TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 389.489 | Formula: C21H31N3O4
H donors: 1 H acceptors: 3 LogP: 4.8 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCCCCCCCCC/C(=N\OCc2ccc(cc2)[N+](=O)[O-])/CCN1
InChi: 1S/C21H31N3O4/c25-21-10-8-6-4-2-1-3-5-7-9-19(15-16-22-21)23-28-17-18-11-13-20(14-12-18)24(26)27/h11-14H,1-10,15-17H2,(H,22,25)/b23-19+
InChiKey: NZIIZCUZXTUPMR-FCDQGJHFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0235	0.0769	0.0809
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.2605	0.9183	1
Echinococcus granulosus	NDR protein kinase	0.0235	0.0769	0.0809
Entamoeba histolytica	protein kinase, putative	0.0235	0.0769	1
Schistosoma mansoni	serine/threonine kinase	0.0235	0.0769	0.0762
Echinococcus granulosus	Rac GTPase activating protein 1	0.0166	0.0525	0.0549
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0027	0.0246
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0166	0.0525	0.0549
Trichomonas vaginalis	AGC family protein kinase	0.0235	0.0769	1
Schistosoma mansoni	serine/threonine protein kinase	0.1302	0.4557	0.4552
Trichomonas vaginalis	AGC family protein kinase	0.0235	0.0769	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0113	0.0111
Echinococcus granulosus	protein kinase c epsilon type	0.0401	0.136	0.1437
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0008	0.0005
Schistosoma mansoni	rac gtpase activating protein	0.0166	0.0525	0.0517
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.1286	0.4501	0.4899
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0021	0.0008	0.0005
Brugia malayi	Partitioning defective-6 homolog alpha	0.0166	0.0526	0.0603
Loa Loa (eye worm)	TK/ALK protein kinase	0.0021	0.0008	0.0005
Trypanosoma brucei	protein kinase, putative	0.0026	0.0026	0.0237
Brugia malayi	Hr1 repeat family protein	0.0235	0.0769	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Brugia malayi	protein kinase C3,putative	0.2438	0.8592	1
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0008	0.0005
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.1286	0.4501	0.4779
Echinococcus multilocularis	protein kinase c iota type	0.2668	0.9409	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0021	0.0008	0.0005
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0004	0.139
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0027	1
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0075	0.0067
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0166	0.0525	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0008	0.0005
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0027	0.0022
Echinococcus multilocularis	lamin	0.003	0.004	0.0033
Giardia lamblia	Protein 21.1	0.0021	0.0008	0.5
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0027	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0113	0.0111
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0235	0.0769	0.0834
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0008	0.0005
Brugia malayi	Protein kinase c protein 2	0.0171	0.0543	0.0623
Plasmodium falciparum	tyrosine kinase-like protein	0.0021	0.0008	0.2057
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0166	0.0525	0.0517
Entamoeba histolytica	diacylglycerol kinase, putative	0.0166	0.0525	0.6787
Trichomonas vaginalis	AGC family protein kinase	0.0235	0.0769	1
Trichomonas vaginalis	AGC family protein kinase	0.0235	0.0769	1
Brugia malayi	diacylglycerol kinase	0.0166	0.0525	0.0602
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0027	1
Trichomonas vaginalis	AGC family protein kinase	0.0235	0.0769	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0235	0.0769	0.0834
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0021	0.0008	1
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0235	0.0769	0.0809
Entamoeba histolytica	hypothetical protein	0.0039	0.0075	0.0874
Trichomonas vaginalis	AGC family protein kinase	0.0235	0.0769	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0401	0.136	0.1352
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0027	1
Trypanosoma cruzi	PB1 domain containing protein, putative	0.0166	0.0526	1
Loa Loa (eye worm)	hypothetical protein	0.0235	0.0769	0.0834
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0235	0.0769	0.0809
Brugia malayi	p70 ribosomal S6 kinase beta	0.0235	0.0769	0.0886
Brugia malayi	Protein kinase domain containing protein	0.0235	0.0769	0.0886
Echinococcus granulosus	Diacylglycerol kinase theta	0.0166	0.0525	0.0549
Brugia malayi	RhoGEF domain containing protein	0.0166	0.0525	0.0602
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.1286	0.4501	0.4779
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0235	0.0769	0.0834
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	PAR-6 protein	0.0166	0.0526	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Entamoeba histolytica	protein kinase domain containing protein	0.0026	0.0026	0.0237
Echinococcus granulosus	intermediate filament protein	0.003	0.004	0.0033
Entamoeba histolytica	hypothetical protein	0.0166	0.0525	0.6787
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0004	0.5
Entamoeba histolytica	hypothetical protein	0.0039	0.0075	0.0874
Entamoeba histolytica	protein kinase, putative	0.0235	0.0769	1
Schistosoma mansoni	protein kinase	0.0026	0.0026	0.0018
Schistosoma mansoni	vav2	0.0166	0.0525	0.0517
Schistosoma mansoni	lamin	0.003	0.004	0.0031
Plasmodium falciparum	protein kinase, putative	0.0021	0.0008	0.2057
Echinococcus granulosus	unc 13 munc13	0.0166	0.0525	0.0549
Schistosoma mansoni	serine/threonine protein kinase	0.0187	0.0599	0.0591
Echinococcus granulosus	serine:threonine protein kinase N2	0.0235	0.0769	0.0809
Entamoeba histolytica	diacylglycerol kinase, putative	0.0166	0.0525	0.6787
Echinococcus granulosus	lamin	0.003	0.004	0.0033
Brugia malayi	RhoGAP domain containing protein	0.0166	0.0525	0.0602
Echinococcus multilocularis	protein kinase c epsilon type	0.0401	0.136	0.1437
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0021	0.0008	0.0005
Trypanosoma brucei	PB1 domain containing protein, putative	0.0166	0.0526	0.6797
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0187	0.0599	0.0628
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0235	0.0769	0.0809
Schistosoma mansoni	protein kinase C	0.0166	0.0525	0.0517
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Entamoeba histolytica	protein kinase, putative	0.0235	0.0769	1
Echinococcus granulosus	lamin dm0	0.003	0.004	0.0033
Toxoplasma gondii	AGC kinase	0.0235	0.0769	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0027	0.0025
Schistosoma mansoni	protein kinase	0.0026	0.0026	0.0018
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0027	0.0362
Brugia malayi	Protein kinase domain containing protein	0.1286	0.4501	0.5234
Schistosoma mansoni	serine/threonine protein kinase	0.0401	0.136	0.1352
Onchocerca volvulus		0.0026	0.0027	0.0349
Onchocerca volvulus	Protein TFG homolog	0.0166	0.0526	0.9664
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0166	0.0525	0.0549
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0166	0.0525	0.0568
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0171	0.0543	0.0569
Loa Loa (eye worm)	TK/ROR protein kinase	0.0021	0.0008	0.0005
Trichomonas vaginalis	AGC family protein kinase	0.0235	0.0769	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0235	0.0769	0.0834
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0171	0.0543	0.0569
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0027	1
Echinococcus multilocularis	serine threonine protein kinase	0.0235	0.0769	0.0809
Schistosoma mansoni	serine/threonine protein kinase	0.0171	0.0543	0.0535
Trypanosoma cruzi	PB1 domain containing protein, putative	0.0166	0.0526	1
Toxoplasma gondii	diacylglycerol kinase, putative	0.0166	0.0525	0.6787
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0166	0.0525	0.0549
Loa Loa (eye worm)	TK/Met protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0027	0.0022
Entamoeba histolytica	hypothetical protein, conserved	0.0166	0.0526	0.6797
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0026	0.0026	0.0348
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0171	0.0543	0.0623
Loa Loa (eye worm)	TK/ACK protein kinase	0.0021	0.0008	0.0005
Echinococcus multilocularis	unc 13 (munc13)	0.0166	0.0525	0.0549
Onchocerca volvulus		0.0166	0.0525	0.9649
Loa Loa (eye worm)	serine/threonine protein kinase	0.0021	0.0008	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0171	0.0543	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0027	0.0362
Schistosoma mansoni	cell polarity protein	0.0166	0.0526	0.0518
Brugia malayi	C1-like domain containing protein	0.0171	0.0543	0.0623
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.004	0.0039
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0026	0.0026	0.0237
Echinococcus granulosus	protein TFG	0.0166	0.0526	0.055
Giardia lamblia	Kinase, NEK	0.0021	0.0008	0.5
Echinococcus multilocularis	partitioning defective protein 6	0.0166	0.0526	0.055
Entamoeba histolytica	hypothetical protein	0.0039	0.0075	0.0874
Onchocerca volvulus		0.0166	0.0525	0.9649
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0235	0.0769	0.0809
Echinococcus multilocularis	protein TFG	0.0166	0.0526	0.055
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0235	0.0769	0.0809
Echinococcus multilocularis	musashi	0.003	0.004	0.0033
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0008	0.0005
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0021	0.0008	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0027	1
Plasmodium vivax	protein kinase, putative	0.0021	0.0008	1
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0166	0.0525	0.0568
Schistosoma mansoni	unc-13 (munc13)	0.0166	0.0525	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0008	0.0005
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0113	0.0105
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0026	0.0026	0.0019
Onchocerca volvulus		0.003	0.004	0.0587
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0027	0.5
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0027	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	zinc finger protein	0.0166	0.0526	0.0569
Schistosoma mansoni	intermediate filament proteins	0.003	0.004	0.0031
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0235	0.0769	0.0834
Trichomonas vaginalis	AGC family protein kinase	0.0235	0.0769	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0027	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0113	0.0111
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0113	0.0105
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0401	0.136	0.1477
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0027	0.0246
Loa Loa (eye worm)	hypothetical protein	0.1281	0.4483	0.488
Brugia malayi	Ras association domain family 1 isoform A	0.0166	0.0525	0.0602
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0027	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0235	0.0769	1
Brugia malayi	diacylglycerol kinase	0.0166	0.0525	0.0602
Loa Loa (eye worm)	TK/EPH protein kinase	0.0021	0.0008	0.0005
Brugia malayi	protein kinase C II.	0.0401	0.136	0.1574
Entamoeba histolytica	protein kinase, putative	0.0235	0.0769	1
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0008	0.0005
Leishmania major	protein kinase, putative	0.0026	0.0026	0.0348
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0008	0.0005
Brugia malayi	Variant SH3 domain containing protein	0.0166	0.0525	0.0602
Echinococcus granulosus	protein kinase c iota type	0.2668	0.9409	1
Giardia lamblia	Kinase, NEK	0.0021	0.0008	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0235	0.0769	1
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0235	0.0769	0.0834
Brugia malayi	Protein kinase domain containing protein	0.0235	0.0769	0.0886
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Echinococcus granulosus	activin receptor type	0.0026	0.0026	0.0019
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0026	0.0026	0.0348
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0235	0.0769	0.0834
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Loa Loa (eye worm)	intermediate filament protein	0.003	0.004	0.0039
Schistosoma mansoni	diacylglycerol kinase theta	0.0166	0.0525	0.0517
Brugia malayi	RhoGAP domain containing protein	0.0166	0.0525	0.0602
Echinococcus granulosus	N chimaerin	0.0166	0.0525	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0526	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0027	0.0025
Schistosoma mansoni	protein kinase	0.0026	0.0026	0.0018
Schistosoma mansoni	protein kinase C mu	0.0166	0.0525	0.0517
Echinococcus multilocularis	myotubularin protein 13	0.0166	0.0525	0.0549
Echinococcus granulosus	myotubularin protein 13	0.0166	0.0525	0.0549
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.023	0.0751	0.9763
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0026	0.0026	0.0019
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0171	0.0543	0.0587
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Brugia malayi	Protein kinase domain containing protein	0.0171	0.0543	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0038	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0235	0.0769	0.0809
Brugia malayi	Protein kinase domain containing protein	0.0171	0.0544	0.0624
Echinococcus multilocularis	protein kinase c eta type	0.0166	0.0525	0.0549
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0026	0.0026	0.0019
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0166	0.0525	0.0549
Loa Loa (eye worm)	TK/INSR protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	STE/STE11/MEKK2 protein kinase	0.0171	0.0544	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0027	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0166	0.0525	0.0517
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0113	0.0119
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0075	0.0071
Loa Loa (eye worm)	TK/DDR protein kinase	0.0021	0.0008	0.0005
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0075	0.0071
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0027	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0008	0.0005
Schistosoma mansoni	serine/threonine protein kinase	0.0235	0.0769	0.0762
Loa Loa (eye worm)	raf kinase	0.0166	0.0525	0.0568
Schistosoma mansoni	serine/threonine protein kinase	0.0235	0.0769	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Echinococcus granulosus	raf serine:threonine protein kinase	0.0187	0.0599	0.0628
Brugia malayi	hypothetical protein	0.0039	0.0075	0.0078
Loa Loa (eye worm)	TK/FAK protein kinase	0.0021	0.0008	0.0005
Brugia malayi	Protein kinase domain containing protein	0.0235	0.0769	0.0886
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0027	0.0362
Schistosoma mansoni	serine/threonine protein kinase	0.0235	0.0769	0.0762
Plasmodium falciparum	protein kinase, putative	0.0026	0.0026	1
Schistosoma mansoni	hypothetical protein	0.0166	0.0525	0.0517
Echinococcus multilocularis	activin receptor type	0.0026	0.0026	0.0019
Onchocerca volvulus		0.0171	0.0544	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0027	1
Echinococcus granulosus	protein kinase c eta type	0.0166	0.0525	0.0549
Onchocerca volvulus		0.0166	0.0525	0.9649
Plasmodium falciparum	tyrosine kinase-like protein	0.0021	0.0008	0.2057
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0166	0.0525	0.0549
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0026	0.0026	0.0237
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0113	0.0122
Leishmania major	hypothetical protein, conserved	0.0166	0.0526	1
Schistosoma mansoni	protein kinase C mu	0.0171	0.0543	0.0535
Brugia malayi	intermediate filament protein	0.003	0.004	0.0037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0113	0.0105
Loa Loa (eye worm)	TK/ABL protein kinase	0.0021	0.0008	0.0005
Schistosoma mansoni	unc-13 (munc13)	0.0166	0.0525	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Trichomonas vaginalis	AGC family protein kinase	0.0235	0.0769	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0021	0.0008	0.0005
Brugia malayi	Pleckstrin Homology Domain	0.0166	0.0525	0.0602
Loa Loa (eye worm)	hypothetical protein	0.1281	0.4483	0.488
Schistosoma mansoni	diacylglycerol kinase theta	0.0166	0.0525	0.0517
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.004	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Echinococcus granulosus	protein kinase C gamma type	0.0235	0.0769	0.0809
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0113	0.0111
Echinococcus granulosus	Protein kinase C brain isozyme	0.0401	0.136	0.1437
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0166	0.0525	0.0549
Schistosoma mansoni	hypothetical protein	0.0039	0.0075	0.0067
Loa Loa (eye worm)	TK/RYK protein kinase	0.0021	0.0008	0.0005
Onchocerca volvulus		0.003	0.004	0.0587
Loa Loa (eye worm)	SRC-1	0.0021	0.0008	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Giardia lamblia	Kinase	0.0021	0.0008	0.5
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0235	0.0769	0.0809
Schistosoma mansoni	serine/threonine protein kinase	0.0401	0.136	0.1352
Entamoeba histolytica	hypothetical protein	0.0039	0.0075	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0027	0.0025
Onchocerca volvulus		0.0166	0.0526	0.9664
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Echinococcus multilocularis	N chimaerin	0.0166	0.0525	0.0549
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0401	0.136	0.1437
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0005
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0235	0.0769	0.0809
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0525	0.0568
Schistosoma mansoni	serine/threonine protein kinase	0.0235	0.0769	0.0762
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0008	0.0005
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0235	0.0769	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0027	0.0022
Schistosoma mansoni	lamin	0.003	0.004	0.0031
Loa Loa (eye worm)	hypothetical protein	0.003	0.004	0.0039
Plasmodium falciparum	protein kinase, putative	0.0021	0.0008	0.2057
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0008	0.0005
Echinococcus multilocularis	lamin dm0	0.003	0.004	0.0033
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0166	0.0525	0.0568

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2252661

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1798855