Detailed information for compound 1809665

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 459.577 | Formula: C29H33NO4
  • H donors: 2 H acceptors: 3 LogP: 4.04 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](CN1CCC(CC1)(O)c1ccccc1)COc1ccccc1C(=O)CCc1ccccc1
  • InChi: 1S/C29H33NO4/c31-25(21-30-19-17-29(33,18-20-30)24-11-5-2-6-12-24)22-34-28-14-8-7-13-26(28)27(32)16-15-23-9-3-1-4-10-23/h1-14,25,31,33H,15-22H2/t25-/m1/s1
  • InChiKey: YQLGIKXRTZJNLK-RUZDIDTESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi photoreceptor-specific nuclear receptor 0.0333 0.3844 0.905
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0333 0.3844 0.8884
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0217 0.1945 0.5
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0326 0.3731 0.3401
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0326 0.3731 0.4651
Loa Loa (eye worm) hypothetical protein 0.0333 0.3844 0.905
Brugia malayi nuclear receptor RXR 0.0176 0.1285 0.0969
Echinococcus granulosus FTZ F1 alpha 0.0333 0.3844 0.3519
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0333 0.3844 0.3519
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0121 0.0395 0.1059
Brugia malayi hypothetical protein 0.0352 0.4145 1
Onchocerca volvulus Bile acid receptor homolog 0.0333 0.3844 0.8884
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0157 0.0979 0.0503
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0333 0.3844 0.4826
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0333 0.3844 0.905
Schistosoma mansoni nuclear hormone receptor 0.0157 0.0979 0.0382
Loa Loa (eye worm) hypothetical protein 0.0333 0.3844 0.905
Loa Loa (eye worm) hypothetical protein 0.0176 0.1285 0.0969
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0326 0.3731 1
Loa Loa (eye worm) steroid hormone receptor 0.0333 0.3844 0.905
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0333 0.3844 0.905
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0176 0.1285 0.0826
Schistosoma mansoni thyroid hormone receptor 0.0333 0.3844 0.4826
Schistosoma mansoni nuclear receptor 0.0157 0.0979 0.0382
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0333 0.3844 0.905
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0121 0.0395 0.1059
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0176 0.1285 0.0826
Echinococcus multilocularis nuclear receptor nhr 48 0.0157 0.0979 0.0503
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0333 0.3844 0.905
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0333 0.3844 0.905
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0157 0.0979 0.0503
Loa Loa (eye worm) hypothetical protein 0.0176 0.1285 0.0969
Echinococcus multilocularis ecdysone induced protein 78C 0.0333 0.3844 0.3519
Schistosoma mansoni retinoic acid receptor RXR 0.0333 0.3844 0.4826
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0326 0.3731 1
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0326 0.3731 0.3401
Schistosoma mansoni thyroid hormone receptor 0.0333 0.3844 0.4826
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0333 0.3844 0.3519
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0157 0.0979 0.0503
Echinococcus multilocularis thyroid hormone receptor alpha 0.0333 0.3844 0.3519
Brugia malayi Steroid receptor seven-up type 2 0.0333 0.3844 0.905
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0176 0.1285 0.0858
Echinococcus multilocularis glutamate receptor NMDA 0.0411 0.51 0.4842
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0333 0.3844 0.4826
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0217 0.1945 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0333 0.3844 0.905
Brugia malayi nuclear hormone receptor 0.0333 0.3844 0.905
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0333 0.3844 0.905
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0333 0.3844 0.905
Brugia malayi hypothetical protein 0.0176 0.1285 0.0969
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0333 0.3844 0.905
Brugia malayi Nuclear hormone receptor-like 1 0.0176 0.1285 0.0969
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0333 0.3844 0.905
Toxoplasma gondii fructose-bisphospatase I 0.0121 0.0395 0.1059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0333 0.3844 0.3519
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0121 0.0395 0.1059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0333 0.3844 0.4826
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0333 0.3844 0.3519
Loa Loa (eye worm) hypothetical protein 0.0176 0.1285 0.0969
Onchocerca volvulus 0.0352 0.4145 0.9818
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0217 0.1945 0.5
Echinococcus granulosus glutamate NMDA receptor subunit 0.0142 0.0732 0.0244
Loa Loa (eye worm) hypothetical protein 0.0352 0.4145 1
Echinococcus multilocularis nmda type glutamate receptor 0.0454 0.5805 0.5584
Schistosoma mansoni nuclear receptor nhr-48 0.0157 0.0979 0.0382
Onchocerca volvulus 0.0333 0.3844 0.8884
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0355 0.4203 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0157 0.0979 0.0503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0333 0.3844 0.905
Loa Loa (eye worm) hypothetical protein 0.0333 0.3844 0.905
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0333 0.3844 0.905
Giardia lamblia Telomerase catalytic subunit 0.0097 0 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0333 0.3844 0.3519
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0333 0.3844 0.4826
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0176 0.1285 0.0969
Schistosoma mansoni nuclear hormone receptor 0.0157 0.0979 0.0382
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0157 0.0979 0.0382
Loa Loa (eye worm) hypothetical protein 0.0333 0.3844 0.905
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0333 0.3844 0.4826
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0326 0.3731 1
Brugia malayi ecdysteroid receptor 0.0333 0.3844 0.905
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0333 0.3844 0.905
Loa Loa (eye worm) hypothetical protein 0.0333 0.3844 0.905
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0333 0.3844 0.905
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0176 0.1285 0.0858
Brugia malayi Telomerase reverse transcriptase 0.0258 0.2624 0.5197
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0333 0.3844 0.905
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0333 0.3844 0.905
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0157 0.0979 0.0503
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0333 0.3844 0.905
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0333 0.3844 0.3519
Schistosoma mansoni coup transcription factor 0.0333 0.3844 0.4826
Leishmania major 0.0326 0.3731 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0157 0.0979 0.0503
Loa Loa (eye worm) hypothetical protein 0.0176 0.1285 0.0969
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0333 0.3844 0.3519
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0333 0.3844 0.905
Schistosoma mansoni nuclear hormone receptor 0.0333 0.3844 0.4826
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0333 0.3844 0.905
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0217 0.1945 0.5
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0217 0.1945 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0333 0.3844 0.3519
Echinococcus granulosus ecdysone induced protein 78C 0.0333 0.3844 0.3519
Brugia malayi Nuclear hormone receptor-like 1 0.0176 0.1285 0.0969
Echinococcus granulosus Nuclear hormone receptor HR96 0.0157 0.0979 0.0503
Schistosoma mansoni zinc finger protein 0.0157 0.0979 0.0382
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0333 0.3844 0.3519
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0333 0.3844 0.3519
Echinococcus granulosus thyroid hormone receptor alpha 0.0157 0.0979 0.0503
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0333 0.3844 0.905
Loa Loa (eye worm) hypothetical protein 0.0333 0.3844 0.905
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0333 0.3844 0.3519
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0333 0.3844 0.3519
Brugia malayi hypothetical protein 0.0176 0.1285 0.0969
Brugia malayi steroid hormone receptor 0.0333 0.3844 0.905
Brugia malayi fructose-1,6-bisphosphatase 0.0326 0.3731 0.8693
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0326 0.3731 0.8693
Plasmodium falciparum telomerase reverse transcriptase 0.0097 0 0.5
Echinococcus granulosus nuclear receptor nhr 48 0.0157 0.0979 0.0503
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0333 0.3844 0.4826
Brugia malayi nuclear receptor NHR-88 0.0333 0.3844 0.905
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0301 0.332 0.2968
Schistosoma mansoni nuclear receptor 0.0157 0.0979 0.0382
Onchocerca volvulus Protein ultraspiracle homolog 0.0333 0.3844 0.8884
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0157 0.0979 0.0503
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0333 0.3844 0.3519
Chlamydia trachomatis glutamine binding protein 0.0217 0.1945 0.5
Loa Loa (eye worm) hypothetical protein 0.0333 0.3844 0.905
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0333 0.3844 0.3519
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0157 0.0979 0.0503
Loa Loa (eye worm) hypothetical protein 0.0333 0.3844 0.905
Loa Loa (eye worm) hypothetical protein 0.0176 0.1285 0.0969
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0142 0.0732 0.0244
Echinococcus granulosus nmda type glutamate receptor 0.0454 0.5805 0.5584
Echinococcus granulosus glutamate receptor NMDA 0.0411 0.51 0.4842
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0121 0.0395 0.1059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0333 0.3844 0.905
Echinococcus multilocularis nmda type glutamate receptor 0.0712 1 1
Toxoplasma gondii fructose-bisphospatase II 0.0326 0.3731 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.0097 0 0.5
Schistosoma mansoni glutamate receptor NMDA 0.0538 0.718 1
Schistosoma mansoni RAR-like nuclear receptor 0.0333 0.3844 0.4826
Schistosoma mansoni steroid hormone receptor ad4bp 0.0333 0.3844 0.4826
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0157 0.0979 0.0382

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 7.24 SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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