Detailed information for compound 181294

Basic information

Technical information
  • TDR Targets ID: 181294
  • Name: 6-carbamimidoyl-N-(4-ethylphenyl)naphthalene- 2-carboxamide
  • MW: 317.384 | Formula: C20H19N3O
  • H donors: 2 H acceptors: 1 LogP: 3.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)NC(=O)c1ccc2c(c1)ccc(c2)C(=N)N
  • InChi: 1S/C20H19N3O/c1-2-13-3-9-18(10-4-13)23-20(24)17-8-6-14-11-16(19(21)22)7-5-15(14)12-17/h3-12H,2H2,1H3,(H3,21,22)(H,23,24)
  • InChiKey: SHHNTNYQWYJYKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-carbamimidoyl-N-(4-ethylphenyl)-2-naphthalenecarboxamide
  • 6-amidino-N-(4-ethylphenyl)-2-naphthamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens plasminogen Starlite/ChEMBL References
Homo sapiens protease, serine, 1 (trypsin 1) Starlite/ChEMBL References
Homo sapiens plasminogen activator, urokinase Starlite/ChEMBL References
Homo sapiens kallikrein B, plasma (Fletcher factor) 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Neospora caninum hypothetical protein Get druggable targets OG5_134971 All targets in OG5_134971
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Toxoplasma gondii PAN domain-containing protein Get druggable targets OG5_134971 All targets in OG5_134971
Toxoplasma gondii PAN domain-containing protein Get druggable targets OG5_134971 All targets in OG5_134971
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Trypsin family protein protease, serine, 1 (trypsin 1) 247 aa 287 aa 21.6 %
Echinococcus granulosus Mastin plasminogen activator, urokinase 414 aa 340 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PAN domain containing protein 0.004 0.0556 0.1886
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.001 0.0047 0.1742
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0237 0.0802
Onchocerca volvulus 0.004 0.0556 0.1537
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1419 0.8594
Onchocerca volvulus 0.004 0.0556 0.1537
Loa Loa (eye worm) PAN domain-containing protein 0.004 0.0556 0.1886
Loa Loa (eye worm) hypothetical protein 0.004 0.0556 0.1886
Onchocerca volvulus 0.0013 0.0102 0.0166
Brugia malayi TAR-binding protein 0.0087 0.134 0.4559
Schistosoma mansoni hypothetical protein 0.0015 0.0129 0.0112
Echinococcus multilocularis musashi 0.0013 0.0102 0.0084
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1419 0.1405
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0021 0.0237 0.0802
Echinococcus multilocularis lysine specific demethylase 5A 0.0029 0.0374 0.0358
Brugia malayi hypothetical protein 0.0017 0.0178 0.0599
Echinococcus multilocularis citrate lyase subunit beta protein 0.0012 0.009 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0048 0.0156
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1419 0.4067
Onchocerca volvulus 0.0127 0.2009 0.5924
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0048 0.0156
Trypanosoma brucei polo-like protein kinase 0.0092 0.1419 0.8594
Loa Loa (eye worm) hypothetical protein 0.004 0.0556 0.1886
Toxoplasma gondii microneme protein MIC17B 0.004 0.0556 0.0884
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0048 0.0156
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0019 0.0209 0.2218
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0012 0.009 0.0447
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0029 0.0374 0.0358
Loa Loa (eye worm) hypothetical protein 0.004 0.0556 0.1886
Toxoplasma gondii LsmAD domain-containing protein 0.0012 0.0088 0.0115
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0237 0.022
Schistosoma mansoni thyroid hormone receptor 0.001 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0556 0.1886
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0048 0.0031
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0237 0.022
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0156
Toxoplasma gondii PAN domain-containing protein 0.004 0.0556 0.0884
Schistosoma mansoni tar DNA-binding protein 0.0087 0.134 0.1325
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0237 0.022
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0012 0.009 0.0447
Toxoplasma gondii microneme protein MIC17A 0.004 0.0556 0.0884
Toxoplasma gondii PAN domain-containing protein 0.0373 0.6106 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0012 0.0088 0.0887
Brugia malayi PAN domain containing protein 0.004 0.0556 0.1886
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0921 0.5537
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0012 0.009 0.0447
Schistosoma mansoni tar DNA-binding protein 0.0087 0.134 0.1325
Brugia malayi Protein kinase domain containing protein 0.0062 0.0921 0.3129
Loa Loa (eye worm) hypothetical protein 0.0008 0.0017 0.0052
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0048 0.0031
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0048 0.0156
Brugia malayi PAN domain containing protein 0.004 0.0556 0.1886
Entamoeba histolytica hypothetical protein 0.0015 0.0129 0.06
Mycobacterium ulcerans hypothetical protein 0.0021 0.0237 1
Mycobacterium ulcerans hypothetical protein 0.0012 0.009 0.3631
Leishmania major hypothetical protein, conserved 0.0012 0.0088 0.0431
Schistosoma mansoni nuclear hormone receptor 0.001 0.0048 0.0031
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0048 0.0031
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0029 0.0374 0.0358
Brugia malayi jmjC domain containing protein 0.0008 0.0017 0.0052
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0015
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0048 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0047 0.018
Schistosoma mansoni kinase 0.0047 0.0666 0.065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0048 0.0156
Toxoplasma gondii PAN domain-containing protein 0.004 0.0556 0.0884
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0015 0.0129 0.0112
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.001 0.0047 0.5173
Onchocerca volvulus 0.004 0.0556 0.1537
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0012 0.009 0.3631
Brugia malayi Kringle domain containing protein 0.0062 0.0921 0.3129
Loa Loa (eye worm) PAN domain-containing protein 0.004 0.0556 0.1886
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0048 0.0031
Brugia malayi Intermediate filament tail domain containing protein 0.0013 0.0102 0.0339
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0152
Giardia lamblia Kinase, PLK 0.0092 0.1419 0.5
Schistosoma mansoni thyroid hormone receptor 0.001 0.0048 0.0031
Schistosoma mansoni hypothetical protein 0.0062 0.0921 0.0905
Onchocerca volvulus 0.0106 0.1659 0.4867
Onchocerca volvulus 0.0021 0.0237 0.0576
Onchocerca volvulus 0.004 0.0556 0.1537
Brugia malayi hypothetical protein 0.0017 0.0178 0.0599
Loa Loa (eye worm) jmjC domain-containing protein 0.0008 0.0017 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0156
Toxoplasma gondii subtilisin SUB12 0.004 0.0556 0.0884
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1419 0.4067
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1419 0.4067
Echinococcus multilocularis tissue type plasminogen activator 0.0062 0.0921 0.0905
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0048 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0237 0.0802
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0048 0.0156
Brugia malayi PAN domain containing protein 0.004 0.0556 0.1886
Echinococcus multilocularis Mastin 0.0021 0.0237 0.022
Brugia malayi hypothetical protein 0.0008 0.0017 0.0049
Echinococcus multilocularis lamin 0.0013 0.0102 0.0084
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0237 0.022
Loa Loa (eye worm) trypsin family protein 0.0021 0.0237 0.0802
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.0309 0.0292
Loa Loa (eye worm) hypothetical protein 0.0127 0.2009 0.6836
Echinococcus multilocularis geminin 0.0084 0.129 0.1275
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0325 0.0308
Brugia malayi Pre-SET motif family protein 0.0026 0.0325 0.11
Trichomonas vaginalis set domain proteins, putative 0.0208 0.3359 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0156
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0007 0.0006 0.5
Toxoplasma gondii hypothetical protein 0.004 0.0556 0.0884
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0048 0.0031
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0048 0.0031
Onchocerca volvulus 0.0021 0.0237 0.0576
Echinococcus granulosus neuropeptide s receptor 0.0187 0.2993 0.2981
Toxoplasma gondii PAN domain-containing protein 0.004 0.0556 0.0884
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0021 0.0237 0.022
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0237 0.022
Schistosoma mansoni hypothetical protein 0.0021 0.0237 0.022
Plasmodium falciparum cysteine repeat modular protein 1 0.0062 0.0921 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0048 0.0156
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.001 0.0047 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0048 0.0004
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0021 0.0237 0.022
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0048 0.0156
Brugia malayi intermediate filament protein 0.0013 0.0102 0.0339
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0019 0.0209 0.0706
Loa Loa (eye worm) PAN domain-containing protein 0.004 0.0556 0.1886
Entamoeba histolytica hypothetical protein 0.0015 0.0129 0.06
Plasmodium vivax JmjC domain containing protein 0.0008 0.0017 0.0119
Loa Loa (eye worm) hypothetical protein 0.0013 0.0102 0.0339
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0047 0.018
Echinococcus granulosus enteropeptidase 0.0021 0.0237 0.022
Brugia malayi AMP-binding enzyme family protein 0.001 0.0047 0.0152
Trypanosoma cruzi PAB1-binding protein , putative 0.0012 0.0088 0.0431
Brugia malayi ecdysteroid receptor 0.001 0.0048 0.0156
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0047 0.1742
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0048 0.0031
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0325 0.0308
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0047 0.5173
Echinococcus granulosus tissue type plasminogen activator 0.0062 0.0921 0.0905
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0012 0.009 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0183 0.2937 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0152
Brugia malayi PAN domain containing protein 0.004 0.0556 0.1886
Echinococcus granulosus transmembrane protease serine 3 0.0021 0.0237 0.022
Brugia malayi nuclear receptor NHR-88 0.001 0.0048 0.0156
Schistosoma mansoni microtubule-associated protein tau 0.0607 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0048 0.0031
Brugia malayi jmjC domain containing protein 0.0029 0.0374 0.1268
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0048 0.0031
Toxoplasma gondii kringle domain-containing protein 0.0062 0.0921 0.1484
Echinococcus granulosus Mastin 0.0021 0.0237 0.022
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0237 0.022
Loa Loa (eye worm) TAR-binding protein 0.0087 0.134 0.4559
Brugia malayi Trypsin family protein 0.0127 0.2009 0.6836
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0156
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0012 0.009 0.3631
Schistosoma mansoni lamin 0.0013 0.0102 0.0084
Loa Loa (eye worm) hypothetical protein 0.0008 0.0017 0.0052
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0237 0.022
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0156
Onchocerca volvulus 0.004 0.0556 0.1537
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0646 0.17
Onchocerca volvulus 0.004 0.0556 0.1537
Schistosoma mansoni tar DNA-binding protein 0.0087 0.134 0.1325
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0325 0.0308
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0127 0.2009 0.1995
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0237 0.022
Loa Loa (eye worm) hypothetical protein 0.0026 0.0325 0.11
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0048 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0048 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0048 0.0156
Brugia malayi RNA binding protein 0.0087 0.134 0.4559
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0021 0.0237 0.022
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1419 0.4145
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0047 0.1742
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0048 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0048 0.0156
Toxoplasma gondii 1,3(4)-beta-glucanase 0.004 0.0556 0.0884
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0237 0.022
Echinococcus granulosus intermediate filament protein 0.0013 0.0102 0.0084
Loa Loa (eye worm) hypothetical protein 0.0127 0.2009 0.6836
Loa Loa (eye worm) hypothetical protein 0.0019 0.0209 0.0706
Brugia malayi jmjC domain containing protein 0.0008 0.0017 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1419 0.4067
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0048 0.0031
Brugia malayi Pre-SET motif family protein 0.0183 0.2937 1
Echinococcus granulosus glycoprotein Antigen 5 0.0021 0.0237 0.022
Brugia malayi jmjC domain containing protein 0.0029 0.0374 0.1268
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0156
Toxoplasma gondii microneme protein, putative 0.004 0.0556 0.0884
Brugia malayi Trypsin family protein 0.0021 0.0237 0.0802
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0048 0.0156
Brugia malayi steroid hormone receptor 0.001 0.0048 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0048 0.0156
Loa Loa (eye worm) hypothetical protein 0.0013 0.0098 0.0325
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0156
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0015
Echinococcus multilocularis neuropeptide s receptor 0.0187 0.2993 0.2981
Mycobacterium ulcerans fatty-acid-CoA ligase 0.001 0.0047 0.1742
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1649 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0008 0.0017 0.0052
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0048 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0325 0.0308
Echinococcus granulosus FTZ F1 alpha 0.001 0.0048 0.0031
Entamoeba histolytica hypothetical protein 0.0015 0.0129 0.06
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0237 0.022
Brugia malayi nuclear hormone receptor 0.001 0.0048 0.0156
Toxoplasma gondii microneme protein MIC4 0.004 0.0556 0.0884
Echinococcus granulosus lamin dm0 0.0013 0.0102 0.0084
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0325 0.0505
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0019 0.0209 0.2218
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0048 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.1649 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0237 0.022
Onchocerca volvulus 0.004 0.0556 0.1537
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0237 0.022
Loa Loa (eye worm) PAN domain-containing protein 0.004 0.0556 0.1886
Schistosoma mansoni tar DNA-binding protein 0.0087 0.134 0.1325
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0048 0.0031
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0048 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0325 0.0308
Brugia malayi PAN domain containing protein 0.004 0.0556 0.1886
Brugia malayi hypothetical protein 0.0012 0.0088 0.0291
Schistosoma mansoni tar DNA-binding protein 0.0087 0.134 0.1325
Echinococcus multilocularis enteropeptidase 0.0021 0.0237 0.022
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1419 0.8594
Loa Loa (eye worm) TK/ROR protein kinase 0.0062 0.0921 0.3129
Brugia malayi jmjC domain containing protein 0.0008 0.0017 0.0052
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0127 0.2009 0.1995
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0374 0.0358
Echinococcus granulosus lysine specific demethylase 5A 0.0029 0.0374 0.0358
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1419 1
Echinococcus multilocularis tar DNA binding protein 0.0087 0.134 0.1325
Loa Loa (eye worm) jmjC domain-containing protein 0.0008 0.0017 0.0052
Entamoeba histolytica hypothetical protein 0.0015 0.0129 0.06
Loa Loa (eye worm) hypothetical protein 0.0012 0.0088 0.0291
Schistosoma mansoni transcription factor LCR-F1 0.0015 0.0129 0.0112
Onchocerca volvulus 0.001 0.0048 0.0004
Echinococcus multilocularis microtubule associated protein 2 0.0607 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0048 0.0156
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0556 0.1886
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0048 0.0031
Toxoplasma gondii PAN domain-containing protein 0.0373 0.6106 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0008 0.0017 0.0119
Onchocerca volvulus 0.0208 0.3359 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0048 0.0031
Trypanosoma brucei PAB1-binding protein , putative 0.0012 0.0088 0.0431
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0374 0.0358
Echinococcus granulosus tar DNA binding protein 0.0087 0.134 0.1325
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0048 0.0156
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0048 0.0031
Echinococcus granulosus geminin 0.0084 0.129 0.1275
Mycobacterium tuberculosis Conserved protein 0.0012 0.009 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0021 0.0237 0.022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0237 0.0802
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0015 0.0129 0.0112
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1419 0.1405
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.001 0.0047 0.1742
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0019 0.0209 0.0706
Echinococcus multilocularis transmembrane protease serine 3 0.0021 0.0237 0.022
Brugia malayi RNA recognition motif domain containing protein 0.0087 0.134 0.4559
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0374 0.1268
Toxoplasma gondii microneme protein MIC17C 0.004 0.0556 0.0884
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0237 0.022
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0048 0.0004
Schistosoma mansoni hypothetical protein 0.0084 0.129 0.1275
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0048 0.0156
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0325 0.0308
Onchocerca volvulus 0.0021 0.0237 0.0576
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0327 0.5333 0.5325
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0374 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0048 0.0156
Onchocerca volvulus 0.0021 0.0237 0.0576
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0646 0.17
Brugia malayi Trypsin family protein 0.0021 0.0237 0.0802
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0556 0.1886
Mycobacterium ulcerans hypothetical protein 0.0012 0.009 0.3631
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.1649 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0087 0.134 0.4559
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0325 0.0308
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0015
Schistosoma mansoni intermediate filament proteins 0.0013 0.0102 0.0084
Leishmania major hypothetical protein, conserved 0.0106 0.1649 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0048 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1419 0.4067
Brugia malayi Trypsin-like protease protein 5 0.0021 0.0237 0.0802
Brugia malayi Trypsin family protein 0.0021 0.0237 0.0802
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0237 0.022
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0156
Loa Loa (eye worm) RNA binding protein 0.0087 0.134 0.4559
Brugia malayi PAN domain containing protein 0.004 0.0556 0.1886
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.001 0.0047 0.5
Schistosoma mansoni hypothetical protein 0.0084 0.129 0.1275
Brugia malayi AMP-binding enzyme family protein 0.001 0.0047 0.0152
Plasmodium vivax SET domain protein, putative 0.0026 0.0325 0.3484
Loa Loa (eye worm) hypothetical protein 0.004 0.0556 0.1886
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0048 0.0156
Mycobacterium ulcerans hypothetical protein 0.001 0.0047 0.1742
Onchocerca volvulus 0.004 0.0556 0.1537
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1419 0.4829
Toxoplasma gondii PAN/Apple domain-containing protein 0.004 0.0556 0.0884
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0012 0.009 0.3631
Toxoplasma gondii hypothetical protein 0.004 0.0556 0.0884
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0013 0.0102 0.0339
Brugia malayi PAN domain containing protein 0.004 0.0556 0.1886
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0048 0.0156
Echinococcus granulosus lamin 0.0013 0.0102 0.0084
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0048 0.0031
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0048 0.0156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0237 0.0802
Plasmodium falciparum ataxin-2 like protein, putative 0.0012 0.0088 0.0887
Echinococcus granulosus citrate lyase subunit beta protein 0.0012 0.009 0.0073
Schistosoma mansoni coup transcription factor 0.001 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0237 0.0802
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.001 0.0047 0.1742
Leishmania major hypothetical protein, conserved 0.0062 0.0921 0.5537
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0015
Onchocerca volvulus 0.004 0.0556 0.1537
Toxoplasma gondii PAN domain-containing protein 0.004 0.0556 0.0884
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0007 0.0006 0.0719
Schistosoma mansoni lamin 0.0013 0.0102 0.0084
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0062 0.0921 1
Echinococcus granulosus neuropeptide receptor A26 0.0187 0.2993 0.2981
Echinococcus multilocularis lamin dm0 0.0013 0.0102 0.0084
Brugia malayi hypothetical protein 0.0015 0.0129 0.0432
Trypanosoma cruzi PAB1-binding protein , putative 0.0012 0.0088 0.0431
Loa Loa (eye worm) PAN domain-containing protein 0.004 0.0556 0.1886
Plasmodium vivax ataxin-2 like protein, putative 0.0012 0.0088 0.0887
Brugia malayi AMP-binding enzyme family protein 0.001 0.0047 0.0152
Schistosoma mansoni hypothetical protein 0.0019 0.0209 0.0192
Brugia malayi PAN domain containing protein 0.004 0.0556 0.1886
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0048 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1419 0.1405
Echinococcus multilocularis glycoprotein Antigen 5 0.0021 0.0237 0.022
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0047 0.1742
Onchocerca volvulus 0.0026 0.0325 0.084
Onchocerca volvulus 0.0021 0.0237 0.0576
Leishmania major 4-coumarate:coa ligase-like protein 0.001 0.0047 0.018
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0237 0.022
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1419 0.8594
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0237 0.022
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0019 0.0209 0.0192
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0048 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1419 0.4067
Loa Loa (eye worm) intermediate filament protein 0.0013 0.0102 0.0339
Loa Loa (eye worm) hypothetical protein 0.0008 0.0017 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1419 0.4067
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0019 0.0209 0.0315
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1419 0.4829
Onchocerca volvulus 0.004 0.0556 0.1537
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0019 0.0209 0.0706
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0015
Echinococcus multilocularis neuropeptide receptor A26 0.0187 0.2993 0.2981
Brugia malayi jmjC domain containing protein 0.0008 0.0017 0.0052
Onchocerca volvulus 0.0013 0.0102 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0048 0.0156
Onchocerca volvulus 0.0062 0.0921 0.2639
Brugia malayi hypothetical protein 0.0021 0.0237 0.0802
Brugia malayi PAN domain containing protein 0.004 0.0556 0.1886
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0237 0.022
Schistosoma mansoni hypothetical protein 0.0021 0.0237 0.022
Onchocerca volvulus 0.004 0.0556 0.1537
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0062 0.0921 0.3129
Loa Loa (eye worm) hypothetical protein 0.001 0.0047 0.0152

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 736 nM Binding affinity to human urokinase-type plasminogen activator (microPa). ChEMBL. 14711304
Ki (binding) = 736 nM Binding affinity to human urokinase-type plasminogen activator (microPa). ChEMBL. 14711304
Ki (binding) = 1320 nM Binding affinity against porcine trypsin was determined. ChEMBL. 14711304
Ki (binding) = 1320 nM Binding affinity against porcine trypsin was determined. ChEMBL. 14711304
Ki (binding) = 3870 nM Binding affinity towards human plasmin. ChEMBL. 14711304
Ki (binding) = 3870 nM Binding affinity towards human plasmin. ChEMBL. 14711304
Ki (binding) = 18100 nM Binding affinity against human plasma kallikrein. ChEMBL. 14711304
Ki (binding) = 18100 nM Binding affinity against human plasma kallikrein. ChEMBL. 14711304
Ki (binding) = 43700 nM Binding affinity against human alpha thrombin. ChEMBL. 14711304
Ki (binding) = 43700 nM Binding affinity against human alpha thrombin. ChEMBL. 14711304
Ki (binding) = 83900 nM Binding affinity towards human Tissue type plasminogen activator. ChEMBL. 14711304
Ki (binding) = 83900 nM Binding affinity towards human Tissue type plasminogen activator. ChEMBL. 14711304

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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