Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.0964 | 0.0964 |
Schistosoma mansoni | nephrin | 0.0147 | 0.0012 | 0.0012 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0332 | 0.0964 | 0.0964 |
Echinococcus granulosus | twitchin | 0.0147 | 0.0012 | 0.0012 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0278 | 0.0689 | 0.0689 |
Schistosoma mansoni | tyrosine kinase | 0.017 | 0.0128 | 0.0128 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0332 | 0.0964 | 0.0954 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0332 | 0.0964 | 0.0954 |
Schistosoma mansoni | tyrosine kinase | 0.0509 | 0.1881 | 0.1881 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0509 | 0.1881 | 0.1881 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.0964 | 0.0964 |
Schistosoma mansoni | tyrosine kinase | 0.0266 | 0.0624 | 0.0624 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.1775 | 0.8409 | 0.8388 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0509 | 0.1881 | 0.1776 |
Echinococcus multilocularis | insulin receptor | 0.017 | 0.0128 | 0.0117 |
Brugia malayi | leucyl aminopeptidase | 0.0332 | 0.0964 | 0.0847 |
Schistosoma mansoni | tyrosine kinase | 0.0278 | 0.0689 | 0.0689 |
Echinococcus granulosus | roundabout 2 | 0.0182 | 0.0195 | 0.0195 |
Schistosoma mansoni | tyrosine kinase | 0.0266 | 0.0624 | 0.0624 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0195 | 0.0195 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0343 | 0.1023 | 0.1012 |
Brugia malayi | FXNA | 0.0332 | 0.0964 | 0.0847 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0509 | 0.1881 | 0.1872 |
Echinococcus granulosus | insulin receptor | 0.017 | 0.0128 | 0.0128 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0332 | 0.0964 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.0964 | 0.0964 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.2084 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0332 | 0.0964 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0278 | 0.0689 | 0.0689 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0332 | 0.0964 | 0.0964 |
Schistosoma mansoni | tyrosine kinase | 0.0343 | 0.1023 | 0.1023 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0332 | 0.0964 | 0.0964 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0332 | 0.0964 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0332 | 0.0964 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.017 | 0.0128 | 0.0128 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0332 | 0.0964 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0332 | 0.0964 | 0.5 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0343 | 0.1023 | 0.1023 |
Echinococcus multilocularis | 0.0155 | 0.0051 | 0.004 | |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0332 | 0.0964 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0509 | 0.1881 | 0.1881 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0332 | 0.0964 | 0.0964 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0343 | 0.1023 | 0.1023 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.1775 | 0.8409 | 0.8409 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0332 | 0.0964 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0332 | 0.0964 | 0.5 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0343 | 0.1023 | 0.1012 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0332 | 0.0964 | 0.0964 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0332 | 0.0964 | 0.0954 |
Leishmania major | hypothetical protein, conserved | 0.0332 | 0.0964 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0278 | 0.0689 | 0.0678 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.017 | 0.0128 | 0.0117 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.2084 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0182 | 0.0195 | 0.0184 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.2084 | 1 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.1668 | 0.7858 | 0.7629 |
Schistosoma mansoni | tyrosine kinase | 0.0278 | 0.0689 | 0.0689 |
Schistosoma mansoni | tyrosine kinase | 0.017 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | TK protein kinase | 0.0381 | 0.1218 | 0.1218 |
Onchocerca volvulus | 0.1618 | 0.7597 | 0.7341 | |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0332 | 0.0964 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0332 | 0.0964 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0381 | 0.1218 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.2084 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0332 | 0.0964 | 0.5 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0332 | 0.0964 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0195 | 0.0195 |
Schistosoma mansoni | nicalin (M28 family) | 0.0332 | 0.0964 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.0964 | 0.0964 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.017 | 0.0128 | 0.0128 |
Schistosoma mansoni | tyrosine kinase | 0.0266 | 0.0624 | 0.0624 |
Echinococcus granulosus | neuroglian | 0.0147 | 0.0012 | 0.0012 |
Brugia malayi | nicalin | 0.0332 | 0.0964 | 0.0847 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0332 | 0.0964 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0332 | 0.0964 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.2084 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Toxicity in Mus musculus Swiss albino (mouse) assessed as mortality at 500 to 2000 mg/kg, po measured after 14 days | ChEMBL. | No reference | |
Activity (ADMET) | Toxicity in Mus musculus Swiss albino (mouse) assessed as abnormal changes in eyes at 500 to 2000 mg/kg, po measured after 14 days | ChEMBL. | No reference | |
Activity (ADMET) | Toxicity in Mus musculus Swiss albino (mouse) assessed as abnormal changes in skin at 500 to 2000 mg/kg, po measured after 14 days | ChEMBL. | No reference | |
Activity (ADMET) | Toxicity in Mus musculus Swiss albino (mouse) assessed as abnormal changes in fur at 500 to 2000 mg/kg, po measured after 14 days | ChEMBL. | No reference | |
Activity (ADMET) | Toxicity in Mus musculus Swiss albino (mouse) assessed as changes in behavioral pattern at 500 to 2000 mg/kg, po measured after 14 days | ChEMBL. | No reference | |
Inhibition (functional) | = 56.5 % | Analgesic activity in Mus musculus Swiss albino (mouse) assessed as inhibition of acetic acid-induced writhing at 160 mg/kg, po administered 30 min prior challenge measured after 5 min of challenge for next 30 min relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.