Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | glucosidase, putative | 0.0122 | 0.0067 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0171 | 0.0251 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1332 | 0.4588 | 0.6376 |
Loa Loa (eye worm) | hypothetical protein | 0.0816 | 0.266 | 0.3274 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0178 | 0.0277 | 0.0211 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0145 | 0.0153 | 0.0189 |
Schistosoma mansoni | alpha glucosidase | 0.0122 | 0.0067 | 0.0083 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0122 | 0.0067 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0122 | 0.0067 | 0.0083 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.203 | 0.7196 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0142 | 0.0142 | 0.0175 |
Trichomonas vaginalis | glycoside hydrolase, putative | 0.0511 | 0.1522 | 0.2115 |
Loa Loa (eye worm) | acetyltransferase | 0.0142 | 0.0142 | 0.0175 |
Loa Loa (eye worm) | hypothetical protein | 0.0522 | 0.1562 | 0.1923 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.203 | 0.7196 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1332 | 0.4588 | 0.6376 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0178 | 0.0277 | 0.0211 |
Onchocerca volvulus | 0.0352 | 0.0927 | 0.0541 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0122 | 0.0067 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.032 | 0.0808 | 0.1123 |
Plasmodium vivax | hypothetical protein, conserved | 0.0171 | 0.0251 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0142 | 0.0142 | 0.0075 |
Toxoplasma gondii | melibiase subfamily protein | 0.0178 | 0.0277 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0304 | 0.0746 | 0.0919 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0142 | 0.0142 | 0.0175 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.203 | 0.7196 | 0.8859 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0122 | 0.0067 | 0.0094 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0122 | 0.0067 | 0.0094 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0122 | 0.0067 | 0.0094 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.2781 | 1 | 0.5 |
Schistosoma mansoni | beta-galactosidase | 0.0522 | 0.1562 | 0.1923 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0122 | 0.0067 | 0.0094 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0633 | 0.1979 | 0.1924 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1332 | 0.4588 | 0.6376 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0153 | 0.0189 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0178 | 0.0277 | 0.0341 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0145 | 0.0153 | 0.0213 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.203 | 0.7196 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0138 | 0.0128 | 0.006 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0122 | 0.0067 | 0.0094 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0633 | 0.1979 | 0.1924 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.203 | 0.7196 | 1 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.2278 | 0.8123 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0122 | 0.0067 | 0.0094 |
Entamoeba histolytica | beta-galactosidase, putative | 0.0216 | 0.042 | 1 |
Echinococcus granulosus | beta galactosidase | 0.0522 | 0.1562 | 0.1504 |
Echinococcus multilocularis | beta galactosidase | 0.0522 | 0.1562 | 0.1504 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0178 | 0.0277 | 0.0211 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1404 | 0.4856 | 0.6748 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.1332 | 0.4588 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1332 | 0.4588 | 0.6376 |
Schistosoma mansoni | alpha-glucosidase | 0.0578 | 0.177 | 0.2179 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0122 | 0.0067 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.0718 | 0.0884 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.2781 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1404 | 0.4856 | 0.6748 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0633 | 0.1979 | 0.2436 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0145 | 0.0153 | 0.0189 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.032 | 0.0808 | 0.1123 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0178 | 0.0277 | 0.0341 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0122 | 0.0067 | 0.0094 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1332 | 0.4588 | 0.6376 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0999 | 0.3346 | 0.465 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0178 | 0.0277 | 0.0341 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.203 | 0.7196 | 0.8859 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0178 | 0.0277 | 0.0341 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0122 | 0.0067 | 0.0083 |
Loa Loa (eye worm) | glycosyl hydrolase family 2 | 0.0112 | 0.0032 | 0.004 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.203 | 0.7196 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0633 | 0.1979 | 0.2436 |
Schistosoma mansoni | alpha-l-fucosidase | 0.2278 | 0.8123 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0122 | 0.0067 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0122 | 0.0067 | 0.0094 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.203 | 0.7196 | 1 |
Brugia malayi | Melibiase family protein | 0.0145 | 0.0153 | 0.0189 |
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | 0.0112 | 0.0032 | 0.004 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1332 | 0.4588 | 0.6376 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0633 | 0.1979 | 0.1924 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.2278 | 0.8123 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0578 | 0.177 | 0.2179 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0999 | 0.3346 | 0.465 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1332 | 0.4588 | 0.6376 |
Brugia malayi | hypothetical protein | 0.0296 | 0.0718 | 0.0884 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.