TDR Targets

Basic information

Technical information

TDR Targets ID: 1806970
Name: N-[(3,4-dimethoxyphenyl)methyl]dodecanamide
MW: 349.508 | Formula: C21H35NO3
H donors: 1 H acceptors: 1 LogP: 6.14 Rotable bonds: 15
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCCCCC(=O)NCc1ccc(c(c1)OC)OC
InChi: 1S/C21H35NO3/c1-4-5-6-7-8-9-10-11-12-13-21(23)22-17-18-14-15-19(24-2)20(16-18)25-3/h14-16H,4-13,17H2,1-3H3,(H,22,23)
InChiKey: LMBRICIUSBTZFS-UHFFFAOYSA-N

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3,4-dimethoxybenzyl)lauramide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	NADH-ubiquinone oxidoreductase chain 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1,domain-containing	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000298,Cytochrome c oxidase, subunit III;IPR000568,ATPase, F0 compl	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000568,ATPase, F0 complex, subunit A,domain-containing	Get druggable targets OG5_128714	All targets in OG5_128714
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)	Get druggable targets OG5_128714	All targets in OG5_128714
Mycobacterium ulcerans	NADH dehydrogenase subunit H	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128714	All targets in OG5_128714
Echinococcus granulosus	NADH dehydrogenase subunit 1	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000568,ATPase, F0 complex, subunit A,domain-containing	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	IPR000883,Cytochrome c oxidase, subunit I;IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1,domain-containing	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma japonicum	IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000568,ATPase, F0 complex, subunit A,domain-containing	Get druggable targets OG5_128714	All targets in OG5_128714
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_128714	All targets in OG5_128714
Candida albicans	NADH dehydrogenase subunit 1	Get druggable targets OG5_128714	All targets in OG5_128714
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase subunit H	Get druggable targets OG5_128714	All targets in OG5_128714

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	hypothetical protein	0.0351	0.5664	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus granulosus	dual specificity	0.0274	0.4404	0.7776
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	Hepatocellular carcinoma associated antigen 59	0.0117	0.1845	0.3258
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Onchocerca volvulus		0.0117	0.1845	1
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0064	0.097	0.1712
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0274	0.4404	0.7776
Echinococcus multilocularis	dual specificity	0.0274	0.4404	0.7776
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0109	0.171	0.2842
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Onchocerca volvulus	Putative chitinase	0.0011	0.0109	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Echinococcus granulosus	dual specificity	0.0274	0.4404	0.7776
Mycobacterium ulcerans	NADH dehydrogenase subunit H	0.0179	0.2859	0.278
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0064	0.097	0.1712
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0351	0.5664	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1845	0.3231
Echinococcus granulosus	Pfam-B_8186 domain containing protein	0.0061	0.0922	0.1628
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0109	0.171	0.2842
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1662	0.2911
Brugia malayi	hypothetical protein	0.0043	0.064	0.1131
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Mycobacterium ulcerans	formate hydrogenlyase HycD	0.0048	0.072	0.0617
Schistosoma mansoni	NADH dehydrogenase subunit 1	0.0048	0.072	0.127
Schistosoma mansoni	serine/threonine kinase	0.0064	0.097	0.1712
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1845	0.3231
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	protein kinase atmrk1, putative	0.0064	0.097	0.2004
Mycobacterium ulcerans	chitinase/cellulase	0.0063	0.0959	0.086
Schistosoma mansoni	amine oxidase	0.0043	0.064	0.1131
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0351	0.5664	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	Glycosyl hydrolases family 18 protein	0.0011	0.0109	0.0192
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Entamoeba histolytica	protein kinase domain containing protein	0.0274	0.4404	1
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0043	0.064	0.3061
Mycobacterium ulcerans	oxidoreductase	0.0043	0.064	0.0537
Echinococcus multilocularis	Glycoside hydrolase, chitinase domain containing protein 1	0.0011	0.0109	0.0192
Onchocerca volvulus	Putative endochitinase	0.0083	0.1282	0.6817
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0064	0.097	0.0875
Mycobacterium tuberculosis	Possible formate hydrogenlyase HycD (FHL)	0.0048	0.072	0.0091
Brugia malayi	NADH dehydrogenase subunit 1, identical	0.0048	0.072	0.127
Brugia malayi	Chitin binding Peritrophin-A domain containing protein	0.0009	0.0077	0.0136
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0064	0.097	0.4957
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0064	0.097	0.0875
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0351	0.5664	1
Brugia malayi	Protein kinase domain containing protein	0.0064	0.097	0.1712
Loa Loa (eye worm)	microfilarial chitinase	0.0072	0.1105	0.1934
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	endochitinase	0.0074	0.1137	0.2007
Schistosoma mansoni	amine oxidase	0.0043	0.064	0.1131
Brugia malayi	Chitin binding Peritrophin-A domain containing protein	0.0009	0.0077	0.0136
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0043	0.064	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Onchocerca volvulus	Putative endochitinase	0.0083	0.1282	0.6817
Leishmania major	serine/threonine kinase-like protein, putative	0.0064	0.097	0.0875
Plasmodium falciparum	MO15-related protein kinase	0.0064	0.097	0.4957
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1662	0.2911
Plasmodium falciparum	protoporphyrinogen oxidase	0.0043	0.064	0.3061
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0064	0.097	0.4957
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0043	0.064	0.3061
Onchocerca volvulus		0.0117	0.1845	1
Brugia malayi	Chitin binding Peritrophin-A domain containing protein	0.0009	0.0077	0.0136
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Loa Loa (eye worm)	cuticular endochitinase	0.0074	0.1137	0.1991
Echinococcus multilocularis	transient receptor potential cation channel	0.0004	0.000000032858	0.000000058014
Plasmodium falciparum	conserved protein, unknown function	0.0117	0.1845	1
Brugia malayi	Hepatocellular carcinoma-associated antigen 59 family protein	0.0117	0.1845	0.3258
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0043	0.064	0.1131
Mycobacterium tuberculosis	Possible chitinase	0.0063	0.0959	0.0369
Echinococcus multilocularis	dual specificity	0.0274	0.4404	0.7776
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0043	0.064	0.3061
Brugia malayi	hypothetical protein	0.0011	0.0109	0.0192
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Entamoeba histolytica	hypothetical protein	0.0109	0.171	0.3728
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0043	0.064	0.1131
Schistosoma mansoni	hypothetical protein	0.0351	0.5664	1
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0064	0.097	0.0875
Entamoeba histolytica	chitinase, putative	0.0074	0.1137	0.2393
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0109	0.171	0.2156
Echinococcus granulosus	mitogen activated protein kinase 15	0.0064	0.097	0.1712
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0274	0.4404	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.0064	0.097	0.2004
Echinococcus granulosus	dual specificity	0.0109	0.171	0.3019
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0351	0.5664	1
Brugia malayi	NADH dehydrogenase subunit 1	0.0048	0.072	0.127
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Loa Loa (eye worm)	haspin protein kinase	0.0351	0.5664	0.9917
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0351	0.5664	1
Schistosoma mansoni	protein kinase	0.0064	0.097	0.1712
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Schistosoma mansoni	serine/threonine protein kinase	0.0109	0.171	0.3019
Loa Loa (eye worm)	chitin binding Peritrophin-A domain-containing protein	0.0009	0.0077	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Brugia malayi	hypothetical protein	0.0048	0.072	0.127
Loa Loa (eye worm)	haspin protein kinase	0.0351	0.5664	0.9917
Schistosoma mansoni	hypothetical protein	0.0061	0.0922	0.1628
Echinococcus multilocularis	transient receptor potential cation channel	0.0004	0.000000032858	0.000000058014
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0043	0.064	0.3061
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0109	0.0191
Onchocerca volvulus	Putative endochitinase	0.0011	0.0109	0.0182
Echinococcus granulosus	Glycoside hydrolase chitinase domain containing protein 1	0.0011	0.0109	0.0192
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Entamoeba histolytica	protein kinase domain containing protein	0.0109	0.171	0.3728
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.064	0.3061
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.064	0.3061
Echinococcus multilocularis	hypothetical protein	0.0061	0.0922	0.1628
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Onchocerca volvulus		0.0043	0.064	0.3187
Entamoeba histolytica	protein kinase, putative	0.0109	0.171	0.3728
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0274	0.4404	0.7711
Schistosoma mansoni	serine/threonine protein kinase	0.0274	0.4404	0.7776
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Brugia malayi	endochitinase	0.0083	0.1282	0.2264
Echinococcus multilocularis	dual specificity	0.0274	0.4404	0.7776
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0064	0.097	0.1698
Onchocerca volvulus	Putative endochitinase	0.0083	0.1282	0.6817
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Onchocerca volvulus		0.0048	0.072	0.3634
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0109	0.171	0.2994
Plasmodium vivax	hypothetical protein, conserved	0.0117	0.1845	1
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0064	0.097	0.1698
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0043	0.064	0.0537
Brugia malayi	hypothetical protein	0.0011	0.0109	0.0192
Brugia malayi	Cell division protein kinase 2	0.0064	0.097	0.1712
Echinococcus multilocularis	cyclin dependent kinase 9	0.0064	0.097	0.1712
Loa Loa (eye worm)	glycosyl hydrolase family 18 protein	0.0011	0.0109	0.0191
Brugia malayi	SWIRM domain containing protein	0.0043	0.064	0.1131
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.0274	0.4404	1
Echinococcus multilocularis		0.0043	0.064	0.1131
Brugia malayi	Endochitinase	0.0083	0.1282	0.2264
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0274	0.4404	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	calcium activated potassium channel	0.0007	0.0043	0.0076
Loa Loa (eye worm)	chitin binding Peritrophin-A domain-containing protein	0.0009	0.0077	0.0134
Onchocerca volvulus	Putative endochitinase	0.0074	0.1137	0.5995
Echinococcus granulosus	transient receptor potential cation channel	0.0004	0.000000032858	0.000000058014
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.097	0.2004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0109	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0077	0.0134
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0109	0.171	0.2842
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.097	0.2004
Leishmania major	chitinase	0.0074	0.1137	0.1319
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Loa Loa (eye worm)	chitinase I	0.0074	0.1137	0.1991
Echinococcus granulosus	Hepatocellular carcinoma associated antigen 59	0.0117	0.1845	0.3258
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Mycobacterium tuberculosis	Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)	0.0179	0.2859	0.2565
Entamoeba histolytica	protein kinase, putative	0.0109	0.171	0.3728
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0043	0.064	0.1131
Schistosoma mansoni	hypothetical protein	0.0179	0.2859	0.5048
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Brugia malayi	amine oxidase, flavin-containing family protein	0.0043	0.064	0.1131
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Schistosoma mansoni	hypothetical protein	0.0117	0.1845	0.3258
Brugia malayi	Protein kinase domain containing protein	0.0109	0.171	0.3019
Mycobacterium ulcerans	monoamine oxidase	0.0043	0.064	0.0537
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0043	0.064	0.5
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0064	0.097	0.1712
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.097	0.1712
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0043	0.064	0.1131
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Giardia lamblia	Kinase, CMGC DYRK	0.0274	0.4404	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus multilocularis	dual specificity	0.0109	0.171	0.3019
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0064	0.097	0.1712
Schistosoma mansoni	chitinase	0.0011	0.0109	0.0192
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Trichomonas vaginalis	G protein-coupled receptor kinase, putative	0.0064	0.097	0.2004
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Entamoeba histolytica	hypothetical protein	0.0061	0.0922	0.1893
Echinococcus granulosus	NADH dehydrogenase subunit 1	0.0179	0.2859	0.5048
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0043	0.064	0.5
Mycobacterium ulcerans	chitinase/cellulase	0.0063	0.0959	0.086
Echinococcus granulosus	calcium activated potassium channel	0.0007	0.0043	0.0076
Trichomonas vaginalis	CMGC family protein kinase	0.0274	0.4404	1
Trichomonas vaginalis	serine/threonine kinase, putative	0.0064	0.097	0.2004
Onchocerca volvulus		0.0048	0.072	0.3634
Brugia malayi	Endochitinase	0.0011	0.0109	0.0192
Loa Loa (eye worm)	NADH dehydrogenase subunit 1	0.0048	0.072	0.126
Brugia malayi	Chitin binding Peritrophin-A domain containing protein	0.0009	0.0077	0.0136
Brugia malayi	Glycosyl hydrolases family 18 protein	0.0011	0.0109	0.0192
Onchocerca volvulus	Putative endochitinase	0.0074	0.1137	0.5995
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0043	0.064	0.1131
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0617	1	1
Echinococcus granulosus	cyclin dependent kinase 9	0.0064	0.097	0.1712
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Echinococcus granulosus	dual specificity	0.0274	0.4404	0.7776
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0573	0.9291	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.064	0.1121
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.097	0.2004
Loa Loa (eye worm)	haspin protein kinase	0.0354	0.5711	1
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0064	0.097	0.1712
Brugia malayi	GSG2	0.0351	0.5664	1
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.0274	0.4404	1
Toxoplasma gondii	hypothetical protein	0.0117	0.1845	0.3201
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.097	0.2004
Wolbachia endosymbiont of Brugia malayi	NADH dehydrogenase subunit H	0.0179	0.2859	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Mycobacterium ulcerans	dehydrogenase	0.0043	0.064	0.0537
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004
Entamoeba histolytica	protein kinase, putative	0.0274	0.4404	1
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0064	0.097	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0959	0.168
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.097	0.2004

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5	Inhibition of Bos taurus (bovine) heart submitochondrial particle NDH1 assessed as NADH-DB reductase activity	ChEMBL.	8573592

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2273100

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1806970