Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma cruzi | glycerolphosphate mutase, putative | 0.0025 | 0.0029 | 0.0029 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0135 | 0.0768 | 1 |
Leishmania major | phosphoglycerate mutase protein, putative | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium ulcerans | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0049 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0025 | 0.0029 | 0.0029 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0025 | 0.0029 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0029 | 0.0049 |
Onchocerca volvulus | 0.0025 | 0.0029 | 0.0029 | |
Giardia lamblia | Hypothetical protein | 0.089 | 0.5843 | 0.5 |
Trypanosoma cruzi | phosphoglycerate mutase family member 5, putative | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium ulcerans | bifunctional RNase H/acid phosphatase | 0.0025 | 0.0029 | 0.0049 |
Plasmodium vivax | phosphoglycerate mutase, putative | 0.0025 | 0.0029 | 1 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0025 | 0.0029 | 0.0029 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.089 | 0.5843 | 1 |
Mycobacterium ulcerans | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0049 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.1509 | 1 | 1 |
Trypanosoma cruzi | phosphoglycerate mutase family member 5, putative | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma brucei | phosphoglycerate mutase protein, putative | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.1483 | 0.9829 | 0.9829 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0025 | 0.0029 | 0.0029 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0025 | 0.0029 | 1 |
Mycobacterium ulcerans | hydrolase MutT1 | 0.0025 | 0.0029 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0029 | 0.0029 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0025 | 0.0029 | 1 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0644 | 0.4185 | 0.4185 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0029 | 0.0029 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0025 | 0.0029 | 1 |
Plasmodium vivax | phosphoglucomutase-2, putative | 0.0025 | 0.0029 | 1 |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0025 | 0.0029 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0025 | 0.0029 | 0.0374 |
Mycobacterium leprae | conserved hypothetical protein | 0.0025 | 0.0029 | 1 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0025 | 0.0029 | 0.0029 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0025 | 0.0029 | 0.0029 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0025 | 0.0029 | 1 |
Leishmania major | phosphoglycerate mutase family member 5, putative | 0.0025 | 0.0029 | 0.0029 |
Brugia malayi | UBASH3A protein homolog | 0.0025 | 0.0029 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0025 | 0.0029 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0025 | 0.0029 | 0.0374 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1483 | 0.9829 | 0.9829 |
Trypanosoma brucei | phosphoglycerate mutase, putative | 0.0025 | 0.0029 | 0.0029 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0025 | 0.0029 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative | 0.0025 | 0.0029 | 0.0029 |
Giardia lamblia | Hypothetical protein | 0.089 | 0.5843 | 0.5 |
Trypanosoma brucei | Serine/threonine-protein phosphatase PGAM5, mitochondrial, putative | 0.0025 | 0.0029 | 0.0029 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0644 | 0.4185 | 0.4185 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0025 | 0.0029 | 0.0374 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0025 | 0.0029 | 1 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0025 | 0.0029 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0025 | 0.0029 | 0.0374 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0025 | 0.0029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0865 | 0.5672 | 0.5672 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium ulcerans | phosphoglyceromutase | 0.0025 | 0.0029 | 0.0049 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma cruzi | phosphoglycerate mutase, putative | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0025 | 0.0029 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.089 | 0.5843 | 1 |
Onchocerca volvulus | 0.0025 | 0.0029 | 0.0029 | |
Mycobacterium ulcerans | phosphohistidine phosphatase SixA | 0.0025 | 0.0029 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0029 | 0.0029 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0025 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0029 | 0.0029 |
Plasmodium falciparum | phosphoglycerate mutase, putative | 0.0025 | 0.0029 | 0.5 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0025 | 0.0029 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.089 | 0.5843 | 1 |
Trypanosoma cruzi | phosphoglycerate mutase protein, putative | 0.0025 | 0.0029 | 0.0029 |
Onchocerca volvulus | 0.1509 | 1 | 1 | |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma brucei | Histidine phosphatase superfamily (branch 1), putative | 0.0025 | 0.0029 | 0.0029 |
Schistosoma mansoni | 6-phosphofructokinase | 0.1509 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1509 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma cruzi | phosphoglycerate mutase, putative | 0.0025 | 0.0029 | 0.0029 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0025 | 0.0029 | 0.0029 |
Treponema pallidum | phosphoglyceromutase | 0.0025 | 0.0029 | 0.5 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0025 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.1509 | 1 | 1 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0025 | 0.0029 | 0.0374 |
Leishmania major | phosphoglycerate mutase, putative | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma cruzi | glycerolphosphate mutase, putative | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma cruzi | phosphoglycerate mutase protein, putative | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0025 | 0.0029 | 0.0374 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1509 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0029 | 0.0029 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0025 | 0.0029 | 1 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0025 | 0.0029 | 1 |
Mycobacterium ulcerans | lipoprotein LpqD | 0.0025 | 0.0029 | 0.0049 |
Plasmodium falciparum | phosphoglucomutase-2 | 0.0025 | 0.0029 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1483 | 0.9829 | 0.9829 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0644 | 0.4185 | 0.4185 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0029 | 0.0029 |
Onchocerca volvulus | 0.0025 | 0.0029 | 0.0029 | |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0025 | 0.0029 | 0.5 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0025 | 0.0029 | 0.0374 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0029 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.1483 | 0.9829 | 0.9829 |
Trypanosoma brucei | glycerolphosphate mutase, putative | 0.0025 | 0.0029 | 0.0029 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0644 | 0.4185 | 0.4185 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1483 | 0.9829 | 0.9829 |
Mycobacterium leprae | conserved hypothetical protein | 0.0025 | 0.0029 | 1 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium ulcerans | acid phosphatase | 0.0025 | 0.0029 | 0.0049 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0025 | 0.0029 | 0.0374 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma cruzi | Histidine phosphatase superfamily (branch 1), putative | 0.0025 | 0.0029 | 0.0029 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0029 | 0.0029 |
Leishmania major | hypothetical protein, unknown function | 0.0025 | 0.0029 | 0.0029 |
Toxoplasma gondii | phosphoglycerate mutase PGMII | 0.0025 | 0.0029 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0029 | 0.0029 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0029 | 1 |
Leishmania major | fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein | 0.0025 | 0.0029 | 0.0029 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0025 | 0.0029 | 1 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0025 | 0.0029 | 0.0029 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0025 | 0.0029 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0029 | 0.0049 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Toxoplasma gondii | phosphoglycerate mutase | 0.0025 | 0.0029 | 1 |
Leishmania major | glycerolphosphate mutase, putative | 0.0025 | 0.0029 | 0.0029 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1509 | 1 | 1 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0025 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0029 | 0.0029 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0025 | 0.0029 | 0.0374 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0025 | 0.0029 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1509 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0025 | 0.0029 | 0.0029 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 64.43 % | Analgesic activity in Mus musculus Swiss albino (mouse) assessed as protection against acetic acid-induced writhing response at 20 mg/kg, po administered 30 min prior to acetic acid challenge measured at 2 hr relative to control | ChEMBL. | No reference |
Activity (functional) | = 87.97 % | Analgesic activity in Mus musculus Swiss albino (mouse) assessed as protection against acetic acid-induced writhing response at 20 mg/kg, po administered 30 min prior to acetic acid challenge measured at 1 hr relative to control | ChEMBL. | No reference |
Activity (functional) | = 97.93 % | Analgesic activity in Mus musculus Swiss albino (mouse) assessed as protection against acetic acid-induced writhing response at 20 mg/kg, po administered 30 min prior to acetic acid challenge measured at 0.5 hr relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.