Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0104 | 0.0104 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.012 | 0.0087 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0037 | 0.0123 | 0.0123 |
Echinococcus granulosus | geminin | 0.0171 | 0.0913 | 0.0913 |
Loa Loa (eye worm) | glutamate decarboxylase GAD1 | 0.0196 | 0.1061 | 0.1061 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.0615 | 0.0615 |
Schistosoma mansoni | ran | 0.0022 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0123 | 0.0123 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0079 | 0.0079 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0913 | 0.0913 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0034 | 0.0034 |
Schistosoma mansoni | transient receptor potential channel | 0.0065 | 0.0292 | 0.0292 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0065 | 0.0292 | 0.0292 |
Brugia malayi | hypothetical protein | 0.0305 | 0.1702 | 0.1702 |
Trypanosoma cruzi | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0196 | 0.1061 | 0.1061 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0099 | 0.0489 | 0.0489 |
Loa Loa (eye worm) | aromatic L-amino acid decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Echinococcus multilocularis | pyridoxal dependent decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | hypothetical protein | 0.1712 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.012 | 0.012 |
Leishmania major | GTP-binding protein, putative | 0.0022 | 0.0034 | 0.0034 |
Trichomonas vaginalis | group II pyridoxal-5-phosphate decarboxylase, putative | 0.0196 | 0.1061 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.012 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0489 | 0.0489 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0034 | 0.4239 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0109 | 0.0109 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0079 | 0.0079 |
Brugia malayi | RNA, U transporter 1 | 0.0084 | 0.0399 | 0.0399 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.012 | 0.012 |
Leishmania major | sphingosine 1-phosphate lyase | 0.1712 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | TDC-1 protein | 0.0196 | 0.1061 | 0.1061 |
Schistosoma mansoni | sphingosine phosphate lyase | 0.1712 | 1 | 1 |
Echinococcus multilocularis | sphingosine 1 phosphate lyase 1 | 0.1712 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0034 | 0.0034 |
Onchocerca volvulus | 0.0305 | 0.1702 | 0.5 | |
Schistosoma mansoni | transient receptor potential channel | 0.0065 | 0.0292 | 0.0292 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0196 | 0.1061 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0079 | 0.0079 |
Trypanosoma brucei | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0196 | 0.1061 | 0.1061 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0913 | 0.0913 |
Echinococcus multilocularis | aromatic amino acid decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0096 | 0.047 | 0.047 |
Schistosoma mansoni | ran | 0.0022 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | sphingosine-1-phosphate lyase 1 | 0.0196 | 0.1061 | 0.1061 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0034 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0817 | 0.4724 | 0.4724 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0047 | 0.0047 |
Trypanosoma brucei | sphingosine 1-phosphate lyase, putative | 0.1712 | 1 | 1 |
Echinococcus granulosus | sphingosine 1 phosphate lyase 1 | 0.1712 | 1 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0047 | 0.0126 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.1712 | 1 | 1 |
Entamoeba histolytica | s phingosine-1-phosphate lyase 1, putative | 0.1712 | 1 | 1 |
Trypanosoma cruzi | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0196 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 0.1702 | 0.1702 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0065 | 0.0292 | 0.0292 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0079 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0079 | 0.0079 |
Echinococcus granulosus | snurportin 1 | 0.0314 | 0.1756 | 0.1756 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.1061 | 0.1061 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0022 | 0.0034 | 0.4239 |
Brugia malayi | glutamate decarboxylase, 67 kDa isoform | 0.0196 | 0.1061 | 0.1061 |
Schistosoma mansoni | transient receptor potential channel | 0.0099 | 0.0489 | 0.0489 |
Echinococcus granulosus | pyridoxal dependent decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.0615 | 0.0615 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0034 | 0.0034 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0109 | 0.0109 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.012 | 0.0087 |
Echinococcus multilocularis | geminin | 0.0171 | 0.0913 | 0.0913 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0096 | 0.047 | 0.047 |
Brugia malayi | Pyridoxal-dependent decarboxylase conserved domain containing protein | 0.0196 | 0.1061 | 0.1061 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0022 | 0.0034 | 0.4239 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0079 | 0.0079 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0065 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0272 | 0.0272 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0047 | 0.0047 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0099 | 0.0489 | 0.0489 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0196 | 0.1061 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0196 | 0.1061 | 0.1061 |
Brugia malayi | glutamate decarboxylase putative | 0.0196 | 0.1061 | 0.1061 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0079 | 0.0079 |
Schistosoma mansoni | hypothetical protein | 0.0314 | 0.1756 | 0.1756 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0202 | 0.0202 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0022 | 0.0034 | 0.0034 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.1712 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0202 | 0.0202 |
Echinococcus granulosus | aromatic amino acid decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0047 | 0.0126 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.012 | 0.012 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0079 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0314 | 0.1756 | 0.1756 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.012 | 0.0087 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.0615 | 0.0615 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0196 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0202 | 0.0202 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Mycobacterium tuberculosis | Probable glutamate decarboxylase GadB | 0.0196 | 0.1061 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0034 | 0.0034 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0099 | 0.0489 | 0.0489 |
Brugia malayi | Aromatic-L-amino-acid decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0314 | 0.1756 | 0.1756 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0079 | 1 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0034 | 0.0034 |
Brugia malayi | hypothetical protein | 0.0036 | 0.012 | 0.012 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0037 | 0.0123 | 0.0123 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0065 | 0.0292 | 0.0292 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0202 | 0.0202 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0022 | 0.0034 | 0.0034 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0047 | 0.0013 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.012 | 0.0087 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0047 | 0.0126 |
Brugia malayi | biogenic amine synthesis related protein 1 | 0.0196 | 0.1061 | 0.1061 |
Brugia malayi | Transient-receptor-potential like protein | 0.0037 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0079 | 0.0079 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.