TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 363.534 | Formula: C22H37NO3
H donors: 0 H acceptors: 1 LogP: 6.32 Rotable bonds: 15
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCCCCC(=O)N(Cc1ccc(c(c1)OC)OC)C
InChi: 1S/C22H37NO3/c1-5-6-7-8-9-10-11-12-13-14-22(24)23(2)18-19-15-16-20(25-3)21(17-19)26-4/h15-17H,5-14,18H2,1-4H3
InChiKey: OMSQGPXFLDSFES-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	NADH-ubiquinone oxidoreductase chain 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	NADH dehydrogenase subunit 1	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1,domain-containing	Get druggable targets OG5_128714	All targets in OG5_128714
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase subunit H	Get druggable targets OG5_128714	All targets in OG5_128714
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)	Get druggable targets OG5_128714	All targets in OG5_128714
Mycobacterium ulcerans	NADH dehydrogenase subunit H	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000568,ATPase, F0 complex, subunit A,domain-containing	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000298,Cytochrome c oxidase, subunit III;IPR000568,ATPase, F0 compl	Get druggable targets OG5_128714	All targets in OG5_128714
Echinococcus granulosus	NADH dehydrogenase subunit 1	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000568,ATPase, F0 complex, subunit A,domain-containing	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000568,ATPase, F0 complex, subunit A,domain-containing	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	IPR000883,Cytochrome c oxidase, subunit I;IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1,domain-containing	Get druggable targets OG5_128714	All targets in OG5_128714

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Plasmodium vivax	hypothetical protein, conserved	0.0117	0.1845	1
Echinococcus multilocularis	hypothetical protein	0.0061	0.0922	0.1628
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0351	0.5664	1
Brugia malayi	NADH dehydrogenase subunit 1, identical	0.0048	0.072	0.127
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0043	0.064	0.3061
Loa Loa (eye worm)	chitin binding Peritrophin-A domain-containing protein	0.0009	0.0077	0.0134
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0064	0.097	0.1712
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Onchocerca volvulus	Putative endochitinase	0.0074	0.1137	0.5995
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0959	0.168
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	Glycosyl hydrolases family 18 protein	0.0011	0.0109	0.0192
Entamoeba histolytica	protein kinase, putative	0.0109	0.171	0.3728
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0064	0.097	0.0875
Echinococcus granulosus	cyclin dependent kinase 9	0.0064	0.097	0.1712
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase subunit H	0.0179	0.2859	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus granulosus	transient receptor potential cation channel	0.0004	0.000000032858	0.000000058014
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	hypothetical protein	0.0351	0.5664	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0064	0.097	0.0875
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0043	0.064	0.5
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0043	0.064	0.3061
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	dual specificity	0.0109	0.171	0.3019
Brugia malayi	hypothetical protein	0.0048	0.072	0.127
Schistosoma mansoni	amine oxidase	0.0043	0.064	0.1131
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0043	0.064	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	endochitinase	0.0074	0.1137	0.2007
Echinococcus granulosus	calcium activated potassium channel	0.0007	0.0043	0.0076
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0043	0.064	0.0537
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0043	0.064	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0064	0.097	0.1712
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.097	0.1712
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0109	0.171	0.2842
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0351	0.5664	1
Schistosoma mansoni	NADH dehydrogenase subunit 1	0.0048	0.072	0.127
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0043	0.064	0.3061
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Schistosoma mansoni	serine/threonine protein kinase	0.0274	0.4404	0.7776
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.0274	0.4404	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Leishmania major	serine/threonine kinase-like protein, putative	0.0064	0.097	0.0875
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0274	0.4404	1
Mycobacterium ulcerans	formate hydrogenlyase HycD	0.0048	0.072	0.0617
Brugia malayi	SWIRM domain containing protein	0.0043	0.064	0.1131
Echinococcus multilocularis	dual specificity	0.0274	0.4404	0.7776
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.064	0.3061
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0064	0.097	0.0875
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0064	0.097	0.1698
Brugia malayi	Hepatocellular carcinoma-associated antigen 59 family protein	0.0117	0.1845	0.3258
Schistosoma mansoni	protein kinase	0.0064	0.097	0.1712
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Loa Loa (eye worm)	chitinase I	0.0074	0.1137	0.1991
Onchocerca volvulus		0.0048	0.072	0.3634
Entamoeba histolytica	hypothetical protein	0.0109	0.171	0.3728
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.097	0.2004
Onchocerca volvulus	Putative endochitinase	0.0074	0.1137	0.5995
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0064	0.097	0.1712
Mycobacterium ulcerans	monoamine oxidase	0.0043	0.064	0.0537
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0064	0.097	0.1698
Brugia malayi	hypothetical protein	0.0011	0.0109	0.0192
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0064	0.097	0.4957
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Onchocerca volvulus	Putative endochitinase	0.0083	0.1282	0.6817
Echinococcus granulosus	NADH dehydrogenase subunit 1	0.0179	0.2859	0.5048
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	NADH dehydrogenase subunit 1	0.0048	0.072	0.127
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Mycobacterium ulcerans	chitinase/cellulase	0.0063	0.0959	0.086
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0064	0.097	0.0875
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)	0.0179	0.2859	0.2565
Loa Loa (eye worm)	cuticular endochitinase	0.0074	0.1137	0.1991
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0043	0.064	0.1131
Brugia malayi	hypothetical protein	0.0043	0.064	0.1131
Brugia malayi	Chitin binding Peritrophin-A domain containing protein	0.0009	0.0077	0.0136
Entamoeba histolytica	protein kinase, putative	0.0109	0.171	0.3728
Onchocerca volvulus	Putative endochitinase	0.0083	0.1282	0.6817
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1845	0.3231
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0043	0.064	0.1131
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0064	0.097	0.4957
Plasmodium falciparum	MO15-related protein kinase	0.0064	0.097	0.4957
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0274	0.4404	0.7711
Echinococcus multilocularis	transient receptor potential cation channel	0.0004	0.000000032858	0.000000058014
Onchocerca volvulus	Putative endochitinase	0.0011	0.0109	0.0182
Loa Loa (eye worm)	glycosyl hydrolase family 18 protein	0.0011	0.0109	0.0191
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0.171	0.3728
Echinococcus multilocularis		0.0043	0.064	0.1131
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0109	0.0191
Brugia malayi	Chitin binding Peritrophin-A domain containing protein	0.0009	0.0077	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0351	0.5664	1
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0043	0.064	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0109	0.171	0.2994
Brugia malayi	Protein kinase domain containing protein	0.0109	0.171	0.3019
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0109	0.171	0.2842
Schistosoma mansoni	amine oxidase	0.0043	0.064	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1662	0.2911
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0064	0.097	0.1712
Loa Loa (eye worm)	NADH dehydrogenase subunit 1	0.0048	0.072	0.126
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	transient receptor potential cation channel	0.0004	0.000000032858	0.000000058014
Loa Loa (eye worm)	chitin binding Peritrophin-A domain-containing protein	0.0009	0.0077	0.0134
Schistosoma mansoni	hypothetical protein	0.0351	0.5664	1
Brugia malayi	Protein kinase domain containing protein	0.0064	0.097	0.1712
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0064	0.097	0.1712
Echinococcus granulosus	mitogen activated protein kinase 15	0.0064	0.097	0.1712
Brugia malayi	Endochitinase	0.0011	0.0109	0.0192
Echinococcus multilocularis	Hepatocellular carcinoma associated antigen 59	0.0117	0.1845	0.3258
Entamoeba histolytica	protein kinase domain containing protein	0.0274	0.4404	1
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Schistosoma mansoni	chitinase	0.0011	0.0109	0.0192
Schistosoma mansoni	hypothetical protein	0.0179	0.2859	0.5048
Brugia malayi	endochitinase	0.0083	0.1282	0.2264
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0617	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0109	0.171	0.3019
Schistosoma mansoni	hypothetical protein	0.0117	0.1845	0.3258
Schistosoma mansoni	hypothetical protein	0.0061	0.0922	0.1628
Giardia lamblia	Kinase, CMGC DYRK	0.0274	0.4404	1
Echinococcus granulosus	Glycoside hydrolase chitinase domain containing protein 1	0.0011	0.0109	0.0192
Schistosoma mansoni	serine/threonine kinase	0.0064	0.097	0.1712
Plasmodium falciparum	conserved protein, unknown function	0.0117	0.1845	1
Brugia malayi	Endochitinase	0.0083	0.1282	0.2264
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0274	0.4404	0.7776
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1662	0.2911
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Leishmania major	chitinase	0.0074	0.1137	0.1319
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0043	0.064	0.3061
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.064	0.3061
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Onchocerca volvulus		0.0117	0.1845	1
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.0274	0.4404	1
Mycobacterium tuberculosis	Possible formate hydrogenlyase HycD (FHL)	0.0048	0.072	0.0091
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	Chitin binding Peritrophin-A domain containing protein	0.0009	0.0077	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0274	0.4404	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	amine oxidase, flavin-containing family protein	0.0043	0.064	0.1131
Brugia malayi	Chitin binding Peritrophin-A domain containing protein	0.0009	0.0077	0.0136
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	serine/threonine kinase, putative	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	Glycoside hydrolase, chitinase domain containing protein 1	0.0011	0.0109	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Onchocerca volvulus	Putative endochitinase	0.0083	0.1282	0.6817
Entamoeba histolytica	chitinase, putative	0.0074	0.1137	0.2393
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Brugia malayi	Glycosyl hydrolases family 18 protein	0.0011	0.0109	0.0192
Mycobacterium tuberculosis	Possible chitinase	0.0063	0.0959	0.0369
Echinococcus multilocularis	dual specificity	0.0274	0.4404	0.7776
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0351	0.5664	1
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.097	0.2004
Entamoeba histolytica	cell division protein kinase 2, putative	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Plasmodium falciparum	protoporphyrinogen oxidase	0.0043	0.064	0.3061
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0109	0.171	0.2842
Loa Loa (eye worm)	haspin protein kinase	0.0351	0.5664	0.9917
Entamoeba histolytica	hypothetical protein	0.0061	0.0922	0.1893
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0351	0.5664	1
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0573	0.9291	1
Echinococcus granulosus	Hepatocellular carcinoma associated antigen 59	0.0117	0.1845	0.3258
Loa Loa (eye worm)	haspin protein kinase	0.0354	0.5711	1
Echinococcus granulosus	dual specificity	0.0274	0.4404	0.7776
Echinococcus granulosus	dual specificity	0.0274	0.4404	0.7776
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	dual specificity	0.0274	0.4404	0.7776
Echinococcus granulosus	Pfam-B_8186 domain containing protein	0.0061	0.0922	0.1628
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Echinococcus granulosus	dual specificity	0.0109	0.171	0.3019
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0109	0.171	0.2156
Mycobacterium ulcerans	oxidoreductase	0.0043	0.064	0.0537
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	GSG2	0.0351	0.5664	1
Mycobacterium ulcerans	NADH dehydrogenase subunit H	0.0179	0.2859	0.278
Toxoplasma gondii	hypothetical protein	0.0117	0.1845	0.3201
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Mycobacterium ulcerans	chitinase/cellulase	0.0063	0.0959	0.086
Echinococcus multilocularis	calcium activated potassium channel	0.0007	0.0043	0.0076
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Loa Loa (eye worm)	haspin protein kinase	0.0351	0.5664	0.9917
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.097	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1845	0.3231
Loa Loa (eye worm)	microfilarial chitinase	0.0072	0.1105	0.1934
Brugia malayi	Cell division protein kinase 2	0.0064	0.097	0.1712
Trichomonas vaginalis	G protein-coupled receptor kinase, putative	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Entamoeba histolytica	protein kinase, putative	0.0274	0.4404	1
Mycobacterium ulcerans	dehydrogenase	0.0043	0.064	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0109	0.0191
Onchocerca volvulus		0.0048	0.072	0.3634
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	cyclin dependent kinase 9	0.0064	0.097	0.1712
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0043	0.064	0.1131
Brugia malayi	hypothetical protein	0.0011	0.0109	0.0192
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0043	0.064	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Onchocerca volvulus		0.0043	0.064	0.3187
Echinococcus granulosus	dual specificity	0.0274	0.4404	0.7776
Onchocerca volvulus	Putative chitinase	0.0011	0.0109	0.0182
Onchocerca volvulus		0.0117	0.1845	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	protein kinase atmrk1, putative	0.0064	0.097	0.2004

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.49	Inhibition of Bos taurus (bovine) heart submitochondrial particle NDH1 assessed as NADH-DB reductase activity	ChEMBL.	8573592

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2273121

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1805114