Detailed information for compound 1801232

Basic information

Technical information
  • TDR Targets ID: 1801232
  • Name: Methyl 3-hydroxybenzoate
  • MW: 152.147 | Formula: C8H8O3
  • H donors: 1 H acceptors: 2 LogP: 1.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cccc(c1)O
  • InChi: 1S/C8H8O3/c1-11-8(10)6-3-2-4-7(9)5-6/h2-5,9H,1H3
  • InChiKey: YKUCHDXIBAQWSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-Hydroxybenzoic acid methyl ester
  • 19438-10-9
  • AI3-31869
  • Benzoic acid, 3-hydroxy-, methyl ester (9CI)
  • Benzoic acid, m-hydroxy-, methyl ester (8CI)
  • EINECS 243-071-5
  • NSC 40536
  • ZINC00388757
  • ARONIS010129
  • 54740_FLUKA
  • ST5210581
  • 252794_ALDRICH
  • BENZOIC ACID,3-HYDROXY,METHYL ESTER
  • InChI=1/C8H8O3/c1-11-8(10)6-3-2-4-7(9)5-6/h2-5,9H,1H
  • Benzoic acid, 3-hydroxy-, methyl ester
  • Benzoic acid, m-hydroxy-, methyl ester
  • Methyl m-hydroxybenzoate
  • Methyl m-oxybenzoate
  • NSC40536
  • m-Carbomethoxyphenol
  • m-Hydroxybenzoic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0922 1 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0016 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0016 0 0.5
Leishmania major lipase domain protein, putative 0.0018 0.0012 0.0012
Giardia lamblia hypothetical protein 0.0018 0.0012 0.5
Mycobacterium leprae putative cytochrome p450 0.0016 0 0.5
Brugia malayi Lipase family protein 0.0018 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0018 0.0012 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0012 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0113 0.0113
Leishmania major hypothetical protein, conserved 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0016 0 0.5
Giardia lamblia hypothetical protein 0.0018 0.0012 0.5
Trypanosoma cruzi lipase, putative 0.0018 0.0012 0.0012
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0113 0.0113
Trypanosoma brucei lipase domain protein, putative 0.0922 1 1
Brugia malayi Lipase family protein 0.0018 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0018 0.0012 0.5
Trypanosoma brucei Lipase (class 3), putative 0.0018 0.0012 0.0012
Loa Loa (eye worm) lipase 0.0018 0.0012 0.0012
Leishmania major lipase, putative 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0016 0 0.5
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0016 0 0.5
Entamoeba histolytica lipase, putative 0.0018 0.0012 0.5
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0016 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0012 0.0012
Giardia lamblia Hypothetical protein 0.0018 0.0012 0.5
Trypanosoma cruzi Triglyceride lipase, putative 0.0018 0.0012 0.0012
Trypanosoma brucei lipase-like protein, putative 0.0018 0.0012 0.0012
Leishmania major lipase, putative;with=GeneDB:LinJ31_V3.0860 0.0018 0.0012 0.0012
Loa Loa (eye worm) lipase 0.0018 0.0012 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0012 0.5
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0922 1 1
Leishmania major lipase precursor-like protein 0.0018 0.0012 0.0012
Brugia malayi Cytochrome P450 family protein 0.0027 0.0113 0.0113
Trypanosoma brucei lipase domain protein, putative 0.0922 1 1
Trypanosoma cruzi lipase domain protein, putative 0.0018 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0018 0.0012 0.5
Trypanosoma cruzi lipase, putative 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0016 0 0.5
Giardia lamblia Hypothetical protein 0.0018 0.0012 0.5
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0922 1 1
Brugia malayi Lipase family protein 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0016 0 0.5
Leishmania major hypothetical protein, unknown function 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0016 0 0.5
Leishmania major hypothetical protein, conserved 0.0922 1 1
Giardia lamblia Hypothetical protein 0.0018 0.0012 0.5
Onchocerca volvulus 0.0922 1 1
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0018 0.0012 0.0012
Trypanosoma cruzi lipase, putative 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0016 0 0.5
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0113 0.0113
Trypanosoma cruzi lipase, putative 0.0018 0.0012 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0113 0.0113
Loa Loa (eye worm) lipase 0.0922 1 1
Toxoplasma gondii lipase 0.0018 0.0012 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0016 0 0.5
Brugia malayi Cytochrome P450 family protein 0.0027 0.0113 0.0113
Entamoeba histolytica hypothetical protein 0.0018 0.0012 0.5
Trichomonas vaginalis lipase containing protein, putative 0.0922 1 1
Entamoeba histolytica lipase, putative 0.0018 0.0012 0.5
Trypanosoma brucei lipase, putative 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0016 0 0.5
Leishmania major hypothetical protein, conserved 0.0018 0.0012 0.0012
Trypanosoma brucei Triglyceride lipase, putative 0.0018 0.0012 0.0012
Trypanosoma brucei Triglyceride lipase, putative 0.0018 0.0012 0.0012
Trypanosoma cruzi lipase domain protein, putative 0.0018 0.0012 0.0012
Plasmodium falciparum lipase, putative 0.0018 0.0012 0.5
Toxoplasma gondii lipase 0.0018 0.0012 1
Trypanosoma cruzi lipase-like protein, putative 0.0018 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0018 0.0012 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0012 0.0012
Trypanosoma cruzi lipase, putative 0.0018 0.0012 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0012 0.0012
Toxoplasma gondii lipase 0.0018 0.0012 1
Trypanosoma cruzi Lipase (class 3), putative 0.0018 0.0012 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0113 0.0113
Trypanosoma cruzi lipase, putative 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0016 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0016 0 0.5
Trypanosoma brucei triacylglycerol lipase, putative 0.0018 0.0012 0.0012
Trypanosoma cruzi lipase, putative 0.0018 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0018 0.0012 0.5
Trypanosoma brucei lipase domain protein, putative 0.0018 0.0012 0.0012
Entamoeba histolytica lipase, putative 0.0018 0.0012 0.5
Brugia malayi Cytochrome P450 family protein 0.0061 0.0491 0.0491
Leishmania major hypothetical protein, unknown function 0.0018 0.0012 0.0012
Toxoplasma gondii lipase 0.0018 0.0012 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0491 0.0491
Trypanosoma cruzi lipase, putative 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0016 0 0.5
Entamoeba histolytica hypothetical protein 0.0018 0.0012 0.5
Entamoeba histolytica lipase, putative 0.0018 0.0012 0.5
Leishmania major hypothetical protein, conserved 0.0018 0.0012 0.0012
Mycobacterium leprae Conserved hypothetical protein 0.0016 0 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0922 1 1
Schistosoma mansoni lipase 0.0018 0.0012 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0016 0 0.5
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0018 0.0012 0.0012
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0016 0 0.5
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0113 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0016 0 0.5
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0016 0 0.5
Leishmania major cytochrome p450-like protein 0.0027 0.0113 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0016 0 0.5
Trichomonas vaginalis lipase containing protein, putative 0.0922 1 1
Brugia malayi Lipase family protein 0.0018 0.0012 0.0012
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0113 0.0113
Entamoeba histolytica hypothetical protein 0.0018 0.0012 0.5
Leishmania major class 3 lipase, putative 0.0018 0.0012 0.0012

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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