Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.0615 | 0.0615 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0196 | 0.1061 | 0.1061 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0202 | 0.0202 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0047 | 0.0126 |
Echinococcus granulosus | aromatic amino acid decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Echinococcus multilocularis | snurportin 1 | 0.0314 | 0.1756 | 0.1756 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0079 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.012 | 0.012 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.012 | 0.0087 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0202 | 0.0202 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0065 | 0.0292 | 0.0292 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0047 | 0.0013 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.012 | 0.0087 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0022 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0079 | 0.0079 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0047 | 0.0126 |
Brugia malayi | Transient-receptor-potential like protein | 0.0037 | 0.0123 | 0.0123 |
Brugia malayi | biogenic amine synthesis related protein 1 | 0.0196 | 0.1061 | 0.1061 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0034 | 0.0034 |
Mycobacterium tuberculosis | Probable glutamate decarboxylase GadB | 0.0196 | 0.1061 | 1 |
Brugia malayi | Aromatic-L-amino-acid decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0314 | 0.1756 | 0.1756 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0099 | 0.0489 | 0.0489 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0034 | 0.0034 |
Brugia malayi | hypothetical protein | 0.0036 | 0.012 | 0.012 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0079 | 1 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0037 | 0.0123 | 0.0123 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0079 | 0.0079 |
Echinococcus granulosus | snurportin 1 | 0.0314 | 0.1756 | 0.1756 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.1061 | 0.1061 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0022 | 0.0034 | 0.4239 |
Brugia malayi | glutamate decarboxylase, 67 kDa isoform | 0.0196 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.0615 | 0.0615 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0034 | 0.0034 |
Echinococcus granulosus | pyridoxal dependent decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Schistosoma mansoni | transient receptor potential channel | 0.0099 | 0.0489 | 0.0489 |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 0.1702 | 0.1702 |
Trypanosoma cruzi | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0196 | 0.1061 | 0.1061 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0065 | 0.0292 | 0.0292 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0079 | 1 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0196 | 0.1061 | 0.5 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0099 | 0.0489 | 0.0489 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0079 | 0.0079 |
Schistosoma mansoni | hypothetical protein | 0.0314 | 0.1756 | 0.1756 |
Leishmania major | hypothetical protein, conserved | 0.0196 | 0.1061 | 0.1061 |
Brugia malayi | glutamate decarboxylase putative | 0.0196 | 0.1061 | 0.1061 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.1712 | 1 | 1 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0022 | 0.0034 | 0.0034 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0202 | 0.0202 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0202 | 0.0202 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.012 | 0.0087 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0109 | 0.0109 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0022 | 0.0034 | 0.4239 |
Brugia malayi | Pyridoxal-dependent decarboxylase conserved domain containing protein | 0.0196 | 0.1061 | 0.1061 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0079 | 0.0079 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0065 | 0.0292 | 0.0292 |
Echinococcus multilocularis | geminin | 0.0171 | 0.0913 | 0.0913 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0096 | 0.047 | 0.047 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0034 | 0.0034 |
Onchocerca volvulus | 0.0305 | 0.1702 | 0.5 | |
Schistosoma mansoni | transient receptor potential channel | 0.0065 | 0.0292 | 0.0292 |
Mycobacterium ulcerans | glutamate decarboxylase | 0.0196 | 0.1061 | 0.5 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Brugia malayi | RNA, U transporter 1 | 0.0084 | 0.0399 | 0.0399 |
Leishmania major | sphingosine 1-phosphate lyase | 0.1712 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0109 | 0.0109 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.012 | 0.012 |
Loa Loa (eye worm) | TDC-1 protein | 0.0196 | 0.1061 | 0.1061 |
Schistosoma mansoni | sphingosine phosphate lyase | 0.1712 | 1 | 1 |
Echinococcus multilocularis | sphingosine 1 phosphate lyase 1 | 0.1712 | 1 | 1 |
Trypanosoma brucei | sphingosine 1-phosphate lyase, putative | 0.1712 | 1 | 1 |
Trypanosoma cruzi | sphingosine 1-phosphate lyase, putative | 0.1712 | 1 | 1 |
Echinococcus granulosus | sphingosine 1 phosphate lyase 1 | 0.1712 | 1 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0047 | 0.0126 |
Entamoeba histolytica | s phingosine-1-phosphate lyase 1, putative | 0.1712 | 1 | 1 |
Echinococcus multilocularis | aromatic amino acid decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0079 | 0.0079 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0913 | 0.0913 |
Trypanosoma brucei | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0196 | 0.1061 | 0.1061 |
Schistosoma mansoni | ran | 0.0022 | 0.0034 | 0.0034 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0096 | 0.047 | 0.047 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0817 | 0.4724 | 0.4724 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0034 | 0.5 |
Loa Loa (eye worm) | sphingosine-1-phosphate lyase 1 | 0.0196 | 0.1061 | 0.1061 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0047 | 0.0047 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0079 | 0.0079 |
Schistosoma mansoni | ran | 0.0022 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0123 | 0.0123 |
Schistosoma mansoni | transient receptor potential channel | 0.0065 | 0.0292 | 0.0292 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0034 | 0.0034 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0913 | 0.0913 |
Brugia malayi | hypothetical protein | 0.0305 | 0.1702 | 0.1702 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0065 | 0.0292 | 0.0292 |
Trypanosoma cruzi | Pyridoxal-dependent decarboxylase conserved domain containing protein, putative | 0.0196 | 0.1061 | 0.1061 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.012 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0104 | 0.0104 |
Echinococcus granulosus | geminin | 0.0171 | 0.0913 | 0.0913 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0037 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | glutamate decarboxylase GAD1 | 0.0196 | 0.1061 | 0.1061 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.0615 | 0.0615 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.012 | 0.012 |
Trichomonas vaginalis | group II pyridoxal-5-phosphate decarboxylase, putative | 0.0196 | 0.1061 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0489 | 0.0489 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0034 | 0.4239 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0109 | 0.0109 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | aromatic L-amino acid decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0099 | 0.0489 | 0.0489 |
Loa Loa (eye worm) | hypothetical protein | 0.1712 | 1 | 1 |
Echinococcus multilocularis | pyridoxal dependent decarboxylase | 0.0196 | 0.1061 | 0.1061 |
Leishmania major | GTP-binding protein, putative | 0.0022 | 0.0034 | 0.0034 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.012 | 0.012 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.3 10'-3M | Inhibition of Musca domestica (house fly) NAIDM head acetylcholinesterase | ChEMBL. | No reference |
IC50 (binding) | = 2 10'-3M | Inhibition of Bos taurus (bovine) erythrocytes acetylcholinesterase | ChEMBL. | No reference |
IC50 (binding) | = 2 10'-3M | Inhibition of drug-susceptible Nephotettix cincticeps Ageo (green rice leafhopper) acetylcholinesterase | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.