Detailed information for compound 1806466

Basic information

Technical information
  • TDR Targets ID: 1806466
  • Name: 1-(2-chlorophenoxy)butan-2-yl N-(phenylmethyl )carbamate
  • MW: 333.809 | Formula: C18H20ClNO3
  • H donors: 1 H acceptors: 1 LogP: 4.69 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(OC(=O)NCc1ccccc1)COc1ccccc1Cl
  • InChi: 1S/C18H20ClNO3/c1-2-15(13-22-17-11-7-6-10-16(17)19)23-18(21)20-12-14-8-4-3-5-9-14/h3-11,15H,2,12-13H2,1H3,(H,20,21)
  • InChiKey: NIUNXXYMLCLITB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2-chlorophenoxy)methyl]propyl N-(phenylmethyl)carbamate
  • N-(phenylmethyl)carbamic acid 1-[(2-chlorophenoxy)methyl]propyl ester
  • N-(benzyl)carbamic acid 1-[(2-chlorophenoxy)methyl]propyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) 15-cis-phytoene desaturase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible oxidoreductase Get druggable targets OG5_136205 All targets in OG5_136205
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0038 0.0017 0.0309
Loa Loa (eye worm) hypothetical protein 0.0073 0.0252 0.1488
Mycobacterium tuberculosis Conserved protein 0.012 0.0558 0.1157
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0038 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0133
Echinococcus multilocularis survival motor neuron protein 1 0.0277 0.1595 0.1595
Brugia malayi jmjC domain containing protein 0.0112 0.0505 0.3166
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0133
Mycobacterium ulcerans hypothetical protein 0.012 0.0558 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0038 0.0017 0.0017
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0038 0.0017 0.0309
Mycobacterium tuberculosis Probable dehydrogenase 0.0233 0.1303 0.2702
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0133
Loa Loa (eye worm) hypothetical protein 0.013 0.0625 0.3851
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0133
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.012 0.0558 0.1157
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.012 0.0558 0.0558
Toxoplasma gondii thioredoxin reductase 0.0102 0.044 0.7889
Brugia malayi Probable ClpP-like protease 0.0089 0.0356 0.2231
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0017 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.0558 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0017 0.0309
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0153 0.0317
Schistosoma mansoni cellular tumor antigen P53 0.0169 0.0882 0.0882
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0144 0.0715 0.0715
Brugia malayi Valyl-tRNA synthetase 0.0038 0.0017 0.0108
Loa Loa (eye worm) hypothetical protein 0.012 0.0558 0.3426
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0153 0.0317
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.004 0.0141
Mycobacterium ulcerans esterase/lipase LipP 0.012 0.0558 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0477 0.2988
Mycobacterium tuberculosis Probable esterase LipL 0.012 0.0558 0.1157
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0791 0.0791
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.004 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0017 0.0133
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.012 0.0558 0.3426
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0477 0.2911
Plasmodium falciparum heterochromatin protein 1 0.0038 0.0017 0.0391
Mycobacterium leprae conserved hypothetical protein 0.012 0.0558 0.3065
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0133
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0356 0.8087
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.0356 0.1536
Trichomonas vaginalis esterase, putative 0.012 0.0558 0.4299
Loa Loa (eye worm) beta-lactamase 0.012 0.0558 0.3426
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0017 0.0133
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0232 0.1362
Loa Loa (eye worm) hypothetical protein 0.012 0.0558 0.3426
Schistosoma mansoni chromobox protein 0.0232 0.1298 0.1298
Trichomonas vaginalis hypothetical protein 0.0038 0.0017 0.0133
Schistosoma mansoni chromobox protein 0.0038 0.0017 0.0017
Loa Loa (eye worm) thioredoxin reductase 0.0102 0.044 0.268
Brugia malayi hypothetical protein 0.0038 0.0017 0.0108
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0356 0.638
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0233 0.1303 0.8703
Echinococcus granulosus thioredoxin glutathione reductase 0.0102 0.044 0.044
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0567 0.3486
Mycobacterium ulcerans beta-lactamase 0.012 0.0558 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0356 0.638
Echinococcus multilocularis chromobox protein 1 0.0232 0.1298 0.1298
Mycobacterium tuberculosis Conserved protein 0.012 0.0558 0.1157
Mycobacterium tuberculosis Probable oxidoreductase 0.0258 0.1474 0.3058
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0038 0.0017 0.0017
Loa Loa (eye worm) glutathione reductase 0.0102 0.044 0.268
Loa Loa (eye worm) hypothetical protein 0.0169 0.0882 0.5484
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.012 0.0558 0.0558
Plasmodium vivax hypothetical protein, conserved 0.012 0.0558 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0258 0.1474 1
Trypanosoma brucei hypothetical protein, conserved 0.012 0.0558 1
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0017 0.0133
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.0558 1
Brugia malayi Associated with TFs and helicases family protein 0.0038 0.0017 0.0108
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0017 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0133
Plasmodium vivax heterochromatin protein 1, putative 0.0038 0.0017 0.0309
Schistosoma mansoni hypothetical protein 0.0073 0.0252 0.0252
Echinococcus multilocularis thioredoxin glutathione reductase 0.0102 0.044 0.044
Loa Loa (eye worm) hypothetical protein 0.012 0.0558 0.3426
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0153 0.0153
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0017 0.0133
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0017 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0017 0.0133
Mycobacterium tuberculosis Probable conserved lipoprotein 0.012 0.0558 0.1157
Trypanosoma brucei trypanothione reductase 0.0102 0.044 0.7889
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.014 0.0875
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0477 0.2988
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0089 0.0356 0.638
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0258 0.1474 0.3058
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0038 0.0017 0.0391
Entamoeba histolytica hypothetical protein 0.0038 0.0017 1
Plasmodium vivax thioredoxin reductase, putative 0.0102 0.044 0.7889
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.012 0.0558 0.3497
Echinococcus multilocularis chromobox protein 2 0.0038 0.0017 0.0017
Trichomonas vaginalis chromobox protein, putative 0.0232 0.1298 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0153 0.0861
Brugia malayi beta-lactamase family protein 0.012 0.0558 0.3497
Onchocerca volvulus 0.012 0.0558 0.6248
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0017 0.0133
Onchocerca volvulus 0.0102 0.0439 0.4879
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0144 0.0715 0.0715
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0252 0.158
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0374 0.2884
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0153 0.0153
Mycobacterium tuberculosis Conserved protein 0.012 0.0558 0.1157
Loa Loa (eye worm) hypothetical protein 0.0102 0.0439 0.2676
Mycobacterium ulcerans lipase LipD 0.012 0.0558 1
Trichomonas vaginalis chromobox protein, putative 0.014 0.069 0.5317
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0038 0.0017 0.0017
Brugia malayi CHD4 protein 0.0038 0.0017 0.0108
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0258 0.1474 0.3058
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.0356 0.638
Brugia malayi SET domain containing protein 0.0038 0.0017 0.0108
Brugia malayi hypothetical protein 0.0037 0.0008 0.005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0133
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0017 0.0133
Toxoplasma gondii ABC1 family protein 0.012 0.0558 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0038 0.0017 0.0108
Brugia malayi Heterochromatin protein 1 0.0232 0.1298 0.8135
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.004 0.004
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.004 0.004
Brugia malayi MH2 domain containing protein 0.0121 0.0567 0.3557
Schistosoma mansoni hypothetical protein 0.0038 0.0017 0.0017
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0017 0.0309
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0038 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0374 0.2884
Trypanosoma cruzi trypanothione reductase, putative 0.0102 0.044 0.7889
Echinococcus multilocularis Chromo domain 0.0038 0.0017 0.0017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0017 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0133
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.0356 0.0356
Leishmania major hypothetical protein, conserved 0.012 0.0558 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0567 0.3486
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0233 0.1303 0.2702
Loa Loa (eye worm) hypothetical protein 0.012 0.0558 0.3426
Echinococcus granulosus jumonji domain containing protein 0.0047 0.008 0.008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0233 0.1303 0.2702
Echinococcus multilocularis Chromobox protein 3 0.0038 0.0017 0.0017
Trichomonas vaginalis chromobox protein, putative 0.0232 0.1298 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0008 0.0008
Echinococcus granulosus survival motor neuron protein 1 0.0277 0.1595 0.1595
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0017 0.0133
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0089 0.0356 0.638
Trichomonas vaginalis D-aminoacylase, putative 0.012 0.0558 0.4299
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0133
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.0505 0.0505
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0038 0.0017 1
Mycobacterium tuberculosis Probable hydrolase 0.012 0.0558 0.1157
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0765 0.4821 1
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0791 0.0791
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0625 0.4815
Brugia malayi chromobox protein homolog 3 0.013 0.0625 0.3917
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.0791 0.0791
Mycobacterium tuberculosis Probable lipase LipD 0.012 0.0558 0.1157
Echinococcus granulosus chromobox protein 1 0.0232 0.1298 0.1298
Echinococcus multilocularis tumor protein p63 0.1154 0.739 0.739
Brugia malayi beta-lactamase 0.012 0.0558 0.3497
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0038 0.0017 0.0391
Echinococcus multilocularis chromobox protein 1 0.0232 0.1298 0.1298
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.012 0.0558 0.3426
Brugia malayi glutathione reductase 0.0102 0.044 0.2759
Schistosoma mansoni hypothetical protein 0.0056 0.014 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0017 0.0133
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0017 0.0133
Echinococcus granulosus tumor protein p63 0.1154 0.739 0.739
Trichomonas vaginalis D-aminoacylase, putative 0.012 0.0558 0.4299
Brugia malayi Protein cec-1. 0.0038 0.0017 0.0108
Schistosoma mansoni microtubule-associated protein tau 0.1549 1 1
Loa Loa (eye worm) hypothetical protein 0.0277 0.1595 1
Mycobacterium tuberculosis Probable reductase 0.0233 0.1303 0.2702
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0038 0.0017 0.0309
Brugia malayi M-phase phosphoprotein, mpp8 0.0038 0.0017 0.0108
Brugia malayi hypothetical protein 0.0277 0.1595 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.0505 0.0505
Leishmania major trypanothione reductase 0.0102 0.044 0.7889
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0356 1
Schistosoma mansoni jumonji domain containing protein 0.0089 0.0353 0.0353
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0017 0.0133
Schistosoma mansoni chromobox protein 0.0038 0.0017 0.0017
Brugia malayi jmjC domain containing protein 0.0041 0.004 0.0248
Plasmodium falciparum glutathione reductase 0.0102 0.044 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.012 0.0558 0.4299
Brugia malayi beta-lactamase family protein 0.012 0.0558 0.3497
Schistosoma mansoni hypothetical protein 0.0037 0.0008 0.0008
Echinococcus granulosus Chromo domain 0.0038 0.0017 0.0017
Onchocerca volvulus 0.0169 0.0882 1
Plasmodium falciparum thioredoxin reductase 0.0102 0.044 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0477 0.2911
Echinococcus multilocularis beta LACTamase domain containing family member 0.012 0.0558 0.0558
Plasmodium vivax glutathione reductase, putative 0.0102 0.044 0.7889
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0038 0.0017 0.0017
Loa Loa (eye worm) heterochromatin protein 1 0.0232 0.1298 0.8114
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0038 0.0017 0.0017
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0017 0.0133
Brugia malayi Thioredoxin reductase 0.0102 0.044 0.2759
Trichomonas vaginalis Heterochromatin protein, putative 0.0038 0.0017 0.0133
Entamoeba histolytica hypothetical protein 0.0038 0.0017 1
Mycobacterium leprae Probable lipase LipE 0.012 0.0558 0.3065
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.012 0.0558 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.014 0.069 0.7775
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0017 0.0133
Schistosoma mansoni survival motor neuron protein 0.0056 0.014 0.014
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0233 0.1303 0.2702
Entamoeba histolytica hypothetical protein 0.0038 0.0017 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.013 0.0625 0.7022
Mycobacterium tuberculosis Probable lipase LipE 0.012 0.0558 0.1157
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0625 0.4815
Schistosoma mansoni chromobox protein 0.0232 0.1298 0.1298
Onchocerca volvulus 0.012 0.0558 0.6248
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0038 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0089 0.0356 0.2146
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0038 0.0017 0.0017
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0233 0.1303 0.2702
Echinococcus granulosus chromobox protein 1 0.0232 0.1298 0.1298
Trichomonas vaginalis chromobox protein, putative 0.014 0.069 0.5317
Trichomonas vaginalis penicillin-binding protein, putative 0.012 0.0558 0.4299
Echinococcus granulosus chromobox protein 2 0.0038 0.0017 0.0017
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0144 0.0715 0.0715
Echinococcus multilocularis microtubule associated protein 2 0.1549 1 1
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.008 0.008
Trichomonas vaginalis penicillin-binding protein, putative 0.012 0.0558 0.4299
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0356 1
Echinococcus granulosus Chromobox protein 3 0.0038 0.0017 0.0017
Onchocerca volvulus 0.0056 0.014 0.1414
Mycobacterium tuberculosis Possible oxidoreductase 0.0558 0.3456 0.7168
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0008 0.0008
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.0356 0.0356
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0089 0.0356 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.012 0.0558 0.1157
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0038 0.0017 0.0133
Loa Loa (eye worm) hypothetical protein 0.012 0.0558 0.3426
Onchocerca volvulus 0.012 0.0558 0.6248
Echinococcus granulosus beta LACTamase domain containing family member 0.012 0.0558 0.0558
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0102 0.044 0.0913

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 4 Inhibition of Capsicum annuum (pepper) zeta-carotene desaturase expressed in Escherichia coli using zeta-carotene as substrate after 8 hr by Dixon plot analysis ChEMBL. 12720390
IC50 (binding) = 7 Inhibition of Synechococcus PCC 7942 phytoene desaturase expressed in Escherichia coli JM101 using phytoene as substrate after 8 hr by Dixon plot analysis ChEMBL. 12720390

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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