TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 394.894 | Formula: C23H23ClN2O2
H donors: 1 H acceptors: 2 LogP: 6.55 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCNc1ncc(cc1C(=O)c1ccc(cc1)Cl)c1ccc(cc1)OCC
InChi: 1S/C23H23ClN2O2/c1-3-13-25-23-21(22(27)17-5-9-19(24)10-6-17)14-18(15-26-23)16-7-11-20(12-8-16)28-4-2/h5-12,14-15H,3-4,13H2,1-2H3,(H,25,26)
InChiKey: BZZFHEMYNAHBTO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholinergic receptor, nicotinic, alpha 7 (neuronal)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-7 precursor, putative	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	Get druggable targets OG5_130932	All targets in OG5_130932
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130932	All targets in OG5_130932
Onchocerca volvulus		Get druggable targets OG5_130932	All targets in OG5_130932
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-7 precursor, putative	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	Get druggable targets OG5_130932	All targets in OG5_130932
Brugia malayi	Cation transporter family protein	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	IPR006201,Neurotransmitter-gated ion-channel;IPR006029,Neurotransmitter-gated ion-channel transmembrane region,domain-containing	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-7 precursor, putative	Get druggable targets OG5_130932	All targets in OG5_130932
Onchocerca volvulus		Get druggable targets OG5_130932	All targets in OG5_130932
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130932	All targets in OG5_130932
Onchocerca volvulus		Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	ko:K04809 cholinergic receptor, nicotinic, alpha 7, putative	Get druggable targets OG5_130932	All targets in OG5_130932

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	cholinergic receptor, nicotinic, alpha 7 (neuronal)	502 aa	513 aa	33.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0084	0.0387	0.1678
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0201	0.0238
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0068	0.0201	0.0238
Echinococcus granulosus	Regulator of G protein signaling 20	0.0068	0.0201	0.0201
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0115	0.0752	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0748	0.8125	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0543	0.574	0.7065
Echinococcus granulosus	expressed protein	0.0068	0.0201	0.0201
Echinococcus multilocularis	regulator of G protein signaling 7	0.0068	0.0201	0.0201
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0115	0.0752	0.0926
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0105	0.0129
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.032	0.3137	0.3861
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0909	1	1
Brugia malayi	A-kinase anchor protein 10, precursor	0.0068	0.0201	0.0247
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0201	0.0247
Echinococcus multilocularis	expressed protein	0.0068	0.0201	0.0201
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0748	0.8125	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0064	0.0162	0.02
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0201	0.0247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0064	0.0153	0.0189
Echinococcus multilocularis	axis inhibition protein axin	0.0068	0.0201	0.0201
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0115	0.0752	0.0752
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0075	0.0288	0.3793
Entamoeba histolytica	hypothetical protein	0.0068	0.0201	0.0247
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0748	0.8125	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0718	0.7768	0.956
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0188	0.0231
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0249	0.2308	0.284
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0115	0.0752	0.0752
Entamoeba histolytica	hypothetical protein	0.0615	0.657	0.8086
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0084	0.0387	0.0476
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0115	0.0752	0.0752
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0056	0.0063	0.0271
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0084	0.0387	0.0476
Echinococcus multilocularis	regulator of G protein signaling 3	0.0068	0.0201	0.0201
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0084	0.0387	0.0476
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0287	0.0353
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0115	0.0752	0.0752
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.022	0.022
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.023	0.0283
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0073	0.0262	0.0322
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0115	0.0752	0.0926
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0064	0.0162	0.0199
Echinococcus granulosus	regulator of G protein signaling 3	0.0068	0.0201	0.0201
Brugia malayi	regulator of G-protein signaling rgs-7	0.0068	0.0201	0.0247
Entamoeba histolytica	hypothetical protein	0.0068	0.0201	0.0247
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0115	0.0752	0.0752
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0056	0.0063	0.0063
Echinococcus multilocularis	regulator of G protein signaling 7	0.0068	0.0201	0.0201
Schistosoma mansoni	regulator of G protein signaling	0.0068	0.0201	0.0201
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0748	0.8125	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0218	0.195	0.24
Trypanosoma cruzi	hypothetical protein, conserved	0.0085	0.04	0.0493
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0073	0.0262	0.0322
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.061	0.6517	0.6517
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.061	0.6517	0.8021
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0584	0.0692
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0069	0.022	0.022
Loa Loa (eye worm)	phosphatidylinositol 3	0.0218	0.195	0.2309
Brugia malayi	Cation transporter family protein	0.0101	0.0584	0.0719
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0056	0.0063	0.0063
Entamoeba histolytica	hypothetical protein	0.0068	0.0201	0.0247
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0748	0.8125	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0064	0.0162	0.02
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0084	0.0387	0.0387
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.005	0	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0056	0.0063	0.0074
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0164	0.1327	0.317
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0056	0.0063	0.0063
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0062	0.013	0.016
Schistosoma mansoni	regulator of G protein signaling	0.0068	0.0201	0.0201
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0075	0.0288	0.1246
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0063	0.0077
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0063	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0201	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0584	0.0692
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0115	0.0752	0.0926
Echinococcus granulosus	regulator of G protein signaling 7	0.0068	0.0201	0.0201
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0064	0.0162	0.02
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0115	0.0752	0.0926
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0084	0.0387	0.1678
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0056	0.0063	0.0271
Echinococcus granulosus	regulator of G protein signaling 7	0.0068	0.0201	0.0201
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0748	0.8125	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0249	0.2308	0.2308
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0201	0.0238
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0053	0.0029	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0201	0.0247
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0453	0.4693	0.5775
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0084	0.0387	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0073	0.0262	0.0322
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.061	0.6517	0.6517
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0084	0.0387	0.0387
Brugia malayi	regulator of G-protein signaling egl-10	0.0068	0.0201	0.0247
Echinococcus multilocularis	regulator of G protein signaling 3	0.0068	0.0201	0.0201
Echinococcus granulosus	axis inhibition protein axin	0.0068	0.0201	0.0201
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0249	0.2308	0.284
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0115	0.0752	0.0926
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0063	0.0077
Onchocerca volvulus		0.0101	0.0584	0.5
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0068	0.0201	0.0201
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0543	0.574	0.7065
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.0188	0.0231
Schistosoma mansoni	axis inhibition protein axin	0.0068	0.0201	0.0201
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.041	0.4185	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0249	0.2308	0.284
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.061	0.6517	0.7718
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0287	0.0353
Brugia malayi	PXA domain containing protein	0.0068	0.0201	0.0247
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0068	0.0201	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0503	0.0596
Schistosoma mansoni	regulator of G protein signaling	0.0068	0.0201	0.0201
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0069	0.022	0.022
Brugia malayi	PXA domain containing protein	0.0068	0.0201	0.0247
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0115	0.0752	0.326
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0201	0.0247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0084	0.0387	0.0476
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0084	0.0387	0.0476
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0084	0.0387	0.0476
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0064	0.0162	0.0199
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.022	0.022
Echinococcus multilocularis	regulator of G protein signaling	0.0068	0.0201	0.0201
Schistosoma mansoni	z-protein (S1r protein)	0.0068	0.0201	0.0201
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0115	0.0752	0.0926
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0161	0.1288	0.1586
Echinococcus multilocularis	Zinc finger, PHD finger	0.0115	0.0752	0.0752
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0249	0.2308	0.284
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0068	0.0201	0.0247
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.061	0.6517	0.7718
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0056	0.0063	0.0077
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0287	0.0353
Schistosoma mansoni	serine/threonine protein kinase	0.0678	0.7304	0.7304
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0201	0.0247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0063	0.0077
Brugia malayi	hypothetical protein	0.0068	0.0201	0.0247
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0615	0.657	0.8086
Echinococcus granulosus	regulator of G protein signaling 3	0.0068	0.0201	0.0201
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0115	0.0752	0.9924
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0056	0.0063	0.0077
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0101	0.0584	0.0584
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0115	0.0752	0.9924
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0101	0.0584	0.0584
Onchocerca volvulus		0.0101	0.0584	0.5
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0678	0.7304	0.899
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0069	0.022	0.026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0073	0.0262	0.0322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0105	0.0129
Loa Loa (eye worm)	RGS-3 protein	0.0068	0.0201	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0453	0.4693	0.5557
Onchocerca volvulus		0.0101	0.0584	0.5
Loa Loa (eye worm)	hypothetical protein	0.0295	0.2847	0.3371
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.027	0.2555	0.2555
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0453	0.4693	0.4693
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0909	1	1
Schistosoma mansoni	regulator of G protein signaling	0.0068	0.0201	0.0201
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.027	0.2555	0.2555
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.005	0	0.5
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0249	0.2308	0.284
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0068	0.0201	0.0247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0063	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0201	0.0238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0064	0.0162	0.0199
Leishmania major	hypothetical protein, conserved	0.0115	0.0758	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0678	0.7304	0.865
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0073	0.0262	0.0322
Loa Loa (eye worm)	phosphatidylinositol 3	0.0776	0.8445	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0249	0.2308	0.284
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0084	0.0387	0.0476
Giardia lamblia	GTOR	0.0084	0.0387	0.0925
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0115	0.0752	1
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0068	0.0201	0.0201
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0115	0.0752	0.0926
Loa Loa (eye worm)	PXA domain-containing protein	0.0068	0.0201	0.0238
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0068	0.0201	0.0247
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0115	0.0752	0.0891
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0084	0.0387	0.0476
Echinococcus multilocularis	axis inhibition protein axin	0.0068	0.0201	0.0201
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0073	0.0262	0.0322
Trypanosoma cruzi	target of rapamycin kinase 3	0.0075	0.0288	0.0354
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0084	0.0387	0.5106
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0748	0.8125	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0287	0.0353
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0064	0.0162	0.02
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0056	0.0063	0.0825
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0068	0.0201	0.0201
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0249	0.2308	1
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0068	0.0201	0.0201
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0068	0.0201	0.0201
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0056	0.0063	0.0077
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0115	0.0752	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0073	0.0262	0.0322
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0453	0.4693	0.4693
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0115	0.0752	0.0926
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0084	0.0387	0.5106
Brugia malayi	hypothetical protein	0.0068	0.0201	0.0247
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0056	0.0063	0.0825
Schistosoma mansoni	regulator of G protein signaling	0.0068	0.0201	0.0201
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0287	0.0353
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0115	0.0752	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0105	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0201	0.0238
Loa Loa (eye worm)	phosphatidylinositol 3	0.0084	0.0387	0.0458
Echinococcus granulosus	axis inhibition protein axin	0.0068	0.0201	0.0201
Schistosoma mansoni	axis inhibition protein axin	0.0068	0.0201	0.0201
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.0201	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0201	0.0238
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0249	0.2308	0.284

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 600 %	Type-1 positive allosteric modulation of human alpha7 nAChR expressed in Xenopus oocytes assessed as maximum modulation of nicotine EC5 response at 10 uM by two-electrode voltage clamp method relative to control	ChEMBL.	24098954
EC50 (binding)	= 0.14 uM	Type-1 positive allosteric modulation of human alpha7 nAChR expressed in Xenopus oocytes assessed as maximum modulation of nicotine EC5 response by two-electrode voltage clamp method	ChEMBL.	24098954

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2440299

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1791480