Detailed information for compound 1796211

Basic information

Technical information
  • TDR Targets ID: 1796211
  • Name: 5-chloro-7-piperidin-1-yl-1,8-naphthyridin-2- amine
  • MW: 262.738 | Formula: C13H15ClN4
  • H donors: 1 H acceptors: 2 LogP: 3.04 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(nc2c1ccc(n2)N)N1CCCCC1
  • InChi: 1S/C13H15ClN4/c14-10-8-12(18-6-2-1-3-7-18)17-13-9(10)4-5-11(15)16-13/h4-5,8H,1-3,6-7H2,(H2,15,16,17)
  • InChiKey: ODQLVHZMEZNAIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-7-(1-piperidyl)-1,8-naphthyridin-2-amine
  • (5-chloro-7-piperidino-1,8-naphthyridin-2-yl)amine
  • AIDS-091750
  • AIDS091750
  • 7-Amino-4-chloro-2-(piperid-1-yl)-1,8-naphthyridine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0076 0.0114 0.1948
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.001 0.011
Schistosoma mansoni hypothetical protein 0.0036 0.0035 0.0525
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0009 0.0016
Loa Loa (eye worm) twinkle helicase 0.0036 0.0035 0.0591
Brugia malayi Bromodomain containing protein 0.0081 0.0123 0.0163
Plasmodium vivax plastid replication-repair enzyme, putative 0.0049 0.006 0.0205
Giardia lamblia Telomerase catalytic subunit 0.1368 0.2704 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0016 0.0042
Leishmania major hypothetical protein, conserved 0.0027 0.0016 0.0042
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0005 0.0085
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0049 0.006 0.0205
Plasmodium falciparum importin beta, putative 0.0029 0.002 0.0057
Plasmodium vivax importin-beta 2, putative 0.0029 0.002 0.0057
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.017 0.0302 1
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0049 0.006 0.0205
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.001 0.011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0009 0.079
Brugia malayi hypothetical protein 0.0027 0.0016 0.0015
Brugia malayi DNA polymerase I family protein 0.0049 0.006 0.0076
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.017 0.0302 0.5
Brugia malayi Bromodomain containing protein 0.0041 0.0044 0.0054
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1368 0.2704 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.1368 0.2704 1
Plasmodium falciparum telomerase reverse transcriptase 0.1368 0.2704 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1368 0.2704 1
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.012 0.0204 0.0736
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0005 0.0015
Plasmodium falciparum plastid replication-repair enzyme 0.0049 0.006 0.0205
Loa Loa (eye worm) hypothetical protein 0.0049 0.006 0.1031
Echinococcus multilocularis twinkle protein, mitochondrial 0.0036 0.0035 0.0179
Mycobacterium ulcerans DNA polymerase I 0.017 0.0302 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0871 0.1707 1
Treponema pallidum DNA polymerase I (polA) 0.017 0.0302 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0349
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.012 0.0204 0.0736
Schistosoma mansoni DNA polymerase I 0.0049 0.006 0.0967
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.002 0.0057
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0016 0.0042
Brugia malayi Telomerase reverse transcriptase 0.364 0.7258 1
Entamoeba histolytica hypothetical protein 0.0024 0.0009 0.079
Leishmania major telomerase reverse transcriptase, putative 0.1368 0.2704 1
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.012 0.0204 0.0736
Toxoplasma gondii RNA-directed DNA polymerase 0.1368 0.2704 1
Echinococcus granulosus twinkle protein mitochondrial 0.0036 0.0035 0.0525
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0049 0.006 0.0205
Trichomonas vaginalis DNA polymerase I, putative 0.0049 0.006 1
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0059 0.008 0.0279
Schistosoma mansoni hypothetical protein 0.0311 0.0586 1
Schistosoma mansoni hypothetical protein 0.0022 0.0006 0.0039
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.009 0.1484
Schistosoma mansoni importin beta-1 0.0029 0.002 0.0281
Trypanosoma brucei telomerase reverse transcriptase 0.1368 0.2704 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0277
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0009 0.079
Leishmania major importin beta-1 subunit, putative 0.0024 0.0009 0.0016
Schistosoma mansoni hypothetical protein 0.0036 0.0035 0.0525
Loa Loa (eye worm) hypothetical protein 0.0046 0.0054 0.0917
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.002 0.0057
Schistosoma mansoni ran 0.0021 0.0005 0.0015
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0049 0.006 0.0205
Brugia malayi Importin beta-1 subunit 0.0029 0.002 0.0021
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0009 0.079
Echinococcus multilocularis snurportin 1 0.0311 0.0586 0.3417
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.012 0.0204 0.0736
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0049 0.006 0.0205
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0039 0.0207
Chlamydia trachomatis DNA polymerase I 0.017 0.0302 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0045 0.076
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.012 0.0204 0.0736
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.017 0.0302 0.5
Echinococcus multilocularis importin subunit beta 1 0.0029 0.002 0.0096
Schistosoma mansoni ran 0.0021 0.0005 0.0015
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.002 0.0057
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0016 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0016 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0016 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0049 0.006 0.0205
Toxoplasma gondii helicase, putative 0.0049 0.006 0.0205
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0039 0.0605
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0049 0.006 1
Echinococcus granulosus snurportin 1 0.0311 0.0586 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0016 0.0042
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0005 0.0005
Brugia malayi PHD-finger family protein 0.0027 0.0016 0.0015
Loa Loa (eye worm) hypothetical protein 0.0044 0.005 0.0847
Schistosoma mansoni bromodomain containing protein 0.0068 0.0098 0.1616
Echinococcus granulosus importin subunit beta 1 0.0029 0.002 0.0281
Brugia malayi RNA, U transporter 1 0.0083 0.0128 0.017
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.009 0.0507
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0016 0.0042
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0006 0.0109
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.0586 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.001 0.0037
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.012 0.0204 0.0736

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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