373	0.0318
Loa Loa (eye worm)	hypothetical protein	0.001	0.0057	0.0104
Brugia malayi	Variant SH3 domain containing protein	0.0015	0.0337	0.0616
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0016	0.0373	0.0463
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.4054	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0018	0.052	0.0289
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.1041	0.1815
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.2471	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0462	0.0483
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0016	0.0373	0.0681
Trypanosoma brucei	aurora B kinase	0.0068	0.3464	0.6241
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.3464	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0125	0.0201
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0146	0.0266
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0146	0.0266
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.4054	1
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0102	0.5474	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0038	0.1684	0.1637
Echinococcus multilocularis	plexin a4	0.0048	0.2301	0.2257
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0462	0.0843
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0018	0.052	0.0289
Schistosoma mansoni	growth factor receptor-bound protein	0.0015	0.0337	0.0353
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0019	0.058	0.0526
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.052	0.0856
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.052	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0462	0.0843
Brugia malayi	exodeoxyribonuclease III family protein	0.0016	0.0373	0.0681
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.1041	0.1815
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.4054	0.402
Loa Loa (eye worm)	matrixin family protein	0.0027	0.1022	0.1866
Onchocerca volvulus		0.0017	0.0462	0.1843
Brugia malayi	SH2 domain containing protein	0.0012	0.0146	0.0266
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.3464	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0015	0.0337	0.0616
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0025	0.0918	0.1481
Schistosoma mansoni	hypothetical protein	0.0017	0.0457	0.0478
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0038	0.1684	0.1637
Echinococcus granulosus	semaphorin 5B	0.0017	0.0462	0.0407
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0102	0.5474	0.5448
Brugia malayi	Hemopexin family protein	0.0017	0.0457	0.0836
Schistosoma mansoni	serine/threonine protein kinase	0.0012	0.0135	0.0141
Echinococcus multilocularis	c src tyrosine kinase	0.0019	0.058	0.0526
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Giardia lamblia	Aurora kinase	0.0068	0.3464	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0018	0.052	0.1361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Echinococcus multilocularis	tyrosine kinase	0.0012	0.0146	0.0089
Echinococcus granulosus	tyrosine protein kinase shark	0.0012	0.0146	0.0089
Entamoeba histolytica	protein kinase domain containing protein	0.0012	0.014	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0078	0.4054	0.7407
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0163	0.0297
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Schistosoma mansoni	tyrosine kinase	0.0019	0.058	0.0606
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.0036	0.1561	0.3653
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0036	0.1561	0.2684
Echinococcus multilocularis	tyrosine protein kinase shark	0.0012	0.0146	0.0089
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0012	0.0146	0.0089
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0102	0.5474	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0146	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1861	0.34
Leishmania major	protein kinase, putative	0.0068	0.3464	0.6059
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0019	0.058	0.0526
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0019	0.058	0.0526
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0102	0.5474	0.5448
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0012	0.0146	0.0089
Schistosoma mansoni	growth factor receptor-bound protein	0.0015	0.0337	0.0353
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0038	0.1684	0.1637
Toxoplasma gondii	exonuclease III APE	0.0016	0.0373	0.063
Schistosoma mansoni	adapter molecule crk	0.0015	0.0337	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0163	0.0297
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0146	0.0266
Loa Loa (eye worm)	TK protein kinase	0.0012	0.0146	0.0266
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0146	0.0266
Echinococcus granulosus	semaphorin 1A	0.0017	0.0462	0.0407
Schistosoma mansoni	tyrosine kinase	0.0019	0.058	0.0606
Schistosoma mansoni	ap endonuclease	0.0016	0.0373	0.039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0012	0.0163	0.017
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.2471	0.5763
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0025	0.0918	0.0959
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.052	0.0951
Brugia malayi	Matrixin family protein	0.0012	0.0163	0.0297
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0019	0.058	0.0526
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.4054	0.402
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0019	0.058	0.0526
Entamoeba histolytica	protein kinase , putative	0.0068	0.3464	1
Brugia malayi	Sema domain containing protein	0.0017	0.0462	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0713	0.1303
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0041	0.1895	0.4505
Brugia malayi	hypothetical protein	0.0017	0.0462	0.0843
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0036	0.1561	0.2328
Echinococcus granulosus	tyrosine protein kinase Lyn	0.002	0.0613	0.0559
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0012	0.0146	0.0089
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0027	0.1041	0.1939
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0012	0.0146	0.026
Brugia malayi	Matrixin family protein	0.0029	0.1163	0.2124
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0918	0.1676
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.3464	1
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0146	0.0266
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0019	0.058	0.0526
Loa Loa (eye worm)	sema domain-containing protein	0.0017	0.0462	0.0843
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0019	0.058	0.0526
Entamoeba histolytica	protein kinase, putative	0.0068	0.3464	1
Brugia malayi	plexin A	0.0048	0.2301	0.4204
Brugia malayi	protein-tyrosine kinase	0.0012	0.0146	0.0266
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0146	0.0266
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0038	0.1684	0.3077
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.3464	0.6328
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0019	0.058	0.0526
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0018	0.052	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0125	0.0229
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.1684	0.1761
Toxoplasma gondii	FATC domain-containing protein	0.0025	0.0918	0.2016
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0016	0.0373	0.0263
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0019	0.058	0.0526
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0044	0.2022	0.1976
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0036	0.1561	0.2776
Onchocerca volvulus	Matrilysin homolog	0.0012	0.0163	0.0099
Trypanosoma cruzi	aurora B kinase, putative	0.0068	0.3464	0.6289
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0012	0.0146	0.0089
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.4054	1
Schistosoma mansoni	tyrosine kinase	0.0019	0.058	0.0606
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.4054	0.4239
Echinococcus granulosus	tyrosine kinase	0.0012	0.0146	0.0089
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0044	0.2022	0.1976
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0015	0.0337	0.0353
Echinococcus multilocularis	serine protein kinase ATM	0.0025	0.0918	0.0866
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0019	0.058	0.0526
Echinococcus multilocularis	NCK adaptor protein	0.0015	0.0337	0.0282
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0016	0.0373	0.0583
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.4054	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0019	0.058	0.0526
Echinococcus granulosus	tyrosine protein kinase Blk	0.0012	0.0146	0.0089
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.4054	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0125	0.0201
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.3464	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0019	0.058	0.0526
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0146	0.0266
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0018	0.052	0.0739
Brugia malayi	Matrixin family protein	0.0012	0.0163	0.0297
Echinococcus granulosus	tyrosine kinase	0.0012	0.0146	0.0089
Onchocerca volvulus		0.0012	0.0163	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0462	0.0843
Onchocerca volvulus		0.0041	0.1861	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0012	0.0146	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0163	0.0297
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0146	0.0266
Brugia malayi	SH2 domain containing protein	0.0012	0.0146	0.0266
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Echinococcus granulosus	serine protein kinase ATM	0.0025	0.0918	0.0866
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.001	0.0057	0.0104
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0018	0.052	0.0856
Toxoplasma gondii	aurora kinase	0.0068	0.3464	0.8496
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.3464	0.3621
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0028	0.1132	0.1184
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0018	0.052	0.0856
Echinococcus multilocularis	semaphorin 5B	0.0017	0.0462	0.0407
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.052	0.0951
Schistosoma mansoni	semaphorin 5-related	0.0017	0.0462	0.0483
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.3464	0.6328
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0102	0.5474	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0015	0.0337	0.0616
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0016	0.0373	0.0583
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.2471	0.2428
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0102	0.5474	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Schistosoma mansoni	tyrosine kinase	0.0172	0.9566	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0012	0.0146	0.0089
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0019	0.058	0.0526
Brugia malayi	SRC-1	0.0019	0.058	0.106
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.2471	0.2428
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0012	0.0146	0.0089
Trichomonas vaginalis	ap endonuclease, putative	0.0016	0.0373	0.0928
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0016	0.0373	0.0318
Brugia malayi	Variant SH3 domain containing protein	0.0015	0.0337	0.0616
Schistosoma mansoni	protein kinase	0.0068	0.3464	0.3621
Schistosoma mansoni	hypothetical protein	0.0024	0.0857	0.0896
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Brugia malayi	Plexin repeat family protein	0.0041	0.1861	0.34
Brugia malayi	Sema domain containing protein	0.0017	0.0462	0.0843
Brugia malayi	Probable ClpP-like protease	0.0078	0.4054	0.7407
Trichomonas vaginalis	ap endonuclease, putative	0.0016	0.0373	0.0928
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0068	0.3464	0.8395
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0068	0.3464	0.8395
Schistosoma mansoni	plexin	0.0041	0.1861	0.1945
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Echinococcus granulosus	c src tyrosine kinase	0.0019	0.058	0.0526
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.4054	1
Brugia malayi	hypothetical protein	0.0012	0.0146	0.0266
Onchocerca volvulus	Matrilysin homolog	0.0027	0.1022	0.5107
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0018	0.052	0.0466
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0068	0.3464	1
Schistosoma mansoni	tyrosine kinase	0.0012	0.0146	0.0152
Brugia malayi	Tyrosine-protein kinase abl-1	0.0019	0.058	0.106
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.052	0.0544
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0146	0.0266
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.1684	0.1761
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0462	0.0843
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0179	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0019	0.058	0.0526
Loa Loa (eye worm)	matrixin family protein	0.0029	0.1163	0.2124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0918	0.2526
Brugia malayi	Sex muscle abnormal protein 5	0.0015	0.0337	0.0616
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0016	0.0373	0.0928
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0019	0.058	0.0526
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Schistosoma mansoni	tyrosine kinase	0.0019	0.058	0.0606
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0068	0.3464	0.3426
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0021	0.0713	0.1211
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0146	0.0266
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.052	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0316	0.0578
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0019	0.058	0.0606
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.4054	1
Schistosoma mansoni	pyruvate dehydrogenase	0.0097	0.5139	0.5372
Schistosoma mansoni	fkbp-rapamycin associated protein	0.001	0.0057	0.006
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.1684	0.1761
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0146	0.0266
Giardia lamblia	GTOR	0.0018	0.052	0.0477
Onchocerca volvulus		0.0017	0.0457	0.1818
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0146	0.0266
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0018	0.052	0.0466
Brugia malayi	kinase, mitochondrial precursor	0.0102	0.5474	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0038	0.1684	0.3077
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0018	0.0523	0.0293
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Schistosoma mansoni	pyruvate dehydrogenase	0.0097	0.5139	0.5372
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.1041	0.1815
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Schistosoma mansoni	hypothetical protein	0.0017	0.0462	0.0483
Brugia malayi	Matrixin family protein	0.0012	0.0163	0.0297
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0068	0.3464	0.3426
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0038	0.1684	0.1637
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0018	0.052	0.0289
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0102	0.5474	0.5448
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0018	0.052	0.1361
Entamoeba histolytica	tyrosin kinase, putative	0.0012	0.014	0.0244
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.4054	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0018	0.052	0.0289
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.4054	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.052	0.0466
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0015	0.0337	0.0282
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0146	0.0266
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.052	0.0739
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0018	0.052	0.0739
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.052	0.0951
Brugia malayi	serine/threonine kinase 12	0.0068	0.3464	0.6328
Brugia malayi	hypothetical protein	0.0017	0.0462	0.0843
Loa Loa (eye worm)	matrix metalloproteinase	0.0012	0.0163	0.0297
Brugia malayi	Protein kinase domain containing protein	0.0012	0.0146	0.0266
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0918	0.1589
Entamoeba histolytica	hypothetical protein	0.0025	0.0918	0.2526
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.052	0.0466
Echinococcus granulosus	NCK adaptor protein	0.0015	0.0337	0.0282
Loa Loa (eye worm)	sema domain-containing protein	0.0017	0.0462	0.0843
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0019	0.058	0.0526
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0018	0.0523	0.086
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0068	0.3464	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0012	0.0146	0.0089
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Brugia malayi	serine/threonine-protein kinase 6	0.0068	0.3464	0.6328
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0462	0.0843
Echinococcus granulosus	aurora kinase A	0.0068	0.3464	0.3426
Echinococcus multilocularis	aurora kinase A	0.0068	0.3464	0.3426
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.052	0.0856
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0018	0.052	0.0289
Loa Loa (eye worm)	TK/FER protein kinase	0.0012	0.0146	0.0266
Trypanosoma cruzi	target of rapamycin kinase 3	0.0018	0.052	0.0856
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.052	0.1361
Echinococcus granulosus	growth factor receptor bound protein 2	0.0015	0.0337	0.0282
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.4054	0.5
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0018	0.052	0.0739
Schistosoma mansoni	plexin	0.0024	0.0857	0.0896
Toxoplasma gondii	hypothetical protein	0.0027	0.1041	0.2331
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.2471	1
Entamoeba histolytica	protein kinase, putative	0.0068	0.3464	1
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0027	0.1022	0.5107
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0462	0.0843
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0015	0.0316	0.0578

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 6.3	Inhibition of LCK (unknown origin)	ChEMBL.	24900590
Ki (binding)	= 6.5	Inhibition of Aurora-B (unknown origin)	ChEMBL.	24900590
Ki (binding)	= 8.2	Inhibition of ITK (unknown origin)	ChEMBL.	24900590

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2441279

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1790633