Detailed information for compound 1802314

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.077 | Formula: C15H12Br2N2
  • H donors: 0 H acceptors: 0 LogP: 4.49 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)N1CN(C2)c2c(C1)ccc(c2)Br
  • InChi: 1S/C15H12Br2N2/c16-12-3-1-10-7-18-9-19(14(10)5-12)8-11-2-4-13(17)6-15(11)18/h1-6H,7-9H2
  • InChiKey: JRRCUQMXEGXHDW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0012 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0012 0.0043
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0218 0.0283
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0499 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0012 0.0008
Echinococcus multilocularis muscleblind protein 1 0.0165 0.1314 0.1744
Echinococcus granulosus JmjC domain containing protein 4 0.0014 0.0054 0.0064
Brugia malayi isocitrate dehydrogenase 0.0034 0.0218 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0012 0.0008
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0031 0.0197 0.0544
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0364
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0031 0.0197 0.0544
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0792 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0219 0.0283
Echinococcus granulosus ATP binding cassette sub family G 0.0031 0.0197 0.0254
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0332 0.045
Brugia malayi jmjC domain containing protein 0.0014 0.0054 0.0066
Brugia malayi MAP kinase sur-1 0.0103 0.0792 0.1085
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0409 0.0537
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0012 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0705
Brugia malayi CXXC zinc finger family protein 0.0064 0.0467 0.0636
Loa Loa (eye worm) hypothetical protein 0.0073 0.0547 0.4137
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0218 0.0626
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0705
Brugia malayi ABC transporter family protein 0.0027 0.0157 0.0208
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.083 0.6302
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0014 0.0054 0.0064
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.0942 0.3378
Schistosoma mansoni hypothetical protein 0.0363 0.2969 0.3951
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0012 0.0007
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0218 0.0626
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0142 0.1042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0012 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0012 0.0008
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0548 0.4143
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0218 0.0283
Echinococcus granulosus lysine specific demethylase 6a 0.0014 0.0054 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0705
Leishmania major telomerase reverse transcriptase, putative 0.0329 0.2684 1
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0219 0.0293
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0012 0.0043
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.0792 0.2807
Echinococcus multilocularis jumonji domain containing 1A 0.0014 0.0054 0.0064
Plasmodium falciparum telomerase reverse transcriptase 0.0329 0.2684 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0054 0.0364
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0067 0.0082
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0012 0.0007
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0012 0.0007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0012 0.0007
Schistosoma mansoni ABC transporter 0.0027 0.0157 0.0201
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0012 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.083 0.1138
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0705
Echinococcus multilocularis dnaJ subfamily B 0.0906 0.7505 1
Echinococcus granulosus cpg binding protein 0.0067 0.0497 0.0655
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0499 0.1692
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.2014
Brugia malayi nuclear receptor NHR-88 0.0009 0.0012 0.0008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0056 0.0705
Echinococcus granulosus jumonji domain containing 1A 0.0014 0.0054 0.0064
Schistosoma mansoni hypothetical protein 0.0026 0.0154 0.0197
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0218 0.0626
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.083 0.1138
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0012 0.0008
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.2014
Schistosoma mansoni cpg binding protein 0.0067 0.0497 0.0655
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0012 0.0008
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0548 0.1879
Echinococcus multilocularis phd:f box containing protein 0.0014 0.0054 0.0064
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0792 0.2807
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0218 0.1865
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0792 0.2807
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0705
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0012 0.0007
Plasmodium vivax ABC transporter G family member 2, putative 0.0031 0.0197 0.0544
Onchocerca volvulus 0.0064 0.0467 0.0456
Loa Loa (eye worm) hypothetical protein 0.0165 0.1314 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0031 0.0197 0.1528
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0012 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0012 0.0043
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.1063 0.1409
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0409 0.3081
Brugia malayi jmjC domain containing protein 0.0014 0.0054 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0332 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0705
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0012 0.0008
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0218 0.0626
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0499 0.1692
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0012 0.0007
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0142 0.0337
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0031 0.0197 0.0544
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0012 0.0007
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0547 0.0747
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0012 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0792 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0705
Loa Loa (eye worm) hypothetical protein 0.0018 0.0083 0.0587
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0792 1
Echinococcus granulosus phd:f box containing protein 0.0014 0.0054 0.0064
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0332 0.2493
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0409 0.0537
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.01 0.0125
Brugia malayi jmjC domain containing protein 0.0014 0.0054 0.0066
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0031 0.0197 0.1528
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0084 0.0104
Echinococcus multilocularis microtubule associated protein 2 0.0762 0.6304 0.8398
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0043
Echinococcus multilocularis ATP binding cassette sub family G 0.0031 0.0197 0.0254
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0499 0.0657
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0409 0.0537
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0364
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0548 0.0748
Schistosoma mansoni hypothetical protein 0.0363 0.2969 0.3951
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0012 0.0007
Plasmodium falciparum ABC transporter G family member 2 0.0031 0.0197 0.0544
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0012 0.0007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0467 0.3524
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0332 0.0435
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0499 0.0657
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.0792 0.1048
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0267 0.0349
Schistosoma mansoni hypothetical protein 0.004 0.0267 0.0349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0332 0.0435
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0705
Leishmania major cytochrome p450-like protein 0.0025 0.0142 0.0337
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0043
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0012 0.0007
Echinococcus multilocularis cpg binding protein 0.0067 0.0497 0.0655
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0012 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0012 0.0043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0499 1
Giardia lamblia Telomerase catalytic subunit 0.0329 0.2684 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0012 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0499 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0219 0.0283
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0098 0.0127
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0012 0.0007
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0218 0.0626
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0218 0.1623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0012 0.0043
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0012 0.0007
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0548 0.1879
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0705
Brugia malayi jmjC domain containing protein 0.0053 0.0379 0.0514
Echinococcus multilocularis lysine specific demethylase 6a 0.0014 0.0054 0.0064
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0012 0.0007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.09 0.7459 0.9938
Brugia malayi Muscleblind-like protein 0.0165 0.1314 0.1805
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.0792 0.2807
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0329 0.2684 1
Brugia malayi jmjC domain containing protein 0.0014 0.0054 0.0066
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0053 0.0379 0.0497
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0043
Echinococcus granulosus ATP binding cassette sub family G 0.0031 0.0197 0.0254
Trypanosoma brucei protein kinase, putative 0.0103 0.0792 0.2807
Schistosoma mansoni jumonji domain containing protein 0.0053 0.0379 0.0497
Schistosoma mansoni microtubule-associated protein tau 0.0762 0.6304 0.8398
Echinococcus granulosus transcription factor Dp 1 0.0042 0.029 0.0379
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.0792 0.2807
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0056 0.0705
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0012 0.0043
Brugia malayi Cytochrome P450 family protein 0.0025 0.0142 0.0188
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0219 0.0283
Loa Loa (eye worm) hypothetical protein 0.0107 0.083 0.6302
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0548 0.0723
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0218 0.0626
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0219 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0705
Loa Loa (eye worm) histone methyltransferase 0.002 0.01 0.0718
Echinococcus multilocularis GPCR, family 2 0.0034 0.0219 0.0283
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0012 0.0007
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.0792 0.2807
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0012 0.0008
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0499 0.0657
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0218 0.0626
Trichomonas vaginalis helicase, putative 0.0014 0.0056 0.0705
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0054 0.0364
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0012 0.0008
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0267 0.0349
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0792 1
Schistosoma mansoni hypothetical protein 0.0906 0.7505 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0548 0.1879
Schistosoma mansoni cpg binding protein 0.0064 0.0467 0.0615
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0053 0.0379 0.0497
Brugia malayi Telomerase reverse transcriptase 0.0875 0.7251 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0332 0.0435
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0332 0.0435
Echinococcus granulosus GPCR family 2 0.0034 0.0219 0.0283
Echinococcus multilocularis lysine specific demethylase 5A 0.0053 0.0379 0.0497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0012 0.0043
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0548 0.0723
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0218 0.0293
Schistosoma mansoni phd/f-box containing protein 0.0014 0.0054 0.0064
Brugia malayi ecdysteroid receptor 0.0009 0.0012 0.0008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0499 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0332 0.0435
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0329 0.2684 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0012 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0043
Echinococcus granulosus muscleblind protein 0.0165 0.1314 0.1744
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0012 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0218 0.0283
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0267 0.0349
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0218 0.0283
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0084 0.0104
Loa Loa (eye worm) hypothetical protein 0.0165 0.1314 1
Toxoplasma gondii RNA-directed DNA polymerase 0.0329 0.2684 1
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0971 0.7376
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0548 1
Schistosoma mansoni phosphatidylserine receptor 0.0014 0.0054 0.0064
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0499 0.0657
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0971 0.7376
Schistosoma mansoni protein phosphatase 2C 0.0014 0.0054 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0332 0.0435
Trypanosoma brucei telomerase reverse transcriptase 0.0329 0.2684 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0219 0.1625
Echinococcus granulosus ATP binding cassette sub family G 0.0031 0.0197 0.0254
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0012 0.0007
Brugia malayi jmjC domain containing protein 0.0057 0.0409 0.0556
Schistosoma mansoni cpg binding protein 0.0067 0.0497 0.0655
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0012 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0142 0.1042
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.2014
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.0792 0.1048
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.0792 0.6011
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.2014
Trypanosoma brucei ATP-binding cassette protein, putative 0.0031 0.0197 0.0544
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0012 0.0007
Loa Loa (eye worm) ABC transporter 0.0027 0.0157 0.1155
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0012 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0705
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0012 0.0007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0219 0.0293
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0218 0.0626
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0056 0.0705
Echinococcus multilocularis muscleblind protein 0.0165 0.1314 0.1744
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.01 0.0125
Schistosoma mansoni jumonji domain containing protein 0.0014 0.0054 0.0064
Echinococcus multilocularis ATP binding cassette sub family G 0.0031 0.0197 0.0254
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0364
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0067 0.0082
Brugia malayi nuclear hormone receptor 0.0009 0.0012 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0014 0.0054 0.0364
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0012 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0012 0.0008
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.0792 0.2807
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0218 0.0283
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0012 0.0007
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0142 0.0337
Schistosoma mansoni hypothetical protein 0.0073 0.0547 0.0722
Schistosoma mansoni hypothetical protein 0.0034 0.0219 0.0283
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0548 0.0723
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0705
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0043
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0012 0.0007
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0218 0.0283
Trypanosoma cruzi ABC transporter, putative 0.0031 0.0197 0.0544
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0031 0.0197 0.1528
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0067 0.0082
Schistosoma mansoni hypothetical protein 0.0034 0.0219 0.0283
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0218 0.0626
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.0792 0.2807
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0067 0.0082
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.0792 0.1048
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0067 0.0082
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0031 0.0197 0.0544
Echinococcus granulosus microtubule associated protein 2 0.0762 0.6304 0.8398
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0012 0.0007
Plasmodium vivax telomerase reverse transcriptase, putative 0.0329 0.2684 1
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.029 0.0379
Schistosoma mansoni coup transcription factor 0.0009 0.0012 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0792 0.1048
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.0792 0.1048
Brugia malayi hypothetical protein 0.004 0.0267 0.0361
Brugia malayi Cytochrome P450 family protein 0.0025 0.0142 0.0188
Brugia malayi steroid hormone receptor 0.0009 0.0012 0.0008
Echinococcus multilocularis geminin 0.0363 0.2969 0.3951
Brugia malayi MH2 domain containing protein 0.0124 0.0971 0.1332
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0012 0.0008
Trypanosoma brucei ABC transporter, putative 0.0031 0.0197 0.0544
Echinococcus granulosus dnaJ subfamily B 0.0906 0.7505 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0043
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0142 0.1042
Loa Loa (eye worm) hypothetical protein 0.0034 0.0219 0.1625
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0012 0.0007
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0031 0.0197 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0056 0.0705
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0218 0.0283
Schistosoma mansoni hypothetical protein 0.0034 0.0219 0.0283
Echinococcus multilocularis ATP binding cassette sub family G 0.0031 0.0197 0.0254
Schistosoma mansoni hypothetical protein 0.0034 0.0219 0.0283
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0548 0.1879
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0142 0.0337
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.0792 0.2403
Echinococcus multilocularis JmjC domain containing protein 4 0.0014 0.0054 0.0064
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0043
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0012 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0012 0.0008
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0012 0.0043
Echinococcus granulosus geminin 0.0363 0.2969 0.3951

Activities

Activity type Activity value Assay description Source Reference
IZ (functional) = 8 mm Antifungal activity against Candida albicans at 250 ug/ml after 72 hrs by disc diffusion method ChEMBL. No reference
IZ (functional) = 8 mm Antibacterial activity against Escherichia coli at 250 ug/ml after 24 to 45 hrs by disc diffusion method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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