Detailed information for compound 1810673

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.428 | Formula: C21H25NO3
  • H donors: 1 H acceptors: 2 LogP: 3.5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](CN1CCCCC1)COc1cccc(c1)C(=O)c1ccccc1
  • InChi: 1S/C21H25NO3/c23-19(15-22-12-5-2-6-13-22)16-25-20-11-7-10-18(14-20)21(24)17-8-3-1-4-9-17/h1,3-4,7-11,14,19,23H,2,5-6,12-13,15-16H2/t19-/m1/s1
  • InChiKey: MPTXJQOIMPAXMB-LJQANCHMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ATP binding cassette sub family B 0.0004 0.0156 0.0156
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.0004 0.0156 0.0156
Brugia malayi ABC transporter transmembrane region family protein 0.0004 0.0156 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.001 0.7365 0.7365
Schistosoma mansoni multidrug resistance protein 0.0004 0.0156 0.0156
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0013 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0004 0.0156 0.0156
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0.0156 0.5
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0004 0.0156 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 1 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.9844 0.9844
Schistosoma mansoni multidrug resistance protein 0.0004 0.0156 0.0156
Brugia malayi ABC transporter family protein 0.0004 0.0156 0.0156
Entamoeba histolytica P-glycoprotein 6, putative 0.0004 0.0156 0.0156
Giardia lamblia Multidrug resistance-associated protein 1 0.0004 0.0156 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0004 0.0156 0.0156
Brugia malayi ABC transporter family protein 0.0004 0.0156 0.0156
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 1 1
Entamoeba histolytica P-glycoprotein-5 0.0013 1 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.001 0.7365 0.7323
Plasmodium vivax hypothetical protein, conserved 0.001 0.7365 0.7323
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 1 1
Echinococcus granulosus SWI:SNF matrix associated 0.001 0.7365 0.7365
Echinococcus granulosus Upstream activation factor subunit UAF30 0.001 0.7365 0.7365
Loa Loa (eye worm) hypothetical protein 0.0004 0.0156 0.0156
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0.0156 0.5
Echinococcus granulosus multidrug resistance associated protein 7 0.0004 0.0156 0.0156
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0009 0.5674 0.5674
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0.0156 0.5
Trichomonas vaginalis ABC transporter, putative 0.0013 1 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.9844 0.9841
Giardia lamblia Multidrug resistance-associated protein 1 0.0004 0.0156 1
Loa Loa (eye worm) brahma associated protein 0.001 0.7365 0.7365
Brugia malayi brahma associated protein 60 kDa 0.001 0.7365 0.7365
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 1 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0004 0.0156 0.0156
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 1 1
Schistosoma mansoni hypothetical protein 0.001 0.7365 0.7365
Trypanosoma brucei p-glycoprotein 0.0004 0.0156 0.5
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0004 0.0156 0.5
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0004 0.0156 0.5
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.001 0.7365 0.7323
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0004 0.0156 0.5
Schistosoma mansoni multidrug resistance protein 0.0004 0.0156 0.0156
Brugia malayi ABC transporter family protein 0.0013 1 1
Entamoeba histolytica P-glycoprotein 6, putative 0.0004 0.0156 0.0156
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 1 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 1 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.001 0.7365 0.7323
Loa Loa (eye worm) hypothetical protein 0.0013 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 1 1
Giardia lamblia MRP-like ABC transporter 0.0004 0.0156 1
Echinococcus granulosus multidrug resistance associated protein 1 0.0004 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0013 1 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0004 0.0156 0.5
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 1 1
Trichomonas vaginalis ABC transporter, putative 0.0013 1 1
Entamoeba histolytica hypothetical protein 0.0004 0.0156 0.0156
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.001 0.7365 0.7323
Trichomonas vaginalis ABC transporter, putative 0.0013 1 1
Trypanosoma brucei multidrug resistance protein E 0.0004 0.0156 0.5
Entamoeba histolytica ATP-binding cassette protein, putative 0.0004 0.0156 0.0156
Schistosoma mansoni multidrug resistance protein 0.0013 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.5674 0.5674
Echinococcus multilocularis multidrug resistance protein 1 0.0009 0.5674 0.5606
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 1 1
Schistosoma mansoni multidrug resistance protein 0.0004 0.0156 0.0156
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 1 1
Entamoeba histolytica multidrug resistance protein, putative 0.0004 0.0156 0.0156
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0004 0.0156 0.5
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 1 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 1 1
Schistosoma mansoni multidrug resistance protein 0.0013 1 1
Brugia malayi P-glycoprotein-like protein 0.0004 0.0156 0.0156
Entamoeba histolytica P-glyco protein 6, putative 0.0013 1 1
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0004 0.0156 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 1 1
Brugia malayi brahma associated protein 60 kDa 0.001 0.7365 0.7365
Leishmania major p-glycoprotein 0.0013 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 1 1
Entamoeba histolytica P-glycoprotein-1 0.0013 1 1
Giardia lamblia ABC transporter, putative 0.0004 0.0156 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0013 1 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0004 0.0156 0.5
Trichomonas vaginalis ABC transporter, putative 0.0013 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 1 1
Loa Loa (eye worm) ABC transporter 0.0004 0.0156 0.0156
Entamoeba histolytica ABC transporter, putative 0.0004 0.0156 0.0156
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 1 1
Loa Loa (eye worm) hypothetical protein 0.0004 0.0156 0.0156
Trichomonas vaginalis abcb9, putative 0.0013 1 1
Schistosoma mansoni smdr2 0.0013 1 1
Trichomonas vaginalis abcb9, putative 0.0013 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0013 1 1
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0004 0.0156 0.0156
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0004 0.0156 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 1 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0013 1 1
Entamoeba histolytica P-glycoprotein-2 0.0013 1 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.001 0.7365 0.7323
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0013 1 1
Schistosoma mansoni multidrug resistance protein 0.0013 1 1
Echinococcus multilocularis SWI:SNF matrix associated 0.001 0.7365 0.7323
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0013 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0009 0.5674 0.5674
Trichomonas vaginalis taga, putative 0.0013 1 1
Entamoeba histolytica P-glycoprotein-2 0.0013 1 1
Schistosoma mansoni brg-1 associated factor 0.001 0.7365 0.7365
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 1 1
Trichomonas vaginalis abcb9, putative 0.0013 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 1 1
Onchocerca volvulus 0.0013 1 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.001 0.7365 0.7365
Plasmodium falciparum multidrug resistance protein 1 0.0013 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 1 1
Brugia malayi ABC transporter 0.0004 0.0156 0.0156
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0004 0.0156 0.5
Brugia malayi hypothetical protein 0.0004 0.0156 0.0156
Schistosoma mansoni smdr1 0.0004 0.0156 0.0156
Brugia malayi SWIB/MDM2 domain containing protein 0.001 0.7365 0.7365
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0004 0.0156 0.0156
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0004 0.0156 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.9844 0.9844
Brugia malayi multidrug resistance related protein 1 0.0004 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0004 0.0156 0.0156
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.001 0.7365 0.7323
Echinococcus multilocularis SWI:SNF matrix associated 0.001 0.7365 0.7323
Schistosoma mansoni hypothetical protein 0.001 0.7365 0.7365
Echinococcus multilocularis SWI:SNF matrix associated 0.001 0.7365 0.7323
Trypanosoma cruzi multidrug resistance protein E, putative 0.0004 0.0156 0.5
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0013 1 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0004 0.0156 0.0156
Brugia malayi ABC transporter family protein 0.0004 0.0156 0.0156
Loa Loa (eye worm) ABC transporter 0.0004 0.0156 0.0156
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0004 0.0156 0.5
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0004 0.0156 0.5
Brugia malayi ABC transporter transmembrane region family protein 0.0004 0.0156 0.0156
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0004 0.0156 0.0156
Schistosoma mansoni multidrug resistance protein 0.0004 0.0156 0.0156
Echinococcus granulosus multidrug resistance protein 1 0.0013 1 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0004 0.0156 0.5
Schistosoma mansoni hypothetical protein 0.001 0.7365 0.7365
Loa Loa (eye worm) ABC transporter 0.0004 0.0156 0.0156
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0013 1 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0013 1 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 5.45 SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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