Detailed information for compound 1800513

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.446 | Formula: C23H22N4O2
  • H donors: 2 H acceptors: 1 LogP: 3.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NCCNn1c(nc2c(c1=O)cccc2)c1ccccc1
  • InChi: 1S/C23H22N4O2/c1-29-19-13-11-18(12-14-19)24-15-16-25-27-22(17-7-3-2-4-8-17)26-21-10-6-5-9-20(21)23(27)28/h2-14,24-25H,15-16H2,1H3
  • InChiKey: CALYLUOWAUNNLX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0098 0.0147
Brugia malayi hypothetical protein 0.0018 0.0035 0.0026
Onchocerca volvulus 0.0018 0.0035 0.0026
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0032 0.0328 0.0328
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.011 0.0146
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0551 0.4537
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0098 0.0256
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0098 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.011 0.0146
Brugia malayi hypothetical protein 0.0042 0.0519 0.0511
Echinococcus multilocularis Small ubiquitin modifier 2 0.0035 0.0376 0.3056
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.011 0.0146
Entamoeba histolytica recQ family helicase, putative 0.0035 0.0388 0.3234
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0206 0.3893 0.5801
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.12 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.0028 0.0042
Giardia lamblia Sgs1 DNA helicase, putative 0.0032 0.0328 0.5404
Echinococcus multilocularis Protein lozenge 0.0063 0.0956 0.7946
Brugia malayi hypothetical protein 0.0042 0.0525 0.0517
Plasmodium falciparum small ubiquitin-related modifier 0.0035 0.0376 0.6635
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0206 0.3893 0.5801
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0035 0.0376 0.3128
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0098 0.1133
Schistosoma mansoni aryl hydrocarbon receptor 0.0018 0.0034 0.0287
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0523 0.0779
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0523 0.4295
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0032 0.0328 0.2654
Entamoeba histolytica hypothetical protein 0.0059 0.0868 0.7232
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0388 0.0561
Giardia lamblia DINP protein human, muc B family 0.0022 0.011 0.0271
Leishmania major ferric reductase, putative 0.0206 0.3893 0.5793
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.011 0.0164
Schistosoma mansoni ap endonuclease 0.0021 0.0098 0.082
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0098 0.1571
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0328 0.0319
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.011 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.011 0.0164
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0206 0.3893 0.5793
Leishmania major small ubiquitin protein, putative 0.0035 0.0376 0.0542
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0098 0.1185
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0018 0.0034 0.0185
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0032 0.0328 0.2654
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.011 0.0146
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.12 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0523 0.8352
Echinococcus granulosus dna polymerase eta 0.0022 0.011 0.082
Loa Loa (eye worm) RecQ helicase 0.0047 0.062 0.062
Mycobacterium leprae Possible regulatory protein 0.0018 0.0028 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0519 0.0519
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0028 0.0232 0.6047
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.011 0.0146
Loa Loa (eye worm) hypothetical protein 0.006 0.0888 0.0888
Loa Loa (eye worm) hypothetical protein 0.0032 0.0328 0.0328
Echinococcus multilocularis dna polymerase kappa 0.0022 0.011 0.082
Loa Loa (eye worm) hypothetical protein 0.0022 0.011 0.011
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0868 0.1293
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0523 0.4354
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0018 0.0034 0.0185
Trypanosoma cruzi small ubiquitin protein, putative 0.0035 0.0376 0.056
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.011 0.0915
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.011 0.0146
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0523 0.0779
Trypanosoma brucei small ubiquitin-related modifier 0.0035 0.0376 0.0542
Schistosoma mansoni ap endonuclease 0.0021 0.0098 0.082
Trichomonas vaginalis DNA helicase recq, putative 0.0047 0.062 1
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0073
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.011 0.0146
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0376 0.5867
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.0028 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0342 0.671 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0162 0.2996 0.4455
Trypanosoma cruzi small ubiquitin protein, putative 0.0035 0.0376 0.056
Brugia malayi Protein kinase domain containing protein 0.0018 0.0035 0.0026
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0018 0.0028 0.5
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0044 0.056 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0523 0.0762
Brugia malayi Bloom's syndrome protein homolog 0.0047 0.062 0.0612
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0293
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.011 0.0164
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0388 0.0578
Schistosoma mansoni lozenge 0.0063 0.0956 0.7968
Echinococcus multilocularis dna polymerase eta 0.0022 0.011 0.082
Brugia malayi isocitrate dehydrogenase 0.0017 0.0012 0.0004
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0523 0.0762
Loa Loa (eye worm) TK/ALK protein kinase 0.0018 0.0035 0.0035
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0042 0.0525 0.4374
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0098 0.082
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.011 0.0146
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0551 0.4537
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0018 0.0028 0.0042
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.12 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0098 0.0098
Onchocerca volvulus 0.0018 0.0035 0.0026
Schistosoma mansoni DNA helicase recq1 0.0032 0.0328 0.273
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0032 0.0328 0.2654
Echinococcus granulosus bloom syndrome protein 0.0047 0.062 0.5116
Trypanosoma brucei unspecified product 0.0022 0.011 0.0146
Mycobacterium ulcerans hypothetical protein 0.018 0.3373 1
Echinococcus granulosus aryl hydrocarbon receptor 0.006 0.0894 0.742
Schistosoma mansoni DNA polymerase eta 0.0022 0.011 0.0915
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0098 0.2368
Plasmodium vivax small ubiquitin-related modifier, putative 0.0035 0.0376 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0042 0.0525 0.0525
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0098 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.011 0.0146
Brugia malayi Ubiquitin-like protein SMT3 0.0035 0.0376 0.0367
Leishmania major protein kinase, putative 0.0018 0.0028 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.011 0.0146
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.011 0.0164
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0523 0.4295
Loa Loa (eye worm) hypothetical protein 0.0042 0.0523 0.0523
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.12 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0032 0.0328 0.2654
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0098 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0009
Schistosoma mansoni DNA helicase recq5 0.0032 0.0328 0.273
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0012 0.0019
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0523 0.0514
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0098 0.1185
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0293
Giardia lamblia Sentrin 0.0035 0.0376 0.6532
Toxoplasma gondii hypothetical protein 0.0055 0.0797 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0012 0.0104
Brugia malayi PAS domain containing protein 0.0018 0.0028 0.002
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.011 0.1379
Loa Loa (eye worm) hypothetical protein 0.0031 0.0293 0.0293
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.011 0.029
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0042 0.0519 0.0519
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0523 0.4295
Echinococcus multilocularis aryl hydrocarbon receptor 0.006 0.0894 0.742
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0328 0.0319
Trichomonas vaginalis DNA helicase recq, putative 0.0035 0.0388 0.608
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0098 0.0128
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.011 0.011
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.011 0.0035
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0342 0.671 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.011 0.1379
Leishmania major DNA polymerase eta, putative 0.0022 0.011 0.0146
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0523 0.4354
Loa Loa (eye worm) hypothetical protein 0.0042 0.0519 0.0519
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0042 0.0525 0.0517
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.0028 0.0042
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0523 0.4295
Schistosoma mansoni blooms syndrome DNA helicase 0.003 0.028 0.2329
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.011 0.082
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0651 0.0953
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.2996 0.4465
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.011 0.0146
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0012 0.0156
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.12 0.1193
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0523 0.4295
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0651 0.097
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0523 0.4354
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0012 0.0156
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.011 0.029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0028
Treponema pallidum hypothetical protein 0.0059 0.0868 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.12 0.1789
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.12 0.1789
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0012 0.0004
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.006 0.0894 0.0894
Onchocerca volvulus Protein cycle homolog 0.0042 0.0525 0.0517
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.011 0.0146
Loa Loa (eye worm) hypothetical protein 0.0502 1 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0523 1
Echinococcus multilocularis bloom syndrome protein 0.0047 0.062 0.5116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0523 0.8352
Leishmania major DNA polymerase kappa, putative 0.0022 0.011 0.0146
Toxoplasma gondii small ubiquitin family modifier, putative 0.0035 0.0376 0.4715
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.011 0.0146
Loa Loa (eye worm) hypothetical protein 0.0116 0.2053 0.2053
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.2996 0.4455
Echinococcus granulosus dna polymerase kappa 0.0022 0.011 0.082
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.12 0.1774
Brugia malayi Blistered cuticle protein 3 0.0322 0.6286 0.6283
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.011 0.0146
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Echinococcus granulosus MAM 0.0018 0.0035 0.0192
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0388 0.0561
Schistosoma mansoni single-minded 0.0018 0.0028 0.0236
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.12 0.12
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0018 0.0028 0.0024
Trichomonas vaginalis DNA helicase recq1, putative 0.0047 0.062 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.011 0.0915
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.011 0.0915
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0012 0.0012
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0098 0.0724
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0328 0.4114
Toxoplasma gondii exonuclease III APE 0.0021 0.0098 0.1235
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0027 0.0219 0.275
Echinococcus multilocularis MAM 0.0018 0.0035 0.0192
Leishmania major protein kinase, putative 0.0018 0.0028 0.0024
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0032 0.0328 0.576
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.011 0.082
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0018 0.0028 0.0042
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0042 0.0519 0.0511
Leishmania major mitochondrial DNA polymerase beta 0.0342 0.671 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.011 0.0146
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.0028 0.0042
Onchocerca volvulus Dual oxidase homolog 0.0322 0.6286 0.6283
Onchocerca volvulus 0.0502 1 1
Loa Loa (eye worm) DOMON domain-containing protein 0.0017 0.0009 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.011 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.018 0.3373 1
Loa Loa (eye worm) SMO-1 protein 0.0035 0.0376 0.0376
Loa Loa (eye worm) blistered cuticle protein 3 0.0322 0.6286 0.6286
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.011 0.0164
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0328 0.4114
Entamoeba histolytica ubiquitin like protein 0.0035 0.0376 0.3128
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0523 0.4295
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0098 0.0147
Loa Loa (eye worm) hypothetical protein 0.0042 0.0519 0.0519
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0651 0.097
Brugia malayi hypothetical protein 0.006 0.0888 0.088
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0342 0.671 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0651 0.097
Loa Loa (eye worm) hypothetical protein 0.0502 1 1
Onchocerca volvulus 0.006 0.0888 0.088
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.12 0.1774
Echinococcus granulosus Small ubiquitin modifier 2 0.0035 0.0376 0.3056
Loa Loa (eye worm) runx1 0.0063 0.0956 0.0956
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0098 0.0724
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0523 0.8352
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.011 0.0101
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0042 0.0525 0.0517

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 8.53 % Induction of sedation-hypnotic activity in Mus musculus Albino Swiss (mouse) assessed as reduction in locomotor activity at 5 mg/kg, po measured after 3 hr by actophotometer ChEMBL. No reference
Activity (ADMET) = 9.03 % Induction of sedation-hypnotic activity in Mus musculus Albino Swiss (mouse) assessed as reduction in locomotor activity at 5 mg/kg, po measured after 0.5 hr by actophotometer ChEMBL. No reference
Activity (ADMET) = 10.43 % Induction of sedation-hypnotic activity in Mus musculus Albino Swiss (mouse) assessed as reduction in locomotor activity at 5 mg/kg, po measured after 1 hr by actophotometer ChEMBL. No reference
Activity (ADMET) = 10.94 % Induction of sedation-hypnotic activity in Mus musculus Albino Swiss (mouse) assessed as reduction in locomotor activity at 5 mg/kg, po measured after 2 hr by actophotometer ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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